cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Bayu Brahma
Contact Email
journal.cancer@gmail.com
Phone
+628176389956
Journal Mail Official
admin@indonesianjournalofcancer.or.id
Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta
Location
Kota adm. jakarta barat,
Dki jakarta
INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 562 Documents
 42   43   44   45   46 
Characteristics of Kidney Cancer Patients At Hasan Sadikin Hospital, Bandung Ardiansyah, Novan; Safriadi, Ferry
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1125

Abstract

Background:  Kidney cancer accounts for 5% and 3% of all malignancies in men and women, respectively, representing the 7th most common cancer in men and the 10th most common cancer in women. In Asia, especially in Indonesia, the incidence of kidney cancer has not been widely reported. Therefore, researchers intend to investigate the characteristics of Kidney Cancer at Hasan Sadikin Hospital, Bandung, during the period 2015–2019. Methods: This research is a descriptive retrospective study taken from the medical records of patients with kidney cancer in the Department of Urology, Universitas Padjadjaran, Hasan Sadikin Hospital. The study was conducted from June 2019 until all the medical record data for the sample were fulfilled. The data included age, gender, and histopathological findings. Results: From the data collection, it was found that there were a total of 126 patients with kidney cancer, occurring in 83 male patients (65.8%) and 43 female patients (34.2%). The age group 0–10 years dominated the occurrence of kidney cancer, with 32 out of 126 patients (25.4%), followed by the 41–50 age group with 30 patients (23.8%), and the 21–30 age group had the fewest diagnoses of kidney cancer. A total of 78 patients (61.9%) were diagnosed with Renal Cell Carcinoma (RCC). Clear cell RCC was more common, with 64 cases (50.7%), compared to papillary RCC with 13 cases (10.3%) and Chromophobe RCC with 1 case (0.8%). The most commonly found kidney cancer was Wilm’s tumor, with 33 patients (26.1%), occurring in individuals under 20 years of age. Conclusion: This study found that kidney cancer is more common in males than in females. RCC is the most frequently diagnosed type, with clear cell subtype being predominant, especially in patients over 40 years of age. Wilm’s tumor dominates kidney cancer cases in individuals under 20 years of age.
The Role of Biphosphonate and Denosumab in Bone Metastasis Cahyanur, Rahmat; Pravita, Aravinda
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1177

Abstract

Metastasis is a major contributor to cancer-related morbidity and mortality. Bone metastasis is prevalent and associated with pain and fractures, particularly in breast cancer where up to 80% of patients may be affected. Bisphosphonates, traditional anti-resorptive drugs, have been crucial in managing bone metastatic cancers. This article reviews the pathophysiology of bone metastasis, focusing on the invasion-metastasis cascade and the role of matrix metalloproteinases (MMPs). The formation of metastatic tissue in bones involves disrupting the balance of the bone remodeling process. The study delves into the three generations of bisphosphonates, elucidating their structural differences and mechanisms of action. First-generation bisphosphonates, such as etidronate and clodronate, lack nitrogen and interfere with cellular processes. Second-generation bisphosphonates, including alendronate and pamidronate, bind to nitrogen and inhibit farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway. Third-generation bisphosphonates like risedronate and zoledronate have a heterogeneous nitrogenous chain, enhancing anti-resorptive activity. Denosumab's distinct pharmacokinetics and potential risks upon discontinuation are discussed. The article emphasizes the need for clinicians to be vigilant about potential adverse effects, especially kidney toxicity with bisphosphonates, and to tailor treatment based on individual patient characteristics.
Prevalence of Sinonasal Cancer in Dr. Sardjito General Hospital Yogyakarta in The Period between January 2017 and December 2022 Indrasari, Sagung Rai; Herdini, Camelia; Yudistira, Danu; Mary, Cynthia
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1087

