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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 611 Documents
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Megavoltage CT/MRI-Guided Radiotherapy with Endorectal Balloon Support for Prostate Cancer Patient with Bilateral Hip Prostheses Hama, Yukihiro; Tate, Etsuko
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1203

Abstract

Introduction: Kilovoltage CT-guided radiotherapy for prostate cancer patients with bilateral hip prostheses can be challenging due to metal artifacts. Case Presentation: To compensate for reduced tissue contrast and suppress metal artifacts, a 76-year-old NCCN very high-risk prostate cancer patient underwent megavoltage CT/MRI fusion image-guided radiotherapy with an endorectal balloon. The post-treatment course was uneventful. There were no recurrences or serious side effects 11 years after radiotherapy. Conclusions: Megavoltage CT/MRI-guided radiotherapy with endorectal balloon support may be a viable alternative for a prostate cancer patient with bilateral hip prostheses.
Major Microbiota Profile of Breast Cancer From Faecal Specimen and Cancerous Breast Tissue: A Comprehensive Systematic Review Annisa, Annisa; Perdana Putri, Rachma Greta; Solikhah, Solikhah
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1030

Abstract

Background: The microbiota population in breast cancer tissue is known to have a crucial role in the tumor microenvironment supporting developmental ability. Despite a heterogeneous profile, the relationship between microbiota and breast cancer is still not fully understood. Therefore, this study aimed to explain the major microbiota profile associated with breast cancer and explore potential biological connections Methods: Following the PRISMA guidelines, the literature review investigated the diverse composition of microbiota profiles in breast cancer patients compared to those in normal conditions. Utilizing the PICO framework, a comprehensive search was conducted on the Pubmed and Google Scholar databases. The searches were restricted to open-access articles from the last 5 years. Additionally, critical appraisals are conducted for quality assessment. Results: A total of 145 articles were identified using the relevant keywords, out of which 17 successfully passed filtering and screening for inclusion in the review. Major microbiota observed in breast cancer patients included firmicutes, proteobacteria, actinobacteria, and bacteroidetes. The microbiota profile was influenced by factors such as cancer subtype, menopausal history, and tumor severity. These microorganisms play a role in the inflammatory response to their metabolite products and modulate hormonal changes, potentially enhancing tumor survival. Conclusions: Generalizing the expression of microbiota profile both in the gut or its tissue might be challenging due to its multifactorial nature, dependent on patient characteristics such as age, menopausal status, BMI, tumor grade, and subtype. The study suggests that the major microbiota that shows increased prevalence in breast cancer include firmicutes, proteobacteria, actinobacteria, bacteroidetes, and blautia, each playing a distinct role in the developmental process. 
Characterization of Classic Meningioma with Use of Conventional Magnetic Resonance and Diffusion Tensor Imaging Fatmawati, Heni; Adji, Novan Krisno; Bumi, Candra; Putri, Komang Yunita Wiryaning
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1133

Abstract

Introduction: The conventional magnetic resonance imaging (MRI) method is widely considered ‘with limited success’ in differentiating the meningioma types but may fail to localize the tumor occupation of white-matter fiber bundles accurately. Diffusion tensor imaging (DTI) is considered as an imaging modality that may elucidate the microstructure of brain tumors. We provide characteristics of meningioma using DTI-based-three-dimensional tracing of white matter to portray meningioma in a noninvasive approach and its structural contact to contiguous tumors and elucidate the influence of occupying lesions on white-matter fiber bundles. Case Presentation: A 28-year-old female presented with visuospatial disturbances and persistent headaches for 2 years. Conventional and advanced MRI studies were performed. Diffusion-weighted Images (DWI) and Apparent Diffusion Coefficient (ADC) values were measured in the lesion using routine MRI sequences. Advanced MRI using DTI was also performed. Conventional MRI outcomes showed tumor parenchyma, peritumoral edema, and compression on the circumnavigated brain tissue. There was hyperintense on DW trace image and isointense on ADC map. On T2-weighted image (T2WI) and Fluid-Attenuated Inversion Recovery (FLAIR) images, there was an increased signal intensity that demonstrated an extra-axial lesion, while T1-weighted imaging signals showed hypointensity. DTI fractional anisotropy (FA) marker is an unclear optic radiation in the concerned area, indicating the shift or destruction of the optic radiation. The mean FA values of solid-enhancing areas of meningioma were 0.28 ± 0.17. Mean ADC values (103 mm2/s) were 0.764 ± 0.172. Conclusions: Classic meningioma in this case has low intratumoral FA and high ADC. DTI displayed that intratumoral microscopic water motion is disorganized.
A Rare Parathyroid Carcinoma in Young Adult Man: Therapeutic Challenges in Tertiary Hospital with its Limitations Sitanggang, Rupita Sari Endangena; Azhar, Yohana; Agustina, Hasrayati
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1172

