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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 179 Documents
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Insidensi dan Profil Penyakit Psoriasis di RS Martha Friska Multatuli Medan Periode Januari−Desember 2022 Viktoria Thanita
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.120

Abstract

Background: Psoriasis is a chronic, recurrent, inherited immunologic disorder. Psoriasis is characterized by changes in epidermal cell growth and differentiation. The mechanism of skin inflammation involves the activation of cytokines, chemokines, and growth factors that results in impaired regulation of keratinocytes, inflammatory cells, and blood vessels. This study aimed to evaluate incidence and profile of psoriasis patients at Martha Friska Multatuli Hospital, Medan, in January-December 2022. Method: This is a descriptive study using retrospective, cross-sectional design, where data collection is carried out from the medical record data of Martha Friska Multatuli Hospital. Results: Most of psoriasis cases (42 cases; 65.63%) in Martha Friska Multatuli Hospital is existing patients. Psoriasis was reported to be more prevalent in women (33 cases; 51.57%). Based on body mass index (BMI), psoriasis was found the most in those whose BMI <24,9 (34 case; 53.14%). Based on age, psoriasis was found the most in elderly (>60 years) with 26 cases (40.64%).
Kasus Morfea Tipe Linier (En Coup de Sabre) pada Wanita Berusia 20 Tahun Achmad Satya Negara; Arie Kusumawardhani
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.121

Abstract

Background: Morphea is a chronic inflammatory disease characterized by sclerosis of the skin which belongs to the group of idiopathic sclerotic diseases. Frontoparietal linear morphea is a unilateral atrophy linear plaque on the forehead that can extend to the eyebrows, nose, lips, and scalps, causing alopecia. The aim of this case report is to establish the diagnosis of frontoparietal linear morphea. Case: A 20-year-old woman presented with a dark brown spot on her forehead. Histopathological examination showed a basket-weave hyperkeratosis and flattening of the rete ridges of epidermal layer, and pigmented cells in the basal cells of the dermal-epidermal junction. Based on the results of physical examination and histopathology, patient was diagnosed with linear morphea en coup de sabre. Patient was treated with topical and systemic corticosteroid. Discussion: Morphea is a rare fibrotic disease of the skin and underlying tissue, characterized with diffuse thickening, induration, or atrophy. Histopathological biopsy examination can be used to confirm the diagnosis and rule out differential diagnosis. Histopathological biopsy of early phase morphea can show inflammation, the dermis looks dense with thickened collagen fibers accompanied by inflammatory cells, especially perivascular lymphocytes between collagen fibers, flattening of the epidermal rete ridges, and atrophy. Topical therapy with corticosteroid as anti-inflammatory drug can be used in active lesions of early-stage linear morphea.
Potensi Tanaman Sukun (Artocarpus altilis) sebagai Agen Antiinflamasi dan Antidiabetes Ni Gusti Ayu Diantari; Debby Yunita; Maria Aurelia Afila Tutonugi; Theresia Helena Tokan; Teresia Kiki Oktavianti; Florentinus Dika Octa Riswanto; Dewi Setyaningsih
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.122

Abstract

Background: Artocarpus altilis is a plant whose every part is beneficial for health. In Indonesia, the distribution of this plant is only found in certain places and has not been cultivated. Breadfruit is basically rich in flavonoid, tannin, and saponin compounds that are known to be potential as antidiabetic and antiinflammatory. Diabetes is a group of metabolic disease characterized by hyperglycemia, due to lack of insulin production and/or sensitivity. Type 2 diabetes is a degenerative disease that is a global health problem. Type 2 diabetes is treated using antidiabetic agents and/or insulin. Inflammation is a local reaction of the body characterized by certain symptoms. Treatment of inflammation using synthetic drugs is associated with various side effects. Objective: This review is aimed to provide information about antidiabetic and anti-inflammatory activities in breadfruit plant. Results: Substance of breadfruit plant with antidiabetic efficacy was found in the stem, leaf, and fruit, showed by results of phytochemical test. Antidiabetic activity was proven by in vivo, in vitro, and AlCl calorimetry tests, while anti-inflammatory substance was found in the leaf and fruit, and the anti-inflammatory activity was showed by results of in vivo and in vitro tests. Conclusion: Breadfruit plants can be potentially developed as an alternative treatment for diabetes and inflammation.
Tinjauan Histopatologi pada Pyoderma Gangrenosum dengan Infeksi Sekunder Wibisono Nugraha; Danu Yuliarto; Eka Devinta Novi Diana; Alfina Rahma; Prasetyadi Mawardi; Frieda; Ambar Mudigdo
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.123

