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Komang Aditya Yudistira
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Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa Gedung F2 Lantai 3, Jl. Terompong No.24 , Sumerta Kelod, Kec. Denpasar Tim., Kota Denpasar, Bali 80239
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Aesculapius Medical Journal
Published by Universitas Warmadewa
ISSN : 28290712     EISSN : 28086848     DOI : https://doi.org/10.22225
Core Subject : Health, Science, Education,
Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
AMJ (Aesculapius Medical Journal) is a peer-reviewed medical journal that published research articles and theoretical articles in medical science. This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. It aims is to provide a place for academics and practitioners to publish original research articles, review articles, and book reviews. The scope of this journal area any topics concerning medical studies in all aspects. AMJ (Aesculapius Medical Journal) published by Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa 3 times a year. AMJ (Aesculapius Medical Journal) is available in print and online version. AMJ (Aesculapius Medical Journal) is Available online at https://www.ejournal.warmadewa.ac.id/index.php/amj/index, since Volume 1 No 1 October, 2021.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
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Search results for , issue "273-283" : 1 Documents clear
The Potential of MIPGLE (Microencapsulation of Psidium guajava Leaf Extract) as a Natural Medicine for Tuberculosis I Putu Anda Tresna Dananta; Putu Prajata Vistara Putera
Aesculapius Medical Journal 273-283
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.6.1.2026.273-283

Abstract

Abstract Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Tuberculosis is one of the 10 diseases that cause the largest number of deaths in the world. Therefore, strategic steps to treat Tuberculosis are very necessary. One effort that can be made as an alternative treatment for Tuberculosis patients is the administration of natural medicine. Natural medicines can be produced through the use of natural ingredients such as guava leaves. Guava leaves contain antibacterial compounds, namely chalcone (flavonoid). This research is an experimental study intended to analyze the potential of chalcone in microencapsulation of Psidium guajava leaves extract as a natural medicine for tuberculosis in silico. The research results showed that microencapsulation phytochemistry showed positive results for flavonoid, tannin, phenol and saponin compounds with flavonoid levels of 201.513 mg/100mg QE. The SEM test results show that the Psidium guajava extract has been encapsulated in the maltodextrin-gelatine coating well and has a particle size of 115.442 ?m. This research proven that chalcone has potential as an antibacterial agent through the results of PASS analysis with Pa of 0.284. chalcone with a single dose of drug 1048 mg/kg is known to be feasible as a drug substance with proven feasibility in various pharmaceutical aspects and 4th toxicity shows a low level of toxic impact to the body if this microencapsulation is consumed orally. Keywords: Microencapsulation, Natural Medicine, Psidium guajava, Tuberculosis

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