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Elmiawati Latifah
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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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ANALGESIC TEST AND TOXICITY OF n-HEXANA FRACTION TREMBESI LEAVES (Samanea saman (Jacq.) Merr.) IN MICE (Mus musculus L.) Rosa Juwita Hesturini; Krisna Kharisma Pertiwi; Meylisa Nurvita Astari; Adellia Ayu Febriana
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3867

Abstract

Trembesi plant (Samanea saman (Jacq.) are used for traditional medicine as an antibacterial, an analgesic, treat headaches and diarrhea. The aims of this research were to determine analgesic activity and toxicity of n-hexana fraction of trembesi leaves in mice. Extraction using maceration method with 70% ethanol solvent, then solid-liquid partitioned. The activity of an analgesic test by induction acetic acid 1% using negative control CMC Na 0,5%, positive control acetosal dose of 360 mg/kgBW, the treatment group n-heksana fraction doses of 200, 350 and 500 mg/kgBW, while the toxicity test used negative CMC Na 0,5%, with the treatment group dose 5, 50, 500 and 5000 mg/kgBW. Analysis analgesic test data using the Hendersot and Forsaith equations for know the amount of stretching mice. Observation irritation gastric done by observation in makroskopis. While the toxicity test is done within 24 hours for calculated LD50 and make observations and Kruskal-Walli’s test in time 7 days to find out the delayed toxic effects. The results obtained the percent of the analgesic of the n-heksana fraction by 37.86%, 55.78% and 70.9% and LD50 values of 5000 mg/kgBW with the results observations made no significant difference (p>0.05). This research conclusion was the n-hexana fraction trembesi leaves having an analgesic doses activity with effective 350 mg/kgBW with a 55,78% analgetika potential and a toxic effect are categorized as toxic mild and there is no on the irritation.
DETERMINATION OF FLAVONOID LEVELS OF AlCl3 METHODE IN THE EXTRACT OF METANOL FLOWERS (Clitoria ternatea L.) Anita Agustina Styawan; Gandis Rohmanti
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3912

Abstract

Telang flowers is one of the medicinal plants that can grow well in Indonesia, but have not been widely used. Previous research stated that methanol extract of telang flowers had secondary metabolite compounds such as tannin, saponin, flavonoid and alkaloid. Flavonoid are natural compounds that have the potential as antioxidants that can capture free radicals that play a role in the emergence of degenerative diseases throught the mechanisme of damage to the body’s immune system, lipid oxidation and protein.The purpose of this study was to determine whether telang flowers content was determined whether by the AlCl3 method and measured by using UV-Vis Spektrophotometry from the methanol extract of telang flowers.The results of this study indicate that the methanol extract of telang flowers contains flavonoid with red color. The level of flavonoids intended is 4.65%.
RELATIONSHIP OF PB LEVELS WITH BLOOD PRESSURE IN TIRE REPAIRMAN ON PANTURA HIGHWAY, PEKALONGAN CITY Tri Minarsih
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3960

Abstract

Lead (Pb) is a type of metal that has an acute effect on blood pressure and causes hypertension if it accumulates in the blood for a long time. Many types of work are at risk to cause accumulation of Pb in the blood. One of the work sectors that is estimated to be potentially contaminated by Pb is the tire repairman that exists along the highway, which comes from paint, dust (residual fuel) engines and others. The purpose of this study was to determine the relationship between Pb levels and blood pressure in tire repairman on Pantura Highway, Pekalongan City. This type of research is Analytic Observational. The sample used in this study was the tire repairman on Pantura Highway, Pekalongan City, who were willing to be a respondent of 13 people. The research data were taken from blood samples of tire repairman to measure their Pb levels, measure blood pressure and questionnaires. The results of this study are the Pb levels in the blood of tire repairman on Pekalongan City's Pantura Highway, all exceeding normal with the lowest value of 19,76 (µg / dL) and the highest of 32,55 (µg / dL). The average systolic blood pressure obtained at the tire repairman was 149.61mm Hg, while the diastolic blood pressure was an average of 92,46 mm Hg In conclusion, the value of R obtained was 0,09995 for the correlation of Pb content with systole and 0,1551 for the correlation of Pb levels with diastole. This shows a correlation that is not so strong 9,99% (the contribution of Pb levels to the system) and 15,51% (the contribution of Pb levels to diastole).
ANALGESIC ACTIVITY OF TRANSDERMAL PATCH ETHANOL EXTRACT PIPER NIGRUM L FRUCTUS WITH SOME ENHANCERS ON MICE Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Regiskha Hermandanie Surya; Alif Ekacahya Wahyudi; Dwi Damayanti Rasdianto
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4033

