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Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa Gedung F2 Lantai 3, Jl. Terompong No.24 , Sumerta Kelod, Kec. Denpasar Tim., Kota Denpasar, Bali 80239
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Aesculapius Medical Journal
Published by Universitas Warmadewa
ISSN : 28290712     EISSN : 28086848     DOI : https://doi.org/10.22225
Core Subject : Health, Science, Education,
Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
AMJ (Aesculapius Medical Journal) is a peer-reviewed medical journal that published research articles and theoretical articles in medical science. This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. It aims is to provide a place for academics and practitioners to publish original research articles, review articles, and book reviews. The scope of this journal area any topics concerning medical studies in all aspects. AMJ (Aesculapius Medical Journal) published by Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa 3 times a year. AMJ (Aesculapius Medical Journal) is available in print and online version. AMJ (Aesculapius Medical Journal) is Available online at https://www.ejournal.warmadewa.ac.id/index.php/amj/index, since Volume 1 No 1 October, 2021.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
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Search results for , issue "366-373" : 1 Documents clear
Kejang pada Tuberkuloma Intrakranial dengan Tuberkulosis Diseminata dan Herpes Zoster Konkomitan: Suatu Pertemuan Klinis yang Jarang Putu Ayu Diah Meita Wulandari; I Ketut Sumada; Desie Yuliani; Ni Made Kurnia Dwi Jayanthi; Yoanes Gondowardaja
Aesculapius Medical Journal 366-373
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.6.1.2026.366-373

Abstract

ABSTRACT Background: Disseminated tuberculosis (TB) with central nervous system involvement represents a severe form of extrapulmonary TB that may lead to intracranial tuberculoma and provoke seizures. Herpes zoster coinfection reflects impaired cellular immunity and is rarely reported concurrently, posing diagnostic and therapeutic challenges. Case Presentation: A 71-year-old man presented with two episodes of focal to bilateral tonic seizures. The patient had a history of miliary TB and was undergoing continuation-phase anti-tuberculosis therapy. Herpes zoster lesions appeared one week prior to admission. On presentation, the patient was stuporous but later improved without focal neurological deficits. Head CT revealed multiple bilateral parietal hypodense lesions, while previous MRI findings were suggestive of multiple intracranial tuberculomas. HIV status was non-reactive. Discussion: Seizures in elderly patients are often associated with structural brain lesions, including tuberculomas resulting from hematogenous spread of disseminated TB and formation of Rich foci. Inflammatory edema and caseous necrosis contribute to decreased seizure threshold. The coexistence of herpes zoster indicates cellular immune dysregulation in elderly patients even in the absence of HIV infection. Conclusion: The combination of seizures, multiple intracranial tuberculomas, disseminated TB, and herpes zoster is rare but clinically important. Neuroimaging evaluation and comprehensive management are essential to improve clinical outcomes. Keywords: Disseminated tuberculosis, tuberculoma, seizures, herpes zoster, central nervous system infection.

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