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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 179 Documents
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Perkembangan Terkini Penyakit Influenza dan Peran Favipiravir dalam Tata Laksana Penyakit Anna Rozaliyani; Asiyah Taqiyya Fakhrur Razi; Ammar Abdurrahman Hasyim; Findra Setianingrum; Rulliana Agustin; Erlang Samudro; Alvin Kosasih
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/3trygg29

Abstract

Influenza virus infection remains a major global health challenge, particularly for vulnerable groups with compromised immune systems. Influenza is primarily caused by infection of influenza A and B viruses, with a varying clinical spectrum, ranging from asymptomatic cases to life-threatening conditions. Influenza viruses tend to undergo rapid genetic mutations, limiting the long-term effectiveness of vaccine-induced immune responses. Diagnosing influenza remains challenging due to the nonspecific signs and symptoms of the disease. The gold standard for influenza diagnosis is reverse transcription polymerase chain reaction (RT-PCR) test. Antiviral drugs are an essential prophylactic and therapeutic strategy to reduce influenza-related morbidity and mortality, especially in high-risk populations. Favipiravir has the potential to be a promising therapy against influenza, SARS-CoV-2, and other RNA virus infections. Prevention and control of influenza virus infections, including vaccination, are management strategies that must be optimized.
Perbandingan Keputusan Tata Laksana Farmakologi dan Rujukan Pasien Epilepsi Baru dengan Pasien yang Pernah Didiagnosis Sebelumnya pada Layanan Telemedik di Indonesia Pukovisa Prawiroharjo; Yulia Puspita Dewi
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/qvn39698

Abstract

Introduction: Epilepsy is a condition or brain disorder characterized by a tendency for recurrent seizures. Telemedicine services use electronic communication facilities to provide medical support or care remotely. In these services, various factors influence doctors in making decisions. Objective: This study aims to compare the pharmacological management decisions and referral decisions for newly diagnosed epilepsy patients versus patients previously diagnosed by doctors in telemedicine services in Indonesia. Methods: This research uses a retrospective cross sectional design using secondary data sources from one of Indonesia's telemedicine services. A total of 100 subjects were selected within the telemedicine service. Pharmacological management decisions and referrals were assessed based on chat history. Results: Analysis of the data showed no significant difference between newly diagnosed patients and previously diagnosed in terms of pharmacological management decisions (p=0.298). However, there is a significant difference between newly diagnosed patients and previously diagnosed in terms of referral decisions (p=0.025). In addition, newly diagnosed patients appear to have a higher referral percentage (18.87%) compared to previously diagnosed patients (4.26%). Discussion: There was no significant difference in pharmacological treatment decisions between newly diagnosed patients and previously diagnosed patients. However, a significant difference was observed in referral decisions. This indicates the need for a larger sample size and further research.  
Analisis In Silico Interaksi antara Interferon Beta dengan Senyawa Turunan Flavonoid dan Terpenoid dari Bunga Carthamus tinctorius Lismayana Hansur; Nurmasita; Paisal; Sandy Vitria Kurniawan
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/nej0dw97

Abstract

Background: Kasumba turatea (Carthamus tinctorius) has long been empirically used by the people of South Sulawesi as a traditional medicine for diseases caused by viral infections. This plant is known to contain compounds such as thymol, carvacrol, carthamon, chalcone, and linalool, which have potential immunomodulatory activity, including relevance to multiple sclerosis. One of the immune mechanisms which play a role is interferon beta (IFN-β), whose function is influenced by β-glucan, which can enhance IFN-β expression. Objective: This study aims to explore the interaction between thymol, carvacrol, carthamon, chalcone, and linalool — compounds with immunomodulatory— and IFN-β through acomputational (in silico) approach. Methods: The method used in this study is molecular docking using AutoDock Tools, AutoDock Vina, and Discovery Studio applications. The 3D structure of interferon beta was obtained from the Protein Data Bank (PDB) with PDB ID 1AU1. Beta-D-glucan (BDG) was used as the control compound. The ligands examined included carthamon, carvacrol, chalcone, linalool, and thymol. Results: Docking results showed that carthamon exhibitedthe highest binding affinity among the ligands. Key residues involved in ligand interaction at the active site of IFN-β were glutamic acid 42, arginine 28, serine 13, asparagine 90, and leucine 9, which interacted via hydrogen bonds. Conclusion:This study provides preliminary evidence that active compounds from kasumba turatea, particularly carthamon, have the potential to interact wit IFN-β. These findings can serve as a foundation for further research to examine the interaction of carthamon with IFN-β, which could enhance immunomodulatory capabilities.
Uji Klinik Terdesentralisasi: Mendefinisikan Ulang Partisipasi, Kuasa, dan Presisi dalam Riset Kesehatan Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/trzykz54

