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Heri Setiyo Bekti
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INDONESIA
JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH
Published by Politeknik Kesehatan Kemenkes Denpasar
ISSN : 1693931X     EISSN : 25803700     DOI : https://doi.org/10.33992/jsh:tjoh
Core Subject : Health,
Dentistry Nursing Public Health
Jurnal Skala Husada merupakan media publikasi karya ilmiah para dosen di lingkungan Politeknik Kesehatan yang ada di Indonesia, khususnya karya ilmiah di bidang teknologi kesehatan. Jurnal Skala Husada terbit setiap 6 bulan, atau terbit 2 kali dalam setahun.
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 94 Documents
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The Anti-Inflammatory Potential of Fermented Red Ginger Extract (Zingiber officinale var. Rubrum) Against In Vitro Protein Denaturation Kusdiharti, Meutia Sri; Dewi, Ni Wayan Rika Kumara; Artika, Made Prita
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4093

Abstract

Background:Red ginger (Zingiber officinale var. Rubrum) is known for many phytochemical components and various pharmacological activities, such as anti-inflammation. However, red ginger also has a high cellulose level. Special treatment is needed to degrade the cellulose so that phytochemicals can be maximally extracted. Trichoderma harzianum, a cellulase enzyme-producing fungus, can degrade cellulose and increase the efficiency of phytochemical extraction. Aims:This study aimed to evaluate the in vitro anti-inflammatory potential of red ginger extract fermented with T. harzianum. Methods:This research is an experimental method involving the fermentation of red ginger powder before extraction, followed by an in vitro protein denaturation inhibition assay using a UV-Vis spectrophotometer. Bovine Serum Albumin (BSA) was used as a negative control, diclofenac sodium as a positive control, and the fermented red ginger extract (FRGE) was tested at concentrations of 25, 50, 75, 100, and 125 ppm. The results: Phytochemical screening of FRGE confirmed the presence of alkaloids, flavonoids, saponins, phenols, and triterpenoids. The extract yield was 14.29%, with the highest inhibition of protein denaturation at 62.62% observed at 125 ppm. The IC50 value is 93.61 ppm. Conclusions: Based on these research results, FRGE had strong antiinflammatory potency in vitro. Keywords: Red ginger, Fermentation, Anti-inflammatory, Protein denaturation, Trichoderma harzianum
Overview of Factors Influencing Medication Adherence in Elderly Hypertension Patients Aprianti, Pande Made Ayu; Marangyana, I Gede Bagus Indra; Sudiastini, Ni Ketut Ayu
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4177

Abstract

Hypertension is defined as a sustained increase in blood pressure with a systolic value of ≥140 mmHg and/or a diastolic value of ≥90 mmHg. The risk of developing hypertension increases progressively with age, with a prevalence of more than 60% among individuals over 60 years old (elderly). Treatment success for hypertension depends not only on accurate diagnosis and appropriate therapy but also on patients' adherence to antihypertensive medication. This study aimed to examine the relationship between factors such as knowledge about hypertension and family support with medication adherence among elderly hypertensive patients. Methods: This was an analytical observational study with a cross-sectional design conducted at Hospital X in Denpasar. A total of 70 elderly hypertensive patients participated in the study. Data were collected using the MMAS-8 (Morisky Medication Adherence Scale) to assess medication adherence, and validated questionnaires to measure knowledge of hypertension and family support. Data analysis was performed using the Spearman correlation test. Results: A significant relationship was found between knowledge about hypertension and medication adherence (p=0.000), with a Spearman correlation coefficient of r=0.657, indicating a strong correlation. A significant relationship was also found between family support and medication adherence (p=0.000), with a correlation coefficient of r=0.546, indicating a moderate correlation. Conclusion: Higher levels of knowledge about hypertension and stronger family support are significantly associated with better medication adherence among elderly hypertensive patients. Educational efforts and family involvement are recommended to improve adherence to antihypertensive therapy.
In Silico Study of Gingerol and Shogaol from Red Ginger Rhizome (Zingiber Officinale var. rubrum) as Anti-Inflamatory Kumara Dewi, Ni Wayan Rika; Sukma Dinda, Ni Made Ayu; Suastini, Ni Made
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4125

