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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 13 Documents
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Search results for , issue "Vol. 9, No. 1" : 13 Documents clear
Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes Sari, Santi Purna; Azizahwati, Azizahwati; Ratimanjari, Diandra Andina
Majalah Ilmu Kefarmasian Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Many diabetics perform self-medication with antidiabetic herbs and synthetic drugs with the aim to obtain a synergistic or additive effects without informing their primary physician, such as the use of creat and glibenclamide. This research was carried out to know the impact of creat herb infusion on glibenclamide in bwering blood glucose levels on diabetic male albino rats. This study used 24 male Sparague-Lawley rats, which are divided into 6 groups, normal control and diabetic control were given 0,5% CMC solution I ml/200 g bw of rat, glibenclamide control were given glibenclamide suspension 0,9 mg/200 g bw of rat, creat control were given creat herb infusion 50 mg/200 g bw of rat, and 2 interaction groups were given creat herb infusion in 2 variant doses (50 and 100 mg/ 200 g bw of rat) and glibenclamide suspension 0,9 mg/200 g bw of rat, each of them were administrated orally. All of groups were induced with alloxan 32 mg/ 200 g bw of rat except normal control. Blood glucose was measured by 0-toluidine method at 2 hours and 4 hours after administration. The result showed that the creat herb infusion at 100 mg/200 g bw gave significant impact on glibenclamide in lowering blood glucose levels week after administration.
Uji Penghambatan Aktivitas alfa-glukosidase Ekstrak dan Fraksi Daun Antidesma neurocarpum Miq. Widihasputri, Rieka; Elya, Berna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Diabetes mellitus is a metabolic dysfunction disease showed by hyperglicemia and abnormality of carbohydrates, fats, and proteins metabolism. It is known can be cured with a-glucosidase inhibitor. Previous experiment reported that methanol extract from leaves of Antidesma neurocarpum Miq. has a strong inhibitory activity of a-glucosidase (IC50 = 2,18 mikrogram/mL). The aim of this experiment was to know about the most active extract and fraction of inhibitory activity of a-glycosidase and also the chemical compounds from those most active extract and fraction. Extraction is done by using multilevel maceration (n-hexane, ethyl acetate and methanol). Inhibitory activity of a-glucosidase tested with microplate reader at 405 nm wavelength. As standard, we used carbose (IC50=38.37 gg/mL). Methanol extract has the strongest inhibitory activity of a-glucosidase as shown the highest inhibitor percentage (89.53%). It is identified the chemical compounds and fracinationed by flash column chromatography. Fractination produced 15 combined fractions. Combined fractions which more than 200 mg tested to know their inhibitory activity of a-glucosidase. Result showed that the most active fraction is the 8th (IC50=40.77 gg/mL) with a competitive inhibitor mechanism to a-glycosidase. Chemical compounds that is found in the methanol extract and 8th fraction of Antidesma neurocarpum Miq. leaves are flavonoids, tannins, glycosides, fenol and alkaloids.
Efek Antidiabetes dan Identifikasi Senyawa Dominan Fraksi Kloroform Herba Ciplukan (Physalis angulata L.) Sediarso, Sediarso; Sunaryo, Hadi; Amalia, Nurul
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Antidiabetic activity of ciplukan (Physalis angulata L.) herb has been widely observed, as an extracts and infusions, proven to reduce blood sugar levels in rats or mice induced by alloxan. The research objective was to evaluate the antidiabetic effect and identify the content of the chloroform fraction ciplukan herb eluated with methanol-ammonia. Antidiabetic effects testing conducted using 30 male white mice (Mus musculus) ddY strain were divided into 6 groups, each consisting of 5 mice. K-1 is a negative control induced by alloxan, K-2, K-3 and K-4 induced by alloxan and treated with the test substance dose of 50 mg/kg bw/day, 100 mg/ kg bw/day, 200 mg/kg bw/day, K-5 is a positive control, induced by alloxan and treated with metformin dose of 65 mg/kg bw, K-6 as normal controls . Each mouse blood samples taken on day 7 and day 14, to test their blood sugar levels. Data were analyzed using one-way anova and multiple differences test. Identification of the content of the chloroform fraction eluated with methanol-ammonia, carried out by gas chromatography mass spectrometry (GC-MS). The results showed that all three doses showed a decrease in blood sugar levels significantly at day 7 , but the decline has not reach normal levels. Blood sugar levels drop significantly and the decline has reached normal occurred on day 14. Dominant content of the chloroform fraction eluated with methanol-ammonia is a class of unsaturated fatty acid chain length is Hexanoic acid, C16H1202, hexadecanoic acid methyl ester, C17H3402, 9-octadecenoic acid methyl ester, C19H3602, Oleic acid butyl ester, C22H4202, 9-octadecenoic acid, C19H3602, Octadecanoic acid, C18H3602, 1,2-Benzendicarboxylic acid, C8H604, and Aplysterylacetate, C31H5202. Another result is that Nordextromethorphan alkaloid compound, Cl 7H23NO. The conclusion is chloroform fraction of ciplukan herb has antidiabetic effects and has a class of compounds content of unsaturated fatty acids, Aplysterylacetate and alkaloid Nordextromethorphan.
