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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 148 Documents
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Case Report: Hyperprolactinemia In Suprasellar Meningioma Nirwan Nugraha; I Wayan Arsana Wiyasa; Donny Wisnu Wardhana; Wino Vrieda Vierlia; Edy Mustofa
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (957.585 KB) | DOI: 10.55561/ajhr.v1i2.22

Abstract

Introduction: Hyperprolactinemia is a condition in which abnormally elevated prolactin levels (normal prolactin levels are 10-28 g/L) is a common endocrine disorder. Establishing the diagnosis and etiology of hyperprolactinemia should include a thorough medical history and the use of drugs, physical examination, laboratory tests, analysis of the pituitary, and sella turcica features. Pituitary tumor imaging analysis using MRI remains the method of choice. The main goals of managing hyperprolactinemia are restoring and maintaining fertility function and preventing osteoporosis. The choice of treatment depends on the underlying etiology. Case Presentation: A 33-year-old woman complained that her right side of vision could not function properly, and her left side of vision began to blur, which started four years ago with irregular menstrual disorders, and milk came out of her breasts. On breast examination, Tanner 5 was found with galactorrhea and pubic hair Tanner stage 3. On Laboratory examination found FSH (5.50 mIU/mL), LH (1.7 mIU/mL) and prolactin (1125 IU/mL). The MRI examination showed an extra-axial solid mass, broad-based on the planum sphenoidal to the dorsum sellae, suggesting a meningioma; with compression of the optic chiasm, middle cerebral artery, and bilateral anterior cerebral arteries, size 3.1 x 2.8 x 2.3 cm. Conclusion: Hyperprolactinemia with meningiomas is a unique case. First-line therapy for prolactinomas is dopamine agonist administration and, in this case, is followed by surgery, which showed significant results.
The Advantages and Disadvantages of Phytoestrogens Sutrisno, M.D., Ph.D, REI
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (605.821 KB) | DOI: 10.55561/ajhr.v1i1.23

Abstract

Phytoestrogens are plant-derived chemicals found in various foods, the most prominent in soy. Many health benefits are attributed to phytoestrogens, including a reduced incidence of osteoporosis, breast cancer, menopausal symptoms, and heart disease; however, many are also classified as endocrine disruptors, which can potentially create adverse health effects. As a result, whether phytoestrogens are good or hazardous to one's health has yet to be answered. The answer is likely complicated, and it could be influenced by factors, namely health, age, and the presence or absence of specific gut bacteria. Because worldwide consumption is continually expanding, clarity on this subject is required. On the other hand, phytoestrogens are frequently advertised as a natural alternative to estrogen replacement therapy and are included in various dietary supplements. Because phytoestrogens have molecular and cellular properties similar to those of artificial endocrine disruptors, such as bisphenol A (BPA), and are also weak estrogen agonists/antagonists, making them valuable models for general understanding of the biologic effects of endocrine disruptors 1–3.
Phaleria macrocarpa Flavonoid as a Potent MMP-1 Inhibitor for Endometriosis Therapy: In silico Study Maharani; Sutrisno
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1604.447 KB) | DOI: 10.55561/ajhr.v1i2.24

Abstract

Introduction: Endometriosis is a gynaecological disorder in women and causes infertility. Several therapeutic were developed to reduce endometriosis cases, one of them was matrix metalloproteinase (MMP) inhibitor. This study investigated the potential activity of the flavonoids in Phaleria macrocarpa fruit as MMP1 inhibitors for endometriosis. Methods: In silico modelling was used in this study. Six flavonoid structures were retrieved from PubChem NCBI database. A targeted protein, MMP1 was taken out from Protein Data Bank with ID 1CGE and predicted the active sites. Six flavonoids and MMP1 was interacted by molecular docking using Molegro virtual Docker version 5 and analyzed using PyMol 2.2 and Discovery Studio version 21.1.1. Three-dimensional complex structure of flavonoids – MMP1 showed interaction in the same active sites and performed an amino acid residue Glu219 as catalytic site. Results: Six flavonoids of Phaleria macrocarpa were divided into two patterns and generated varied binding energy. Glycitin and Catechin 7-O-beta-D-xyloside showed low score of binding energy and depicted similar structure with four aromatic rings. 8-Prenylnaringenin performed lower binding energy than naringenin, eriodictyol, and 5-O-methylgenistein. Conclusion: In silico analysis suggested that six flavonoids compounds is potent as MMP1 inhibitor and might be interfered endometriosis pathophysiology. In vivo and in vivo investigations are required for further analysis.
Zinc Deficiency as Predictor of COVID-19 Severity: A Systematic Review and Meta-Analysis Ayu Rizky Widowati; Sutrisno Sutrisno
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (808.841 KB) | DOI: 10.55561/ajhr.v1i2.27

