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Komang Aditya Yudistira
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Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa Gedung F2 Lantai 3, Jl. Terompong No.24 , Sumerta Kelod, Kec. Denpasar Tim., Kota Denpasar, Bali 80239
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Aesculapius Medical Journal
Published by Universitas Warmadewa
ISSN : 28290712     EISSN : 28086848     DOI : https://doi.org/10.22225
Core Subject : Health, Science, Education,
Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
AMJ (Aesculapius Medical Journal) is a peer-reviewed medical journal that published research articles and theoretical articles in medical science. This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. It aims is to provide a place for academics and practitioners to publish original research articles, review articles, and book reviews. The scope of this journal area any topics concerning medical studies in all aspects. AMJ (Aesculapius Medical Journal) published by Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa 3 times a year. AMJ (Aesculapius Medical Journal) is available in print and online version. AMJ (Aesculapius Medical Journal) is Available online at https://www.ejournal.warmadewa.ac.id/index.php/amj/index, since Volume 1 No 1 October, 2021.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
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Search results for , issue "298-309" : 1 Documents clear
Tinjauan Literatur: Pertimbangan Klinis Antiinflamasi Nonsteroid selama Kehamilan Berdasarkan Profil Risiko dan Keuntungan Terapeutik Kemuning Pancar Wangi; Cut Nadia Anne Sanha; Noor Cahaya
Aesculapius Medical Journal 298-309
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.6.1.2026.298-309

Abstract

Abstract [Literature Review: Clinical Consideration for Nonsteroidal Antiinflammatory Drugs in Pregnancy Based on Risk Profile and Therapeutic Benefits] The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in pregnant women is an important topic in clinical practice, given the potential risks to both the mother and the fetus. NSAIDs are commonly used to treat pain, inflammation, and fever, but their use during pregnancy should be approached with caution due to evidence linking them to various complications. This study aimed to evaluate the impact of NSAIDs administration based on the type of drug, trimester of exposure, and maternal clinical condition, thus influencing NSAIDs therapy in pregnant women. The method used in this study was a literature review using PubMed and Google Scholar databases, resulting in five articles selected through inclusion and exclusion. Nonselective NSAIDs such as ibuprofen, naproxen, ketoprofen, and indomethacin are associated with an increased risk of prematurity, major congenital malformations, and oligohydramnios, especially when used in the first trimester or long-term. Given these risks, the use of NSAIDs during pregnancy requires careful consideration. In contrast, low-dose aspirin has been shown to have protective benefits in preventing pregnancy complications such as preeclampsia and preterm birth in high-risk pregnancies, particularly when initiated in the first trimester. Based on evidence from cohort studies and randomized controlled clinical trials, NSAIDs use during pregnancy should be selective, considering the type, dose, and timing of administration, and should be closely monitored by a healthcare professional. Keywords: NSAIDs, pregnancy, trimester, prematurity, preeclampsia

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