Skrining Fitokimia dan Uji Penghambatan Aktivitas alfa-glukosidase pada Ekstrak Etanol dari Beberapa Tanaman yang Digunakan sebagai Obat Antidiabetes Munim, Abdul; Azizahwati, Azizahwati; Andriani, Ayu
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglicemia and associated with abnormalities in carbohydrate, fat, and protein metabolisms. Patients with DM in the world continue to increase along with population growths. Starting from this condition, searching for sources of DM treatment is always performed. One therapy of DM is a-glucosidase inhibitor. a-Glucosidase is an enzyme that can break down a complex carbohydrate into simple sugar. lhe inhibiton of this enzyme can retard the rate of carbohydrate digestion resulting in a delay in glucose absorption. The purpose of this studywas to identify the content of chemical compound and to test the a-glucosidase inhibitory activity in ethanolic extracts of some plants used as antidiabetic. a-Glucosidase inhibitory activity test carried out by spectrophotometric method. The simplisia powder was extracted by reflux using 80% ethanol. Based on a-glucosidase inhibitory activity test, all the plant extracts were active in inhibiting a-glucosidase. lhe three most active extracts were Ceiba pentandra (L.) Gaetern bark extract, Saccharum offcinarum root extract, and Persea americana Mill. bark extract with IC50 of 5.16, 10.35 and 10.83 ppm, respectively. They contain glycoside, tannin, and saponin. The test results of the kinetics enzyme inhibition showed that Randu bark extract had competitive inhibitory activity.
Pengaruh Pemberian Sari Buah Mengkudu (Morinda citrifolia Linn.) Terhadap Glibenklamid dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes Sari, Santi Purna; Munim, Abdul; Fitriani, Sri Wulandah
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Drug interactions can occur in the use of two or more drugs simultaneously, including the use of synthetic drug with herbal medicine. Combination of glibenclamide with noni juice (Morinda citrifolia Linn.) often used by diabetic patient to decrease their blood glucose level. lhe aim of this research was to know the interaction between glibenclamide and noni juice administration on blood glucose level. This research used 24 Sprague-Dawley male rats which were divided into 6 groups. Before the experiment, the rats were first induced by alloxan, except group 1, which was the normal control. Group 2 was the control of diabetic without given any drugs. Group 3 and 4 were the control of glibenclamide (0.9 mg/200g body weight of rat) and of noni juice (2.5 ml/200g body weight of rat) respectively. Group 5 and 6 were the interaction test group which were given glibenclamide (0.9 mg/ 200 g body weight rat) and noni juice (2.5 ml or 5.0 ml/200 g body weight of rat) with an hour interval. The blood glucose level was measured by using spectrophotometer with o-toluidine as reagent. The result of this research shows that noni juice at a dose 5.0 ml/200 g body weight rat was able to increased the reduction of blood glucose levels by glibenclamide after two weeks administration
Archaeosomes and Tetraether Lipid Liposome Freisleben, Hans-Joachim
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Archaea have phytanyl ether lipids which is one of the characteristics that separates them from bacteria and eukaryotes. Some archaea have also unique membrane spanning tetrae ther lipids (T EL); in Sulfolobus and Ihermoplasma species these TELmake up the majority of total membrane lipids. Archaeal lipids are able to form stable liposomal structures, both from membrane factions, mainly the polar membrane fraction, i.e. archaeosomes, or from highly purified TEL (tetraether lipid liposomes). Liposomes of the main polar lipid (MPL) from thermoacidophilic archaeon Ihermoplasma acidophilum were thoroughly inevstigated. Archaeosomes and TEL liposomes exhibit extremely low proton permeability and high stability at low pH, which makes them suitable to delivery of therapeutics and vaccines via the gastro-inetestinal route. Liposomes from egg lecithin can be stabilized by incorporation of 11-12 mole% MPL. MPL liposomes show long-term shelf stability even at high temperatures without conservation. The size of MPL liposomes between 100 nm (unilamellar) and several gm (multilamellar) depends mainly on the method of preparation. Toxicity and mutagenicity have not been detected in toxicological screening. This is a review report on the lipid from archaea to be developed as an alternative to conventional liposome for various industrial applications, especially for pharmaceutical industry.