Abstract

Background: Sinonasal cancer is considered a rare disease and data concerning the disease in Indonesia still requires extensive research. This study aimed to describe the factors that contribute to the incidence and outcome of sinonasal cancer. Methods: This was a descriptive study conducted at the Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Sardjito General Hospital Yogyakarta between January 2017 and December 2022. Data regarding histopathological type, sex, age, location of tumor, presence of metabolic syndrome, staging, treatment, overall survival, and cancer recurrence were extracted from the patient’s medical records. All patients diagnosed with sinonasal cancer within the period were included in the study. Results: A total of 117 patients were included in this study ranging from 11 to 85 years of age and averaging 54,5 years. Most patients were diagnosed within the age range of 51 – 60 years. SCC was found to be the most common and it was more prevalent in males than in females. More patients were found to have suprastructure tumors. Most patients were not recorded to have metabolic syndrome. The majority of patients were diagnosed in the late stage of sinonasal cancer and overall survival for most cases was death. More patients received 2 or less therapy, followed by patients who received all 3 types of treatment. Recurrency was found in only 1,7% of all cases. Conclusion: Several conditions can affect the incidence and outcome of sinonasal cancer which include sex, age of diagnosis, presence of risk factors (e.g. metabolic syndrome), location of tumor, staging, treatment, recurrence, and the histopathological type.
Identification of CDH4 Gene Copy Number Alteration and Its Association with Clinical Profile of Colorectal Cancer Patient Ayu Dewi, Ni Nyoman; Rompis, Andreliano Yosua; Mulyawan, I Made; Ekawati, Ni Putu; Sun, H Sunny
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1135

Abstract

Background: The genes cadherin 4 (CDH4), Kirsten rat sarcoma viral oncogene homolog (KRAS), V-Raf murine sarcoma viral oncogene homolog B (BRAF), and microsatellite instability (MSI) each play a role in the development of colorectal cancer (CRC). CDH4 gene is located in chromosome 20q13.33 and its amplification or gain is the earliest mutational event found in the majority of CRC and colon polyps. This study aimed to identify copy number alteration in the CDH4 gene and its association with the clinical profile of CRC patients, including gender, age, tumor location and differentiation, frequency of BRAF and KRAS mutations, and MSI status. Methods: The DNA was extracted from 50 tumors and adjacent normal tissues based on the manufacturer’s instructions. Detection of MSI status was carried out by pentaplex polymerase chain reaction (PCR) and PCR products were size separated by capillary electrophoresis (CE) using an ABI 310 Genetic Analyzer. Both KRAS and BRAF mutations were identified by PCR and sequencing while CDH4 copy measurement was measured using TaqManTM Copy Number Assay. Results: Our findings showed 22 (44%) samples with no changes in the copy number of CDH4 gene. Interestingly, 21 (42%) cases had an amplification of the CDH4 gene or CDH4 gene gain, and seven (14%)  cases decreased in CDH4 gene expression or CDH4 gene loss. We found an association between changes in the CDH4 gene and gender (p=0.001). However, there was no association between changes in the CDH4 gene and age (p=0.979), tumor location (p=0.145) and differentiation (p=0.648), the frequency of BRAF (p=0.171) and KRAS mutations (p=0.184) and MSI status (p=0.923). Conclusions: Copy number alteration in CDH4 gene in CRC patients and this alteration is significantly associated with gender. Further studies with a larger number of samples are essential to confirm this result and to identify the cause of CDH4 copy number alteration and its biological significance.
Profile of Primary Brain Tumor Patients Who Received Radiotherapy at Hasan Sadikin General Hospital Bandung in 2020-2021 Rahmawaty, Siti Fira; Kusumadjati, Adji; Utama, Marhendra Satria
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1006

