cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Siska Musiam
Contact Email
siska@stikes-isfi.ac.id
Phone
+62511-3301610
Journal Mail Official
jiis@stikes-isfi.ac.id
Editorial Address
Jl. Flamboyan III/7c Kayu Tangi 70123 Banjarmasin Kalimantan Selatan
Location
Kota banjarmasin,
Kalimantan selatan
INDONESIA
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 21 Documents
 1   2   3 
Search results for , issue "Vol 4 No 2 (2019): JIIS" : 21 Documents clear
OPTIMASI KONDISI SINTESIS NANOPARTIKEL TEMBAGA MENGGUNAKAN EKSTRAK BIJI MELINJO (Gnetum gnemon L.) Hilda Aprilia Wisnuwardhani; Arinda Roosma; Yani Lukmayani; Anggi Arumsari; Sukanta Sukanta
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.202 KB) | DOI: 10.36387/jiis.v4i2.343

Abstract

Copper nanoparticles (CuNPs) is one of metal nanoparticles, which have many benefits especially in medicinal science. The aim of this research is to determine CuNPs synthesis optimum condition using melinjo seed extract as a bioreductor. In this work, copper (II) sulphate pentahydrate is used as a precursor. Melinjo seed extract was prepared at 600C using aquadest as a solvent. Two stabilizers were used i.e. β-cyclodextrin (BCD) and citric acid. The result showed that the optimum ratio condition of CuNPs synthesis is extract: CuSO4 1 mM: β-cyclodextrin 10 mg/mL = 1:1:1 (v/v/v). The CuNPs were synthesized by reflux method at 900C for 4 hours. It was observed that the addition of sonication process for 2 hours affected the stabilization of CuNPs. The average size of particles is 364,1 nm in diameter and 0,296 in polydispersity index.
ANALISIS BIAYA ANTIBIOTIKA DAN BIAYA PERAWATAN FRAKTUR TULANG DALAM PENETAPAN PEMBIAYAAN KESEHATAN BERDASARKAN INA- CBG’S DI RSUD ULIN BANJARMASIN Amaliyah Wahyuni; Mochammad Maulidie Alfiannor Saputera
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.653 KB) | DOI: 10.36387/jiis.v4i2.344

Abstract

The government implements a universal health insurance system for all Indonesian citizens, called the BPJS (National Health Insurance Provider). In the BPJS service there is a fixed financing package system based on INA-CBG's. The INA-CBG package for bone fractures requires planning. With the INA-CBG package rates, it is expected to be able to reduce the high health costs including the cost of treatment for the fracture. The purpose of this study was to determine the magnitude of the percentage of the total cost of using antibiotics and plates of the total cost of treating bone fracture patients in real accordance with the INA-CBG rates at Ulin Hospital Banjarmasin. This research was an observational study which presented quantitative descriptive data with retrospective data collection. The study sample used BPJS patients with the main diagnosis of bone fractures according to data from the medical records during the period January - December 2018 at Ulin Hospital Banjarmasin in accordance with the criteria. The average value of bone fracture treatment costs by class are class III: Rp. 16,317,084, class II: Rp. 15,119,497, class I: Rp. 17,983,348, and according to severity, namely severity level I: Rp.14.825.222, severity level II: Rp. 29.409,525, severity level III: Rp.26,997,643. There is a mismatch / difference between the real treatment costs and the INA-CBG package rates for bone fracture patients. And the percentage of the total cost of using antibiotics is 0.9% and 45.92% of the total real cost of treating bone fracture patients at Ulin Hospital Banjarmasin
PENGARUH PEMBERIAN FRAKSI ETIL ASETAT BUAH KASTURI (Mangifera casturi Kosterm) TERHADAP TOKSISITAS AKUT, GAMBARAN MAKROSKOPIS DAN MIKROSKOPIS JANTUNG TIKUS PUTIH JANTAN Sutomo Sutomo; Gita Meliawati; Arnida Arnida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.704 KB) | DOI: 10.36387/jiis.v4i2.345

