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LPPM Universitas Sari Mulia Gedung D Lantai 1 JL. Pramuka No. 02 Banjarmasin Kelurahan Pemurus Luar Kecamatan Banjarmasin Timur Kota Banjarmasin Kalimantan Selatan Indonesia
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Journal of Pharmaceutical Care and Sciences
Published by Universitas Sari Mulia
ISSN : -     EISSN : 28284828     DOI : https://doi.org/10.33859/jpcs.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Journal of Pharmaceutical Care and Sciences published by the LPPM Sari Mulia UniversityPharmacy department of Sari Mulia University offers a forum for publishing the original research related to pharmaceutical science and clinical research. our focus and scope are Pharmaceutical Technology, Pharmacology & Toxicology, Drug Delivery Development, Pharmacokinetic & Biopharmaceutics, Pharmacoeconomy, Pharmacoepidemiology, Pharmacovigilance, Clinical Pharmacy, Community Pharmacy, Chemical Pharmacy, and Chemical Analysis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 180 Documents
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Biosintesis Nanosilver Menggunakan Ekstrak Kulit Buah Rambutan (Nephelium Lappaceum) L. Di Bawah Iradiasi Sinar Matahari Ibrahim, Ibrahim; Utami, Umi Baroroh Lili; Mustikasari, Kamilia
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.815

Abstract

Background: The development of more environmentally friendly and sustainable methods for nanosilver synthesis has become crucial. Biosynthesis using plant extracts as reducing agents offers an attractive alternative due to its simple process, low cost, and absence of hazardous waste. Rambutan (Nephelium lappaceum) fruit peel is agricultural waste that potentially contains bioactive compounds, such as phenolic compounds, which can act as reducing agents in the synthesis of metal nanoparticles. The utilization of solar energy as an energy source in the synthesis process is also in line with the principles of green chemistry. Objective: This research aims to synthesize nanosilver using rambutan fruit peel extract and characterize it using UV-Vis spectrophotometry and SEM-EDS. Method: Rambutan fruit peel was macerated with distilled water at 80℃ for 15 minutes. The obtained extract was characterized using UV-Vis spectrophotometry. Nanosilver biosynthesis was carried out by mixing a 50 mM AgNO3 solution with the rambutan peel extract in variations of 1:1, 1:2, 2:0.5, and 2:1. The mixture was homogenized and exposed to sunlight for 15 minutes, then left to stand for 24 hours in a dark room. The formed nanosilver was characterized using UV-Vis spectrophotometry and SEM-EDS. Results: The IR spectra of the rambutan fruit peel extract identified the presence of phenolic OH functional groups at wavenumbers 3300−3400 cm-1 and C=O absorption at 1650 cm-1. The presence of phenolics acted as a reducing agent. The formed nanosilver had a pore size of 78.8-204 nm. The absorption peak of surface plasmon resonance (SPR) was in the range of 360−413 nm. Conclusion:  The formed nanosilver has pores of 78.8-204 nm and tends to be spherical in shape, with a Surface Plasmon Resonance (SPR) absorption peak at 360-413 nm.
Potensi Antioksidan Kombinasi Ekstrak Daun Cocor Bebek (Kalanchoe pinnata L.) Dan Ekstrak Daun Kratom (Mitragyna speciosa Korth.) Dengan Metode DPPH Meisa, Devina; Rohama, Rohama; Rahmadani, Rahmadani; Nastiti, Kunti
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.816

Abstract

Background: Indonesia is a country that has plants that are widely used by the public as traditional medicine, including bebek cocor leaves (Kalanchoe pinnata L.) and kratom leaves (Mitragyna speciosa Korth.) which have been proven to contain antioxidants and are empirically proven to be a pain reliever. Objective: To determine the IC50 of the combined extract of cocor bebek leaves (Kalanchoe pinnata L.) and kratom leaves (Mitragyna speciosa Korth.). Methods: In this study, simplicia leaves of cocor bebek (Kalanchoe pinnata L.) and kratom leaves (Mitragyna speciosa Korth.) were extracted by maceration. Phytochemical screening and antioxidant activity tests were carried out on each extract. Antioxidant activity testing was carried out using the DDPH (2,2-diphenyl-1-picrylhydrazyl) method. Antioxidant activity was tested quantitatively using Uv-Vis spectrophotometry at a wavelength of 528 nm with the comparison standard used being Vitamin C. Results: The results show that the ethanol extract of Cocor Bebek leaves and Kratom leaves alone has very strong antioxidant activity with IC50 values ​​of 17,96 ppm and 14.43 ppm. The combination with a ratio of 2:1 obtained the lowest IC50 value, namely, 10.60 ppm compared to 1:1 with an IC50 of 15.14 ppm and 1:2 with an IC50 of 12.72 ppm Conclusion: The highest antioxidant activity is found in a combination of ethanol extract of Cocor Bebek leaves and Kratom leaves in a ratio of 2:1 with a lower IC50 than either alone.
Review Jurnal Daun Sembung (Blumea balsamifera) Sebagai Tanaman Obat Modern Putri, Jelita Annisa; Hakim, Ali Rakhman; Amanda, Era Dea; Ihyadin, Hafiz; Irpiana, Irma; Putri, Lidia Risma
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.818

