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Laury Marcia Ch. Huwae
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Jurusan Biologi - Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Pattimura Jl. Ir. M. Putuhena, Kampus Poka, Ambon, 97234, Maluku, Indonesia
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Biofaal Journal
Published by Universitas Pattimura
ISSN : -     EISSN : 27234959     DOI : https://doi.org/10.30598/biofaal.v1i1y2020
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Materials Science & Nanotechnology Medicine & Pharmacology
Biofaal Journal merupakan jurnal online yang menerima dan mempublikasikan tulisan-tulisan ilmiah dalam bentuk artikel hasil penelitian terbaru, short communication, maupun review terhadap artikel dari bidang keilmuan Biologi, Faal Tumbuhan, Faal Hewan, Faal Manusia dan Faal Olahraga. Biofaal Journal diterbitkan oleh Profesi Ahli Ilmu Faal, Jurusan Biologi FMIPA Universitas Pattimura. Dalam setahun Biofaal Journal memiliki 1 volume dan 2 Issue. Dewan editor, berasal dari rumpun ilmu biologi dan fisiologi yang aktif dalam publikasi ilmiah skala nasional dan internasional, sehingga mampu melakukan proses review secara profesional. Artikel yang diterima akan diterbitkan sesuai dengan waktu yang ditentukan yaitu pada bulan Juni dan Desember, dan akan tersedia gratis bagi pembaca
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 89 Documents
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Effectiveness of Acupressure on Improving Sleep Quality of The Elderly Jotlely, Hery; Herwawan, Joan Herly; Tasijawa, Fandro Armando; Nindatu, Maria
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp67-75

Abstract

Sleep disorders increase with age, with prevalence approaching 50% in the elderly (65 years and above). In Indonesia, about 30% of the elderly experience sleep disorders. Several studies have shown that older people who have poor sleep patterns or who experience sleep disorders are at risk of dementia, mental illness, including anxiety and depression, hypertension, and cardiovascular disease. Sleep disorders can be treated with medication, but it can cause side effects such as drowsiness, poor concentration, and dementia. These side effects contribute to the risk of falls, accidents, and cognitive impairment. So to avoid these effects, a non-pharmacological approach can be taken, one of which is acupressure. Acupressure is the application of finger or thumb pressure on acupoints. This study aims to determine the effectiveness of acupressure on sleep quality in the elderly. The research used quantitative methods with a quasi-experimental research design. This design has a comparison group (control) and an intervention/treatment group, but before being given treatment (intervention), a pretest and posttest are carried out. The number of samples in this study amounted to 96 respondents, with the sampling technique used being purposive sampling. 96 respondents will be divided into control groups and intervention groups. The statistical analysis method used is the Wilcoxon test. The difference in the quality of elderly sleep before and after applying acupressure in the intervention group with an average (mean) of 0.479. As for the control group, -0.021. It can be seen that in the control group, there was an increase in value after applying acupressure. The p-value of the intervention group is 0.001 (p <α), where it can be concluded that there is a real (significant) difference in the average improvement in the quality of elderly sleep as seen from the value of each assessment before and after acupressure is applied.
The Use of Marine Invertebrates As An Early Indicator of Marine Pollution in The Coastal Zone of Negeri Latu, West Seram Regency Tuhumury, Fiyogi Derandy Alfarego; Kaliky, Nunun Ainun Putri Sari Banun; Patty, Ahmad Ramdani; Rettob, Mujahiddin Permata Roman; Barcinta, Muhammad Fahrul; Sari, Anggun Permata
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp76-89

Abstract

The coastal area of Negeri Latu, West Seram Regency, possesses a relatively high marine biodiversity and is a vital natural resource for the local economy, particularly in fisheries. However, increasing human activities around the coastal zone, such as the disposal of domestic waste, garbage, and industrial effluents, have exerted significant pressure on the quality of the marine environment. This study examines the utilization of aquatic biota as early pollution indicators in the coastal area of Negeri Latu, West Seram Regency. This research employs a descriptive quantitative approach. The coastline of Negeri Latu spans approximately 900 meters, with nine transects established perpendicular to the shoreline, each spaced 100 meters apart. Ten observation plots (1×1 m) were placed alternately along each transect at 10-meter intervals. Marine biota were observed, quantified, and identified to determine their species. The analysis results indicate that the pollution status in these waters falls under the Moderately Polluted category. This classification reflects a significant disturbance to water quality, although it has not yet reached severe pollution. The decline in water quality is attributed to various anthropogenic factors, particularly the local population’s high volume of waste disposal into the sea. The waste includes both organic and inorganic materials, contributing to marine environmental degradation through physical (e.g., water turbidity and discoloration), chemical (e.g., pH changes, increased levels of heavy metals and toxic compounds), and biological (e.g., reduced diversity and abundance of marine organisms) means.
Phytochemical and Bioactivity Study of Sargassum duplicatum as a Candidate Natural Biolarvicide Compound Pattimura, Nadira; Pattimura, Nastain Abubakar
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp90-104

