cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Ratna Kumalasari
Contact Email
medicinus@dexagroup.com
Phone
+6287808191388
Journal Mail Official
medicinus@dexagroup.com
Editorial Address
Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224
Location
Kota tangerang selatan,
Banten
INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 179 Documents
 14   15   16   17   18 
Persistent Jaundice in a Tuberculosis Patient After Treatment: A Rare Case of Primary Sclerosing Cholangitis Endro Tanoyo; Fahmi Indrarti; Deshinta Putri Mulya; Nur Rahmi Ananda; Naomi Yoshuantari; Bestari Ariningrum Setyawati
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/9gdf2175

Abstract

Primary sclerosing cholangitis (PSC) presents diagnostic challenges due to its overlapping features with other conditions. This case report describes a 28-year-old woman with a history of pulmonary tuberculosis who developed jaundice weeks after completing antituberculosis treatment, initially resembling drug-induced liver injury (DILI). In 2021, patient was diagnosed with tuberculous sclerosing cholangitis and showed improvement with antituberculosis therapy. However, in 2022, patient experienced recurrent jaundice, fever, dark urine, and weight loss, without gastrointestinal symptoms. Laboratory tests revealed elevated bilirubin (total 13.8 mg/dl, direct 12.9 mg/dl), increased liver enzymes (SGOT 177 U/l, SGPT 91 U/l), and a positive antinuclear antibody indirect immunofluorescence (ANA IF) test with a centromere pattern. Magnetic resonance cholangiopancreatography (MRCP) and liver biopsy findings supported a diagnosis of PSC, overlapping with tuberculous sclerosing cholangitis. Treatment with ursodeoxycholic acid, methylprednisolone, and mycophenolic acid led to significant improvement in bilirubin and liver enzyme levels, although they remained above the normal range. This case highlights the diagnostic complexity of PSC in tuberculosis patients, particularly in the absence of typical gastrointestinal symptoms. The relationship between tuberculosis and PSC remains unclear, necessitating further investigation. Despite treatment, serum bilirubin and transaminase levels were fluctuated but persisted above the normalrange, highlighting the challenges in managing PSC with concurrent tuberculosis. This report emphasizes the importance of comprehensive diagnostic approaches, including imaging and histopathology, in identifying atypical presentations of PSC.
Pendekatan Integratif dalam Manajemen Dengue Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/699q0n64

Abstract

Dengue, as one of the most challenging tropical diseases of the 21st century, continues to present significant clinical and epidemiological complexities in developing countries, including Indonesia. With the increasing incidence of global dengue infections and the limited availability of definitive therapeutic options, clinical management is shifting toward optimizing supportive therapy and exploring adjuvant strategies to improve key clinical parameters such as hemodynamic and platelet count. By emphasizing the role of two interventions, Gelafusal (gelatin solutions) as a colloid fluid for resuscitation and Psidii (Psidium guajava folium extracts) as a platelet production-stimulating agent, through the lens of bioethics, pharmacodynamics, and evidence-based clinical strategies, this review offers a critical reflection on the opportunities and limitations of applying multimodal interventions in dengue management.
Update Manajemen Perioperatif pada Gangguan Tiroid dan Adrenal Brilliant Van Fitof S.R.
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6n8rts34

Abstract

Surgical patients with endocrine disorders require special consideration during perioperative evaluation and postoperative management. Several endocrine disorders encountered in the perioperative period include thyroid and adrenal diseases. Both conditions require optimal perioperative preparation to ensure that intraoperative and postoperative interventions proceed without complications. This preparation involves the collaboration of various medical disciplines, ranging from primary care physicians to consultant physicians in the hospitals. Patients with thyroid disorders require thorough preoperative assessment to prevent complications such as thyroid storm, which may occur during or after surgery. A similar approach is essential for patients with adrenal insufficiency. This article discusses the perioperative management in endocrine disorders, particularly thyroid and adrenal diseases, to enable clinicians such as surgeons, anesthesiologists, and internists provide appropriate therapeutic approaches for patients.
Inovasi dan Praktik Terbaik dalam Model Tikus Hasil Rekayasa Genetik untuk Penelitian Praklinis dan Translasional Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/26jxqx92