Abstract

Background: The use of traditional medicinal plants in Indonesia has long been an integral part of public health culture, one of which is sembung leaf (Blumea balsamifera). This plant is widely known for its bioactive compounds such as flavonoids, essential oils, triterpenoids, and alkaloids, which contribute to its antibacterial, antioxidant, anti-inflammatory, and potential anticancer activities. Objective: This article aims to review recent research findings on the chemical constituents and biological activities of sembung leaf through a literature review approach. Method: This study employed a journal review method by collecting and analyzing scientific articles that discuss Blumea balsamifera. Results: Based on the analysis of several studies, sembung leaf has been proven to possess strong antibacterial and antioxidant activities, as well as potential as an anticancer and anti-inflammatory agent. However, although its benefits have been demonstrated in vitro, further clinical research is needed to confirm its efficacy and safety in modern medicine. This review is expected to serve as a foundation for the future development of herbal medicines based on sembung leaf. Conclusion: Blumea balsamifera is a medicinal plant with great potential in modern therapeutics. Moreover, its widespread traditional use further supports its efficacy in herbal medicine.
Analisis Rasionalitas Penggunaan Obat Anticemas Pada Pasien Gangguan Cemas Menyeluruh Di Poli Jiwa Rawat Jalan Rumah Sakit Swasta X Kota Bekasi Anggarany, Ariska Deffy; Kartika, Elsa
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.881

Abstract

Background: Anxiety is a normal basic emotion that appears in the survival of every individual human being. Pathologically elevated anxiety can be considered a generalized anxiety disorder characterized by prolonged and excessive anxiety and worry that can occur indefinitely in certain circumstances. Objective: This study aims to evaluate the suitability of the use of anti-anxiety drugs in patients with generalized anxiety disorders in one of the Bekasi Private Hospitals for the 2022 period. Methods: This study used a cross- sectional, non-probability study design with retrospective data. The sample used was 85 medical records of patients with generalized anxiety disorders with the majority of patients being women (53%). Data is presented in the form of percentages, tables and charts. The study’s results revealed Evaluation of drug use of patients with comprehensive anxiety disorders showed the use of a single drug of 2 patients and a combination drug of 83 patients, treatment dominated by SSRIs, Antipsychotics, and Benzodiazepines. Accuracy assessment based on 4 parameters, namely appropriate indication (100%), appropriate drug (79%), appropriate dose (67%) and drug inaccuracy (21%) and dosage inaccuracy (33%). Conclusion: These findings highlight the need to improve dosing accuracy and treatment management. Future research should adopt a prospective design to assess dosing, duration, side effects, and drug interactions for more comprehensive patient care.
Analisis Efektivitas Biaya Terapi Antidiabetik Oral pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Rumah Sakit Islam Jakarta Charles, Charles; Rianto, Leonov; Sari, Liska Marlinda; Yulita, Yulita
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.989