Abstract

Decentralized clinical trials (DCTs) have emerged as a transformative force in biomedical research, breaking down traditional boundaries and reshaping how evidence is generated, validated, and applied. By leveraging digital health technologies, real-world data, and remote engagement infrastructures, DCTs have the potential to democratize clinical research by improving inclusivity and accessibility. However, these opportunities come with challenges related to regulatory governance, technological ethics, and socio-political representation. This brief article explores both the conceptual and empirical foundations of DCTs, drawing from recent studies, international policy documents (such as white papers), regulatory initiatives, and global practice surveys. It examines the epistemological, operational, and normative shifts introduced by DCTs and proposes a framework for understanding their impact on three core dimensions of clinical science: participation, power, and precision. Ultimately, this article argues that DCTs are not merely a digital enhancement, but rather a fundamental reconfiguration of how health knowledge is generated and governed.
Cytomegalovirus Infection in Immunocompetent Individual: A Case Report Gede Agung Setya Wibawa; Ketut Agus Somia
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/kpftgp50

Abstract

Cytomegalovirus (CMV) is virus that can infect people with immunocompromised conditions. Cytomegalovirus is DNA virus that need host to replicate their self. There was a case report: male, 49 years old was reported infected by CMV. Patientcame to the hospital with erythroderma in all of his body. This condition is about a month ago before patient came to the hospital. After a skin biopsy examination there was inclusion body that was sign for infection of CMV. IgG and IgM against CMV also positive in this patient. Viral load for CMV also detected in the blood stream of the patient. Valganciclovir was the first drug of choice in this patient, and patient was treated with valganciclovir for one day. After treatment, erythrodermawas improved. The patient, before being diagnosed with CMV, was not using any immunosuppressive medications. The HIV infection is negative, confirmed by a rapid HIV test, and there are no symptoms indicating that the patient has diabetesmellitus.
Epigenom yang Berkembang: Fungsi dan Aplikasinya Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/1cyz2p11

Abstract

Epigenome is a set of reversible modifications that synergistically regulate gene expression without altering the DNA sequence. The epigenome serves as a functional bridge between the genome and the environment, enabling precise spatiotemporal regulation of gene expression, which is crucial for cellular identity and development of organisms. Unlike the static genome, the epigenome is dynamic and responsive to endogenous and exogenous signals, including developmental, metabolic, environmental stress, and pathological conditions. This paper comprehensively reviews the fundamental mechanisms of epigenetic dynamics, its role in phenotype formation, and its implications in disease etiology and therapeutic innovation. By integrating cutting-edge findings from developmental biology, oncology, neurobiology, and regenerative medicine, the epigenome can be understood as a multidimensional lens for interpreting biological memory, developmental plasticity, and potential molecular engineering.
The Effect of Phaleria macrocarpa Bioactive Fraction (Proliverenol) Supplementation on Liver Damage in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) Irsan Hasan; Saut Horas Hatoguan Nababan; Raymond R. Tjandrawinata; Danang Agung Yunaidi; Liana W. Susanto
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/a4ba3z37

Abstract

Liver is considered one of the most vital organs, acting as the center of metabolism of nutrients and excretion of waste products. Non-alcoholic fatty liver disease (NAFLD) is one of the main causes of chronic liver disease. The management of NAFLD continues to evolve, and clinicians are currently faced with a variety of alternative options, both nonpharmacotherapeutic and pharmacotherapy, to avoid more severe liver disease. Phaleria macrocarpa (Scheff.) Boerl., namely, mahkota dewa in Indonesia, has been used empirically to treat cancer, allergy, and diabetes mellitus. Proliverenolis a proprietary bioactive fraction derived from the dried fruit of Phaleria macrocarpa (Scheff.) Boerl. Proliverenol was reported to have hepatoprotective, anti-inflammatory, antioxidant, and antifibrotic effects. The study found that Proliverenol bioactive fraction, at a dosage of 1000 mg twice daily for at least 4 weeks of treatment, is effective in improving liver damage with a good safety profile.
Tinjauan Terpadu terhadap Terapi Presisi dan Standardized Herbal Drug untuk Non-Alcoholic Fatty Liver Disease (NAFLD): Kemajuan Molekuler, BuktiKlinis, serta Implikasi Integratif Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/mh4ry926

