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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 179 Documents
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Diagnosis dan Tata Laksana Mild Cognitive Impairment (MCI) Celine Anindytha Pranata
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/txsmb181

Abstract

The number of elderly population in the world is increasing nowadays. In 2020, there were 1.4 billion people in the world aged ≥60 years and it is predicted to double by 2050. Decline in cognitive function and memory is one of the consequences of the aging process that can affect a person’s quality of life. MCI is a pathological condition also preclinical and transitional stage between normal aging and dementia. Early detection and intervention of MCI may delay onset and prevent the progressivity of MCI to dementia. This article aims to provide an overview of MCI which includes risk factors, subjective and objective clinical signs, disease course, diagnosis, and recommendation of MCI management based on existing studies and guidelines.
Hubungan Antara Obesitas dan Hipertensi dengan Kanker Payudara pada Pasien di Rumah Sakit Siloam Lippo Village Gedung B Nicoline Naomy Lamria; Heru Sutanto Koerniawan
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/t7vk9k12

Abstract

Background: Breast cancer has become one of the most common cancers in Indonesia, and being one of the largest contributors to cancer deaths. Several studies have shown association between breast cancer with obesity and hypertension, both as modifiable risk factors. Methods: This study was conducted using unpaired categorical comparativeanalytic method with a case control design. Samples were collected using medical record data using consecutive sampling method. Sample were 160 patients aged 20–55 years at Siloam Lippo Village Hospital Building B; consisting of 80 casegroup samples and 80 control group samples. Data was analysed using Chi-square test. Result: Data analysis resultshowed that there was an association between obesity and breast cancer in patients at Siloam Lippo Village Hospital Building B (p=0.000; OR=11.238; 95% CI=5.360–23.563). There was also association between hypertension and breast cancer in patients at Siloam Lippo Village Hospital Building B (p=0.007; OR=7.567;95% CI=1.648–34.740). Conclusion:There is a significant association between obesity and hypertension with the incident of breast cancer in patients at SiloamLippo Village Hospital Building B.
Diagnosis dan Tata Laksana Thyroid Storm yang Dipicu oleh Perikarditis Akut Ida Bagus Aditya Nugraha; LP Dea Sasmita P; Wira Gotera
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/jvnvem23

Abstract

Thyroid storm is a life-threatening condition that requires prompt diagnosis and emergency treatment. This condition manifests as multiple organ decompensation characterized by loss of consciousness, high fever, heart failure, diarrhea,and jaundice. We report a case of a 51-year-old man with a chief complaint of fever that has been felt since the night before admission. Body temperature was up to 38°C and started while he was resting. Patient also reported dry, intense cough, since five days ago, accompanied with shortness of breath when lying down. The patient also felt palpitations sincethe previous night and still felt until the morning of admission, and did not improve with rest. The patient was diagnosed by observation of suspension shock due to cardiogenic shock, suspect Graves’ disease (thyroid storm), ADHF profileB et causa suspect CAD, AF RVR, type 2 DM, myofascial pain syndrome with differential diagnosis: headache related toinfection, hyponatremia chronic asymptomatic hypoosmolar hypervolemic et causa suspect dilution, hypoalbuminemia etcausa suspect chronic inflammation, and upper respiratory tract infection. Thyroid storm cases require a multidisciplinaryapproach in terms of diagnosis and therapy. In this case, the patient is referred to the internal medicine, cardiac, andneurology departments.
Ashy Dermatosis: Suatu Laporan Kasus Jarang Fatimah Fitriani; Moerbono Mochtar
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/ge4ev827