Abstract

Dengue hemorrhagic fever (DHF) is an endemic disease found in nearly all provinces of Indonesia. The occurrence of DHF is closely associated with climatic factors on spatial, temporal, and spatio-temporal scales. The search for new methods to eliminate the sources of dengue virus transmission is both urgent and essential. Sargassum duplicatum, a species of brown seaweed native to Indonesia, has been shown to possess potential antioxidant properties. This alga contains bioactive compounds, including steroids, alkaloids, phenols, flavonoids, saponins, and tannins, which are suspected to be toxic to insects. This study aimed to evaluate the larvicidal activity and determine the LC₅₀ and LC₉₀ values of ethanol extract from Sargassum duplicatum against the larvae of Aedes aegypti mosquitoes. A completely randomized design (CRD) was employed, consisting of five treatment groups with three replications each. A total of 300 third-instar Aedes aegypti larvae were introduced into treatment containers containing predetermined concentrations of Sargassum duplicatum ethanol extract, with each container holding 20 larvae. Observational data were analyzed using ANOVA and probit analysis. Phytochemical screening of the ethanol extract from Sargassum duplicatum confirmed the presence of flavonoids, saponins, tannins, and alkaloids. The extract demonstrated increased larval mortality in Aedes aegypti with increasing concentrations. A concentration of 75 ppm exhibited larvicidal efficacy comparable to that of 1% Abate. The LC₅₀ value of the ethanol extract was calculated to be 9.098 ppm, while the LC₉₀ value was 20.485 ppm.
Evaluation of Antibacterial Potential of Ethanol Extract from Kirinyuh (Chromolaena odorata L.) Leaves Against Salmonella typhi Hastuti, Nita; Surung, Emerensiana Surasma
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp105-113

Abstract

Kirinyuh leaves (Chromolaena odorata L.) are known to possess antibacterial activity against Salmonella typhi, the causative agent of typhoid fever. The leaves contain secondary metabolites such as flavonoids, saponins, tannins, and steroids, which contribute to their inhibitory effect on bacterial growth. This study evaluated the antibacterial efficacy of ethanol extract of C. odorata leaves at concentrations of 50%, 75%, and 100% using the Total Plate Count (TPC) method. Five treatment groups were tested: ciprofloxacin (positive control), distilled water (negative control), and kirinyuh extract at three concentrations. The results revealed five distinct statistical subsets, with significant differences observed between treatments in different subsets. Mean bacterial counts increased progressively from 24.7 in the positive control to 138.3 in the negative control. These findings demonstrate that ethanol extract of kirinyuh leaves effectively inhibits S. typhi growth, with the degree of inhibition varying according to extract concentration.
Phytotherapy for Diabetes: A Preclinical Study of Ethanol Extract of Winged Bean (Psophocarpus tetragonolobus L.) Leaves in Diabetic Rat (Rattus norvegicus) Models Moniharapon, Mechiavel; Tahapary, Patrcik Indurian; Kaihena, Martha; Eddy, La
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp125-140

Abstract

The long-term use of synthetic hypoglycemic agents is known to cause adverse side effects and induce drug resistance. Winged bean (Psophocarpus tetragonolobus L.), a traditional medicinal plant from Maluku, contains secondary metabolites such as flavonoids, saponins, and tannins, which are believed to have potential in lowering blood glucose levels. This study aimed to investigate the effect of ethanolic extract of winged bean leaves on blood glucose reduction and β-cell regeneration in the pancreas of white rats (Rattus norvegicus) as a diabetic model. Thirty rats weighing between 150–200 g were divided into five groups: Group I (negative control), Group II (positive control), and Groups III, IV, and V (diabetic rats treated with ethanolic extract of winged bean leaves at doses of 2.52 mg/g BW, 5.04 mg/g BW, and 7.56 mg/g BW, respectively). Streptozotocin (STZ) was administered to Groups II–V to induce diabetes. Rats with blood glucose levels exceeding 200 mg/dL were subsequently treated with the designated doses of the extract in Groups III–V. On the final day, blood glucose levels were measured, and pancreatic organs were harvested for histological analysis. The results demonstrated that the ethanolic extract of winged bean leaves at a dose of 7.56 mg/g BW effectively reduced blood glucose levels in diabetic rats.
The Effect of Clove Leaves (Syzygium aromaticum L) on Controlling the Maize Weevil (Sitophilus zeamis) Infestation in Stored Maize Seeds Moniharapon, Debby Dijola; Tetiwar, Karina Novalin
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp149-158

