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All Journal Microbiology Indonesia Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Dentino: Jurnal Kedokteran Gigi Jurnal Surya Medika Anterior Jurnal Jurnal Farmasi Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Borneo Journal of Medical Laboratory Technology Jurnal Farmagazine Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesia Jurnal Farmasi SYIFA Borneo Journal of Pharmacy Journal of Pharmascience

Mohammad Rizki Fadhil Pratama

Universitas Muhammadiyah Palangkaraya

Author-ID : 1168020

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Studi Docking Molekular Senyawa Turunan Kuinolin Terhadap Reseptor Estrogen-Α Mohammad Rizki Fadhil Pratama
Jurnal Surya Medika (JSM) Vol 2 No 1 (2016): Jurnal Surya Medika
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Estrogen-α (ER-α) is the main target for ER + therapy. Inhibition of ER-α is known to slow the proliferation of ER + breast cancer cells. Quinoline derivatives are known to have anticancer activity by inhibiting several types of receptors. It is not known whether quinoline can inhibit ER-α. This study aims to determine the interaction between ER-α with quinoline derivative compounds. Molecular docking of ER-α showed that quinine gave the most negative bond-free energy and the smallest inhibition constant, respectively -8.73 kcal/mol and 0.398 μM. These results provide predictions that quinine has activity as an ER-α inhibitor and has the potential to be developed in the treatment of ER + breast cancer. However, the affinity shown by quinine was lower than that of 4-hydroxytamoxifen, a potent inhibitor of ER-α.

In-Vitro Study of Antioxidant Activities from Ethanol Extracts of Akar Kuning (Arcangelisia flava) Suratno Suratno; Muhammad Ikhwan Rizki; Mohammad Rizki Fadhil Pratama
Jurnal Surya Medika (JSM) Vol 4 No 2 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

This study aims to determine the antioxidant activity of akar kuning (Arcangelisia flava) stem extract from Central Kalimantan using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. This research includes extraction of simplicia and test of antioxidant activity by DPPH method. Based on the analysis of antioxidant activity on ethanol extract from yellow root plant stem IC50 values of 136.81 ppm were obtained. This IC50 value indicates the antioxidant strength of the yellow root plant stems including in the moderate category. Further research on antioxidant activity in the fraction of akar kuning stems needs to be done to determine the composition of the antioxidant compounds in each solvent.

Introducing a two‐dimensional graph of docking score difference vs. similarity of ligand‐receptor interactions Mohammad Rizki Fadhil Pratama; Hadi Poerwono; Siswandono Siswodihardjo
Indonesian Journal of Biotechnology Vol 26, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.62194

Observation of molecular docking results was generally performed by analyzing the docking score and the interacting amino acid residues separately either in tables or graphs. Sometimes it was not easy to rank the tested ligands’ docking results, especially if there were many ligands. This study aims to introduce a new way to analyze docking results with a two‐dimensional graph between the difference in docking score and the similarity of ligand‐receptor interactions. Molecular docking was performed with one reference ligand and several test ligands. The docking score difference was obtained between the test and the reference ligands as the graph’s x‐axis. Meanwhile, the y‐axis contains the similarity of ligand‐receptor interactions, obtained from the ratio of amino acid residues and the types of interactions between the test and reference ligands. Docking result analysis was more straightforward because two critical parameters were presented in one graph. This graph could be used to support the analysis of the docking results.

UNDERSTANDING THE INTERACTION BETWEEN GLUTATHIONE AND ACETAMINOPHEN: A DOCKING STUDY APPROACH Mohammad Rizki Fadhil Pratama; Eko Suhartono
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5381

Background:Acetaminophen (PCT) is known for its pro-oxidant properties, which neutralized by the presence of internal antioxidants such as glutathione (GSH). GSH has two forms: monomers and dimers, mainly distinguished by the presence of thiol group. Purpose:This study aims to see the difference in interaction between PCT with both forms of GSH. Method:Molecular docking was performed using Autodock Vina 1.1.2 on whole GSH surfaces. The main parameter used was the free energy of binding as affinity marker, as well as the position of PCT toward GSH. Result:The docking results show that PCT has a slightly higher affinity to the dimeric form of GSH than its monomeric form with the free energy of binding -2.7 kcal/mol and -2.2 kcal/mol, respectively. The interesting thing is the acetyl group of PCT is in a position far from the thiol group in the monomeric form of GSH, in contrast to its dimeric form. Conclusion:These results show that difference in affinity of PCT to both GSH forms is influenced by the position of the acetyl group against the thiol group of cysteine in GSH. The proximity of the pro-oxidant group to the thiol group leads to an increase in the affinity of the pro-oxidant to GSH.