Abstract

ABSTRACTInflammation occurs when the enzyme phospholipase A2 (PLA2) releases arachidonic acid from cell membranes, leading to the production of pro-inflammatory mediators. Gingerol and shogaol are bioactive compounds with anti-inflammatory properties found in red ginger (Zingiber Officinale var. rubrum). This research aims to investigate the potential anti-inflammatory activity of gingerol and shogaol against osteoarthritis using in silico methods. The in silico tests utilized Hyperchem 8, Chimera 1.10.1, and molecular docking was performed using AutoDock Tools, supplemented with Autogrid and Autodock 4. The results of molecular docking showed hydrogen bonds and binding energy. The binding energy values for 10-gingerol were -9.01 kcal/mol, 10-shogaol -8.85 kcal/mol, 8-shogaol -8.72 kcal/mol, and 6-gingerol -8.07 kcal/mol. The results indicate that gingerol and shogaol compounds have higher binding energies compared to the target protein Phospholipase A2 (Sodium Diclofenac) at -7.57 kcal/mol. This suggests that gingerol and shogaol compounds from red ginger rhizome (Zingiber Officinale var. rubrum) have potential as anti-inflammatory agents.Keywords:  gingerol; shogaol; anti-inflammatory; phospoliphase A2; in silicoABSTRAKInflamasi atau peradangan terjadi akibat enzim phospoliphase A2 (PLA2) yang melepaskan asam arakidonat dari membran sel, sehingga menghasilkan mediator proinflamasi. Gingerol dan shogaol merupakan senyawa bioaktif yang memiliki kandungan antiinflamasi pada tanaman jahe merah (Zingiber Officinale var. rubrum). Penelitian ini bertujuan untuk mengetahui potensi aktivitas dari gingerol dan shogaol sebagai antiinflamasi terhadap penyakit osteoartritis secara in silico. Uji in silico menggunakan program Hyperchem 8, Chimera 1.10.1 dan pengujian molecular docking menggunakan program  AutoDock Tools, dilengkapai dengan program (Autogrid dan Autodock 4). Hasil pengujian molecular docking adalah ikatan hidrogen dan energi ikatan. Nilai energi ikatan pada senyawa 10-gingerol sebesar -9,01 kkal/mol, 10-shogaol sebesar -8,85 kkal/mol, 8-shogaol sebesar -8,72 kkal/mol dan 6-gingerol sebesar -8,07 kkal/mol, Hasil menyatakan bahwa senyawa gingerol dan shogaol memiliki energi ikatan yang lebih besar dibandingkan dengan protein target Phospholiphase A2 (Natrium Diclofenac) sebesar -7,57 kkal/mol. Hal ini menunjukan bahwa senyawa gingerol dan shogaol dari Rimpang Jahe Merah (Zingiber Officinale var. rubrum) berpotensi sebagai antiinflamasi.Kata kunci:gingerol; shogaol; antiinflamasi; phospoliphase A2; in silico
Verification of Total Plate Count Testing Method on Dairy Goat Milk Referring to SNI 2897: 2008 Suryaningsih, Putu ayu; Suyasa, Ida Bagus Oka
Jurnal Skala Husada : The Journal of Health Vol 22, No 2 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i2.3975

Abstract

Background: A method must be verified and validated because each laboratory has varying conditions. This diversity can occur due to differences in facilities, personnel competence, equipment and chemicals used. In addition, accredited testing laboratories have an obligation to carry out method validation and verification processes before implementing the method. Objective: In this study, the ALT testing method for dairy goat milk was verified using accuracy and precision test parameters from samples with low, medium, high and uncontaminated concentrations. Method: This research uses descriptive research, namely describing the results of verification of the ALT testing method on fresh goat's milk which refers to SNI 2897:2008. Results: The SNI 2897:2008 ALT testing method on dairy goat milk for all microbial concentrations can be applied at the Denpasar Ministry of Health Health Polytechnic Integrated Laboratory because the RSD and Percent Recovery values do not exceed the limits set in SNI 2897:2008. Conclusion: The Total Plate Number testing method according to SNI 2897:2008 with a dairy goat's milk matrix can be applied as a testing method at the integrated laboratory of the Health Polytechnic of the Ministry of Health, Denpasar.

Page 10 of 10 | Total Record : 94

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