Abstract

Background: A brain tumor is a tumor that is most known for its dangerous progressivity. Brain tumor is classified into primary and metastatic types. One of the management for primary brain tumors is radiotherapy. This study aims to elucidate the medical profiles and Karnofsky Performance Status (KPS) of patients with primary brain tumors with radiotherapy in Hasan Sadikin General Hospital based on a hospital-based cancer registry (HCBR) in 2020-2021.Methods: This study was conducted with a descriptive method. The sampling technique was total sampling using 22 medical records of primary brain tumor patients with radiotherapy from the year 2020-2021 which were registered in HCBR at the Radiotherapy Department, Hasan Sadikin General Hospital.Results: Primary brain tumor patients with radiotherapy were mostly from the 25-34 years age group (27.3%), male gender (68.2%), with a regional origin of West Priangan (45.5%), the chief complaint was headache (45.5%), with topography presence of overlapping lesion in the brain (ICD-O code C71.8) (27.3%), histopathological type is predominantly astrocytic tumors (22.7%), majority of patients underwent subtotal resection (59.1%), adjuvant radiation therapy was mostly indicated (40.9%), with all patients using Linac external beam radiotherapy (EBRT) radiation device. Almost all patients can finish radiotherapy (95.5%). The waiting time for radiotherapy is mostly 5-6 weeks (31.8%).Conclusions: Primary brain tumor infects more men than women, with a predominant age group of 25-34 years old. Histopathological findings are mostly of the astrocystic tumor type with most chief complain being headaches. The most common treatment is subtotal resection followed by radiotherapy using EBRT Linac with a positive one-year-postradiotherapy prognosis.
The Relationship between Degree of Differentiation with the Incidence of Lymphovascular Infiltration Triple Negative Breast Cancer in West Sumatera Hidayat, Nur Latifah Alfaina; Yenita, Yenita; Khambri, Daan
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1010

Abstract

Background: The degree of differentiation and the incidence of lymphovascular infiltration in Triple Negative Breast Cancer (TNBC) are several determinants of the prognosis and survival of sufferers. This disease has a more aggressive clinical course than other breast cancer phenotypes. Targeted therapy has not been able to improve survival in TNBC patients. This study aims to analyze the relationship between the degree of differentiation and lymphovascular infiltration in Triple Negative Breast Cancer in West Sumatra. Methods: This is an observational analytic study with a cross-sectional approach. The number of study samples was 44 TNBC patients at the Ropanasuri Special Surgery Hospital, Ibnu Sina Islamic Hospital, and RSUP Dr. M. Djamil, Padang, in 2016–2021. The data studied were the degree of differentiation and lymphovascular infiltration from the results of anatomical pathology examination which were analyzed using the Chi Square test. Results: The most histopathological types in TNBC were Invasive Carcinoma Mammae of No Special Type (79,5%) with the most age range of patients over 60 years (43,2%). The majority of the degrees of differentiation found were grade II (75%), lymphovascular infiltration negative category (65,9%), and there was a significant relationship (p 0,001) between the degree of differentiation and lymphovascular infiltration in TNBC Conclusions: There was a relationship between the degree of differentiation and lymphovascular infiltration in TNBC, namely the higher the histopathological grade of cancer cells, the higher the probability of experiencing lymphovascular infiltration.
Marginal Excision as a Surgical Treatment for The Schwannoma of Posterior Aspect of Femur: A Case Report Raditya, Risang Haryo; Wiratnaya, I Gede Eka
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1151

Abstract

Introduction: Schwannoma is a benign nerve sheath neoplasm attached to a peripheral nerve that often develops in the middle-aged population. It usually presents as an asymptomatic mass at first but can be transformed into a pain, swelling, neurologic, or mechanical symptom in several patients. In this study, we are reporting a case of a schwannoma of the posterior aspect of the thigh, in a young adult male. Case Presentation: We reported a 31-year-old male complained of sharp pain, tingling sensation, and mechanical block in the posterior aspect of the right thigh. Radiological imaging showed the tumor of the posterior aspect of the right thigh, with associated soft tissue edema, the cortex is not invaded. Surgical resection was performed on the patient and the tumor was excised with marginal excision surgery technique. Conclusions: The schwannomas of the femur can successfully be excised with no postoperative complications. There is no sign of a recurrent tumor in six months after the procedure.
The Impact of COVID-19 Pandemic on Ocular Oncology Services at Cipto Mangunkusumo Hospital, Indonesia Anggraini, Neni; Nursanti, Hanifah Rahmani; Mahyuddin, Mutmainah
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1011