Abstract

Background: Ashy dermatosis is a rare, acquired, benign, and idiopathic hypermelanotic disease. It is manifested asashy-colored lesion with no signs of inflammation. Commonly affected sites of the body include the trunk, neck, face, also proximal and distal extremities. Case: A 33-year-old woman came to Dr. Moewardi Hospital, Surakarta, with chief complaints asymptomatic, ashy colored macule that appear on her right arm. Physical examination in general region shows ashy-colored macule and multiple discrete patches of hyperpigmentation with irregular border. Dermoscopy examinationmacules showed bluish-gray skin markings over bluish background. Histopathological examination showed thin epidermis layer, hyperkeratosis, incontinentia pigmenti, dropping melanin resembles the basal layer civatte bodies. At dermis focal fibrosis was found with infiltrates, incontinentia pigmenti, and dropping melanin. Discussion: Ashy dermatosis or known as erythema dyschromicum perstans is a rare hyperpigmentation disorder that started with reddish, active-bordered lesions, then disappear, leaving a round or oval shape, polycyclic, and ashy macule on the proximal region of the trunk andneck. Onset of symptoms usually at young adult, between first and second decade of life. Etiology of ashy dermatosis is still unclear, and many factors were thought to be involved. Dermoscopy examination showed bluish-gray macules overbluish background. Histopathological examination showed lichenoid reactions and an increase melanin on the dermis. This report aims to describe the diagnosis a rare condition based on anamnesis, physical examination, dermoscopy, and histopathological examination. Clinical findings in this patient were in accordance with the result of previous studies.
Potensi farmakologi Kasumba Turatea (Carthamus tinctorius L.) sebagai antibakteri Lismayana Hansur; Ami Febriza; Dito Anurogo; Dara Ugi Aras; Endah Dwijayanti
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6zstjd88

Abstract

Kasumba turatea (Carthamus tinctorius L.) is a plant that has been used as traditional medicine in South Sulawesi. Themain component of C. tinctorius L. flowers is hydroxysafflor yellow A, which functions as an anti-inflammatory, antioxidant,and platelet aggregation inhibitor. This review highlights pharmacological potential of C. tinctorius L. as an antibacterialagent. The method involves a literature review from various databases such as PubMed, Google Scholar, and Scopus. Theresults show that C. tinctorius L. extracts are effective against various pathogenic bacteria such as Listeria monocytogenes,Streptococcus iniae, Staphylococcus aureus, and Escherichia coli. Bioactive compounds like carthamin, phenolics, and flavonoids exhibit significant antibacterial activity. Additionally, C. tinctorius L. extracts also show potential as anthelminticand antioxidant agents. Further research is required to isolate and characterize specific bioactive compounds, followed by in vivo validation and clinical study to confirm their efficacy as well as safety. 
Miskonsepsi Umum dalam Evidence-Based Medicine: Tantangan dan Aplikasinya dalam Praktik Klinis Raymond R Tjandrawinata
MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/1vaa8680

Abstract

Evidence-based medicine (EBM) telah menjadi fondasi dalam praktik medis modern, terutama dengan menekankan penggunaan bukti terbaik untuk memandu pengambilan keputusan klinis. Namun dalam penerapannya, beberapa miskonsepsi muncul, khususnya dalam ketergantungan berlebihan pada randomized controlled trials (RCT) sebagai standar emas dalam hierarki bukti. Meskipun RCT menawarkan keunggulan tertentu dalam menghindari bias, terdapat banyak situasi di mana RCT tidak diperlukan atau bahkan tidak cocok. Artikel ini mengeksplorasi miskonsepsi umum dalam EBM, pentingnya mempertimbangkan “direct evidence”, dan bagaimana pendekatan EBM yang lebih fleksibel dapat lebih sesuai dengan praktik klinis nyata.
Keadilan Bermartabat dalam Akses terhadap Obat: Relevansi, Tantangan, dan Implikasi Kebijakan dalam Sistem Kesehatan Global Raymond R Tjandrawinata; Teguh Prasetyo
MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/jd584b81

Abstract

Akses terhadap obat-obat esensial yang aman, efektif, dan terjangkau telah menjadi salah satu masalah utama dalam sistem kesehatan global, di mana terjadi ketidakadilan struktural yang mendalam antara negara maju dan berkembang. Tantangan ini tidak hanya menyangkut aspek ekonomi dan distribusi, namun juga berkaitan erat dengan nilai-nilai etika, moral, dan martabat manusia. Artikel ini mengeksplorasi perumusan kebijakan akses obat global dapat diperbaiki dengan menggunakan pendekatan teori keadilan bermartabat.1,2 Analisis teoretis dan praktis tentang bagaimana keadilan bermartabat dapat membantu mengatasi ketimpangan akses terhadap obat akan dibahas secara komprehensif, di mana nilai utama konsep ini adalah kepastian bahwa martabat manusia ditinggikan.. Artikel ini pada akhirnya akan mengusulkan model kebijakan yang responsif terhadap tantangan etika dan sosial, di samping memberikan rekomendasi strategis bagi pemangku kebijakan untuk menciptakan sistem kesehatan yang lebih berkeadilan dan manusiawi.
Inovasi Terbaru dalam Diagnosis dan Pengobatan Penyakit Arteri Koroner: Mengurangi Risiko Kardiovaskular melalui Teknologi dan Terapi Modern Raymond R Tjandrawinata
MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/cjyvsw40