Abstract

Piper nigrum L fructus with active compound piperin had been known have an analgesic effect. Ethanol extract of Piper nigrum formulated to transdermal patch to reduce side effect of analgesic oral. The aim of this research was to know the effect of sodium lauryl sulphate, Tween 80, isopropyl myristate as enhancer of transdermal patch ethanolic extract of Piper nigrum L. Analgesic effect of Piper nigrum L. carried out by writhing method after acetic acid induction in mice. Parameters used were the number of writhing and macrophage from peritoneal fluid of mice at the end of this study. Based on this study, ethanol extract of Piper nigrum had an analgesic effect. The used of sodium lauryl sulphate 5%, Tween 80 5%, isopropyl myristate6% as enhancer increased the analgesic effect of Piper nigrum L.
THE CORRELATION BETWEEN ACID FAST BACILLI OF THE INTENSIVE AND CONTINUATION PHASE IN PULMONARY TUBERCULOSIS PATIENTS’ CATEGORY 1 Oki Nugraha Putra; Widyananda Kartikasari; Hardiyono _; Ana Khusnul Faizah
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4039

Abstract

Tuberculosis (TB) is a communicable disease caused by M. tuberculosis and known as Acid Fast Bacilli (AFB). The purpose of this study was to analyze the correlation between AFB at the end of the intensive phase and continuation phase and to analyze the variables that associated with sputum conversion at the end of continuation phase in pulmonary TB patient’s category I in several primary public health in Surabaya. This was an observational analytic with a retrospective cohort design. Data were collected by medical records of TB patients from January 2017 to December 2019. One hundred twenty-four of TB patients met the inclusion criteria with 69 male and 55 females, and mean of age was 44.09 ± 12.05 years old. The initial AFB was mostly 1+ (41%). There was a significant correlation between AFB at the end of intensive phase and continuation phase (p-value=0.000; r=0.657) by Kendal-Tau test. Age was significantly associated with sputum conversion at the end of continuation phase (p-value=0.022). The conclusion of this study that there was a significant correlation between AFB at the end of intensive phase and continuation phase
THE EFFECT OF VARIATIONS IN ROASTING TEMPERATURE ON YIELD AND PERCENTAGE OF INHIBITION OF DPPH RADICAL REDUCTION IN CANDLENUT OIL THE UV-Vis SPECTROPHOTOMETRIC METHOD Aldi Budi Riyanta; Maulani Fitrie Nabila; Akhmad Aniq Barlian
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4131

Abstract

Antioxidant compounds are able to dampen free radicals by donating electrons to pair with free radicals and become harmless to the body. One of the plants that can be used as an antioxidant is candlenut. Candlenut (Aleurites moluccana (L.) Willd.) Candlenut is a plant that has many benefits. Chemical content contained in candlenut seeds is such as flavonoids have the ability as antioxidants. This research aims to determine the roasting temperature of yield and inhibition percentage of DPPH radical reduction (1,1-diphenyl-2-picylhydrazyl) contained in candlenut oil using the UV-Vis spectrophotometric method. The variations in roasting temperature used were 30, 70, 75, 80, 85, and 90˚C. The yield obtained from the extraction was 42,12 %, 38,47 %, 36,44%, 32,58 %, 31,06 %, and 25,38 % which indicated that the higher the roasting temperature the lower the yield obtained. While the percentage of DPPH radical reduction showed a value of 24,689±0,23%; 27,399±0,02%; 38,464±0,01%; 44,562±0,04%; 37,222±0,03% and 22,657±0,03% which shows that 80°C is the best temperature to produce the biggest DPPH radical scavenging.
ALPHA-GLUCOSIDASE INHIBITORY ACTIVITIES OF KEDABU FRUIT (Sonneratia ovata BACKER) ETHANOL EXTRACT AND FRACTION Rahma Dona; Haiyul Fadhl; Mustika Furi; Tyasakti Viryana
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4165

Abstract

One of the antidiabetic activity tests is carried out through inhibition testing of the ɑ-glucosidase enzyme. Sonneratia ovata Backer is a mangrove plant that has been used traditionally in medicine. The antidiabetic activity of the fruit samples of Kedabu (Sonneratia ovata Backer) was tested by measuring the inhibition of the ɑ-glucosidase enzyme in vitro. The test sample used ethanol extract (EE) and 3 fruit fractions of Kedabu. The calculation result of the IC50 value obtained at EE was 1.86 µg / mL, the calculation result of the IC50 value obtained in the n-hexane (FH) fraction of Kedabu fruit was 193.32 µg / mL, the calculation result of the IC50 value obtained in the ethyl acetate fraction (FE) of fruit Kedabu is 2.32 µg / mL and finally the calculation result of the IC50 value of water fraction (FA) is 2.29 µg / mL. The positive control in this study, Akarbose, obtained an IC50 result of 0.75 µg / mL. Based on the results obtained, the ethanol extract of Kedabu (Sonneratia ovata Backer) fruit is very active and has the potential as an inhibitor of the ɑ-glucosidase enzyme, followed by the water fraction and ethyl acetate fraction, while the potentially inactive sample is in the n-hexane fraction.
POTENTIAL OF MATOA FRUIT EXTRACT (POMETIA PINNATA) AS ANTIOXIDANT SOURCE Widya Rahmah; Hasyrul Hamzah; Siti Hajar; Sylvan Septian Ressandy; Erlisa Maharani Putri
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4240

