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Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa Gedung F2 Lantai 3, Jl. Terompong No.24 , Sumerta Kelod, Kec. Denpasar Tim., Kota Denpasar, Bali 80239
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Aesculapius Medical Journal
Published by Universitas Warmadewa
ISSN : 28290712     EISSN : 28086848     DOI : https://doi.org/10.22225
Core Subject : Health, Science, Education,
Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
AMJ (Aesculapius Medical Journal) is a peer-reviewed medical journal that published research articles and theoretical articles in medical science. This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. It aims is to provide a place for academics and practitioners to publish original research articles, review articles, and book reviews. The scope of this journal area any topics concerning medical studies in all aspects. AMJ (Aesculapius Medical Journal) published by Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa 3 times a year. AMJ (Aesculapius Medical Journal) is available in print and online version. AMJ (Aesculapius Medical Journal) is Available online at https://www.ejournal.warmadewa.ac.id/index.php/amj/index, since Volume 1 No 1 October, 2021.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
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Search results for , issue "330-348" : 1 Documents clear
Neuroanatomi DID: Hipokampus, Amigdala, dan Trauma Masa Kanak-kanak Angeline Rosemarie Yohana Hutahaean
Aesculapius Medical Journal 330-348
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.6.1.2026.330-348

Abstract

Abstract [Neuroanatomy of DID: Hippocampus, Amygdala, and Childhood Trauma] Dissociative Identity Disorder (DID) is a complex dissociative disorder characterized by identity fragmentation, amnesia, and emotional dysregulation. Repeated childhood trauma has been shown to be a major factor in the etiology of DID, leaving persistent changes in the hippocampus and amygdala, which play a crucial role in memory and emotional regulation. The review revealed reduced hippocampal volume in DID patients, particularly in the CA2–3 subfield, CA4–dentate gyrus, and subiculum, which is associated with impaired memory consolidation and dissociative amnesia. Conversely, the amygdala exhibits hyperactivity to emotional stimuli, triggering hypervigilance and emotional dysregulation. Neuroimaging studies, including fMRI perfusion and PET, consistently support the existence of two primary identities: the Apparently Normal Part (ANP) and the Emotional Part (EP), with distinct brain activation patterns that cannot be replicated in healthy individuals. These findings strengthen the neurobiological validity of DID. Thus, childhood trauma plays a central role in the development of DID through dissociative mechanisms and neuroanatomical changes in the hippocampus and amygdala, opening up opportunities for the development of biomarkers for more accurate diagnosis and trauma-based therapeutic interventions. Keyword: Dissociative Identity Disorder, childhood trauma, hippocampus, amygdala, neuroimaging.

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