Abstract

Penyakit arteri koroner (coronary artery disease/CAD) konsisten menjadi penyebab utama kematian di seluruh dunia, dengan dampak yang signifikan terhadap kualitas hidup jutaan orang. Data dari World Health Organization (WHO) menunjukkan bahwa CAD bertanggung jawab pada sekitar 9 juta kematian setiap tahun, menjadikannya sebagai penyebabutama kematian global. Di Amerika Serikat, sekitar 365.000 orang meninggal setiap tahun akibat penyakit jantung koroner, yang merupakan satu dari tujuh penyebab kematian di negara tersebut (Centers for Disease Control and Prevention, 2020). Di Indonesia, prevalensi penyakit jantung koroner juga meningkat secara signifikan. Menurut data dari KementerianKesehatan Republik Indonesia, penyakit jantung koroner menjadi salah satu dari tiga penyebab utama kematian di Indonesia. Prevalensi penyakit ini diperkirakan sekitar 1,5% dari populasi, dengan angka kejadian lebih tinggi di daerah perkotaan dibandingkan pedesaan. Data tersebut menunjukkan pentingnya penelitian dan inovasi dalam pencegahan serta pengobatan penyakit arteri koroner untuk meningkatkan kualitas hidup dan menurunkan angka kematian
Coronary Atherosclerotic Calcification Sony Hilal Wicaksono; Christian Setiawan; Indah Fitriani
MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/00pm8d52

Abstract

Coronary artery disease is a significant public health concern in Southeast Asia, including Indonesia. It is characterized by the buildup of atherosclerotic plaques within the coronary arteries, leading to reduced or interrupted blood flow to myocardium. A hallmark of atherosclerosis is calcification, which may occur during both plaque progression and regression. To date, it remains unclear whether the progression of atherosclerotic lesions follows a linear pattern. The formation of microcalcifications initiates the calcification process and warrants further investigation. Several imaging modalities, which have significantly advanced, may help measure the coronary artery calcification burden and guide appropriate management. Concerns about radiation exposure have positioned coronary artery calcium scoring as the most effective,efficient, and readily observable parameter among both invasive and non-invasive imaging techniques. Identifying highrisk plaque characteristics and severe or extensive calcification is essential in order to provide optimal treatment. However, the progression of calcification remains uncertain, and ongoing research is being conducted to explore potential methods to reverse it. Various tools and complex techniques have been developed to address different types of calcified lesions. Further studies are needed to identify patients who experience more rapid calcification progression, in order to optimize preventive strategies.
Perbandingan Uji TB IGRA Menggunakan Metode T-SPOT.TB dan CLIA Juliani Dewi
MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/n2hdkv05

Abstract

Diagnosis tuberkulosis laten (latent tuberculosis infection/LTBI) merupakan kunci penting dalam pengendalian kejadian tuberkulosis (TB). Uji interferon gamma release assay (IGRA) umumnya digunakan untuk mendeteksi interferon gamma (IFN-γ) sebagai penanda LTBI, dengan metode seperti T-SPOT.TB yang telah diimplementasikan secara luas. Akhir-akhir ini, metode chemiluminescent immunoassay (CLIA) dengan analyzer yang sepenuhnya otomatis, juga telah digunakan untuk deteksi dan kuantifikasi IFN-γ. Penelitian ini bertujuan untuk membandingkan antara kedua metode tersebut. Dua puluh sampel darah heparin dari 20 pasien diambil di Laboratorium Rampal Diagnostika. Hasil penelitian ini menunjukkan bahwa metode otomatis CLIA sebanding dengan metode T-SPOT.TB dalam mendeteksi IFN-γ dengan signifikansi 0,625 dan korelasi 0,857. Terdapat kasus yang tidak sesuai antara kedua metode sebanyak 4/20 (20%). Dapat disimpulkan bahwa CLIA-IGRA merupakan pemeriksaan yang sebanding dengan metode T-SPOT.TB untuk mendeteksi LTBI.

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