Abstract

The kasturi plant (Mangifera casturi Kosterm) derived from the genus Mangifera, has a compound that can be utilized in the treatment. The fraction of ethyl acetate from methanol extract of M. casturi fruit contains phenolic compounds such as flavonoids and tannins with very strong of antioxidant activity. The purpose of this study was to determine the effect of ethyl acetate fraction of M. casturi on acute toxicity, macroscopic and microscopic organ picture of male rat heart. This study used a complete randomized experimental design method in the laboratory. Research on the effect of fractionation of ethyl acetate of M. casturi fruit in 4 test groups and 1 control group on acute toxicity and histology of the heart of male white rat using qualitative laboratory examination by observing the number of mouse deaths, macroscopic picture and microscopic picture of cardiac organ after giving fraction the ethyl acetate of M. casturi and the quantitative examination of LD50. Each group consisted of 5 animals given treatment once for 14 days, after which the mouse was dissected and the heart organ was taken to be observed. LD50 obtained for 2290.867 mg / kgBB. The result of analysis using Kruskal Wallis test showed that the fraction of ethyl acetate of kasturi fruit did not differ significantly between control group and treatment (p> 0.05) at mouse heart volume. All treatment groups did not show signs or inflammatory conditions, so it can be concluded that the fraction of ethyl acetate of M. casturi did not give the effect of inflammation in mouse heart organ.
UJI AKTIVITAS ANTIBAKTERI FORMULASI SALEP HIDROKARBON DAUN PEPAYA (Carica papaya L.) SEBAGAI SALAH SATU ALTERNATIF OBAT PENYEMBUH LUKA Erna Prihandiwati; Anna Khumaira Sari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.542 KB) | DOI: 10.36387/jiis.v4i2.348

Abstract

Papaya (Carica papaya L) is a plant that can live in various places in Indonesia and requires a relatively short time to grow. Papaya leaves contain karpain alkaloid, karikaksantin, violaksantin, papain, saponins, flavonoids, tannins, karposid and saponins. The compounds that have antibacterial properties are karpain alkaloids. Ointment is one of the pharmaceutical preparations that is suitable for wound healing drugs with papaya leaf extract. This ointment is able to treat infections caused by staphylococcus aureus with great effectiveness and small side effects when compared with the use of chemicals. This study aims to determine the most effective formulations of hydrocarbon base ointment with physical properties test. Papaya leaf extract was obtained by maceration method for five days with 96% ethanol. Macerate is then evaporated with water bath until it becomes a thick extract of papaya leaves. Papaya leaf extract is then formulated at formula 2 and then carried out an antibacterial test with extract concentrations of 5; 10; 20; 30 and 40%. This research is experimental research. The results showed that formula 2 was the most effective based on the physical properties test of the ointment. Antibacterial test results showed that the highest inhibition zone diameter was obtained in the ointment of papaya leaf extract concentration of 40% in the amount of 11.63 ± 0.671441 mm and the smallest in the concentration of 5% in the amount of 5.63 ± 0.550757.
PROFIL SENYAWA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN SEPAT (Mitragynaspeciosa) DAN DAUN DADANGKAK (Hydrolea spinosa L.) Rakhmadhan Niah; Eka Kumalasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.91 KB) | DOI: 10.36387/jiis.v4i2.352

Abstract

Sepat folium (Mitragynaspeciosa) and dadangkak folium (Hydrolea spinosa L.) are plants in South Kalimantan. These plants are often used traditionally to reduce blood sugar and antibacterial levels. The effectiveness is suspected because there is strong antioxidant activity in flavonoid compounds. Flavonoid compounds work through the mechanism of capturing free radicals, reducing oxidative stress. The purpose of this study was to determine the profile of flavonoid compounds of sepat folium and dadangkak folium by test the antioxidant activity with DPPH (1,1-diphenyl-2picrylhydrazyl) method. Extract of sepat folium and dadangkak folium were made by the maceration method using methanol as a solvent. Profiles of flavonoid compounds were obtained quantitatively by the standard solution of quercetin. The extract obtained was tested for antioxidant activity by the DPPH (1,1-diphenyl-2picrylhydrazyl) method. The results showed that the total flavonoid value in methanol solvent was the extract of dadakak folium is 51.19 mg QE / g extract and extract of sepat folium is 43.25 mg QE / g extract. Very strong antioxidant activity (<50 μg / mL) was found in methanol extracts of sepat folium with a value of 34.70 μg / mL and methanol extracts of dadangkak folium with a value of 38.41 μg / mL.
PENAPISAN VIRTUAL BERBASIS STRUKTUR DARI DATABASE BAHAN ALAM ZINC SEBAGAI INHIBITOR BRUTON TYROSINE KINASE Fauzan Zein Muttaqin; Wayan Ayu Puje Astuti; La Ode Aman; Ellin Febrina; Aiyi Asnawi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.31 KB) | DOI: 10.36387/jiis.v4i2.354

