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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE Madyawati Latief; Anggun Tri Fisesa; Putri Maya Sari; Indra Lasmana Tarigan
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4532

Abstract

Anti-inflammatory compounds play a role by inhibiting the formation of prostaglandin mediators, inhibiting the migration of leukocytes to the area of ​​inflammation, and inhibiting the release of prostaglandins from the cells where they are located. Several plant-derived compounds that can act as anti-inflammatory candidates are flavonoids, saponins, alkaloids, and phenols. This study aims to determine the anti-inflammatory activity of the ethanol extract of Sungkai leaves and to determine the effect of the concentration given on the level of anti-inflammatory activity. The method used was the formation of granuloma pockets and edema on the mice's backs by inducing subcutaneous carrageenan using ethanol extract of Sungkai leaves with various concentrations of 5%, 10%, and 15%, respectively. The results of anti-inflammatory activity showed that the ethanol extract of Sungkai leaves had a significant effect on the average exudate volume and the percentage of inflammation inhibition. At a concentration of 15%, the extract was able to reduce the volume of exudate by 46,67 ± 5,506 µl and inhibition of inflammation by 87.78%. In addition, the ethanol extract of Sungkai leaves significantly affected lymphocytes, stem neutrophils, and segment neutrophils, but did not significantly affect the number of monocyte cells. At a concentration of 15%, the ethanol extract of Sungkai leaves showed the smallest number of leukocyte cell types, namely 50.11 ± 2.389 lymphocyte cells; stem neutrophil cells 10,44 ± 0,475; segmented neutrophil cells were 19.78 ± 0.596 and monocyte cells 2,0 ± 0,236. It can be concluded that the ethanol extract of Sungkai leaves has anti-inflammatory activity but has not approached the effect of anti-inflammatory drugs in general.
ANTI-FUNGAL ACTIVITY TEST OF PLETEKAN LEAVES LIQUID SOAP (Ruellia tuberosa L.) ON CANDIDA ALBICANS Ahmad Fuad Masduqi; Mighfar Syukur
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4563

Abstract

The fungus Candida albicans is a pathogenic species that causes candidiasis. Pletekan plant has potential as a medicinal plant. This plant is proven to have one of the effects as an antimicrobial. The purpose of this study was to determine whether the pletekan leaf extract liquid soap could inhibit the growth of Candida albicans and whether there were differences in the antifungal activity of the liquid soap pletekan leaf extract at a concentration of 20%, 40%, and 60%. This study used maceration extraction methods, screening for secondary metabolites and continued with TLC tests. Liquid soap formulations from extracts with different concentrations. Furthermore, the research was carried out to test the antifungal activity by using the good method on liquid soap for the pletekan leaf extract against the growth of Candida albicans. Screening and TLC results showed that the pletekan leaf extract contained flavonoids, steroids, triterpenoids, and alkaloids. Liquid soap preparations including organoleptic, pH, homogeneity, and viscosity are included in the criteria for the Indonesian National Standard. The results showed that pletekan leaf extract in a liquid soap preparation could inhibit the growth of Candida albicans. The results of statistical tests show that the data are normally distributed and homogeneous. There were differences in the antifungal activity of the liquid soap for pletekan leaf extract with a concentration of 20%, 40%, and 60% which resulted in a succession of 8,456mm; 12,186mm; and 14,293mm. The antifungal activity showed that the extract concentration was directly proportional to the resulting inhibition zone
THE EVALUATION OF ANTI-EPILEPTIC DRUGS DOSAGE IN MALNOURISHED CHILDREN: CASES IN INDONESIAN COMMUNITY OF EPILEPSY Nialiana Endah Endriastuti; Masita Wulandari Suryoputri; Dewi Latifatul Ilma
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4662

Abstract

Anti-epileptic drug (AED) has a narrow therapeutic index of drugs that a slight increase in dosage showed toxic effects. The therapeutic response is difficult to predict in malnutrition status because the patient with nutritional deficiency have more complicated problems likes hypoalbuminemia, macronutrient and micronutrients deficiency that affected the levels of AEDs. The nutritional deficiency could be a direct and indirect cause of ineffective AEDs therapy and also recurrent epilepsy. This study aims to describe the use of antiepileptic drugs in Indonesian children with poor nutritional status. The research design was observational studies with cross sectional random sampling to evaluate the AED doses of malnutrition status in children. All information was collected by spreading electronic forms and interviewing the parents by phone. The data were analyzed descriptively. Total of 8 malnourished children mostly included in the range of ages from >2 to 12 years (n=5; 62.50%) with means 3,9±2,7 years. The study showed valproic acid was bigger used in monotherapy (n=5; 62,50%) than polytherapy with carbamazepine or sodium phenytoin and phenobarbital. The means estimation of valproic acid monotherapy concentration in females’ group (n=2; 33,33%) showed sub-therapeutics level were Cssmin 26,09±0,57 mg/L and Cssmax 64,17±1,39 mg/L, also the means in males’ group (n=2; 33,33%) of valproic acid monotherapy were Cssmin 22.07±2,71 mg/L and Cssmax 54.27±6.66 mg/L. All of them included in good clinical outcome of free seizure > 6 months.
THE EFFECTS OF HANDWASHING HABITS ON HEALTH PROTOCOLS ON SKIN HYDRATION LEVELS AND INCIDENCE OF IRRITANT CONTACT DERMATITIS Sustiawati _; Indri Hapsari; Irsalina Nurul Putri
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4667