Abstract

Introduction: Parathyroid carcinoma is a rare malignant neoplasm. The symptoms that arise are related to hyperparathyroid conditions, which are clinically difficult to distinguish between benign and malignant disorders. These conditions make the diagnosis and treatment of parathyroid carcinoma challenging. Case Presentation: : In this case report, a 27-year-old male presented with weak limbs and a history of multiple recurrent fractures. Serum calcium ions and parathyroid hormone levels were increased. A comprehensive history taking, laboratory testing, and radiographic examination were used to confirm the diagnosis of parathyroid cancer. However, a histological study is still necessary to make a certain diagnosis. The patient underwent parathyroidectomy accompanied by intraoperative frozen section examination, then confirmed to have parathyroid carcinoma. Calcium serum evaluations were performed on the patient after surgery. Conclusions: Parathyroid carcinoma is a very rare case. Clinical manifestations and the results of investigations that are not typical and rarely found together in one patient’s condition make the diagnosis of this case very difficult. Although recommendations or standard protocols in the management of parathyroid carcinoma do not yet exist, the results of case reports are expected to increase the knowledge and management of parathyroid carcinoma patients.
Profile of Thyroid Cancer at Dr. Kariadi General Hospital Semarang in 2020 Sudarmanto, Alif Muhammad; Prajoko, Yan Wisnu; Istiadi, Hermawan; Yudhanto, Eka
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1017

Abstract

Background: Thyroid cancer is ranked ninth among the most common type originating from the endocrine glands globally, accounting for approximately 59.7% of cases in Asia. According to 2020 health data, thyroid cancer ranked twelfth in Indonesia, comprising 13,114 cases. Despite the number of cases recorded, there is a lack of comprehensive data regarding the condition of thyroid cancer in the country. Therefore, this research aimed to describe the thyroid cancer profile in Dr. Kariadi General Hospital Semarang.Methods: This descriptive research was carried out using 154 medical records selected through consecutive sampling from Dr. Kariadi General Hospital Semarang from January to December 2020. Categorical scale data were described through frequencies and percentages, while numerical scale data were presented as mean and standard deviation.Results: This research discovered that 57.8% of patients belonged to the 40–59-year-old age group, predominantly consisting of 79.9% females. Additionally, 39.6% of patients had normal thyroid function, with Papillary Thyroid Cancer being the most common type, constituting 92.7% of cases. The results showed that 46.8% of cases were bilateral, 37.7% had a condition of T3, 59.7% had N0, and 89.6% had M0, while 66.2% were classified as stage I.Conclusions: The majority of thyroid cancer patients were 45–64 years old and female. The results showed Papillary Thyroid Cancer as the most prevalent type, with the majority of cases diagnosed at stage I and showing bilaterally presentation. Most of the data correlated with previous research, except thyroid function and histopathology-type percentages.
Impact of Artificial Intelligence on Mammography Interpretation by Breast Radiologists, Non-Breast Radiologists, and Senior Residents Darmiati, Sawitri; Afifi, Rahmi; Billy, Christy Amanda; Panigoro, Sonar Soni; Kartini, Diani; Prihartono, Joedo
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1100