Abstract

Introduction: Despite the fact that zinc deficiency is asymptomatic, its incidence is rising over the world, with no visible clinical manifestation. Mineral and vitamin supplementation to prevent the inflammatory response is a major concern during the COVID-19 pandemic. Zinc may play a role in the development of a stronger immunological response. Nonetheless, there is insufficient information to investigate the benefits of zinc on its own. The impact of zinc deficiency on the severity of COVID-19 infection will be discussed in this systematic study. Material and Methods: We used the search phrases "COVID-19" or "SARS-CoV-2" and "Zinc Deficiency" to look for publications published between 2020 and April 2021 in scholar google, PubMed, SCOPUS, and Proquest. All of the information was examined qualitatively. Results: There are three papers that discuss the benefits of zinc and indicate that zinc deficiency has a key influence in the severity of COVID-19. According to one study, there is no link between zinc deficiency and COVID-19 severity. Conclusions: COVID-19 infection is linked to low zinc levels in the blood. It may become a risk factor for COVID-19 severity or a contributing factor that goes unnoticed in regular practice. Zinc supplementation or zinc baseline serum may play a role in determining potential daily supplementation and treatment for patients at risk of zinc insufficiency in the COVID-19 group in RCT and better design studies.
Unilateral Uterine Artery Embolization Therapy For Secondary Postpartum Hemorrhage In Pseudoaneurysma Of The Sinistra Uterinary Artery Post-Cesarean Section Arghya Wicaksana; Agung Setiawan
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.967 KB) | DOI: 10.55561/ajhr.v1i2.31

Abstract

Introduction: Uterine artery pseudoaneurysm is one of the rare malformations of uterine blood vessels due to incomplete closure of the torn uterine artery wall. This condition accounts for about 3% of postpartum hemorrhage cases that could be life-threatening. Transcatheter arterial embolization has recently emerged as a safe and highly effective alternative treatment. Case Presentation: A 30-year-old woman complained of abdominal pain accompanied by a large amount of blood from the birth canal, which was felt on the 28th day after a cesarean section. The patient underwent laparotomy and had grade III intra-abdominal adhesions. On CT-Angiography investigation, we found saccular type aneurysm in the left uterine artery, hematometra, and fluid collection on the right side of the periuterine, multiple paraaortic lymphadenopathies, hepatomegaly, and left adnexal cyst. With the pseudoaneurysm, the patient was planned to undergo uterine artery embolization. The patient was discarded. During follow-up, results of CT-scan pelvic angiography include dilated and convoluted right uterine artery. Conclusion: In this case report, uterine artery embolization (UAE) was performed; this procedure was chosen because the effectiveness of embolization was 97% and could maintain the desire for future pregnancies. The fertility prognosis in this case report was quite good after unilateral uterine artery embolization was performed concerning regular menstrual cycles.
Comparison of Phytochemical Content and Antifungal Activity of Bajakah Tampala Stem (Spatholobus Littoralis Hassk.) Methanol and Ethanol Extracts Against Candida Albicans Herdian Fitria Widyanto Putri; Qatrunnada Naqiyyah Khusmitha; Galih Puspita Citra Mahardhika; Dwi Yuni Nur Hidayati; Tri Yudani Mardining Raras; Eviana Norahmawati
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1001.827 KB) | DOI: 10.55561/ajhr.v1i2.40

