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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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INDUCED BREAST CANCER MCF-7 CELLS APOPTOSIS FROM EXTRACT COMBINATION OF JENGKOL PODS (Archidendron jiringa) AND PETAI CINA LEAVES (Leucaena leucocephala) Harry Noviardi; Sitaresmi Yuningtyas; Lydia Agustin
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3426

Abstract

The jengkol pod exocarp and petai cina leaves potentially as breast anticancer due to its highly toxic. The activity of cytotoxicity to the MCF-7 cells by the combination of jengkol pod exocarp and petai cina leaves is included in the potential category. The research aimed to determine the influence of the combination of jengkol pod exocarp and petai cina leaves on induction of the MCF-7 breast cancer apoptosis. Induction cell apoptosis of MCF-7 from a combination of extracts by using a double staining method. The cytotoxicity test from the extract combination of jengkol pod exocarp and petai cina leaves was determined by the MTT method. The extracts were made by comparing the mass of jengkol pod exocarp and petai cina leaves with comparisons of 5:1, 7:1, and 9:1. The IC50 values of the combination of jengkol pod exocarp and petai cina leave the ratio of 5:1, 7:1, and 9:1 were 11.7; 7.5; and 1.9 ppm, respectively. Apoptosis activity of the extract combination of the double staining test results showed MCF-7 cells experiencing orange and bright green fluorescence. The cellular form becomes wrinkled from the initial condition of the cell. Based on the results of the study showed a combination of jengkol pod exocarp and petai cina leaves could induce the MCF-7 breast cancer apoptosis cell.
PARENT'S KNOWLEDGE REGARDING INFLUENZA DISEASE AND VACCINE IN INDONESIA Dwi Endarti; Viva Starlista; Tri Murti Andayani
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3440

Abstract

Influenza vaccine is a vaccine that is not included in the national immunization program. An approach to support decision making for the introduction of influenza vaccine into national immunization programs by conducting a survey knowledge of parents in Indonesia that influences decision making for vaccinations. The purpose of this study was to determine the level of parental knowledge about influenza and influenza vaccines and to know the factors that influence. The research design used is observasional with a multi-center cross-sectional approach. The research instrument used a questionnaire to determine sociodemographic characteristics and level of knowledge. Data was collected through a survey of 500 parents respondents in 5 provinces in Indonesia, namely in West Java, DIY, Lampung, Central Sulawesi and Central Kalimantan using convenience sampling techniques. Data were analyzed using the Mann Whitney test. Resul of the study showed the average knowledge of respondents related to influenza disease and vaccine was 78.55±12.43. Only 145 (29%) parents know that influenza vaccines are not included in Indonesia's national immunization program. There was a significant difference in the value of knowledge between groups of characteristics in the experience of hearing influenza vaccine (p = 0,000) and the source of disease information (p = 0.045). It is recommended for government and health workers to carry out educational programs related to influenza and influenza vaccines to achieve equitable distribution of information and increase public knowledge.
SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES CONTAIN CURCUMIN AS AN EARLY CANDIDATE FOR ANTICANCER DRUG Ersalina Nidianti; Devyana Dyah Wulandari; Fadlilah Nur Aini; Herliani Rahmania Sari
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3458

Abstract

Cancer treatment can be done with tumor surgery, radiotherapy, immunotherapy, and chemotherapy. These treatments effectively kill cancer cells but have side effects and are resistant to patients. Based on this, further research is needed related to cancer drugs based on herbal plants, one of which is by using curcumin from Curcuma longa or turmeric in the form of nanoparticles to increase bioavailability and solubility. Especially silver nanoparticles with a mixture of curcumin. The aim of this study was to determine the characterization and screening of candidate activities to be used as anticancer drugs from curcumin extract and silver nanoparticles (AgNO3) containing curcumin carried out solubility test, thin layer chromatography (TLC) analysis, UV-Vis spectrophotometer analysis, and morphological analysis with XRD. The results obtained in this study were curcumin extract insoluble in water while silver nanoparticles could dissolve in water. TLC analysis on chloroform mixture: ethanol Rf = 0,92 and Rf = 0,94; chloroform: hexane obtained Rf = 0,36; Rf = 0,36: Rf 0,38; Rf = 0,3. While chloroform: benzene: methanol eluent has no Rf value. UV-Vis spectra obtained a maximum absorbance of 4,267 at a wavelength of 290 nm. The morphological analysis of XRD silver nanoparticles containing curcumin was 17,45 nm. In conclusion, curcumin extract and silver curcumin nanoparticles have the potential as initial candidates for anticancer drugs.
THE POTENCY OF CUCUMBER (CUCUMIS SATIVUS L.) PEEL EXTRACT AS ANTICHOLESTEROL Resita Putri; Devina Ingrid Anggraini
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3493