Mitragyna speciosa as a Potential Substitute Therapy in Opioid Dependence: A Case Report Khalid, Karniza; Wong, Jason S.K.; Jamaluddin, Ruzita
Pharmaceutical Sciences and Research Vol. 9, No. 1
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Preclinical data have consistently suggested the pharmaceutical potential of kratom (Mitragyna speciosa), including as a substitute therapy in opioid dependence. In this case report, we present a case of a man with a long history of kratom use to help him cope with his opiate withdrawals while abstaining from illicit drug use. This is the first published detailed case report highlighting the potential use of kratom to aid opioid dependence encountered in the clinical setting. Our article is also supported by literature review with regards to kratom’s safety profile and pharmacological potential.
Association of Environmental Pollutants Exposure with Pulmonary Fibrosis: A Mini Review of Molecular Mechanism Mediated Siswanto, Soni; Wardhani, Bantari W.K.
Pharmaceutical Sciences and Research Vol. 9, No. 1
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Pulmonary fibrosis is a specific form of chronic progressive interstitial lung disease. Deposition of extracellular matrix, mainly collagen, is the pathogenic characteristic of pulmonary fibrosis. Many reports show that environmental pollutants, particularly asbestos, silica, mercury, cadmium, and benzo(a)pyrene, are contributed in the etiology of lung injury and a risk factor in the development of idiopathic pulmonary fibrosis (IPF) in humans. Based on its physicochemical properties, environmental pollutant-induced pulmonary fibrosis can be developed after a particular type or dose of exposure. To date, some studies have focused on variant pollutants that are induced. However, the molecular mechanism of various pollutants to cause lung injury, which leads to pulmonary fibrosis, remained unexplored. Hence, this narrative review articles describe its molecular mechanism in generating pulmonary fibrosis comprehensively. It is helpful to portray the IPF pathogenesis and its drug discovery and development. Collectively, this article also revealed animal models which can be useful for IPF drug development research.
Challenge and Development Strategy for Colon-Targeted Drug Delivery System Iswandana, Raditya; Putri, Kurnia Sari Setio; Putri, Fathia Amalia; Gunawan, Maxius; Larasati, Sekar Arum
Pharmaceutical Sciences and Research Vol. 9, No. 1
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Colon-Targeted Drug Delivery System (CTDDS) is able to improve local therapeutic effects in the treatment of colon-specific diseases, such as Crohn’s disease, Ulcerative Colitis (UC), and Irritable Bowel Syndrome (IBS). A colon can also be a suitable site for systemic delivery of drugs susceptible to extreme gastric pH, such as peptides and protein therapeutics. The physiological conditions of the gastrointestinal tract and the physicochemical properties of drugs are being considered to develop strategies and approaches to overcome emerging challenges. This review will discuss factors, challenges, strategies, and approaches to developing a colon-targeted drug delivery system.
CRISPR/Cas9 Genome Editing: Future Treatment of Duane Retraction Syndrome Zulfikar, Muhammad Raihan; Renesteen, Editha; Wardhani, Bantari W.K.
Pharmaceutical Sciences and Research Vol. 9, No. 1
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Duane Retraction Syndrome (DRS) is characterized by limited eye movement. One of its causes is a mutation in the CHN1, MAFB, or SALL4 gene. Nowadays, the treatment for DRS is limited to glasses, occlusion, and surgery. However, this treatment has not been able to cure the disease’s hereditary issue. Another strategy to be considered for the treatment is CRISPR/Cas9, a tool for performing gene editing with a wide range of applications, including treating genetic diseases. We made sgRNA as a first step in using CRISPR/Cas9 as a treatment for DRS in silico using the CCTop website. By computing sgRNA, conducting tests, and analyzing the results, CRISPR/Cas9 may repair genetic mutations. Currently, there are no reports on the use of CRISPR/Cas9 in DRS. Hence, this study would be very useful as a starting point for using CRISPR/Cas9 as a DRS treatment. However, it needs to be further proven through in vivo, in vitro, and clinical trials study.

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