Abstract

Background: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis, characterized by sterile, painful, necrotic ulcer, and is associated with systemic conditions. PG manifests as papules and vesicles that evolve into painful ulcers. Incidence of PG is relatively rare in Dr. Moewardi Hospital, so it is important to identify and correctly diagnose PG based on its’ histopathological features. Case A 54-year-old man complained of painful scab on several body parts. Hematoxylin and eosin staining in the epidermal layer showed a basket-weave orthokeratosis with necrotic tissue, acanthosis, and basal cell hypermelanosis. In the dermis layer there is a lymphocyte and neutrophil cell infiltrate with slight appearance of leukocytoclastic. Discussion: Pyoderma gangrenosum is a reactive, non-infectious inflammatory dermatosis (neutrophilic dermatoses). In this case, PG occurs in 54-year-old man as painful scab on back and legs. Classical PG characterized by papules, pustules, crusted or necrotic plaque, which typically have undermined, overhanging, dusky purple edges with surrounding induration and erythema. In this patient, the epidermal layer showed ulceration and slight appearance of leukocytoclastic vasculitis in the dermis area and lymphocyte infiltrate with slight neutrophil in the perivascular accompanied by erythrocyte extravasation, which support the diagnosis of PG.
Modalitas Terapi Striae Ambar Aliwardani; Putti Fatiharani Dewi; Fiska Rosita; Indah Julianto
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.124

Abstract

Striae or strechmark is a form of benign skin lesion manifested as inflammatory streaks perpendicular to the direction of skin tension which has cosmetic morbidity and possesses risk of secondary infection in severe case. Various therapeutic modalities have been introduced, such as topical therapy, physical therapy using devices, lasers, and the latest is celullar therapy using platelet-rich plasma. Such varied treatment modalities are reported to have varied results.
Elemen Zink sebagai Penopang Pertumbuhan dan Kehidupan Janin Intrauterin Pribadi, Adhi
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/2x5pd478

Abstract

Zink (zinc/Zn)adalah mineral penting yang diketahui mempunyai fungsi fisiologis yang berpengaruh terhadap sistem kekebalan tubuh. Zink memainkan peran yang sangat penting dalam berbagai fungsi tubuh manusia, termasuk sintesis protein dan metabolisme asam nukleat. Zink juga merupakan salah satu nutrisi dasar yang dibutuhkan selama kehamilan untuk perkembangan normal dan pertumbuhan janin di samping mikronutrien lainnya seperti besi dan kalsium. Kekurangan zink selama kehamilan menyebabkan dampak permanen pada bayi baru lahir seperti gangguan pertumbuhan, abortus spontan, cacat bawaan, dan luaran kehamilan yang buruk. Zinc memainkan peran yang sangat penting dan kritis dalam berbagai fungsi tubuh manusia termasuk sintesis protein dan metabolisme asam nukleat. Dampak defisiensi Zn sangat menonjol bahkan pada kehidupan janin intrauterin. Studi suplementasi Zn pada populasi yang pernah dilakukan sebelumnya menunjukkan hasil yang bertentangan pada berbagai outcome kehamilan. Defisiensi Zn menyebabkan potensi peningkatan stres oksidatif dan berakhir dengan kematian sel. Beberapa penelitian yang dilakukan mengenai status Zn pada ibu hamil menunjukan kadar Zn yang rendah pada neonatus dengan status kecil pada masa kehamilan serta peningkatan kasus preterm. Suplementasi zink oral merupakan upaya potensial untuk mengurangi risiko kelahiran bayi dengan berat badan rendah dan pada akhirnya mencegah morbiditas dan mortalitas bayi baru lahir yang terkait dengan kondisi ini. Fungsi Zn pada ibu termasuk mendukung pertumbuhan uterus selama kehamilan dan menurunkan potensi preeklamsia, namun bukti yang mendukung suplementasi zink secara rutin masih belum tersedia. Dampak defisiensi Zink relatif buruk selama kehamilan, meskipun demikian bukti penelitian mengenai kebutuhan suplementasi rutin yang diberikan pada semua ibu hamil masih menjadi perdebatan, karena manfaatnya yang secara metaanalisis tidak terlalu nyata. Suplementasi lebih disarankan pada populasi risiko tinggi agar tidak terjadi outcome yang buruk pada kehamilan. 
Profil Pasien Infeksi Menular Seksual di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi Surakarta Periode Januari 2016−Desember 2020 Achmad Satya Negara; Ammarilis Murastami
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/8bjbj417