Abstract

The liver has a very important role in the human body. However, these organ tissues are also very susceptible to be tissue damage. Fatty liver disease (steatosis) is a disease caused by high cholesterol. Physically, cholesterol is a yellowish subtance, lumps like wax, and is an arrangement of steroid groups. Non-alcoholic steatohepatitis (NASH) occurs due to excess cholesterol levels in the liver. Liver function can be affected as a result of liver damage. So, a hepatoprotector is needed. The flavonoid content of cucumber skin has potential as an anticholesterol. The purpose of this research is to analyze the ability of the ethanol extract of cucumber peel (Cucumis sativus L.) as a cholesterol lowering agents as indicated by the EC50 value. Maceration extraction method used in this study using 96% ethanol as solvent. Qualitative analysis of ethanolic extract of cucumber peel is known to have flavonoids, steroids, alkaloids as indicated by the appearance of color changes, and saponins which are indicated by the appearance of foam. Lieberman-burchad reagent was used for quantitative analysis of anticholesterol using a UV-Visible spectrophotometer. The analysis was carried out at a maximum wavelength of 665,0 nm with an incubation time of 15 minutes. The concentration variations of the extract used were between 25-150 with a range of 25 ppm. The results showed that the ethanolic extract of cucumber peel could potentially be an anticholesterol with the percentage reduction of 28.50%; 35.45%; 39.59%; 45.82%; 51.24%; and 55.12% at 5 variations of concentration. The EC50 value was achieved at a concentration of 122.04 ppm.
TEST THE POTENTIAL OF PINEAPPLE (Ananas comosus L.) JUICE TO REDUCE CONTENT OF COPPER (Cu) METAL BY ATOMIC ABSORPTION SPECTROPHOTOMETRY (AAS) Dinna Fitria; Devina Inggrid Anggraini
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3511

Abstract

Accumulation of copper (Cu) metal in the body causes tissue damage. Metals that can’t be excreted into the blood or bile by the liver can cause cirrhosis, so the body needs antidotes to reduce metal content. Pineapple (Ananas comosus L.) contains 78% citric acid of total acid. Citric acid was able to form complex compounds with metal. The aims of this research were to know the ability of pineapple juice (Ananas comosus L.) to reduce content of copper (Cu) metal and the concentration of pineapple (Ananas comosus L.) juice that can reduce the highest content of copper (Cu) metal. Pineapple juice was made in five series of concentration (20%, 40%, 60%, 80%, and 100%). Copper metal of 20 ppm was given the addition treatment of each concentration series of pineapple juice. The solution of each concentration was separated using chloroform. The water phase which was the residual copper (Cu) metal that does not react with citric acid, was analyzed using Atomic Absorption Spectrophotometry (AAS) at a wavelength of 324.7 nm. The results of this research were showed that the concentration of pineapple juice 80% can reduce the content of copper (Cu) metal of 24.6896 %.
OPTIMIZATION ANTIBACTERIAL PRODUCTION TIME OF ACTINOMYCETES ISOLATES (TE 235 ISOLATES) AGAINS ANTIBACTERIAL ACTIVITY ON ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS Sutiara Prihatining Tyas; Alfian Syarifuddin; Ni Made Ayu Nila Septianingrum
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3547

Abstract

The search for new Antibiotics is needed in the hospital because of the multi-resistance Antibiotics that result in an increase in deaths due to Antibiotic abuse in dealing with infectious diseases, so it is necessary to explore to get potential new antibiotics. Actinomycetes are microorganisms that can produce is antibiotics. Actinomycetes isolate (isolate TE 235) has been isolated from rizosphere soil of sugarcane root crops. This study aimed to determine the optimal time of TE 235 isolates in producing secondary metabolites in the form of antibiotics that can test bacteria Escherichia coli and Staphylococcus aureus and the growth profile of TE 235 isolates were reviewed based on the production of cell biomass. The activity test method used in this study is a suitable test method. The results showed that the liquid culture of Actinomycetes isolates (isolate TE 235) had an optimal time to produce secondary metabolites (Antibiotics) against Staphylococcus aureus bacteria after incubation for ten days with inhibition zone diameter of 6.67 ± 0.94 mm, whereas against Escherichia coli bacteria on the seventh day with a diameter of inhibitory zone of 10.00 ± 0.82 mm. The results of research on the growth of Actinomycetes bacteria isolate TE 235 based on the weight of cell biomass that underwent the stationary phase on the 9th day. The incubation time of the culture of Isolate TE 235 to obtain optimal approval of antibiotics after ten days of incubation in terms of antibiotic activity on Staphylococcus aureus and Escherichia coli and the growth phase of TE235 isolates as the stationary phase.
PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF ANTHRAQUINONES OF RHEUM AUSTRALE D. DON Dwi Hartanti; Arinda Nur Cahyani
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3699

