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Prof. Diah Ayu Maharani, DDS, PhD
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Makara Journal of Health Research
Published by Universitas Indonesia
ISSN : 23563664     EISSN : 23563656     DOI : https://doi.org/10.7454/msk
Core Subject :
Makara Journal of Health Research (MJHR) is a peer-reviewed and scientific journal published by Universitas Indonesia. Starting from 2019 onwards, MJHR is redirecting its scope, focusing on publishing research articles relevant to non-communicable diseases (NCDs) addressing issues of surveillance, disease management and health policy in the Asia Pacific and Mediterranean countries. Relevant academic articles regarding NCDs analyzed from an integrated perspective including individual and population level, experimental and clinical approaches, epidemiology, public health, disease prevention and health promotion, diagnosis, treatment, prognosis and palliative care are welcome.
Arjuna Subject : -
Articles 270 Documents
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Gene expression of selected apoptotic markers in human oral squamous carcinoma HSC-3 cell line treated with Myrmecodia pendans plant extract Lestari, Widya; Yusry, Wan N A W; Iskandar, Siti H; Ichwan, Solachuddin J A; Irfan, Nining I; Suriyah, Wastuti H
Makara Journal of Health Research Vol. 23, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Myrmecodia pendans (M. pendans), or Sarang Semut, is an epiphyte with anticancer potential. It was recently reported that it induces apoptotic activity in the human oral squamous carcinoma (HSC-3) cell line. This study aimed to investigate the effect of M. pendans treated samples on the expression of apoptotic markers, Bax and Bcl-2. Methods: M. pendans was purchased from West Papua, Indonesia. The hypocotyl was dried thoroughly and then extracted aqueously. The apoptotic activity was detected via flow cytometry. Bax and Bcl-2 expression was analyzed by quantitative real-time polymerase chain reaction. Results: Results of our cell cycle analysis reveal that aqueous extract of M. pendans induced apoptosis in 2.5 and 5 mg/mL but no change between these two concentrations. Apoptosis was observed at 24 h but not at 48 h. Bax and Bcl-2 expression in HSC-3 cells was affected by M. pendans. At 24 h, upregulation of Bax was observed at 2.5 mg/mL. However, after 48 h, Bax expression showed no changes at any concentration. Bcl-2 was significantly downregulated after 48 h of treatment. Conclusions: M. pendans extract induced apoptosis in HSC-3 cells, which might occur via the proapoptotic (Bax) and antiapoptotic (Bcl-2) pathways
Evaluation of the frequency of mucous retention cysts in the maxillary sinus in a Turkish population using cone-beam computed tomography Lacin, Nihat; Tatar, Birkan
Makara Journal of Health Research Vol. 23, No. 2
Publisher : UI Scholars Hub

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Background: Mucous retention cyst (MRC) of the maxillary sinus (MS) is an asymptomatic pathology generally found during routine radiographic examination. This study aimed to investigate the frequency of MRCs in the MS from a Turkish population using randomly selected cone-beam computed tomography (CBCT) images. Methods: CBCT images of randomly selected systemically healthy subjects (n = 300; of which 156 were men and 144 were women with a mean age of 40.18 [age range: 18–65 years]) were included in this retrospective study. The images were evaluated, and MRC was detected as a dome-shaped radiopaque lesion on the floor or walls of the MS. Results: MRC was detected in 30 (10%) of 300 patients via CBCT imaging; 14 patients had bilateral MRC and 16 had unilateral MRC. The cysts were detected on CBCT images obtained from 17 men and 13 women. No significant differences were observed in the incidence of MRC based on location (right or left side) and gender (p > 0.05). Conclusions: CBCT is a useful tool that facilitates three-dimensional evaluation of pathologies, such as MRCs, in the MS.
Management of grade IV blunt renal trauma in adults: Systematic review and meta-analysis Bramono, Ikhlas A; Irdam, Gampo A; Rodjani, Arry; Wahyudi, Irfan
Makara Journal of Health Research Vol. 23, No. 2
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Background: Irrespective of the high incidence of grade IV renal trauma, there is still an ongoing debate regarding the use of conservative and surgical approaches for its treatment. This study aimed to conduct pooled analyses of published studies that concluded evidences regarding the management of grade IV renal trauma. Methods: Published studies between 1995 and 2015 from Cochrane Library, EBSCO, Embase, ProQuest, PubMed, and Scopus were reviewed and pooled analysis of eligible studies was conducted using random effects model. Heterogeneity was presented with I2 and p value. Results: Eleven studies reporting on 703 adults were included in the analysis. Conservative approach was used in 611 patients (conservative group) and surgical approach in 92 patients (surgical group); success rate and morbidity were comparable between the groups (risk ratio (RR): 1.15, 95% confidence interval (CI): 0.72–1.83; RR: 0.77, 95% CI: 0.27–2.21, respectively). The trend of mortality was higher in the surgical group than the conservative group. Conclusions: A comparable success rate was observed between the groups. Mortality was higher in the surgical group than the conservative group. As advocated by many guidelines, conservative management may decrease unnecessary exploration, which can ultimately reduce reconstruction and/or nephrectomy rate without causing morbidity or mortality.
