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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 11 Documents
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Search results for , issue "Vol. 8, No. 1" : 11 Documents clear
Aktivitas Antiplasmodium in vivo fraksi N-butanol kulit batang Mahoni (Swietenia mahagoni) dan Asam Klorogenat Lukmayani, Yani; Supriyatna, Supriyatna; P. S, Glorida; Muis, Abdul
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Abstract

An antiplasmodial activity of n-butanol fraction from mahoni bark extract (Swietenia mahagoni Jacq.) and pure compound chlorogenic acid were investigated on white male miceSwiss derivated strain which were infected by Plasmodium berghei ANKA strain. Samplewere administrated i.p ., which n-butanol fraction with convertion dose 100, 200 and 400 mg/kgBW and chlorogenic acid with dose 0,01; 0,1; 1 and 10 mg/kg BW respectively for a period of 4days, consecutively started one day after parasit inoculation.Parasit persentage was counted daily (H0 to H4).The best aniplasmodial activity was shown by n-butanol fraction with convertion dose 200mg/kg BW (fraction dose 81,89 mg/ kg BW )with inhibition persentage 45.05% and chlorogenic acidwith dose 10 mg/kg BW with inhibition persentage 55,51%.
Efek Antidiabetes dan Identifikasi Senyawa Dominan Fraksi Kloroform Herba Ciplukan (Physalis angulata L.) Sediarso, Sediarso; Sunaryo, Hadi; Amalia, Nurul
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Antidiabetic activity of ciplukan (Physalis angulataL.) herb has a lot to do, as an extracts and infusions, proven to reduce blood sugar levels in rats or mice induced by alloxan. The research objective was to evaluate the antidiabetic effect and identify the content of the chloroform fraction ciplukan herb eluated with methanol-ammonia. Antidiabetic effects testing conducted using 30 male white mice (Mus musculus) ddY strain were divided into 6 groups, each consisting of 5 mice. K-1 is a negative control induced by alloxan, K-2, K-3 and K-4 induced by alloxan and treated with the test substance dose of 50 mg/kg bw/ day, 100 mg/ kg bw/day, 200 mg/kg bw/day, K-5 is a positive control, induced by alloxan and treated with metformin dose of 65 mg/kg bw, K-6 as normal controls. Each mouse blood samples taken on day 7 and day 14, to test their blood sugar levels . Data were ana- lyzed using one-way anova and multiple differences test. Identification of the content of the chloroform fraction eluated with methanol-ammonia , carried out by gas chromatography mass spectrometry (GC-MS). The results showed that all three doses showed a decrease in blood sugar levels significantly at day 7 , but the decline has not reach normal levels. Blood sugar levels drop significantly and the decline has reached normal occurred on day 14 . Dominant content of the chloroform fraction eluated with methanol-ammonia is a class of unsaturated fatty acid chain length is Hexanoic acid, C16H12O2, hexadecanoic acid methyl ester, C17H34O2, 9-octadecenoic acid methyl ester, C19H36O2, Oleic acid butyl ester, C22H42O2, 9-octadecenoic acid, C19H36O2, Octadecanoic acid, C18H36O2, 1,2-Benzendicarboxylic acid, C8H6O4, and Aplysterylacetate, C31H52O2. Another result is that Nordextromethorphan alkaloid compound, C17H23NO. The conclusion is chloro- form fraction of ciplukan herbhas antidiabetic effects and has a class of compounds content of unsaturated fatty acids, Aplysterylacetate and alkaloid Nordextromethorphan.
Analisis Adduct DNA Setelah Pemberian Natrium Nitrit dan Dimetilamin Secara Berulang Pada Tikus Meilianti, Sherly; Harahap, Yahdiana; Hayun, Hayun
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Nitrosodimethylamine is a carcinogenic compound which can be formed from the reaction of nitrite and dimethylamine that is found in food. Nitrosodimethylamineis activated in liver and alkylates the DNA base and producing a DNA adductssuch as O6-methylguanine and N7-methylguanine that have a role incarcinogenesis. In this research, DNA was isolated from rat’s blood which waspreviously given nitrosodimethylamine’s precursor, sodium nitrite anddimethylamine. DNA adducts can be obtained from hydrolysis in hydrochloricacid 0.1 N for 30 minutes at 7000C. Then the adducts were analyzed using High Performance Liquid Chromatography (HPLC), with a strong cation exchangecolumn (Supelcosil LC-SCX, 5 μm, 250 x 4.6 mm), mobile phase consisting ofammonium phosphate with a final concentration of 40 mM, pH 3.00, flow rate 1.5mL/minute, column temperature 30oC and detected at exitation wavelength 286 nm and emission wavelength 366 nm. This method gave an acceptable validation result according to accuracy and precicion test results that fulfill the requirementand linear calibration curve with a quantitation limit of 22,5403 ng/mL. Rats were divided into six groups that two groups were given nitrosodimethylamine aspositive control, three groups were given prekursor, and the other was normalcontrol. Blood samples were collected in 1,2 and 4 hour after last induced. Aftergiving sodium nitrite 110 mg/kg bw and dimethylamine (1:5) orally for a week,N7-methylguanine and O6-methylguanine had not been detected in rat’s blood.
Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution study showed that PEC could retard the release of famotidin for 10 hours. PEC in combination with HPMC could retard the release of famotidin for 20 hours. Tablet that only contains PEC as matrix could remain buoyant for 12 hours while tablet with combination of PEC and HPMC could remain buoyant for 24 hours.
Pengembangan Sistem Penghantaran Obat Solid Self-Emulsifying Mikropartikel Gliklazid untuk Meningkatkan Disolusi Suryani, Mega; Sutriyo, Sutriyo
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Gliclazide is a Hypoglycemicdrug, second-generation sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Gliclazide exhibit poor aqueous solubility, so that their low bioavailability. Objectivesthis study is to develop solid self-emulsifying (SE) microparticles of poorly soluble gliclazide to dissolution enchancement. These microparticles were prepared by spray drying method, using three surfactant (acripol, tween 80 and sodium lauryl sulphate) with various concentration. SE microparticles characterized in terms of morphology (SEM), particle size distribution (PSA), x-ray diffraction (XRD), thermal analysis (DSC), functional group analysis (FTIR), solubility test, and dissolution test. The all gliclazide SE microparticlesexhibited particle size smaller than pure gliclazide. The dissolution rate of gliclazide SE microparticles at one hour was increased about 2 to 3 times than gliclazide.
Preliminary Characterization, Antioxidant and Antiproliferative Properties of Polysaccharide from Caulerpa taxifolia Bayro, Ariane Marie; Manlusoc, Joanne Katherine; Alonte, Renaliza; Caniel, Catherine; Conde, Patrick; Embralino, Carlo
Pharmaceutical Sciences and Research Vol. 8, No. 1
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Macroalgae are abundant sources of bioactive polysaccharides and prospective candidates for effective and non-toxic substances. This study aims to preliminary characterize and determine the in vitro antioxidant activity and cancer cell growth inhibitory activity against human lung adenocarcinoma cell (A549) of the polysaccharide from an invasive green alga, Caulerpa taxifolia. Crude polysaccharide (CP) was extracted from the dried algal sample of C. taxifolia by hot water extraction followed by absolute ethanol precipitation. CP was subjected to preliminary chemical characterization, including protein, carbohydrate, and sulfate content analysis by Kjeldahl titrimetry, acid hydrolysis, gravimetry, and ashing-acid water digestion ion chromatography, respectively. Functional groups present in the CP were determined by Fourier transform infrared spectroscopy (FT-IR). Antioxidant activity was evaluated by 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH) free radical scavenging activity assay. The cancer cell growth inhibitory activity against A549 cells was evaluated by MTT assay. Chemical composition of the CP shows 68.4 % (w/w) carbohydrate, 9.4% (w/w) protein, and 0.74% (w/w) sulfate. FT-IR showed the presence of -OH group, C-H stretch groups, C=O groups, and C-O groups and suggested a pyranose configuration of the sugar structure. MTT assay showed the highest inhibition at 25 μg/mL concentration with 35.50% ± 1.66 SEM with a relative IC50 of 45.44 μg/mL. However, the DPPH assay did not exhibit remarkable free radical scavenging capacity than other studies of polysaccharides with only 18.33% at 1 mg/mL. This exploratory study paves the way to explore the mechanism of action of polysaccharides from marine algae as a possible anticancer treatment.
Interpersonal Relationship and Its Effect on Treatment Compliance in Patients with Type-2 Diabetes Mellitus Renaldi, Fransiskus Samuel; Riyadina, Woro; Qamar, Muhammad; Sauriasari, Rani
Pharmaceutical Sciences and Research Vol. 8, No. 1
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Type-2 diabetes mellitus has become a chronic disease that can lead to serious complications and can only be prevented by compliant treatment of the patients. Compliance can be influenced by various factors, one of which is interpersonal factors. This study aimed to identify various interpersonal relationship problems between patients and healthcare workers that can affect their treatment compliance behavior. This study employed a qualitative design with phenomenological methods. This research was conducted in Central Bogor City in March-August 2020. The data were collected by conducting in-depth interviews with 20 type-2 diabetes mellitus patients who had been confirmed by the Community Health Center and focus group discussions with 12 healthcare workers consisting of doctors, pharmacists, nutritionists, and nurses. The data were then transcribed and content clouds analysis was carried out. The results showed that most of the patients (76%) followed the advice given by healthcare workers to carry out routine controls. This is a form of patients’ trust in healthcare workers as their health consultants. The trust arises from the convenience of interaction between the two parties. Providing adequate information will increase patients’ understanding and encourage them to take appropriate action for themselves. As many as 12 out of 20 patients chose the Community Health Center for their routine control because the services were sufficient in treating type 2 diabetes mellitus. From this study, it can be concluded that patients tend to comply if they feel trust in the health workers, which arises if they can feel the benefits during their therapy.