Abstract

Bruton’s tyrosine Kinase (BTK) plays a critical role in many cellular signalling pathways making it a potential target to treat autoimmune diseases and cancer. In this study, we have implemented structure-based virtual screening against natural product ZINC database by using pharmacopore model followed by molecular docking to identified the inhibitor of BTK (PDB ID 6E4F). By using structure based pharmacophore, a four-point pharmacophore hypothesis was derived, with three hydropobic, one aromatic rings, four hydrogen bond acceptor and nine hydrogen bond donor. Screening of 12 natural product ZINC databases (151,837 compounds) against pharmacophore returned 1,345 hits with matching chemical features of 58.81. Docking these hits against the ATP-binding site of the BTK kinase domain through a virtual screening docking-based by using vina wizard and autodock wizard (PyRx 8.0) returned 148 and 75 hits, respectively. Three hit compounds with high affinity towards BTK were identified, and it could be used as a potent lead molecule for designing BTK inhibitor.
EVALUASI TINGKAT KEPATUHAN MINUM OBAT HIPERTENSI PADA PASIEN PROGRAM RUJUK BALIK DI APOTEK MITRA BANJARMASIN Novia Ariani; Noverda Ayuchecaria
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.148 KB) | DOI: 10.36387/jiis.v4i2.359

Abstract

Hypertension is a major factor causing cardiovascular disease and the highest cause of death in Indonesia. Mortality due to hypertension in Southeast Asia is around 1.5 million/year. In Indonesia based on 2018 Riskesdas amounted to 34.1%, with the highest prevalence in South Kalimantan 44.1%. The level of adherence to taking medication is one of the benchmarks in the success of antihypertensive drug therapy and can be used to determine the most appropriate intervention method used in increasing adherence to taking a patient's medication and knowing the effectiveness of hypertension therapy that is being undertaken by the patient. The purpose of this study was to determine the level of adherence to taking the antihypertensive medication in the patient's Program Rujuk Balik in Mitra Banjarmasin Pharmacy. This type of research is a non-experimental prospective observational with the presentation of data descriptively. The study was conducted at the Mitra Banjarmasin Pharmacy in February to March 2019 with sampling using the saturated sample method of 163 populations. Data collection is done by completing the Medication Adherence Report Scale (MARS) compliance questionnaire sheets. Data processing is processed in the form of an excel recapitulation. Data analysis uses simple frequency distribution tables which are grouped into high, medium and low levels of compliance. The results showed that of the 163 respondents used in this study who had a high level of adherence were 45 respondents (27.61%) and the moderate level of adherence was 118 respondents (72.39%). The conclusions in this study indicate that the level of adherence to taking antihypertensive drugs in patient's Program Rujuk Balik in Mitra Banjarmasin Pharmacy is moderate
PROFIL RENCANA KEBUTUHAN OBAT DI DINAS KESEHATAN PADA DAERAH TERTINGGAL, PERBATASAN DAN KEPULAUAN (STUDI DI KABUPATEN BELU NUSA TENGGARA TIMUR) Eva Taulabi; Wahyu Utami; Abdul Rahem
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.62 KB) | DOI: 10.36387/jiis.v4i2.361

Abstract

Drug Requirement Plan (DRP) is the basic consideration of providing drug availability in a remote area. Both types and the amount of drugs must be considered along with the drugs availability because the drugs presence is irreplaceable in health service. Therefore, drug management must be effective, efficient and in line with the needs of health services. The aim of this research is to know the profile of DRP and drug availability in remote areas. This research was conducted as descriptive research. Primary data were obtained through direct observation and conducting interview, secondary data from reviewing documents in the previous years, such as drug mutation report in IFK Belu, drug acceptance sheets as well as damaged and expired drug elimination report from 2015 until 2017. So far, DRP conducted in Belu District has been ineffective and inefficient, as observed from its drug availability which is at the very low level of “secure” category. This is due to the method used in drug requirement quantification, which has not been in accordance with the standard guidelines of DRP guidelines. One of factors affecting drug availability is the amount of drug accepted as the result of the procurement, which is not in accordance with the number discrepancy of demand and drug acceptance. There were even drugs that were not delivered at all. However, the fulfillment of DRP in accordance with the National Formulary has improved in 2015 (75,6%), in 2016 (90,7%), and in 2017 (90%). Method used in counting DRP has been ineffective and inefficient, due to nonconsistent and non-thorough implementation of the plan. One of factors causing the DRP ineffectivity is insufficient drug delivery which has not reached 100% of the amount written in the procurement. However, there is annual improvement in the implementation of National Formulary as the basic of drug selection.
SINTESIS NANOKITOSAN DARI LIMBAH CANGKANG HALILING (Filopaludina javanica) KALIMANTAN SELATAN Siska Musiam; Noor Aisyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.547 KB) | DOI: 10.36387/jiis.v4i2.362