Abstract

Introduction: Candida albicans causes the second most frequent vaginal infection, vulvovaginal candidiasis (VVC). Bajakah Tampala is a natural plant of Kalimantan that has the potential to be used as a traditional remedy for various diseases. This study aims to determine the phytochemical content and antifungal potential of methanol and ethanol Bajakah Tampala stem extract against the growth of Candida albicans. Methods: Flavonoids, tannin, phenol, and saponin were identified through qualitative analysis of the phytochemical content. Different concentration of Bajakah Tampala methanol and ethanol extract (1.56%, 3.175%, 6.25%, 12.5%, 25%, 50%, and 100%) was tested for antifungal potency using dilution method. The extract that could inhibit the growth of Candida albicans colonies was continued with the concentration density (35%, 37.5%, 40%, 42.5%, 45%, 47.5%, and 50%) in order to determine the Minimum Inhibitory Concentration (MIC) and Minimum Killing Concentration (MKC) by counting the number of colonies. Results: The methanol extract of Bajakah Tampala contains flavonoids, tannins, phenol, and saponin. In contrast, no flavonoids were detected in the ethanol extract. Candida albicans colonies were not inhibited by concentrations of 1.56%, 3.125%, 6.25%, 12.5%, and 25% in ethanol and methanol extracts, respectively. At concentrations of 50% and 100%, methanol extract inhibits colony growth, but ethanol extract is still growing. The antifungal activity of methanol extract showed a MIC of 35% and a MKC of 47.5%, as measured by its concentration density. Conclusion: Flavonoids are present in the Bajakah Tampala methanol extract, which inhibits and kills the growth of Candida albicans but not ethanol.
Effectiveness of Hepatitis B Vaccination on Various Populations: A Systematic Review Dewi Ratna Sulistina
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (906.007 KB) | DOI: 10.55561/ajhr.v1i2.43

Abstract

Introduction: Hepatitis B vaccination is important to protect individuals from Hepatitis B virus (HBV) infection. The aim of this study was to conduct a systematic review of the necessity of Hepatitis B vaccination among humans, especially among infants, children, teenagers, adults, risk groups, and health care workers. Methods: Three databases were used in this study, Scopus, Web of Science, and PubMed. We reported the study using PRISMA-P guidelines. The keywords were used in this study (TITLE-ABS-KEY (vaccine) AND TITLE-ABS-KEY (hepatitis AND b) AND TITLE-ABS-KEY (boost)), and we obtained 275 articles. In the web of science, we used ((ALL=(vaccine)) AND ALL= (Hepatitis B)) AND ALL=(Boost), and we obtained 374 articles. In the PubMed, we used ((Vaccine [MeSH Terms]) AND (Hepatitis b [MeSH Terms])) AND (booster immunization [MeSH Terms]), and we obtained 417 articles. Results: There were 60 articles included in this systematic review. The systematic review results showed that infants, children, and teenagers, as well as adult groups who receive the hepatitis B vaccine, can protect for 5-30 years. Meanwhile, risk group and health care workers were suggested to obtain hepatitis B vaccine booster with low anti-HBsAg titer Conclusion: It needs to conduct anti-HBs Ag titer testing to decide whether they need a hepatitis B vaccination booster. Hepatitis B vaccine booster required for the group with anti-HBs Ag titer less than 10 mIU/mL.
Effect of Pravastatin on eNOS and PECAM-1 Expression in the Placenta of Pre-Eclampsia Rat (Rattus norvegicus) Model Bambang Rahardjo; Kunawati Tungga Dewi; Anita Dwi Rahmawati; Fauqo Wildatil Jannah; Mukhamad Nooryanto; Anin Indriani
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (992.174 KB) | DOI: 10.55561/ajhr.v1i2.44