Abstract

Background:: Delay of diagnosis and treatment in ocular oncology services due to the COVID-19 pandemic is very disadvantageous. This study aimed to evaluate the impact of COVID-19 on new patients with suspected eye tumors in terms of volume, characteristics, and waiting time for a procedure. Methods: : A retrospective study based on hospital records of new patients was held in the ocular oncology clinic of Cipto Mangunkusumo Hospital, a tertiary eye care center in Jakarta, Indonesia. Patients were analyzed descriptively based on three time periods: pre-COVID-19, COVID-19 social restriction, and post-COVID-19 social restriction. Each patient was stratified according to case priority during the COVID-19 pandemic suggested by Indonesia’s Ophthalmologist Association (IOA). Results: During the COVID-19 social restriction between March to June 2020, new patient volume decreased by 73.1%, with a 75.5% decline in referrals from the governmental hospital. Elderly, pediatric, and highly educated patients were less likely to visit the clinic. Patients with acute onset, invasive or metastatic tumors, and advanced T-stage were more likely to be referred to the hospital. Third-priority cases referred with a lower ratio during COVID-19 social restriction (29% vs 44.9% in pre-COVID-19 and 35.1% in post-COVID-19 social restriction) and had to wait longer for the procedure (41 (18–60) days vs 28.5 (11–63) days in pre-COVID-19 and 16.5 (7–67) days in post-COVID-19 social restriction). Conclusions: : As the healthcare service was overwhelmed by COVID-19 patients, referral to ocular oncology services was severely disrupted, particularly in elderly, pediatric, and early T-stage patients. Strategies are needed to ensure that highly prioritized cases may access the services.
Total Knee Replacement of Synovial Haemangioma of The Knee Joint in a 44-Year-Old Male: A Case Report Idulhaq, Mujaddid; Saputra, Rhyan Darma; Wasita, Brian; Sabariyah, Lely; Gardjito, Fajar Baskoro; Nursulistyo, Fajar
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.911

Abstract

Introduction: Synovial hemangioma is a rare illness frequently misdiagnosed, leading to years of inaction. In this study, we aim to discover the consequences of untreated hemangioma of the knee joint. Case Presentation: Our patient was a 44-year-old male who experienced recurring pain in his left knee. The previous year, the patient experienced pain in his left knee while walking, which has subsided with rest. Although he has been performing radiography at multiple hospitals since 2019, no problems have been recorded. We detected a mass after performing magnetic resonance imaging. The T1-weighted sequence + contras near the medial femoral condyle revealed a homogeneous mass with high intensity. We decided to conduct surgical intervention and total knee replacement. Postsurgical, the patient regained symptom-free. Conclusions: Because of the limited radiographic capacity, synovial hemangioma is uncommon and challenging to diagnose on an outpatient basis. Magnetic resonance imaging and angiography are highly beneficial. If intraarticular hemangiomas are not considered, they can cause bony dysplasia and multiple clinical manifestations. Initial total excision can be conducted to decrease the chance of hemarthrosis.
Supraventricular Tachycardia Induced by Cisplatin in a Patient with Breast Cancer: A Case Report Laksono, Sidhi; Kusharsamita, Hillary
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1066

Abstract

Introduction: Cisplatin is one of the most extensively used chemotherapeutic agents for treating many malignancies. Cisplatin chemotherapy, on the other hand, is linked to cardiotoxicity, which may vary from silent arrhythmias to heart failure to sudden cardiac death. In this article, we describe a case of supraventricular tachycardia induced by cisplatin in a breast cancer patient. Case Presentation: Our patient had no history of heart disease and had SVT during cisplatin administration. This condition resolved when the infusion was stopped and amiodarone was administered intravenously. The electrolyte levels were within the usual range. No abnormalities were detected on her echocardiography imaging. Primary cardiotoxicity from cisplatin was subsequently determined to be this patient's root cause of SVT. The patient also had an excellent response to the subsequent cycles of treatment. Conclusions: It is important to note that cisplatin therapy is associated with cardiac toxicity. Arrhythmias such as SVT have been associated with chemotherapy drugs. Hence the ECG has to be closely monitored during cisplatin administration. In addition, An ECG and echocardiogram should be done regularly to rule out the possibility of a secondary form of chemotherapy-induced arrhythmia. 