Abstract

Latar belakang: Infeksi menular seksual (IMS) merupakan infeksi yang disebabkan oleh bakteri, virus, maupun parasit yang sebagian besar ditularkan melalui hubungan seksual secara vaginal, anal, atau oral. Prevalensi IMS di seluruh dunia diperkirakan mencapai 333 juta kasus per tahun dan setiap hari terjadi lebih dari 1 juta kasus IMS. Pelaporan data IMS saat ini diestimasikan hanya mewakili 50−80% dari total keseluruhan penyakit IMS di Amerika Serikat, yang mencerminkan keterbatasan screening, kurangnya informasi mengenai transmisi penyakit, serta rendahnya tingkat pelaporan data. Data mengenai IMS penting diketahui sebagai bahan kajian perencanaan dalam upaya pencegahan dan pengendalian penyakit. Tujuan: Mengetahui profil penyakit IMS di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi periode Januari 2016 sampai Desember 2020. Metode: Penelitian ini merupakan penelitian retrospektif dengan menggunakan data sekunder berupa rekam medis dan buku registrasi di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi, Surakarta, periode Januari 2016−Desember 2020. Hasil: Didapatkan jumlah kasus baru IMS rawat jalan di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi sebanyak 275 kasus selama 5 tahun terakhir. Terdapat 192 kasus kondiloma akuminata, 16 kasus ulkus genital, 35 kasus keluarnya cairan dari genitalia laki-laki, dan 20 kasus keluarnya cairan dari genitalia perempuan. Kesimpulan: Penderita IMS yang berobat di RSUD Dr. Moewardi mayoritas berjenis kelamin laki-laki dengan diagnosis terbanyak adalah kondiloma akuminata. Data ini dapat menjadi acuan dalam upaya pengendalian IMS dengan meningkatkan anamnesis, pemeriksaan fisik dan penunjang, serta memberikan edukasi terkait tindakan preventif pada pasien.
Laporan Kasus Terapi Methylprednisolone Intravena pada Neuritis Optik Franz Zakharia Simanjuntak
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/e2deny63

Abstract

Latar belakang: Neuritis optik ditandai dengan penurunan fungsi penglihatan secara unilateral dan disertai nyeri. Kondisi ini umumnya terjadi pada usia dewasa muda dan sebagian besar terjadi pada usia 15−45 tahun, dengan penyebab utama yang belum dapat diketahui secara pasti hingga saat ini. Kasus: Seorang wanita berumur 40 tahun datang dengan keluhan mata kiri dirasakan buram selama 2 minggu dan semakin memburuk. Keluhan yang sama tidak dirasakan pada mata kanan. Selain itu, mata kiri terasa berat sehingga pasien lebih nyaman jika menutup matanya. Sebelumnya, pasien belum pernah memeriksakan diri untuk keluhan mata buram. Tidak ada riwayat trauma. Pasien belum lama menjalani perawatan di rumah sakit dengan diagnosis demam berdarah 3 minggu sebelumnya, dengan obat yang dikonsumsi hanya tablet pantoprazole 20 mg dan Lesichol 600 mg. Demam, riwayat hipertensi, dan diabetes disangkal. Diskusi: Neuritis optik terutama terjadi pada dewasa muda dan sering berperan sebagai manifestasi awal penyakit multiple sclerosis (MS). Diperlukan ketepatan diagnosis dan terapi untuk mengoptimalkan fungsi penglihatan.
Herlyn-Werner-Wunderlich: A Rare Disease Yoki Citra Perwira; Jeffy Winarya Wahyudi
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/b65m7m40

Abstract

Herlyn-Werner-Wunderlich (HWW) is a rare Mullerian disorder characterized by uterine didelphys, hemivaginal obstruction, and ipsilateral renal agenesis. This paper aimed to describe a rare case of HWW in order to give better understanding of the disease, as well as diagnosis and treatment. Then urgent action is taken in the form of incision and drainage of pus. Methods: We searched medical record of a 17-year-old girl complaining of vaginal pain since menarche. Ultrasound examination found hematocolpos and vaginal septum, pelvic MRI found uterus didelphys and left renal agenesis, then the septal incision was performed to facilitate pus drainage. Conclusion: Herlyn-Werner-Wunderlich is a rare condition with varying age of onset. Anamnesis, physical examination, ultrasonography, and MRI are needed to confirm diagnosis. As an urgent measure, a septal incision and pus drainage are performed to reduce symptoms and complications that could occur in the future. In addition, the patient needs to undergo septal resection as a follow-up treatment which can only be done in a hospital where urogenital and reconstruction divisions are available.
Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl Wanda B. Putri; Friesca S. Nurhaidah; Helmy Yusuf; Maria L.A.D. Lestari
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/af7svb90

Abstract

The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin HCl released from MUPS tablets was faster than the uncompacted sustained release pellets. The similarity of the dissolution profile (f2) between MUPS tablets and uncompacted metformin HCl pellets was lower than 50 as the minimum acceptance value. The tablet tensile strength obtained was below the requirements (<1.7 MPa). Tablet disintegration time was approximately less than 2 minutes. In conclusion, drug release profile of the MUPS tablets showed damage of the pellets due to compaction process. Nevertheless, pellets compacted at low compaction pressure using FFRE with a deeper cup depth (size 0.80 mm) showed a slightly better protection compared to other punch shapes and cup depth sizes applied.

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