Abstract

Introduction: Preeclampsia has two stages: improper placental and maternal circulation. Abnormal trophoblast invasion causes uteroplacental ischemia and hypoxia. Ischemia in the placenta produces endothelial cell dysfunction, which is defined by a change in endothelial cell activity to a reduced ability to vasodilate (decreased eNOS) and prothrombotic conditions (decreased PECAM-1). Reduced maternal eNOS activity and PECAM-1 can cause preeclampsia. Pravastatin is the statin class's most hydrophilic medication, and it limits placental transfer. Pravastatin can reduce endothelial dysfunction by targeting pleiotropic effects in pregnancy. The aim was to show the effects of pravastatin on the eNOS and PECAM-1 expression in the placenta of preeclampsia rat model. Materials and Methods: This is a true experimental study with only a post-test and a control group design. The sample was biological material in the form of placental tissue from a pravastatin-treated preeclampsia rat model (using L-NAME exposure). This research was divided into five groups, each with five samples. The parameters studied were eNOS and PECAM-1 expression. Results: The Shapiro-Wilk test result was significant (p>0.05). Annova tests on eNOS (p=0.000) and PECAM-1 expression (p=0.000) confirmed the hypothesis. The Tukey test showed significant differences in eNOS (sig. 0.001) and PECAM-1 (sig. 0.000) expression between normal and preeclampsia rats. Positive controls and treatment groups P1, P2, and P3 all showed significant changes in eNOS and PECAM-1 expression. Pravastatin dose considerably increased eNOS (p=0.015; r=0.536) and PECAM-1 (p=0.000; r=0.734) expression.. Conclusion: Pravastatin has been shown to increase eNOS and PECAM-1 expression in the placenta of preeclampsia rat model.
Anaemia and Family Income are associated with Preeclampsia Maternal Death in Jember District, Indonesia Mergy Gayatri; Nurul Fathiyyah; Jesica Mulyadi; Diadjeng Setya Wardani; I Wayan Agung Indrawan
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.36 KB) | DOI: 10.55561/ajhr.v1i2.45

Abstract

Introduction: Preeclampsia is a pregnancy-related complication causing maternal morbidity and mortality. This study aimed to determine the relationship between anaemia and family income, and maternal death from preeclampsia in Jember district. Materials and Methods: Case-control, using medical maternal autopsy verbal, from January 2016 to December 2019. 43 mortality cases from preeclampsia, and 43 controls were included in this study. Chi-square test was to test the relationship between anaemia and family income, and maternal death from preeclampsia. Results: Mothers who died from preeclampsia were more likely to have anaemia (83.72%), and being low income (86.05%). Anaemia (OR 3.703, 95% CI p-value 0.009) and low income (OR 4.032, 95% CI, p –value 0.007) were associated with preeclampsia maternal mortality. Conclusions: To reduce the prevalence of death from preeclampsia, preventive measurement for anaemia during pregnancy should be undertaken. In addition, women with low income during pregnancy should be encouraged to have health insurance.
Is There A Link Between Climate Change and Human Health? Sutrisno, MD, PhD OG (REI)
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.629 KB) | DOI: 10.55561/ajhr.v1i2.52

Abstract

According to the final report of the Lancet panel on climate change [1,2], " climate change is the biggest global danger of the 21st century". The world's climate has permanently changed over time. Some regions of the Earth that are presently relatively warm were once covered in ice millions of years ago. In more recent decades, average temperatures have cycled up and down due to variations in solar radiation or the recurrent eruption of volcanoes [3]. There is broad scientific agreement that Human-caused greenhouse gas emissions are a vital contributor to global warming that is currently taking place. Global carbon dioxide emissions are rising, reaching a new high last year. Indonesians seek to fight the risk of poverty being undermined by climate change. Its effects are escalating the dangers and vulnerabilities that face the poor, adding to the strain on their already overworked coping mechanisms. Infectious diseases, malnutrition, stunting, degenerative diseases, cancer, autoimmune disease, maternal and perinatal mortality, and many more having close connection with climate change. Natural disaster to be more prevalent and aggravates the bad impact.  It is need to addresses the effects of climate change on health, contemporary sociopolitical views, and the need for public health and climate change policy that places a strong emphasis on the advantages to manage climate changes in reducing health impact in Indonesia and around the world [4].

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