Abstract

Genetically engineered mouse models (GEMMs) have undergone significant evolution since their initial development in the late 1980s. Over the past decade, advancements in genome editing technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, base editing, and prime editing, have sparked a new wave of innovation in the design and application of GEMMs. This article explores the historical development of GEMMs, recent technical advancements beyond CRISPR, their broad-spectrum applications across diseases, including autoimmune and cardiovascular, integration of multiomics approaches, and the role of GEMMs in pharmacokinetic and pharmacodynamicstudies. It also addresses aspects of colony management, experimental animal ethics, international regulations, convergence with artificial intelligence, and case studies of successful clinical translation based on studies using GEMMs. By synthesizing the latest literature from various international databases, this article provides a strategic guide for researchers to optimize the potential of GEMMs in improving the accuracy and translational relevance of innovative therapy development.
Analisis Drug Related Problems (DRPs) Potensial Pada Pasien Geriatri Penderita Osteoporosis di Salah Satu Rumah Sakit Kota Bandung Yared Yehuda
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/h8v8c036

Abstract

Osteoporosis is a skeletal disorder characterized by decreased bone density, which predisposes individuals to an increased risk of fractures of the bones. The prevalence of osteoporosis is quite high among the geriatric patient population. Age-related complex medical problems are common in elderly, making them prone to drug-related problems (DRPs) that can affect therapeutic outcomes. This study aimed to identify and assess the incidence of potential DRPs in geriatric patients with osteoporosis, with or without comorbid condition. A cross-sectional, retrospective study was conducted using secondary data from medical records from January 2018 to December 2020. The sampling method used was purposive sampling, with a total sample of 100 geriatric patients. Inclusion criteria were patients aged >60years, outpatients, diagnosed with osteoporosis with or without comorbid conditions. Exclusion criteria were patients with incomplete or illegible medical record. Classification of DRPs was based on Pharmaceutical Care Network Europe (PCNE) version 9.1. The results showed that there were: drug interaction (43 cases, 39.09%), polypharmacy (29 cases, 26.36%), subtherapeutic doses (9 cases, 8.18%), less frequent drug administration (9 cases, 8.18%), untreated indication (6 cases, 5.45%), drug selection not within guidelines (5 cases, 4.55%), treatment duration too short (5 cases, 4.55%),drug administration without indication (3 cases, 2.73%), and drug duplication (1 case, 0.91%). Total incidence of DRPs was 58%. The most common drug for DRPs is calcium (48,30 %). A multivariate analysis using logistic regression showsthat the number of drugs could significantly affect the incidence of DRPs in patients (p<0.05) by 10.63 times.
Critical Care of Eclampsia with Partial HELLP Syndrome in Resource-Limited Setting: A Case Report Rizqhan, Muhammad; Wiedjaja, Aryasena Andhika
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/3d3d3g27

Abstract

Background: Eclampsia is a hypertensive disorder of pregnancy characterized by life-threatening seizures and often requires intensive care among obstetric patients. HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome is a complication of hypertensive disorders in pregnancy, marked by hemolysis, elevated liver enzymes, and thrombocytopenia. Developing countries have high maternal mortality rates due to inadequate antenatal maternal care services.Case Report: Mrs. D, 25 years old, married, a housewife, was referred to the emergency unit of Encik Mariyam Regional Hospital, Lingga, with seizures and decreased consciousness for the past 3 hours prior to admission. The patient wasdiagnosed with eclampsia complicated by partial HELLP syndrome and was scheduled for an emergency cesarean section (SC) by the obstetrician. General anesthesia was administered, and the patient received care in the intensive care unit (ICU) for 5 days under resource-limited conditions.Conclusions: Maternal mortality due to eclampsia and HELLP syndrome accounts for a significant proportion, especially in developing countries. Early diagnosis and prompt treatment by the ICU team can prevent complications and reduce morbidity and mortality. Emerging complications require early multidisciplinary intervention and treatment, including ventilator support, intensive monitoring, and the use of vasoactive medications, all of which can mitigate the progression of organ dysfunction and improve prognosis.
Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Dengue Severity in Patients Treated at Bethesda Hospital, Yogyakarta Jingan, Forensius; Christiane Marlene Sooai; Loury Priskila; Pradita Sri Mitasari; Wiwiek Probowati; Priskila, Loury
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/11a64f98

Abstract

Background: Dengue fever, a mosquito borne viral infection, remains a major public health concern in Indonesia, with the challenges in early identification of severe cases. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potentialbiomarker for assessing the disease severity.Objective: This study aimed to investigate the association between NLR and dengue severity in patients treated at Bethesda Hospital, Yogyakarta.Methods: A cross-sectional, quantitative study was conducted using medical record data from dengue patients admitted between 2022 to 2024. The NLR values were calculated from complete blood count results and disease severity was classified according to WHO guidelines. Statistical analysis was performed using the chi-square test and Fisher’s exact test.Results: Among the 68 patient samples, a significant association was found between NLR and dengue severity (p<0.001). Patients with lower NLR values were more likely to develop dengue hemorrhagic fever (DHF) compared to those with higher NLR values.Conclusion: The NLR plays a role in determining the severity of dengue infection and may serve as a predictive biomarker. This examination can be a practical tool in the clinical management of dengue fever patients, particularly for early detectionand optimizing therapeutic decision-making.
A Patient with Non-Hodgkin's Lymphoma of the Spinal Region with Tuberculosis Spondylitis Infection: A Case Report Helen Widiani; Losen Adnyana
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/jzvag666