Abstract

Diabetes melitus merupakan penyakit kronik yang memerlukan pengobatan jangka panjang dengan biaya tinggi. Analisis efektivitas biaya (Cost Effectiveness Analysis, CEA) digunakan untuk menentukan pilihan terapi yang efisien antara biaya dan hasil klinis. Tujuan penelitian ini untuk mengetahui terapi antidiabetik oral yang paling cost-effective pada pasien rawat jalan diabetes melitus tipe 2 di Rumah Sakit Islam Jakarta. Metode Penelitian ini menggunakan desain deskriptif observasional cross sectional dengan data retrospektif dari rekam medis pasien bulan November 2024. Sampel meliputi 250 pasien BPJS dan 47 pasien umum. Analisis dilakukan terhadap biaya medis langsung (obat, laboratorium, konsultasi) dan efektivitas penurunan kadar gula darah sewaktu (GDS). Nilai Average Cost Effectiveness Ratio (ACER) dan Incremental Cost Effectiveness Ratio (ICER) digunakan untuk menentukan terapi yang paling efisien. Hasil penelitian menunjukkan pada pasien BPJS, terapi Glimepiride monoterapi memiliki nilai ACER terendah (Rp1.103,05) dan efektivitas 100%. Kombinasi Metformin–Glimepiride menunjukkan ACER Rp1.934,14 dan efektivitas 69,44%. Pada pasien umum, kombinasi Glucophage XR–Glimepiride memiliki ACER Rp5.128,10 dan efektivitas 100%.. Kesimpulan: Terapi Glimepiride merupakan regimen paling cost-effective untuk pasien BPJS, sedangkan kombinasi Glucophage XR–Glimepiride paling efisien untuk pasien umum.
Evaluasi Kualitatif Penggunaan Antibiotik Pada Pasien Infeksi Saluran Kemih Di RSUD Sultan Imanuddin Menggunakan Metode Gyssens Muzdalifah, Siti; Irawan, Yogie; Makani, Mawaqit
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.995

Abstract

Pendahuluan: Infeksi Saluran Kemih (ISK) merupakan salah satu infeksi bakteri tersering yang membutuhkan terapi antibiotik. Penggunaan antibiotik yang tidak rasional dapat menimbulkan resistensi dan menurunkan efektivitas pengobatan. Penelitian ini bertujuan untuk mengetahui pola dan rasionalitas penggunaan antibiotik pada pasien ISK di RSUD Sultan Imanuddin Pangkalan Bun menggunakan metode Gyssens. Metode: Penelitian ini bersifat deskriptif analitik dengan pendekatan retrospektif terhadap data rekam medik pasien ISK rawat inap tahun 2024. Sampel sebanyak 83 pasien diambil dengan purposive sampling. Evaluasi rasionalitas dilakukan menggunakan metode Gyssens berdasarkan ketepatan indikasi, dosis, interval, rute, dan durasi. Hasil: Golongan antibiotik yang paling banyak digunakan adalah sefalosporin (95,0%) dengan Ceftriaxone (70,4%) sebagai jenis terbanyak, diikuti Cefotaxime (16,0%) dan Cefixime (4,9%). Berdasarkan metode Gyssens, sebanyak 41 pasien (49,6%) tergolong rasional (kategori 0) dan 42 pasien (50,4%) tidak rasional, dengan ketidaktepatan terutama pada lama pemberian dan pemilihan antibiotik. Simpulan: Pola penggunaan antibiotik pada pasien ISK masih didominasi sefalosporin. Berdasarkan metode Gyssens, tingkat rasionalitas penggunaan antibiotik sebesar 49,6%, menunjukkan perlunya peningkatan pengawasan terapi antibiotik di rumah sakit.
Uji Ketoksikan Akut Ekstrak Etanol Combretum indicum (L.) DeFilipps Metode Fixed Dose Hadi, Samsul; Indriani, Erika; Rahmawati, Nanda Hesti; Khadijah, Nor; Febriani, Noor Rahmi; Ulfah, Nahdiati; Nastiti, Kunti; Noval, Noval
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.1012

Abstract

Latar belakang: Penelitian ini dilatarbelakangi oleh meningkatnya penggunaan obat herbal di masyarakat yang sering kali belum disertai data keamanan toksikologis yang memadai. Combretum indicum (L.) DeFilipps merupakan tanaman obat tradisional yang banyak dimanfaatkan, namun informasi ilmiah mengenai ketoksikan akut ekstrak etanolnya masih terbatas. Tujuan: mengevaluasi profil ketoksikan akut ekstrak etanol C. indicum sebagai dasar penentuan keamanan penggunaannya. Metode: Penelitian dilakukan secara eksperimental menggunakan metode fixed dose sesuai pedoman OECD(Kpemissi et al., 2020). Hewan uji berupa tikus putih betina galur wistar yang diberikan ekstrak etanol C. indicum secara oral pada dosis 50, 100, 300, dan 2000 mg/kgBB. Parameter yang diamati meliputi kondisi umum, gejala klinis toksik, perubahan berat badan, dan mortalitas selama 14 hari pengamatan. Hasil: Hasil penelitian menunjukkan bahwa seluruh hewan uji tetap aktif dan tidak menampilkan gejala toksik maupun kematian pada seluruh dosis yang diuji. Berat badan tikus menunjukkan peningkatan normal tanpa perbedaan signifikan antar kelompok. Temuan ini mengindikasikan bahwa ekstrak etanol C. indicum memiliki tingkat toksisitas akut yang rendah dengan perkiraan LD50 lebih dari 2000 mg/kgBB Simpulan: ekstrak etanol C. indicum relatif aman pada paparan akut dan berpotensi dikembangkan sebagai sediaan herbal, meskipun uji toksisitas lanjutan masih diperlukan untuk memastikan keamanan jangka panjang
Uji Ketoksikan Akut Ekstrak Etanol Combretum indicum (L.) DeFilipps Metode Fixed Dose
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.1013