Page 44 of 57 | Total Record : 562

 42   43   44   45   46 

Filter by Year

2007 2025


Reset
Filter By Issues
All Issue Vol 19, No 3 (2025): September Vol 19, No 2 (2025): June Vol 19, No 1 (2025): March Vol 18, No 4 (2024): December Vol 18, No 3 (2024): September Vol 18, No 2 (2024): June Vol 18, No 1 (2024): March Vol 17, No 4 (2023): December Vol 17, No 3 (2023): September Vol 17, No 2 (2023): June Vol 17, No 1 (2023): March Vol 16, No 4 (2022): December Vol 16, No 3 (2022): September Vol 16, No 2 (2022): June Vol 16, No 1 (2022): March Vol 15, No 4 (2021): December Vol 15, No 3 (2021): September Vol 15, No 2 (2021): June Vol 15, No 1 (2021): March Vol 14, No 4 (2020): December Vol 14, No 3 (2020): September Vol 14, No 2 (2020): June Vol 14, No 1 (2020): March Vol 13, No 4 (2019): December Vol 13, No 3 (2019): September Vol 13, No 2 (2019): June Vol 13, No 1 (2019): March Vol 12, No 4 (2018): October-December Vol 12, No 3 (2018): July-September Vol 12, No 2 (2018): April-June Vol 12, No 1 (2018): Jan - Mar Vol 11, No 4 (2017): October- December 2017 Vol 11, No 3 (2017): July - September 2017 Vol 11, No 2 (2017): April - June Vol 11, No 1 (2017): Jan-Mar Vol 10, No 4 (2016): October - December 2016 Vol 10, No 3 (2016): July - September 2016 Vol 10, No 2 (2016): April - June 2016 Vol 10, No 1 (2016): Jan - Mar 2016 Vol 9, No 4 (2015): Okt - Des 2015 Vol 9, No 3 (2015): Jul - Sept 2015 Vol 9, No 2 (2015): April-Juni 2015 Vol 9, No 1 (2015): Jan - Mar 2015 Vol 8, No 4 (2014): Oct - Dec 2014 Vol 8, No 3 (2014): Jul - Sep 2014 Vol 8, No 2 (2014): April-Juni 2014 Vol 8, No 1 (2014): Jan - Mar 2014 Vol 7, No 4 (2013): Oct - Dec 2013 Vol 7, No 3 (2013): Jul - Sep 2013 Vol 7, No 2 (2013): Apr - Jun 2013 Vol 7, No 1 (2013): Jan - Mar 2013 Vol 6, No 4 (2012): Oct - Dec 2012 Vol 6, No 3 (2012): Jul - Sep 2012 Vol 6, No 2 (2012): Apr - Jun 2012 Vol 6, No 1 (2012): Jan - Mar 2012 Vol 5, No 4 (2011): Oct - Dec 2011 Vol 5, No 3 (2011): Jul - Sep 2011 Vol 5, No 2 (2011): Apr - Jun 2011 Vol 5, No 1 (2011): Jan - Mar 2011 Vol 4, No 4 (2010): Oct - Dec 2010 Vol 4, No 3 (2010): Jul - Sep 2010 Vol 4, No 2 (2010): Apr - Jun 2010 Vol 4, No 1 (2010): Jan - Mar 2010 Vol 3, No 4 (2009): Oct - Dec 2009 Vol 3, No 3 (2009): Jul - Sep 2009 Vol 3, No 2 (2009): Apr - Jun 2009 Vol 3, No 1 (2009): Jan - Mar 2009 Vol 2, No 4 (2008): Oct - Dec 2008 Vol 2, No 3 (2008): Jul - Sep 2008 Vol 2, No 2 (2008): Apr - Jun 2008 Vol 2, No 1 (2008): Jan - Mar 2008 Vol 1, No 4 (2007): Oct - Dec 2007 Vol 1, No 3 (2007): Jul - Sep 2007 Vol 1, No 2 (2007): Apr - Jun 2007 Vol 1, No 1 (2007): Jan - Mar 2007 More Issue