Abstract

Storage is a crucial post-harvest handling process; however, during storage, agricultural products are susceptible to various types of deterioration. Post-harvest losses reach approximately 15–20% annually, with about 0.5–2% of those losses caused by the maize weevil (Sitophilus zeamais). Clove (Syzygium aromaticum L.) is an important spice plant, with its most commercially valuable part being the flower buds, which are predominantly used in the cigarette industry (around 80–90%). Clove leaves, which produce a characteristic aroma, contain an essential oil component called eugenol, known for its fungicidal, bactericidal, nematicidal, and insecticidal properties. This study aimed to determine the effectiveness and optimal weight of clove leaves (Syzygium aromaticum L.) in controlling Sitophilus zeamais. The research employed a Completely Randomized Design (CRD) consisting of five treatments and three replications. The treatments included K1 = 0 g (control, without clove leaves); K2 = 10 g clove leaves per 100 g maize; K3 = 15 g clove leaves per 100 g maize; K4 = 20 g clove leaves per 100 g maize; and K5 = 25 g clove leaves per 100 g maize. Observations were conducted once for each replicate, resulting in three data points per treatment. The collected data were analyzed using ANOVA. The results indicated that clove leaves can be used to control maize weevil (Sitophilus zeamais M.) infestations in stored maize. A total clove leaf weight of 70 g resulted in the highest mortality rate, with 9.08 individuals, yet this treatment was still not considered effective as it did not achieve more than 80% mortality of Sitophilus zeamais
Antioxidant Activity Test of Ethanol Extract of White Ginger (Zingiber officinale var amarum) Using DPPH Method Hasanela, Nurani; Bijang, Catherina Manukpadang
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp114-124

Abstract

Antioxidants are substances that can delay, slow down, and prevent the oxidation process caused by free radicals. The aim of this research is to determine the phytochemical content and antioxidant activity of fresh white ginger and ginger powder (Zingiber officinale Rosc.) using the DPPH method. Fresh white ginger and ginger powder were extracted using the maceration method with ethanol as the solvent. The yield obtained for the ethanol extract of fresh white ginger was 70.042%. Meanwhile, the ethanol extract of ginger powder yielded 59.984%. Phytochemical test results for the ethanol extracts of fresh white ginger and ginger powder showed positive results for flavonoids, phenolics, and saponins, while steroids yielded negative results. In the determination of antioxidant activity, a UV-Vis spectrophotometer was used with the DPPH method. The antioxidant activity test on the ethanol extract of fresh white ginger yielded an IC50 value of 19.85 ppm, while the ginger powder extract showed an IC50 value of 31.58 ppm.
Organoleptic Test of Nutmeg Pulp Residue Tea (Myristica fragrans Houtt) As a Nutriceutical Baszary, Chomsa Dintasari Umi; Sahertian, Dece Elisabeth
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp141-148

Abstract

Nutmeg (Myristica fragrans Houtt) is a native Indonesian spice, and its pulp is often discarded as waste after juice production. However, the residue still contains essential oils and active compounds such as flavonoids, phenols, and myristicin, which may benefit human health. This study aims to evaluate the potential of nutmeg pulp residue as a nutraceutical herbal tea through organoleptic testing, assessing aroma, taste, clarity, and color. The research employed a completely randomized design with three replications. Organoleptic and hedonic tests were carried out on 25 panelists using Friedman and Wilcoxon tests. Results showed that tea clarity scored highest in preference (3.72), followed by aroma (2.28), taste (2.18), and color (1.82). The nutmeg pulp tea was generally acceptable, although improvements in color and flavor intensity are needed. This innovation offers an ecological and economic solution for waste utilization, with potential for rural product diversification and health benefits.
Diagnostic and Prognostic Relevance of Circulating microRNAs across Multiple Cancer Types Putri, Ghea Farmaning Thias; Husna, Firda Asmaul; Widyawati, Dwi; Nurfatihah Z, Zahara
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp159-172

Abstract

Cancer represents a global health burden characterized by high morbidity and mortality,underscoring the urgent demand for reliable, non-invasive biomarkers to enhance early detection,prognostication, and therapeutic monitoring. Circulating microRNAs (c-miRNAs) are short non-coding RNAs present in body fluids that have attracted attention as potential biomarkers, because of their stability, ease of detection, and close relationship with tumor biology. This review evaluates the diagnostic and prognostic potential of c-miRNAs and their integration into precision oncology. A systematic search was performed across PubMed, Scopus, and ScienceDirect for publications from 2010 to 2025 that investigated c-miRNAs in human body fluids in relation to diagnosis, prognosis, or treatment response. Twelve studies met the eligibility criteria, encompassing breast, lung, colorectal, and gallbladder cancers. Frequently dysregulated c-miRNAs, particularly miR-21, miR-155, miR-210, and Let-7a, demonstrated consistent associations with tumor detection, patient survival, and disease progression. Analytical platforms ranged from quantitative RT-PCR to advanced biosensor-based technologies, enabling sensitive and rapid quantification. Collectively, the evidence highlights c-miRNAs as non-invasive biomarkers capable of complementing conventional clinical tools. Their clinical adoption could reduce reliance on invasive tissue biopsies, support earlier and more accurate diagnosis, assist in tailoring patient-specific treatment strategies, and promote the broader implementation of precision medicine in cancer care.

Page 9 of 9 | Total Record : 89

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