Effects of toothache on the educational and social status of children Dogan, Mehmet S; Aras, Ahmet; Atas, Osman; Karaali, Abdullah E; Gunay, Ayse; Akbaba, Haluk M; Yavuz, Izzet
Makara Journal of Health Research Vol. 23, No. 2
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Background: Untreated tooth cavities and the resulting toothaches have significant effects on children’s social and psychological development. The aim of this study was to evaluate the impact of toothache on children’s educational and social activities. Methods: For this retrospective study, we issued a 15-question survey to the parents of 515 children between ages of 5–16 years in Diyarbakır, Turkey. The chi-square test was used to test the strength of the relationship between two variables (p ≤ 0.05). Results: 318 (61.7%) parents reported having difficulty in feeding their children, 94 (18.3%) left a game due to toothache, 173 (33.6%) had school absences, 167 (32.4%) avoided laughing, and 439 (85.2%) parents felt that dental problems influenced their child’s success in school. Conclusions: Tooth pain has a negative impact on school and the social lives of children. Families need education about this issue, and health policies should be developed to address this problem.
Factors influencing Indonesian male partners’ support in the postpartum period Agil, Hilda M; Watanabe, Kumi; Tanaka, Emiko; Afiyanti, Yati; Anme, Tokie
Makara Journal of Health Research Vol. 23, No. 2
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Background: Lack of male partners’ postpartum support can cause postpartum depression (PPD), a serious mood disorder, in women. Thus, to prevent PPD, it is important to clarify the factors influencing male partners’ postpartum support. Methods: In total, 62 male partners of postpartum women at 1 week–6 months after delivery, living in South Jakarta, were invited by assistance from community volunteers. Focus group interviews were employed; participants were grouped depending on their residences and asked about their behaviors in supporting postpartum women. Interviews were documented using two voice recorders and two video recorders. The content analysis method and Bertalanffy’s system theory of internal and external factors of health behaviors was utilized to develop units and codes. Results: The analysis identified five codes of individual-level factors: (1) knowledge; (2) belief; (3) social and life adaptation skills; (4) psychological disposition; and (5) physiological condition. Three codes of community-level factors included: (1) social support; (2) media; and (3) socio-cultural and economic. Two codes of social policy-level factors included (1) health care system and; (2) Indonesian societal laws and regulations. Conclusions: Various internal and external factors influence Indonesian male partners’ postpartum support. Different interventions for these factors might be impactful in preventing PPD.
Applying bootstrap quantile regression for the construction of a low birth weight model Yanuar, Ferra; Yozza, Hazmira; Firdawati, Firdawati; Rahmi, Izzati; Zetra, Aidinil
Makara Journal of Health Research Vol. 23, No. 2
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Background: Most investigators use ordinary least squares (OLS) methods to model low birth weight. When the data are non-normal or contain outliers, OLS become ineffective. However, the quantile method of forecasting low birth weight has not been fully evaluated, although it has good potential for overcoming problems associated with linear regression. Methods: The present study reports our comparison between the OLS and quantile regression methods for modeling low birth weight when the data are right skewed and outliers are presented. Additionally, we evaluated the performance of the associated algorithm in recovering the true parameter using the bootstrap method. Results: Our study found that a mother’s education level, the number of maternal parities, and the last birth interval significantly impacted low birth weight at any selected low quantile. Based on the bootstrap simulation study, the proposed model was considered to be acceptable since both methods generated nearly identical estimates of the parameter model. An accuracy test proved that the quantile method was an unbiased estimator. Conclusions: The present study found that low birth weight is significantly affected by the mother’s educational level, the number of maternal parities, and the last birth interval.
Effect of coral Goniopora Sp scaffold application on human osteoblast-like MG-63 cell activity in vitro Julia, Vera; Abbas, Basril; Bachtiar, Endang W; Latief, Benny S; Kuijpers-Jagtman, Anne M
Makara Journal of Health Research Vol. 23, No. 2
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Background: Coral is an osteo-conductive biomaterial that can act as an alternative scaffold for osteogenesis. In this in vitro study we analyzed the activity of osteoblast-like cells after treatment with the coral Goniopora. Methods: Human osteoblast-like MG-63 cells were incubated in α-minimal essential medium supplemented with 10% fetal bovine serum and 300 ng/mL amphotericin B plus 1% penicillin-streptomycin and stored in a 5% CO2 incubator at 37°C. The Goniopora were smashed into size A (20 mesh), B (1–2 mm), and C (200 mesh) particles, sterilized using gamma radiation and applied to cells. Protein and alkaline phosphatase (ALP) concentrations were evaluated after incubation for 24 and 48 h. Results: The protein assay of 24 h and 48 h cultured osteoblasts illustrated that treated cells, whether with coral size A, B and C exhibited a lower mean value compared to the untreated cells. For ALP levels there were statistically significant differences at 48 h between B and C (p = 0.004), and A and C (p = 0.09). Conclusions: No significant differences in total protein concentrations were found among all groups after 24 and 48 h. Smaller coral size and longer incubation time tended to facilitate osteogenesis. These results require further empirical validation.