Abstract

Background: Handwashing using soap or hand sanitizer is one of the health protocols that must be implemented by society to prevent the spreading of SARS-COV2 virus which can cause pneumonia, acute respiratory syndrome and death. The implementation of health protocols during the COVID-19 pandemic caused the habit of handwashing increase. Hence, it can lead to cause irritant contact dermatitis and dry hand skin due to frequent contact with soap or hand sanitizers. Method: This study is an observational study with the sample from the villager of Banyumas regency. The data collection was taken by cluster random sampling and accidental sampling. Results: Considering the health protocol, most of the villager used to wash their hands regularly and 3 respondents (3.00%) of them did not. 100 respondents took the data and 19 respondents (19.00%) have irritant contact dermatitis and the rest did not. Furthermore, for skin hydration levels with dehydration category (0% - 29%) are 50 respondents (50.00%), normal category (30% - 50%) are 38 respondents (38.00%) and hydration category (51% - 100 %) are 12 respondents (12.00%). Chi-Square analysis showed that there was no significant relationship between handwashing habit and the incidence of irritant contact dermatitis with the value of “P” is 0.394> 0.05 and there was a significant relationship between hand washing habits and skin hydration levels with the value of “P” is 0.010 <0, 05. Conclusion: Handwashing habits have a significant relationship to skin hydration levels.
THE INFLUENCES OF KNOWLEDGE, BEHAVIOUR AND ATTITUDE IN SELECTING POWDER TYPE: THE INCIDENCE OF ACNE VULGARIS Anggita Nur Fauzana; Indri Hapsari; Irsalina Nurul Putri; Githa Fungie Galistiani
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.4668

Abstract

Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. The purpose of this study was to analyze the effect of the level of knowledge, attitudes and behavior of choosing the type of powder on the incidence of acne vulgaris in Banyumas Regency. This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). The level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.
COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR Anita Puspa Widiyana
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4827

Abstract

The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted by computer programs and online servers. Substituents are added at positions 2 and 3 to the quinazoline-4(3H)-on ring, such as -H, -NO2, -OCH3, -N(CH3)2, -SO2NH2, -OH, and –OCH3. QSAR as COX-2 inhibitor analysis was performed by SPSS Ver. 21 software. Lipinski’s rule of five for determining bioavailability is performed by an online server at http://ilab.acdlabs.com. The best QSAR equation used to predict the COX-2 inhibitors from these compounds is RS-pred = 0.372 Log P + 0.014 MR + 0.979 Etot – 4.859, with n= 12, R = 0.998; SE = 0.356, F = 805.252 and sig = 0.001. Six compounds were predicted to have good oral bioavailability, such as 3-(benzylideneamino)-2-(2,4-dichlorophenyl)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-methoxybenzilidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-methoxybenzylidene)amino)quinazolin-4(3H)-one, and 2-(((2-(2,4-dichlorophenyl)-4-oxoquinazolin-3(4H)-yl)imino)methyl)- benzenesulfonamide. This research can be used as an in vitro and in vivo study for BDCQ derivatives as anticancer drugs.
IRRITATION TEST OF BAWANG DAYAK (Eleutherine bulbosa(Mill.) Urb.) EXTRACT CREAM WITH HUMAN PATCH TEST METHOD Syahrida Dian Ardhany; Susi Novaryatiin; Mohammad Rizki Fadhil Pratama; Zulkhurnain Utar
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4854

Abstract

Topical agents indicated for the treatment of acne have the potential to cause irritation or allergic contact dermatitis. This study investigates the irritancy potential of anti-acne cream of bawang dayak (Eleutherine bulbosa (Mill.) Urb.) previously tested for microbiological effectiveness with the lowest concentration of 5% and the highest concentration of 20%. The method used in this study is the human patch test. A total of 20 volunteers were recruited for the patch test study, testing the cream. The result showed that all volunteers did not experience irritation both in the 5% or 20% bawang dayak extract cream formulations. However, the interview results were found that some volunteers experienced a slight itching without any significant skin adverse reactions on the cream application. Therefore, based on these initial findings it can be safely concluded that the cream of bawang dayak does not cause significant skin adverse reaction and good enough for further development for anti-acne cream dosage form.
ANTIBACTERIAL ACTIVITY OF FENNEL LEAVES ETHANOL EXTRACT (FOENICULUM VULGARE MILL) AGAINST PSEUDOMONAS AERUGINOSA Ahwan Abdul; Fadilah Qonitah; Partonowati _
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4873