Abstract

Pometia pinnata or commonly known as matoa is a typical plant of Eastern Indonesia or Papua that grows throughout the Papua archipelago. Matoa contains alkaloids, saponins, tannins, flavonoids, phenolic compounds, terpenoids, and vitamins A, C, E which can boost the immune system. The study aims to examine whether the matoa (Pometia pinnata) has acted as a source of antioxidants where one of the functions of the antioxidants themselves is to increase the body's immune system by fighting free radicals. This study uses a narrative review approach, which is a secondary research method that does not have specific guidelines in its preparation (non-systematic review) using data collected assembled with research topics from various electronic and non-electronic libraries. Based on the results of the study using comparisons with other foods such as lime, spirulina, and carrots, it turns out that the fruit and fruit skins of Matoa contain more vitamin C. It is known that the skin of the fruit and matoa fruit contains vitamin C which works as an antioxidant to increase the body's immune system by fighting free radicals. Also, based on several studies, it is known that the extract of the stem and matoa bark obtained an IC50 value of more than 70 ppm where this value is classified as strong antioxidant activity.
IMPROVING PKK CADRES LEVEL OF KNOWLEDGE OF ANTIBIOTIC MANAGEMENT THROUGH PHARMACISTS-DELIVERED EDUCATION INTERVENTION IN BOJONGSARI, BANYUMAS Masita Wulandari Suryoputri; Heny Ekowati; Ika Mustikaningtias; Laksmi Maharani; Nialiana Endah
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4357

Abstract

The prevalence of infectious diseases in Indonesia is high, so it can increase the use of antibiotics. The use of antibiotics which is around 40-60%. Inaddition to relatively long antibiotic therapy regimen, the lack of public knowledge in the rational use of antibiotics can cause patients to be less the risk of occurrence of antibiotic resistance, this study aims to determine the level of knowledge of PKK Cadres and to determine the level of community knowledge after providing PKK Cadres education with pharmacist assitance on antibiotic management. PKK cadres are the driving force behind village communities to carry out local health programs. The research method is a comparative descriptive with a cross sectional approach using an instrument in the form of a questionnaire and it is carried out before and after the implementation of pharmacist education. Collecting data by purposive sampling. Knowledge data of pretest and posttest were analyzed bivariately. The results of the evaluation of the education process indicated that there was an increase in the knowledge of PKK Caders. The results of pre-test dan post-test average showed increased of knowledge among PKK cadres from 69.28 to 85. The results of Wilcoxon test showed a significant difference in the PKK cadres level knowledge from the pre-test and post-test data of antibiotic management after receiving education from the pharmacist (p<0.005). Providing education on antibiotic management to PKK cadres by pharmacists has increased PKK cadres’ knowledge of antibiotic management. It is hoped that PKK cadres can disseminate this knowledge to the wider community to preventing antibiotic resistance.
ANALYSIS OF TOTAL FLAVONOID LEVEL AND ANTIOXIDANT ACTIVITY TEST PURPLE CABBAGE (BRASSICA OLERACEA L. VAR. CAPITATA F. RUBRA) AND WHITE CABBAGE (BRASSICA OLERACEA L. VAR. CAPITATA F. ALBA) ETHANOL EXTRACT USING DPPH METHOD (1,1-DIFENIL-2-PIKRILHIDRAZIL) Any Guntarti; Ratna Yuningtyas; Hari Susanti; Zainab Zainab
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4369

Abstract

Antioxidants are compounds that are needed by the body to protect the body from free radical attacks that can trigger the emergence of degenerative diseases. One of the compounds that has free radical scavenger activity by inhibiting Reactive Oxygen Species (ROS) is flavonoids found in purple cabbage and white cabbage. This study aims to determine the total levels of flavonoids expressed as quercetin equivalent (EK) and antioxidant activity using the DPPH method (1,1-diphenyl-2- picrylhydrazyl). Identification of flavonoid compounds by Willstater test and determination of total flavonoid levels using spectrophotometry, AlCl3 reagent. Flavonoid levels were calculated using linear regression equations. Qualitative test for the presence of antioxidant activity using TLC and antioxidant activity test using the DPPH method with the parameter value of ES50. The qualitative test results showed that the ethanol extract of purple cabbage and white cabbage contained flavonoids. The total flavonoid content of ethanol extract of purple cabbage was 5.17% w/w (EK) and ethanol extract of white cabbage was 3.84% w/w (EK). Qualitative test with TLC showed antioxidant activity. The standard antioxidant activity values ​​of quercetin, ethanol extract of purple cabbage and white cabbage were 2.138±0.064 µg/mL; 154.445±0,999 µg/mL and 373.546±1.336 µg/mL. The antioxidant activity of purple cabbage is weak and white cabbage is very weak.

Page 11 of 26 | Total Record : 259

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