The effect of sappan wood extracts in treating diabetes induced in mice Sakir, Noviana A I; Kim, Jae G
Makara Journal of Health Research Vol. 23, No. 2
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Background: Since 2015, an estimated 415 million people had diabetes worldwide. Although, there is no scientific research related to the effectiveness of chemical substance (brazilin) in Caesalpinia sappan L. that can decrease blood glucose level in humans, many people in Sulawesi consume this wood for diabetes treatment. This study aimed to prove the effect of sappan wood extract on decreasing blood glucose levels in mice and to identify the most effective dose. Methods: Experimental research (pretest and posttest randomized controlled group design) was conducted on 20 male albino mice [body weight (bw): 20–30 g] used as alloxan-induced diabetic models and were divided into four treatment groups according to alloxan dose: control and 0.25, 0.50, and 0.75 g/kg bw (n = 5 for all groups) groups. Results: Significant effects of sappan wood extract on decreasing blood glucose levels in mice were noted in the pretest and posttest (p values are 0.754 and 0.901 respectively). Conclusions: Sappan wood extract could reduce blood glucose levels in mice with diabetes induced by alloxan at 0.25, 0.50, and 0.75 g/kg bw. The extract with 0.50 g/kg bw dose was the most effective in decreasing glucose levels in hyperglycemic mice.
Quality of life of primary brain tumor patients before and 3 months after discharge from a hospital in Bandung, Indonesia Ganefianty, Amelia; Kariasa, I Made; McAllister, Susan; Fahmi, Ismail; Sarjono, Kalih; Faried, Ahmad; Sutiono, Agung B; Derrett, Sarah
Makara Journal of Health Research Vol. 23, No. 1
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Background: The quality of life of patients with primary brain tumor in Indonesia is poorly understood. Therefore, this study aimed to investigate the health‐related quality of life of patients admitted to the Neurosurgery Department of Dr. Hasan Sadikin Hospital, Bandung, Indonesia, up to 3 months after discharge. Methods: Baseline data were collected from patients aged ≥18 years who were admitted to the hospital between October 9, 2015, and February 17, 2016. In‐person interviews were then conducted 1–2 days pre‐discharge (n = 65) and follow-up telephone interviews were made 1, 2, and 3 months post-discharge (n = 58, 55, and 54, respectively) to collect socio-demographic data, clinical characteristics, and EQ‐5D‐5L data. Results: Prior to discharge, one‐third or less of the 65 patients interviewed reported “no problems” with mobility (32%), self‐care (32%), usual activities (18%), and pain/discomfort (43%), whereas 74% reported “no problems” with anxiety/depression. By contrast, at 3 months post-discharge, an increased proportion of patients reported “no problems” with mobility (61%), self‐care (67%), usual activities (56%), and pain/discomfort (76%), with little change in anxiety/depression (“no problems” 70%). Conclusions: While there was improvement, many patients were still reporting problems at 3 months post-discharge, highlighting the need for ongoing support and care to ensure the best possible outcomes.
Assessment of peripartum psychological disturbances in relation to modes of delivery Radeef, Ali S; Al-Kubaisi, Muna Kh; John, Akbar B; AI, Nur Khairulnisa
Makara Journal of Health Research Vol. 23, No. 1
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Background: Anxiety disorders are common during peripartum period. This study aimed to identify which mode of delivery was more prone to develop psychological disturbances. Methods: This prospective cohort study conducted among 541 pregnant women presented for spontaneous labour, induction or elective caesarean section in a Malaysian hospital. The severity of depression, anxiety and stress symptoms are assessed by using self-rated depression anxiety and stress scales in four different occasions; pre-labour/operation, 24 hours postnatal, 2 weeks, and at 6 weeks. Results: In the prenatal period, there was no statistically significant difference in the mean score of depression between women coming for labour (4.17±5.28) and elective CS (4.21±5.87). During puerperium; at 24 hours postnatal, 2 weeks and 6 weeks assessments there was no significant difference in depression score among patients with different modes of delivery. The overall scores were (4.23±5.46, 3.26±4.85, 0.78±2.37, 0.18±0.93) for patients going through vaginal delivery, instrumentation, emergency or elective CS. The same trend was found when anxiety and stress were analysed. Conclusions: The most prominent peripartum psychological disturbances symptom is anxiety. Minority of patients will experience persistence anxiety by the end of 6 weeks postpartum. The caesarean section and induction of labour does not increase the psychological impact.

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