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a progressive hepatic disorder that has become a central component of the global metabolic syndrome spectrum. Its complex pathogenesis involves insulin resistance, chronic inflammation,oxidative stress, and activation of fibrogenic pathways. Along with the deepening understanding of molecular mechanisms,precision therapies targeting farnesoid X receptor (FXR) agonists, peroxisome proliferator-activated receptor (PPAR) modulators, incretin mimetics, and RNA-based technologies are being developed, although challenges remain concerningside effects and accessibility. In this context, Veprolin containing Proliverenol, a bioactive fraction of Phaleria macrocarpa, offers potential as an adjuvant standardized herbal drug with anti-inflammatory, antifibrotic, and reparative effects, as demonstrated in preclinical studies. This review highlights the importance of integrative, precision-oriented, and sustainable multimodal therapeutic strategies.
Laporan Kasus: Tantangan dalam Manajemen Epilepsi Katamenial pada Menstruasi Tidak Teratur Gabriella, Nadia; Kennytha Yoesdyanto
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/kmv0je25

Abstract

Introduction: Catamenial epilepsy (CE) is characterized by periodic seizures, defined as ≥2-fold increase in seizure frequency during a specific period of the menstrual cycle. The prevalence of CE ranges from 10 to 70%, affecting over 40% of women with epilepsy. It is particularly prevalent among women with focal epilepsy, especially in cases of temporal lobe epilepsy (TLE). Exacerbation of seizures in CE is attributed to the fluctuations in reproductive steroid levels, which affect neuronal excitability. As of now, there is no definitive treatment available for CE. We reported a case of CE in a female patient with TLE.Case Report: A 20-year-old female patient with irregular periods presented with cluster seizures occurring within three days of her menstrual period. Seizure semiology is described as focal to generalized tonic-clonic seizures, with rightsidelateralization. No neurological deficits were found. Brain magnetic resonance imaging showed no abnormality. The electroencephalogram revealed sharp waves in both left and right temporal lobe. The patient was already treated with phenytoin 400 mg/day. However, due to persistence of seizures during the perimenstrual period, clobazam 20 mg/day was added. Seizure frequency has decreased but the patient remains under close observation.Discussion: The patient has been diagnosed with CE due to the cyclic exacerbation of seizures coinciding with her menstrual cycle. Her seizures consistenly occur within the perimenstrual phase, which is marked by a sudden withdrawal of progesterone and corresponding increase in seizure frequency. The recommended approach involves administering an add-on antiepileptic drug (AED) prior to and during menstruation. However, given the patient’s irregular periods, the mainchallenge lies in determining the optimal timing for this intervention.
The Role of Systemic Immune-Inflammation Index on The Clinical Degree of Dengue Hemorrhagic Fever Patients at Bethesda Hospital Yogyakarta Amumpuni, Antonia Namelia Wahyu; Sooai, Christiane Marlene; Wicaksono, Hendi; Probowati, Wiwiek; Priskila, Loury
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/y6daha15

Abstract

Background: Dengue hemorrhagic fever (DHF) is a mosquito-borne infectious disease caused by the dengue virus and transmitted primarily by Aedes aegypti. According to the World Health Organization (WHO), DHF remains a major globalhealth concern, particularly in tropical and subtropical regions. The disease can result in severe complications, including hemorrhage and hypovolemic shock, which may lead to death. Despite ongoing vector control initiatives, DHF continues to pose a significant public health challenge, especially in areas with inadequate sanitation and limited healthcare infrastructure.Objectives: To evaluate the role of systemic immune-inflammation index (SII) in determining the clinical severity of denguehemorrhagic fever (DHF) among patients at Bethesda Hospital Yogyakarta.Methods: This was a cross-sectional study utilizing medical records from 333 DHF patients at Bethesda Hospital Yogyakarta. Records were screened based on predefined inclusion and exclusion criteria. A total of 172 eligible cases were selected using odds ratio-based sample size calculations. Consecutive sampling was employed as the samplingtechnique. Data analysis was performed using SPSS and Microsoft Excel to determine statistical significance.Results: The findings demonstrated that neutrophil, lymphocyte, and platelet counts significantly influenced the clinical severity of dengue hemorrhagic fever (DHF). Chi-square analysis revealed a statistically significant association between the systemic immune-inflammation index (SII) and disease classification (DF/DHF) (p<0.001). However, the relationshipbetween SII levels and clinical severity did not follow a linear pattern. Contrary to established theories—where elevated SII values are typically associated with increased disease severity—this study observed variations that may be attributed toconfounding factors such as patient age, comorbidities, and individual immune response.Conclusion: The systemic immune-inflammation index (SII) is significantly associated with the clinical severity of DHF in patients at Bethesda Hospital Yogyakarta, although its correlation may be influenced by additional patient-specificvariables such as patient age, comorbidities, and individual immune responses.Keywords: systemic immune-inflammation index (SII), dengue hemmorhagic fever (DHF), dengue severity, clinicalseverity.

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