A Review: Composition of Neonatal Meconium Microbiota and Its Role for Potential Probiotic Oktaviyani, Devi; 'Alawiyyah, Raden Zulfa; Nusaiba, Putri; Malik, Amarila
Pharmaceutical Sciences and Research Vol. 8, No. 1
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Early-life period (≤ 1 month after birth) is critical for determining long- and short-term health of neonates. Composition of neonates’ gut microbiota varies greatly between individuals whose development is influenced by various factors including differences in maternal diet and lifestyle during pregnancy, related to population and ethnicity. Balanced microbial composition can create symbiosis among commensal microbes, immunomodulatory compound production, and subsequent immune response regulation. Unbalanced microbiota composition, characterized by more pathogenic organism, less diversity, and less resistance to disease, is called dysbiosis. Probiotic bacteria are a bacteria group contributing to the balance of neonates’ gut microbiota. Probiotic bacterial strains, such as Lactobacillus, Bifidobacterium and Streptococcus strains, are present in neonatal meconium microbiota. Meconium, a biological material formed during pregnancy, is a useful source of information in describing in utero microbial environment. This review aims to describe probiotic potential in profile composition of neonates’ microbiota meconium of multiple ethnicities as marker of neonates’ health level. Molecular-based sequencing method, such as Next-Generation Sequencing (NGS), is the preferred method for analyzing complex microbiota communities, such as gut microbiota. Neonatal meconium samples are collected and DNA extractions are carried out, then the target genes are amplified by PCR. The amplicons obtained are sequenced and characterized to determine the presence of potential probiotic strains in sample. Whether the probiotic strains can be used to measure neonates’ health level during period of growth and development is also described. Those probiotic strains could be developed as microbial therapeutic agent in gastrointestinal tract disorder therapy.
Comprehensive In Silico Analysis of Christinin Molecular Behaviour from Ziziphus spina-christi Leaves on Propionibacterium acnes Darusman, Fitrianti; Fakih, Taufik Muhammad
Pharmaceutical Sciences and Research Vol. 8, No. 1
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The role of in silico studies in the discovery of new drugs is very important and interesting in the recent years, where the results can be used as confirmation of the results of in vitro tests carried out experimentally in the laboratory. One of the herbal ingredients is Ziziphus spina-christi leaves with effective antibacterial activity, such as for acne-causing bacteria, namely Propionibacterium acnes. This is because it contains main secondary metabolites with saponins as the major components which contain christinin as its active compound. There are four known types of christinin, namely christinin-A, christinin-B, christinin-C, and christinin-D. In this study, the molecular interaction of the christinin compound was tested to predict its affinity for Propionibacterium acnes compared to clindamycin, as well as to determine the level of safety on the skin so that it can be applied as a topical anti-acne dosage form. In silico studies, including molecular docking and toxicity prediction, were used to assess the activity of four molecules of the christinin compound on c-Jun N-terminal kinase (JNK) macromolecules. The christinin molecules form a strong and stable molecular interaction with the active site of the binding of c-Jun N-terminal kinase (JNK) macromolecules. Interestingly, the christinin compound molecules also has a fairly good level of safety based on the three identified parameters. Based on this results christinin compound molecules has potential to be developed as c-Jun N-terminal kinase (JNK) inhibitors candidate to control of skin infections caused by Propionibacterium acnes which has potential as a topical anti-acne.
Identification of Adverse Drug Reactions in Congestive Heart Failure Patients in a Tertiary Care Hospital, West Nusa Tenggara, Indonesia Lupitaningrum, Dita Marina; Ramdaniah, Putri; Yuliana, Depi
Pharmaceutical Sciences and Research Vol. 8, No. 1
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Congestive Heart Failure (CHF) is a progressive health problem with high mortality and morbidity and has the potential to develop adverse drug reactions (ADRs). This study was conducted to determine the prevalence of potential ADRs, the types of drugs that cause ADRs, the types of ADRs, and the risk factors that affect the ADRs in CHF patients. Data were collected using medical record of hospitalized patient at the West Nusa Tenggara (NTB) Provincial Hospital, Indonesia, in 2017 to 2019. The assessment of the causality and severity of ADRs used the Naranjo algorithm and the Hartwig and Siegel scale. This study used 325 CHF patients’ data. Of 325 CHF patients, 223 patients (69%) were recorded as having ADRs with 446 total cases of ADRs, consisted of 4 (0.9%) highly probable, 187 (41.9%) probable, and 255 (57.2%) possible. The drugs that cause ADRs with a highly probable status are bisoprolol and ramipril. The most ADRs categories were level 1 (76.0%), followed by level 2 (17.3%), level 3 (6.5%), and level 4A (0.2%). The most affected organ systems were the muscles, joints, and nervous system (n=136, 37.7%), followed by renal, and gastrointestinal system. No association between ADRs with several risk factors, such as gender, age, and comorbidities. The prevalence of ADRs in CHF patients in this study was 69%, with the highly probable category in causing ADRs were bisoprolol and ramipril. ADRs that mostly occurred were in the mild category. ADRs monitoring in CHF patients is especially important to achieve optimal therapeutic results.

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