Pharmacophore Optimization Of Berberine As HER2 Inhibitor Mohammad Rizki Fadhil Pratama; Guntur Satrio Pratomo
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Previous research has shown that berberine, an alkaloid found in several plants such as akar kuning (Arcangelisia flava) shows the potential for inhibition of Human epidermal receptor-2 (HER2). Pharmacophore modification on the berberine was predicted could increase the affinity of berberine derivatives against HER2. The present study aims to determine the main pharmacophore of berberine with the highest influence towards berberine affinity against HER2. Molecular docking was performed on several modified pharmacophore of berberine against HER2. The docking results show that O atom at position number 23 has the most important influence on the berberine affinity towards HER2, where modification of O atom resulting in a decrease of berberine affinity. The highest affinity showed by derivate berberine-6 with the free energy of binding score and dissociation constant -10.80 kcal/mol and 12.17 nM, respectively. In contrast with other berberine derivatives, the berberine-6 derivate does not interact with the amino acid threonine at position 862. It provides a prediction that interaction of that amino acid potentially decrease the berberine activity towards active site of HER2. Further, derivate berberine-6 could be developed into HER2 inhibitor and should be potential to be developed as HER2-positive breast cancer therapy.

Pemberdayaan Masyarakat melalui Edukasi Cara Pembuatan Pangan Olahan yang Baik, Bahan Tambahan Pangan, dan Kemasan Pangan untuk Penguatan Jaminan Keamanan pada Pelaku UMKM Bidang Makanan di Balikpapan Juni Ekowati; Rosita Handayani; Dewi Melani Hariyadi; Mohammad Rizki Fadhil Pratama; Putri Hamidah Khairunnisa; Melanny Ika Sulistyowaty; Rossa Auli Tasha; Imamatin Nufus Melania; Ersanda Nurma Praditapuspa; Muhamad Ilham Royyan Nafi’
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 6 (2021): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v6i6.2676

Food safety is a complex issue that involves stakeholders in its handling. The point of food safety is growing widely and is becoming a concern in the community because it is related to the quality of consumers' good health and well-being. The community service activities based on quality education focused on Good Processed Food Manufacturing Practices (CPPOB), safe use of Food Additives (BTP), and consideration of packaging selection that ensures food safety. Education is carried out to increase the understanding of SMEs actors regarding regulations of CPPOB, the use of BTP, and provisions on Food Packaging. The education process is carried out online using the Zoom Meeting platform. Learning activity is carried out in one direction through lectures and questions and answers sessions. The increase in participants' understanding was measured by comparing the distribution of average scores, pretest, and post-test statistical tests. The effectiveness and quality of the educational process were measured using an evaluation questionnaire with predetermined indicators. The education carried out related to CPPOB, the use of BTP, and the selection of food packaging performed by the community service team of the Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga to SMEs in Balikpapan has proven to increase the understanding of business actors. It can fulfill their needs and target activity evaluation indicators that have been determined.

Development of Micro, Small and Medium Enterprises Rattan Woven Crafts in Central Kalimantan, Indonesia Iin Nurbudiyani; Sonedi Sonedi; Endang Sri Suyati; Mohammad Rizki Fadhil Pratama
Anterior Jurnal Vol 18 No 2 (2019): Anterior Jurnal
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

This study discusses the development of small and medium micro enterprises (MSMEs) in Central Kalimantan with rattan woven craft industries being used as samples to represent other MSME sectors. The purpose of this study is to describe the improvement in the performance and strategy of the MSME group covering various aspects such as job training, capital support, equipment/technology assistance, and access to information and communication. The findings of this study indicate that the development of MSMEs carried out by regional governments in Central Kalimantan has gone in the right direction, with several factors still making improvements possible. Support in the form of training should be conducted regularly and scheduled with the topic of continuous training and productive participants. Aid in the form of equipment requires periodic evaluations, such as a reward-punishment system for business groups that have received various support to ensure the support provided is on target. Another strategy is to form the centre of the MSME industry in the Capital of the Province, to facilitate the access of tourists who just want to visit looking for typical Central Kalimantan souvenirs. The easiest way to do this now is to implement a movement of love for standard Central Kalimantan handicraft products to be displayed in various offices, offices, and government agencies as well as different infrastructure and public facilities.

AKAR KUNING (Arcangelisia flava) SEBAGAI INHIBITOR EGFR : KAJIAN IN SILICO Mohammad Rizki Fadhil Pratama
Jurnal Farmagazine Vol 3, No 1 (2016): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v3i1.1