Abstract

Haliling (Filopaludina javanica) is usually consumed as a side dish by the people of South Kalimantan by taking part of the meat, then the shell is disposed as untapped waste. This research utilizes the waste from the haliling shell as raw material for chitosan synthesis. Chitosan is a multipurpose natural polymer used in the biomedical field as a protective active drug. Haliling shell powder deproteinated with a solution NaOH 4%(w/v) of 10:1 ratio by refluxing for 2 hours at 100°C. The results of the deproteination reaction were demineralized with a solution of HCl 1 N of 15:1 ratio which was stirred for 2 hours at room temperature. Furthermore, the demineralization reaction results are depigmented with a solution of NaOCl 0.315%(w/v) of 10:1 ratio which was stirred for 2 hours at 40°C to obtain chitin. Deacetylation reaction was carried out on chitin using a solution of NaOH 60%(w/v) of 20:1 ratio by refluxing it for 2 hours at 80°C so that chitosan was obtained. Chitosan nanoparticles were synthesized using the ionic gelation method with sodium tripolyphosphate crosslinker. The product obtained is known as chitosan based on the results of FTIR analysis which shows the emergence of the -NH2 amine group at wave number 3300-3500 cm-1 with an average size of chitosan nanoparticles of 500 nm.
PENINGKATAN PRODUKTIVITAS LIMBAH PERTANIAN DAUN BAWANG DAYAK (Eleutherine Palmifolia L. Merr ) SEBAGAI ALTERNATIF KRIM ANTI AGING ALAMI Eka Kumalasari; Erna Prihandiwati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.819 KB) | DOI: 10.36387/jiis.v4i2.363

Abstract

Eleutherine palmifolia L. Merr are typical plants of Borneo. Pharmacologically the part tubers are proven to have a therapeutic effect. Eleutherine palmifolia grow in the tropics, one of which is in the Petuk Katimpun area of ​​Palangkaraya, Central Borneo, where there land are vast Eleutherine palmifolia. After harvesting Eleutherine palmifolia will produce agricultural waste in the form of leaves that are not utilized and left to rot. Eleutherine palmifolia leaves waste extract contains flavonoid compounds and has antioxidant potential. Eleutherine palmifolia leaves antioxidants can be used to inhibit the aging of the skin and as an alternative to synthetic antioxidants which are harmful to health. Until now there has been no research that to take advantage of Eleutherine palmifolia leaves waste into active substances in antiaging creams. Therefore it is necessary to conduct research to obtain cream preparations with waste active ingredients as antiaging. Waste extract has a very strong antioxidant activity with an IC50 value of 45.33 ppm. One way ANOVA analysis that all cream had significantly different antioxidant attenuation (p < 0,05). Post Hoc analysis Formula III is a the formula with the damping antioxidant reduction the very biggest that is 63.84% ± 0.0891. From the results of the study, the waste of Eleutherine palmifolia leaves can be used as an alternative to anti-aging creams, which one of the efforts increased productivity of agricultural waste.

Page 2 of 3 | Total Record : 21

 1   2   3 

Filter by Year

2019 2019


Reset
Filter By Issues
All Issue Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina Vol 9 No 2 (2024): JIIS Vol 9 No 1 (2024): JIIS Vol 8 No 2 (2023): JIIS Vol 8 No 1 (2023): JIIS 2023: Webinar Nasional & Call For Paper Vol 7 No 2 (2022): JIIS Vol 7 No 1 (2022): JIIS Vol 6 No 2 (2021): JIIS Vol 6 No 1 (2021): JIIS Vol 5 No 2 (2020): JIIS Vol 5 No 1 (2020): JIIS Vol 4 No 2 (2019): JIIS Vol 4 No 1 (2019): JIIS Vol 3 No 2 (2018): JIIS Vol 3 No 1 (2018): JIIS Vol 2 No 2 (2017): JIIS Vol 2 No 1 (2017): JIIS Vol 1 No 2 (2016): JIIS Vol 1 No 1 (2016): JIIS More Issue