Abstract

Fennel leaf (Foeniculum vulgare Mill) is an herbal plant that is used for treatment. Flavonoid compounds and essential oils contained in fennel leaves have an antibacterial effect. The purpose of this study was to determine the activity of fennel leaf extract against Pseudomonas aeruginosa bacteria. Testing of antibacterial activity using a pure experimental method with a randomized design with a unidirectional pattern using the extraction method, namely maceration and bacterial activity testing with the diffusion method. The parameter measured is the diameter of the inhibition formed in the paper disc area. The data were measured using the Anova statistical approach. Fennel leaf extract has an inhibitory effect on the growth of Pseudomonas aeruginosa bacteria, namely at concentrations of 15% (11.04 ± 1.59 mm), 25% (13.68 ± 3.54 mm), 50% (18.14 ± 2.04 mm), 75% (20.53 ± 0.88 mm) and 100% (22.82 ± 0.32 mm) compared with 1% Dimethyl Sulfoxide (DMSO) negative control (00.00 ± 0.00 mm), while the test with positive control Gentamicin 1% (22.82 ± 0.32 mm) with a strong category (10 - 20 mm), namely at concentrations of 15%, 25% and 50%, very strong category (>20mm), namely at concentrations of 75% and 100%, the statistical significance value of ANOVA was p<0.05. It can be concluded that the ethanol extract of fennel leaf (Foenicullum vulgare Mill) has antibacterial activity against Pseudomonas aeruginosa. The value of the minimum inhibitory concentration (MIC) of ethanol extract of fennel leaf (Foenicullum vulgare Mill) against Pseudomonas aeruginosa bacteria was 15% w/v.
EVALUATION OF DRUG MANAGEMENT IN SALAMAN 1 PRIMARY HEALTH CENTER MAGELANG DURING THE COVID 19 PANDEMIC Endaryanti Wulandari; Aris Widayati
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4960

Abstract

The scope of drug management in Primary Health Center (PHC) includes planning/selection, procurement, storage, distribution, control of use, and documentation and reporting. During the COVID-19 pandemic, there were many changes in regulation and management in Primary Health Center. Such a situation certainly has an impact on the drug management of Primary Health Center. The purpose of this study is to evaluate drug management in Salaman 1 Primary Health Center in Magelang District, Central Java Province, during the COVID-19 pandemic in 2020. This research is an evaluative study using a descriptive design with a qualitative approach. The data was obtained by three methods, i.e., direct observation, interview, and secondary data. Direct observation was applied to observe the medicines' storage space. Interviews were conducted with five informants selected purposively according to the research's purpose. The assessments of secondary data were performed from the available and relevant data documentations. Data were analyzed by triangulation approach of the three types of data produced, namely observation data, interview data, and secondary data assessment. The results show several problems regarding drug management in Salaman 1 PHC during the COVID-19 pandemic. The drug selection is not precisely suitable for the needs, while drug procurement cannot always be arranged according to the planning. Furthermore, drug distribution is relatively impeded. Control of use found the number of expired and almost expired drugs increases. Drug storage and documentation are the two steps in the drug management cycle conducted appropriately in Salaman 1 PHC during the COVID-19 pandemic. This evaluative study concludes that the COVID-19 pandemic affected the drug management cycle in Salaman 1 PHC in Magelang District in 2020. Therefore, coordination among stakeholders must be improved to anticipate unforeseen circumstances, especially during the pandemic situation. The impacts of new policy implementations must be anticipated by testing, monitoring, and evaluating.
ANALYSIS OF TOTAL FLAVANOID LEVELS OF FENNEL LEAVES (FOENICULUM VULGARE) ETHANOL EXTRACT BY SPECTROPHOTOMETRY VISIBEL Alifia Ni’ma; Novena Yety Lindawati
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4972

Abstract

Flavonoid is the compounds in nature that play a role in increasing body immunity. Flavonoids in green plants can be sourced from fennel leaves. The aims of the study were to determine the total levels of flavonoids in fennel leaves (Foeniculum vulgare) using Visible Spectrophotometry. Maceration extracted samples using ethanol 96% solvent. Qualitative analysis of flavonoids using dilute NaOH, Wilstater-cyanidin method, and AlCl3. Quersetin used as standard solution. Quantitative analysis was carried out by colorimetric method with ALCl3 reagent as a complex compound. Quantitative analysis was continued with Visible Spectrophotometry on operating time at the 28th minute and a wavelength of 430.5 nm. Qualitative analysis indicate that the ethanol extract of fennel leaves was positive flavonoids. The total flavonoid content of fennel leaves ethanol extract was 99.2 mg QE/g extract with a coefficient of variation 1.27%.

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