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Biofaal Journal
Published by Universitas Pattimura
ISSN : -     EISSN : 27234959     DOI : https://doi.org/10.30598/biofaal.v1i1y2020
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Materials Science & Nanotechnology Medicine & Pharmacology
Biofaal Journal merupakan jurnal online yang menerima dan mempublikasikan tulisan-tulisan ilmiah dalam bentuk artikel hasil penelitian terbaru, short communication, maupun review terhadap artikel dari bidang keilmuan Biologi, Faal Tumbuhan, Faal Hewan, Faal Manusia dan Faal Olahraga. Biofaal Journal diterbitkan oleh Profesi Ahli Ilmu Faal, Jurusan Biologi FMIPA Universitas Pattimura. Dalam setahun Biofaal Journal memiliki 1 volume dan 2 Issue. Dewan editor, berasal dari rumpun ilmu biologi dan fisiologi yang aktif dalam publikasi ilmiah skala nasional dan internasional, sehingga mampu melakukan proses review secara profesional. Artikel yang diterima akan diterbitkan sesuai dengan waktu yang ditentukan yaitu pada bulan Juni dan Desember, dan akan tersedia gratis bagi pembaca
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 97 Documents
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Evaluation of Physical and Organoleptic Characteristics of Rice Bran Fermented With 2% EM4 At Different Fermentation Durations Windiana Windiana; Mita Arifa Hakim; Rini Anggereini; M. Zahran Putra Risyada; Muh. Rezaldy Pratama J
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp10-17

Abstract

Rice bran is widely used as an animal feed ingredient due to its availability and relatively good nutrient content. Fermentation is commonly applied to improve its quality and stability. However, fermentation duration may influence the physical and organoleptic characteristics of the final product. This study aimed to evaluate the changes in physical and organoleptic characteristics (color, aroma, and texture) of rice bran fermented with 2% EM4 at different fermentation durations (2, 4, 6, 8, 10, and 12 days). This research employed a descriptive qualitative approach through direct visual and sensory observation. The observed parameters included color, aroma, and texture changes during the fermentation process. The results showed gradual and consistent changes over time. From day 4 to day 10, the rice bran exhibited a more homogeneous yellowish-brown color, a distinctive and stable fermented aroma, and a moist, smoother texture. On day 12, a slight decrease in moisture was observed, although the aroma and color remained stable. These findings indicate that fermentation duration influences the physical and organoleptic quality of rice bran, with day 8 to day 10 showing the most optimal characteristics. This study provides practical information regarding the appropriate fermentation duration to obtain physically stable and acceptable fermented rice bran as animal feed material
Determination of the Nutritional Profile of Rice Flour Subtituted with Moringa (Moringa oleifera) Leaf Flour as an Intermediate Product St Hartini Djalil; Irwan Irwan; Ariella Ramadhani Putri; Arfina Sukmawati Arifin; Noor Aliyah Haris
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp18-31

Abstract

Abstract Rice flour is a widely used as an intermediate ingredient in various processed food products; however, it has limitations in terms of protein and micronutrient ontent. The utilization of broken rice as a by-product of rice processing and the substitution of moringa leaf flour are expected to enhance the protein and micronutrient content of rice flour. This study aimed to evaluate the nutritional profile of rice flour substituted with moringa (Moringa oleifera) leaf flour as an intermediate product for functional food development. Substitution was conducted at moringa leaf flour concentrations of 0%, 5%, 10%, and 15% based on the total flour weight. Proximate analysis was performed to determine moisture, ash, protein, fat, carbohydrate, and dietary fiber contents. The results showed that increasing the proportion of moringa leaf flour significantly increased moisture, ash, fat, protein, and dietary fiber contents, while carbohydrate content decreased with higher levels of moringa leaf flour substitution. These findings indicate that rice flour substituted with moringa leaf flour has strong potential as a nutrient-enriched intermediate product and may support the development of locally based healthy food products. Further studies are recommended to evaluate the physicochemical, functional, and sensory characteristics of final products derived from this composite flour.
Screening of Antioxindant Activity of Fruit Peel and Stem Bark Extracts od Garcinis mangostana L Using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) Method La Eddy; Nunun Ainun Putri Sari Banun Kaliky
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp49-58

Abstract

Mangosteen stem bark and rind are known to contain various bioactive compounds such as xanthones, flavonoids, and polyphenols, which can function as antioxidants. To measure the level of antioxidant ability of stem bark and mangosteen fruit peel extracts, one method that is often used is the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. The purpose of this study was to determine the antioxidant activity of stem bark and fruit peel extracts of Garcinia mangostana L using the 2,2- Diphenyl-1-Picrylhydrazyl (DPPH) method. Samples of stem bark and fruit peel were extracted by maceration method after that followed by antioxidant activity testing with DPPH method. The results showed that the stem bark extract of G. mangostana L. had an LC50 value of 42,95 ppm, while the fruit peel extract showed a lower LC50 value of 12,13 ppm, indicating that both had very strong antioxidant activity. The content of bioactive compounds such as phenolics, flavonoids, and xanthones is the main cause of the high antioxidant activity, making G. mangostana L. stem bark and fruit peel extracts potential therapeutic agents in the prevention and treatment of oxidative stress-related diseases.
The Effectiveness of Stem Cell Therapy Compared to Conventional Therapy on Improving Pancreatic Beta Cell Function in Type 2 Diabetes Patients: A Systematic Review Maulana Setiawan; Made Ratan Saraswati; Agus Eka Darwinata
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp32-48