Abstract

Background: Artificial intelligence (AI) is recognized to have tremendous potential to revolutionize breast cancer management through mammography. However, the extent of its impact on radiologists with different levels of experience remains largely unexplored. Therefore, this study aimed to comprehensively show how AI could assist radiologists of varying expertise including breast and non-breast radiologists, as well as senior residents, in performing mammogram interpretation.Methods: This retrospective study analyzed eligible mammograms from Cipto Mangunkusumo Hospital between January 2017 and March 2021. Mammographic readings were conducted independently by two breast radiologists, two from other subspecialties, and three senior residents, all blinded to clinical information. AI standalone performance, as well as radiologists with and without AI assistance, was measured. Results: The results showed that a total of 886 eligible mammograms were analyzed. AI standalone performance, assessed using ROC curve analysis, yielded an AUC of 0.946 (95% CI, 0.925–0.967) with sensitivity and specificity of 90.1% and 93.6%, respectively. AI assistance significantly improved the sensitivity and specificity of all radiologists, regardless of experience level, with a median increase of 19.4% (IQR, 10.4–33.5%) and 12.1% (IQR, 5.2–16.2%), respectively. Moreover, there was a trend toward a higher increase with AI assistance in dense compared to fatty breasts.Conclusions: AI proved to be a highly effective diagnostic supplement for radiologists across varying experience levels, specifically in non-breast radiologists, offering the potential to add even greater value in cases of dense breast tissue. The results were derived from a national referral tertiary hospital that generally received many breast cancer cases referred from other hospitals for further treatment. Therefore, further studies incorporating different levels of hospitals were needed.
The Association of Circumcision and Genitourinary Cancer, Especially Penile Cancer and Prostate Cancer: A 30-Year Systematic Review and Meta-Analysis Surya, Prima Ardiansah; Putratama, Alfin; Surya, Radika Naufal Hadi; Ananda, Gede Yogi Prema
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1123

Abstract

Background: The relationship between genitourinary cancer and circumcision has been debated for a long time. Two types of genitourinary cancer that are often discussed in relation to circumcision are penile cancer and prostate cancer. Methods: A systematic review was conducted on the Science Direct database and Perish with the following databases: Pubmed, Google Scholar, and Crossref. Case-control studies were assessed with the Newcastle-Ottawa Scale. Meta-analysis was performed on penile cancer in situ, invasive penile cancer, and prostate cancer. Meta-analysis of proportions was carried out on penile cancer. Results: 10 studies were analyzed for penile cancer and prostate cancer, and 9 studies were analyzed for penile cancer proportion. Total OR in circumcision and penile cancer in situ (OR = 0.90; 95% CI 0.48–1.69; p = 0.74). Total OR in circumcision and invasive penile cancer (OR = 1.04; 95% CI 0.27–3.94; p = 0.95). Total OR in circumcision and prostate cancer (OR = 0.97; 95% CI 0.79–1.19; p = 0.78). The uncircumcised proportion among penile cancer cases (0.82; 95% CI 0.60–0.97). Conclusions: There was no significant relationship between circumcision and genitourinary cancer. Malignant cells in penile cancer and prostate cancer occur due to a chronic inflammatory process.
The Role of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients: A Literature Review Giselvania, Angela; Sekarutami, Sri Mutya; Munandar, Arie; Halim, Devina Adella; Wijovi, Felix
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1190

Abstract

Background: Globally, hepatocellular carcinoma (HCC) is the most prevalent kind of primary liver cancer. Treatment options for HCC include radiotherapy, immunotherapy, surgery, targeted therapy, transarterial chemoembolization, and hepatic arterial infusion chemotherapy. Limited efficacy was observed since 70-80% of cases are diagnosed late and unresectable. Growing evidence reported that SBRT is a viable option for locoregional treatments like radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) for patients who did not respond to those treatments. Methods: A thorough search of electronic databases including PubMed, Cochrane Library, and Embase was conducted for studies on Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma published in English over the past 10 years. The review process followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to ensure a systematic approach. Inclusion criteria encompassed studies focusing on SBRT use in HCC treatment, with extracted data synthesized to provide a comprehensive overview of current evidence. Any discrepancies during the review were resolved through consultation with a third reviewer when necessary. Results: In comparison to conventional radiation therapy, Stereotactic Body Radiation Therapy (SBRT) offers precise administration of the high dose of radiotherapy, given in fewer fractions, and may be used in conjunction with other therapy modalities. Global guidelines, including in Indonesia, have proposed the implementation of SBRT. Local control was reportedly achieved in around 90–95% of HCC patients. Multimodal therapies, combined with TACE, showed superior results regarding the local control and overall survival. SBRT may eventually become the definitive treatment for early-stage HCC patients and has a critical role as a transitional therapy for patients awaiting liver transplantation. Improved outcomes and quality of life were also observed in patients with portal vein thrombosis (PVT) and extrahepatic metastases who underwent SBRT. Conclusions: SBRT results in promising local control, raises overall survival, and improves the quality of life in HCC patients with various stages.
Epidemiological Characteristics and 3-year Overall Survival Outcome of Nasopharyngeal Cancer in Central Java: A Single Institution Retrospective Study Liemiyah, Rikha; Ruspita, Dian Ayu; Naftali, Zulfikar; Muyassaroh, Muyassaroh; Farokah, Farokah
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1083