Akar kuning (Arcangelisa flava) diketahui memiliki berbagai aktivitas farmakologi seperti antikanker. Beberapa metabolit sekunder akar kuning menunjukkan aktivitas antiproliferasi sel kanker. Overproliferasi pada sel kanker salah satunya disebabkan oleh kelainan pada EGFR, kelompok reseptor yang berperan pada saat inisiasi proliferasi sel. Inhibisi pada EGFR dapat menghambat proses proliferasi sel kanker. Penelitian ini bertujuan mengetahui metabolit sekunder dari akar kuning dengan potensi paling besar sebagai inhibitor berbagai EGFR. Metode yang digunakan adalah molecular docking beberapa metabolit sekunder akar kuning terhadap EGFR-1, EGFR-2, EGFR-3, dan EGFR-4. Hasil docking menunjukkan berberin memberikan energi bebas ikatan paling negatif dan konstanta inhibisi paling kecil pada seluruh EGFR, dengan afinitas paling tinggi ditunjukkan pada EGFR-2 dengan ΔG dan ki secara berturut-turut sebesar -9,34 kcal/mol dan 141,81 nM. Over-ekspresi aktivitas dari EGFR-2 sendiri seringkali terjadi pada kanker payudara, terutama kanker payudara HER2-positif. Hasil tersebut memberikan prediksi bahwa berberin memiliki aktivitas sebagai inhibitor EGFR terutama EGFR-2 dan berpotensi untuk dikembangkan pada terapi kanker payudara HER2-positif. Keyword : Akar Kuning, EGFR, Antikanker, Docking

IRRITATION TEST OF BAWANG DAYAK (Eleutherine bulbosa(Mill.) Urb.) EXTRACT CREAM WITH HUMAN PATCH TEST METHOD Syahrida Dian Ardhany; Susi Novaryatiin; Mohammad Rizki Fadhil Pratama; Zulkhurnain Utar
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4854

Topical agents indicated for the treatment of acne have the potential to cause irritation or allergic contact dermatitis. This study investigates the irritancy potential of anti-acne cream of bawang dayak (Eleutherine bulbosa (Mill.) Urb.) previously tested for microbiological effectiveness with the lowest concentration of 5% and the highest concentration of 20%. The method used in this study is the human patch test. A total of 20 volunteers were recruited for the patch test study, testing the cream. The result showed that all volunteers did not experience irritation both in the 5% or 20% bawang dayak extract cream formulations. However, the interview results were found that some volunteers experienced a slight itching without any significant skin adverse reactions on the cream application. Therefore, based on these initial findings it can be safely concluded that the cream of bawang dayak does not cause significant skin adverse reaction and good enough for further development for anti-acne cream dosage form.

The Antifungal Activity of Artesunate toward Candida albicans: Two Opposite Activities MOHAMMAD RIZKI F ADHIL PRATAMA; DARYONO HADI TJAHJONO; TUTUS GUSDINAR
Microbiology Indonesia Vol. 13 No. 3 (2019): September 2019
Publisher : Indonesian Society for microbiology

The artemisinin and its derivatives antifungal activity continue to be an interesting research object, with the potential shown to be developed as an antifungal compound. Artesunate, one of the artemisinin derivatives known to have antifungal activity against various pathogenic fungi, including Candida albicans. This study aims to determine the effect of artesunate on antifungal activity toward C. albicans in vitro at concentrations below 1 mg -1m L . The method used is yeast-plate count, with a parameter of observation were the number of C. albicans colonies viable after exposure with artesunate for five days. The concentration of artesunate used was divided into -1 -2 -3 -4 -1si x groups, which were 10; 1; 10 ; 10 ; 10 ; and 10 mg mL . Compared to control, a significant decrease in -1c olony counts was only shown at the highest concentration of 10 mg mL . Interestingly, at the lowest -4 -1c oncentration of 10 mgmL , it showed an increase in a number of colonies almost twice of the blank. These results suggest that while at higher concentration of artesunate may inhibit the growth of C. albicans, a lower concentration of artesunate may stimulate their growth.

Co-Authors Ardina, Rinny Caroline Caroline Chusna, Nurul Daryono Hadi Tjahjono Daryono Hadi Tjahjono Dewi Melani Hariyadi Dewi Sari Mulia Dwi Purbayanti Eko Suhartono Endang Sri Suyati Evi Mulyani Evi Mulyani Evi Mulyani Guntur Satrio Pratomo Hadi Poerwono Handayani, Rosita Iin Nurbudiyani Imamatin Nufus Melania Juni Ekowati Maria Anabella Jessica Martha Ervina Melanny Ika Sulistyowaty Muhamad Ilham Royyan Nafi’ Muhamad Riza Syah Fahlevi Muhammad Ikhwan Rizki Praditapuspa, Ersanda Nurma Punet Kumar Puranti, Iswatun Desyla Putri Hamidah Khairunnisa Rossa Auli Tasha Siswandono, Siswandono Sonedi Sonedi Suratno Suratno Suratno Suratno Suratno Suratno Suratno Suratno Susi Novaryatiin Syahrida Dian Ardhany TUTUS GUSDINAR Tutus Gusdinar Kartawinata Utar, Zulkhurnain Wahyu Pandaran Windya Nazmatur Rahmah Zulkhurnain Utar

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