Abstract

Anthraquinones are phenolic compounds known best for their laxative activity. Rheum australe D. Don (Indian rhubarb, Polygonaceae) is a prominent medicinal plant with anthraquinones as the bioactive compounds, among a few others. The online literature search was carried out to collect data on the phytochemistry and pharmacological activity of anthraquinones, particularly those isolated from R. australe. Anthraquinones are commonly found in the genera of Rheum, Senna, Aloe, Frangula, and Rubia, which can be quantitatively and qualitatively determined using both conventional and advanced analytical methods. The anthraquinones of R. australe were found in free and glycosidic forms, which were best extracted by the microwave-assisted extraction method. Various chromatographic techniques were commonly conducted to isolate the pure compounds. In addition to its laxative activity, anthraquinones of R. australe also showed potential antibacterial, cytotoxic, and antioxidant properties.
A SURVEY OF PHARMACY STAFF KNOWLEDGE RELATED TO ANTIBIOTICS IN SIDOARJO, INDONESIA Ilil Maidatuz Zulfa; Fitria Dewi Yunitasari
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3795

Abstract

Antibiotics resistance still remains the problem in treating infection disease both in developing and developed country. One of the factor contribute to the increase of antibiotics resistance is irrational antibiotics use without prescriptions. There is still lack of information about factors related to the antibiotics dispense by pharmacy staff. This study was aimed to observe pharmacy staff knowledge about the pharmacology and the regulation of antibiotics. A cross sectional online survey using questionnaire was conducted to pharmacy staff who work for service in Sidoarjo from February to April 2020. The knowledge of antibiotics was classified into lack, enough, and good knowledge. A total of 233 respondents from 56 pharmacy recruited in this study. Of them, 17,17% were pharmacist; 10,73% were pharmacy technician; 52,36% were pharmacy assistant and 19,74% non pharmacy worker. Overall the majority of respondents had a good knowledge about antibiotics (48,93%). However, most of them did not know that only pharmacist who had responsible to dispense antibiotics based on prescriptions (58,37%), fail to describe antibiotics indications (46,35%) and had poor knowledge about the minimum length of antibiotics course (58,37%). Educating and upskilling pharmacy personel about antibiotics will minimize the irrational use of antibiotics which lead to the increase of antibiotics resistance caused by the lack information received by patients.
LITERATURE REVIEW: CHEMICAL CONTENT AND PHARMACOLOGICAL ACTIVITY OF KERSEN LEAF (Muntingia calabura L.) Asman Sadino; Sri Adi Sumiwi; Sari Sumarni
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3802

Abstract

Kersen (Muntingia calabura L.) is known as a plant that is often used as a tree to absorb air pollution and shade on the roadside. Low economic value and public knowledge about the benefits of cherry as a medicinal and food ingredient is still minimal. The part that can be used as a medicinal ingredient comes from cherry leaves. The purpose of this review article is to provide information related to the chemical content and pharmacological activity of cherry leaves that can treat various diseases. The method used in making this article review is a literature study. The literature sources in this article review were obtained from national journals and international journals published in the last 10 years (2010-2020), which were carried out online through the search engines Google Scholar, Pubmed, and NCBI, using the keywords "Kersen leaves", "Activities cherry leaf”, “Pharmacological activity of Muntingia calabura”, “Chemical content of cherry leaf”, “Muntingia calabura L.”. Journals that enter the inclusion criteria are national and international journals that discuss the pharmacological activity and chemical content of cherry leaves, journals published in the last 10 years (2010-2020), and journals in full text. The chemical constituents contained in cherry leaves are flavonoids, saponins, tannins, and terpenoids. Cherry leaves are scientifically proven to have several pharmacological activities as antidiabetic, antioxidant, antibacterial, anthelmintic, antihyperlipidemic, and anti-inflammatory.
EFFECTIVENESS OF BAKUNG EXTRACT (CRINUM ASIATICUM L) AS AN ANALGESIC IN ACETIC ACID-INDUCED MICE Teodhora Simangunsong; Elzius Fransiscus Lumban Gaol; Sister Sianturi
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3806

Abstract

Crinum asiaticum L. leaves is a plant that has a pharmacological effect, which is to relieve pain. The purpose of this study was to determine the effect of the ethanol extract of daffodils as an analgesic effect on male mice DDY. The extract was obtained through the maceration extraction method and was administered by oral administration with three dose variations, namely 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW. Ibuprofen 52 mg/kgBW was used as a positive control and Na-CMC 0,5% as a negative control. 30 minutes after induced with 1% acetic acid the amount of stretching was observed every 5 minutes to 60 minutes. The results showed the best analgesic effect at dose III 800 mg/kg BW with the percentage of analgesic protection of 80,66%. The results of effectiveness at dose III 800 mg/kg BW of 99,37% which is almost the same as the effectiveness of Ibuprofen at a dose of 52 mg/kgBW of 100%

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