Abstract

Background: This study was motivated by the increasing use of herbal medicines in the community, which is often not accompanied by adequate toxicological safety data. Combretum indicum (L.) DeFilipps is a widely used traditional medicinal plant, but scientific information regarding the acute toxicity of its ethanol extract is still limited. Objective: To evaluate the acute toxicity profile of the ethanol extract of C. indicum as a basis for determining its safety. Methods: The study was conducted experimentally using a fixed-dose method in accordance with OECD guidelines (Kpemissi et al., 2020). The test animals were female white Wistar rats given C. indicum ethanol extract orally at doses of 50, 100, 300, and 2000 mg/kgBW. Parameters observed included general condition, clinical toxic symptoms, weight changes, and mortality over 14 days of observation. Results: The results showed that all test animals remained active and did not display toxic symptoms or mortality at all doses tested. The rats' body weight showed a normal increase with no significant differences between groups. These findings indicate that the ethanol extract of C. indicum has a low level of acute toxicity, with an estimated LD50 of more than 2000 mg/kgBW. Conclusion: The ethanol extract of C. indicum is relatively safe upon acute exposure and has the potential to be developed as a herbal preparation, although further toxicity testing is still needed to ensure long-term safety.
Analisis Efektivitas Biaya Terapi Antidiabetik Oral Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan Di Rumah Sakit Islam Jakarta
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a chronic disease that requires long-term treatment with high costs. Cost Effectiveness Analysis (CEA) is used to determine the most efficient therapeutic option in terms of cost and clinical outcomes. This study aimed to identify the most cost-effective oral antidiabetic therapy among outpatients with type 2 diabetes mellitus at the Jakarta Islamic Hospital. The study employed a descriptive observational cross-sectional design using retrospective data from patient medical records in November 2024. The sample consisted of 250 BPJS (national insurance) patients and 47 general (non-insured) patients. The analysis included direct medical costs (drugs, laboratory tests, and consultations) and the effectiveness of reducing random blood glucose (RBG) levels. The Average Cost Effectiveness Ratio (ACER) and Incremental Cost Effectiveness Ratio (ICER) were used to determine the most efficient therapy. The results showed that among BPJS patients, Glimepiride monotherapy had the lowest ACER value (IDR 1,103.05) with 100% effectiveness. The Metformin–Glimepiride combination had an ACER of IDR 1,934.14 and 69.44% effectiveness. Among general patients, the Glucophage XR–Glimepiride combination had an ACER of IDR 5,128.10 and 100% effectiveness. Conclusion: Glimepiride monotherapy was the most cost-effective regimen for BPJS patients, while the Glucophage XR–Glimepiride combination was the most efficient therapy for general patients.
Evaluasi Kualitatif Penggunaan Antibiotik Pada Pasien Infeksi Saluran Kemih Di RSUD Sultan Imanuddin Menggunakan Metode Gyssens
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.1015

Abstract

Background: Urinary Tract Infection (UTI) is one of the most common bacterial infections requiring antibiotic therapy. Irrational use of antibiotics can lead to resistance and reduce treatment effectiveness. This study aimed to determine the pattern and rationality of antibiotic use in UTI patients at Sultan Imanuddin Hospital Pangkalan Bun using the Gyssens method.Methods: This research was descriptive-analytic with a retrospective approach on inpatient medical records in 2024. A total of 83 patients were included using purposive sampling. The rationality of antibiotic use was evaluated using the Gyssens method based on accuracy of indication, dosage, interval, route, and duration. Results: The most commonly used antibiotic group was cephalosporins (95.0%), with Ceftriaxone (70.4%) as the most frequently prescribed type, followed by Cefotaxime (16.0%) and Cefixime (4.9%). According to the Gyssens method, 41 patients (49.6%) were categorized as rational (category 0), while 42 patients (50.4%) were irrational, mostly due to inappropriate duration and antibiotic selection.Conclusion: The pattern of antibiotic use in UTI patients was dominated by cephalosporins. Based on the Gyssens method, the rationality rate of antibiotic use was 49.6%, indicating the need for improved antibiotic therapy monitoring in hospitals.

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