Abstract

More than 800 million people worldwide experience type 2 diabetes mellitus (T2DM), characterized by progressive pancreatic β-cell deterioration inadequately addressed by conventional treatments. This review assesses stem cell-based interventions versus standard therapy for β-cell functional restoration. Systematic review aims to comprehensively evaluate and compare the effectiveness of stem cell therapy versus conventional therapy in improving pancreatic β-cell function in type 2 diabetes patients. Systematic searches of PubMed, Cochrane Library, Web of Science, and Scopus from January 2015 to October 2025 retrieved 125 records. After duplicate removal and screening, 17 studies met the general inclusion criteria, of which six randomized controlled trials (RCTs) involving 339 participants were eligible for analysis. Primary outcomes were C-peptide concentrations, HOMA-β, HbA1c, insulin requirements, and safety parameters. The results showed that stem cell interventions consistently elevated fasting C-peptide levels to 1.9±1.0 ng/mL (versus 0.7±0.4 ng/mL in controls). Mean HbA1c reductions reached 0.67% (intervention 7.52±1.07% versus placebo 8.19±1.02%). Insulin dosage requirements decreased markedly, with reductions approaching 46.7%. Safety assessment remained limited due to incomplete adverse event documentation across included studies. Interpretation is further constrained by small trial sizes (23–91 participants) and protocol heterogeneity across cell sources, administration routes, and follow-up durations. Stem cell-based therapies demonstrate encouraging potential for enhancing pancreatic β-cell function in T2DM patients. Insufficient long-term follow-up data and inadequate safety surveillance preclude definitive clinical recommendations, supporting their application exclusively within structured clinical trial settings.
Population Structure Durian (Durio zibethinus L.) in Barito River Banks Sungai Gampa Village Barito Kuala Regency Muhammad Ilham Setiyawan; Dharmono Dharmono
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp70-77

Abstract

Study of population structure is important in determining the status of a plant. Durian (Durio zibethinus L.) is commonly used by the village community of Sungai Gampa as a boundary for rice fields, in addition to its fruit and seeds, which are edible. The study aims to describe the population structure of durian (Durio zibethinus L.) along the banks of the Barito river in the village of Sungai Gampa. This is a quantitative descriptive study using data collection using transcet techniques along the Barito river. The results show that the pyramid formed is a polygonal pyramid or a pyramid with a wide base, meaning that the population of young individuals is greater than that of adult individuals. In addition, durian is included in the "non-critical" category because there are 53.33 adult individuals per km2
Utilization of Lime Leaf (Citrus aurantilofia) Extract as an Eco-Friendly Alternative Strategy for the Management of Sitophilus zeamays Debby Dijola Moniharapon; Evelin Tuhumuri; Mechiavel Moniharapon; Cindri Tasane
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp78-89

Abstract

The maize weevil (Sitophilus zeamays) is a major postharvest pest that frequently damages stored grains, as evidenced by characteristic feeding perforations. The use of botanical insecticides represents an environmentally friendly alternative for pest management. One promising natural resource is lime leaf (Citrus aurantifolia). This study aimed to evaluate the effectiveness of lime leaf extract on the mortality of the maize weevil (Sitophilus zeamays). A laboratory-based experimental approach was employed using five dosage treatments (0 g as the control, 3 g, 8 g, 13 g, and 18 g), each replicated three times. Observations were conducted at 0, 12, 14, 16, and 18 hours after exposure. Data were analyzed using a two-way analysis of variance (two-way ANOVA) to simultaneously assess the effects of dosage and exposure time on pest mortality. The results indicated that lime leaf extract was effective as a botanical insecticide, with mortality rates increasing in proportion to both dosage and duration of exposure. The most effective treatment was 18 g, which resulted in the highest mortality rate of 98.34% after 18 hours. These findings suggest that lime leaf extract has strong potential for development as a botanical insecticide for sustainable and environmentally safe storage pest management.
Phytopharmaceutical Potential of Clove Tea Bags as an Antihyperuricemic Agent in a Hyperuricemic Rat Model Adrien Jems Akiles Unitly; Amos Killay; Maria Nindatu; Debby Dijola Moniharapon; Veince Benjamin Silahooy; Beatrix Belina Sikafir; Mechiavel Moniharapon; Theresia Natalia Seimahuira; Kezia Josawel Lesbatta; Eka Safitri Sillehu; La Eddy; Nia Doritha Laratmase
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp59-69

Abstract

High protein dietary patterns, particularly those rich in animal protein containing high purine levels, may lead to hyperuricemia characterized by elevated blood uric acid levels. This study aimed to evaluate the phytopharmaceutical activity of clove tea bags on changes in blood uric acid levels in hyperuricemic Rattus norvegicus rats. The study employed a completely randomized design consisting of five treatment groups with three replications. The groups included a negative control without potassium bromate induction or clove tea administration, a positive control induced with 29 g potassium bromate to establish a hyperuricemia model, and three treatment groups induced with hyperuricemia followed by clove tea administration at doses of 0.234 g/head/day, 0.351 g/head/day, and 0.468 g/head/day for 14 days. Data were analyzed to determine differences in blood uric acid levels among groups. The results demonstrated that clove tea administration reduced blood uric acid levels, with the most effective dose being 0.234 g/head/day. These findings suggest that clove tea has potential as a natural therapeutic agent for managing hyperuricemia and contributes to the development of plant-based functional interventions.

Page 10 of 10 | Total Record : 97

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