Abstract

Primary non-Hodgkin’s lymphoma (NHL) of spinal origin is very rare, accounting for only 0.1% of all NHL, with spinal cord compression is the first symptom. Tuberculosis (TB) spondylitis is a chronic granulomatous inflammatory disease of thespine caused by Mycobacterium tuberculosis. Some patients will experience neurological deficits. If the M. tuberculosis bacterial infection affects the vertebral body, the resulting damage causes spinal instability and disruption of the surrounding structures. Patients can experience paraparesis or tetraparesis due to compression of the spinal cord. This disease has symptoms such as back pain, kyphosis, and constitutional syndrome. A case of a 75-year-old male patient with non-Hodgkin’s lymphoma diffuse large cell region spine stage IV ECOG 4, tuberculosis spondylitis on antituberculosis drugs special regimen intensive phase.
The Role of Biologic Agent in The Management of Ankylosing Spondylitis : A Case Report Gede Dilajaya Robin; Gede Kambayana; Robin, Gede Dilajaya
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/7nbqyy62

Abstract

Background: Ankylosing spondylitis (AS) is a chronic immune-related arthritis primarily affecting the spine, sacroiliac joints, and surrounding tissues. The estimated incidence of AS ranges from 1.30–1.56 million in Europe and from 4.63–4.98 million in Asia. However, data on the current prevalence of AS in Indonesia remains limited. Various treatmentmodalities are available, one of them are biological agents that play a significant role in managing disease progression and preventing complications. Case: A 25-year-old male presented with a four-year history of chronic back pain. Laboratoryresults showed an elevated C-reactive protein (CRP) level of 31.20 mg/dl. Pelvic and thoracolumbar X-ray showed kyphotic deformity, bamboo spine, and dagger spine appearance. The patient was diagnosed with high disease activity ankylosingspondylitis (ASDAS-CRP: 2.9). Initial treatment with nonsteroidal anti-inflammatory drug (NSAID) alone did not result in clinical improvement. Due to the severity of disease activity, combination therapy using NSAID and a tumor necrosis factor (TNF) inhibitor was used, and reported to give satisfactory clinical response. Additionally, patient also underwent corrective spinal surgery due to severe deformity. Conclusion: TNF inhibitors are currently considered as the first-line biological therapy in the management of ankylosing spondylitis, due to their superior efficacy and safety in controlling disease progression compared to other biological agents.
The Multifaceted Nature of Clopidogrel Resistance: Integrating Pharmacodynamic, Pharmacokinetic, and Pharmacogenomic  Andika Yusuf Ramadhan
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/pex51w69

Abstract

Clopidogrel is a second-generation thienopyridine drug that acts as a platelet aggregation agent and widely used to treat cardiovascular disease by preventing the formation of thrombus.  Growing studies in the cardiovascular field have led to a new term, which is clopidogrel resistance. The mechanism of clopidogrel resistance could be the consequence of several factors such as decreased bioavailability due to pharmacokinetic changes, PK/PD interactions with other drugs, and genetic polymorphisms. Genetic polymorphisms affect the metabolism of clopidogrel prodrug, leading to sub-therapeutic concentrations of active metabolites. In addition, mutations in the P2Y12 receptor gene also impact platelet activity against agonis and antagonist ADP.  Measurement of platelet activity and pharmacogenomics profiling could help in diagnosing and monitoring clopidogrel therapy with suspicion of clopidogrel resistance.

Page 16 of 18 | Total Record : 179

 14   15   16   17   18 

Filter by Year

2020 2025


Reset
Filter By Issues
All Issue Vol. 38 No. 12 (2025): MEDICINUS Vol. 38 No. 11 (2025): MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS Vol. 38 No. 5 (2025): MEDICINUS Vol. 38 No. 4 (2025): MEDICINUS Vol. 38 No. 3 (2025): MEDICINUS Vol. 38 No. 2 (2025): MEDICINUS Vol. 38 No. 1 (2025): MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS Vol. 37 No. 1 (2024): MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS Vol 34 No 1 (2021): MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS Vol. 33 No. 1 (2020): MEDICINUS More Issue