Abstract

Background: Nasopharyngeal cancer (NPC) has a high incidence and mortality rate in Indonesia, indicating poor survival outcomes. We aimed to evaluate the survival rate of NPC patients and the influence of specific underlying epidemiological characteristics on the overall survival (OS) rate of NPC patients. Methods: We reviewed the medical data from Dr. Kariadi General Hospital's clinical registry system for all newly diagnosed NPC patients between January and December 2018. We retrieved NPC patients' medical record data that met our inclusion/exclusion criteria. The overall survival rate (OS) was estimated using the Kaplan-Meier method. Between-group stratified three-year OS comparisons were conducted using weighted log-rank tests. All statistical analysis was performed in R statistical software. Results: A total of 50  NPC patients were included in the study. Majority of NPC patients were diagnosed in younger age group (58.0%). Male NPC patients dominated this study (74.0%). NPC patients were mostly diagnosed at the advanced stage (76.0%). Nonkeratinizing histology types were frequently found in the study (82.0%). NPC patients achieved a desirable better performance status (78.0%) and had no comorbidities (74.0%). Most NPC patients demonstrated a complete response to therapy (58.0%). The mean follow-up was 26.36 ± 9.5 months and drop-out rate was 18.0%. The three-year OS was 60.8%. Age, sex, stage, histological classification, performance status, comorbidity, therapy response, and therapy drop-out stratified OS did not statistically differ among NPC patients. Conclusions: We found a satisfactory NPC three-year OS. The underlying epidemiological characteristics did not significantly influence the NPC patients' three-year OS.
The Correlation of PD-L1 Overexpression With Tumor Budding In Cervical Carcinoma Lestari, Desak Putu Oki; Analysa, Analysa; Armerinayanti, Ni Wayan; Riasa, I Nyoman Putu; Artha, I Gusti Alit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1103

Abstract

Background: Several studies have proven the relationship between PD-L1, which is known as an immunotherapy target, and poor prognosis. The presence of a tumor budding (TB) group tumor outside the main tumor is also associated with a poor prognosis. The purpose of this study was to determine the relationship between PD-L1 and the grade of TB in cervical carcinoma. Methods: The design of this research is a case-control study with a retrospective approach. The sample is from a paraffin block of the primary cervical cancer tumor from the results of surgery in Balimed Denpasar Hospital between 2020 and 2023. From the statistical formula for the case-control study, a minimum sample of 15 is obtained for the case group with the criteria of high-grade TB, while 15 people were in the control group with low-grade TB. Immunohistochemistry (IHC) PD-L1 is positive if the membrane or cytoplasm is brown, and is negative if there is no brown color on the membrane or cytoplasm. Inferential statistics were used to evaluate the relationship between PD-L1 overexpression and low- and high-grade TB in cervical carcinoma using a chi-square test. Results: The results of this research revealed (p = 0.273) that there was no correlation between PD-L1 expression and high- and low-grade TB. Overexpression of PD-L1 was associated with a 2.250-fold increased risk of high-grade TB (OR = 2.250 with a 95% confidence interval of 0.103–1.915). Conclusions: The severity of TB does not correlate with PD-L1 expression. The functions of PD-L1 and other variables in the carcinogenesis of TB development are the cause of this weak association.

Page 42 of 62 | Total Record : 611

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