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Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga.
Published by Universitas Muhammadiyah Malang
ISSN : 0216759X     EISSN : 2614476     DOI : https://doi.org/10.22219/
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Journal of Saintika Medika is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures, treatment, or other health issues that is important for the development of health care system are also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 564 Documents
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The Effectiveness Of Squeeze Of Sambiloto (Andrographis Paniculata) Leaves On The Mortality Of Larvae Aedes Aegypti Graffico Eryza Oldiara; Riandini Aisyah; Safari Wahyu Jatmiko; Devi Usdiana Rosyidah; Rochmadina Suci Bestari
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11120

Abstract

Dengue hemorrhagic fever has become a deadly disease since 2013. Dengue fever is a disease caused by dengue virus transmitted to humans through the bite of the Aedes aegypti. Eradication using chemical larvacides still has many disadvantages so that natural larvacides from plants are needed, one of which is larvacide from the squeeze of the sambiloto (Andrographis paniculata) leaves. The squeeze of the sambiloto leaf (Andrographis paniculata) contains flavonoids, alkaloids, tannins and saponins which have natural larvacidal activity. This research aims to determine the killing power of the squeeze of sambiloto (Andrographis paniculata) leaves against Aedes aegypti larvae and determine the most effective concentration as larvicide. This research was experimental laboratory with post test only controlled group design method. There are 600 instar III Aedes aegypti Larvae randomly divided into 6 groups (5%, 10%, 15%, 20%, aquadest and abate). Using 4 repetitions each group was observed every 6 hours for 24 hours. Based on the results of the Kruskal-Wallis non-parametric statistical test obtained p-value = 0,001 which means there are significant differences in larvicidal effects between groups. The concentration of 15% and 20% are the most effective in killing the larvae of Aedes aegypti.
Determinant of Dental Caries in Pre-School Children at TK Permata Hati Bangkalan Lidia Aditama Putri; Diani Octaviyanti Handajani
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11253

Abstract

Dental caries is one of the problems that often occurs in pre-school age children (3-6 years) as a result of unfavorable habits of children in maintaining dietary and brushing habits. The purpose of this study was to analyze the factors associated with the occurrence of dental caries in pre-school children. The type of research was observational analytic with cross sectional design. The samples were 81 children by using simple random sampling technique. The analysis of the data used univariate and bivariate using the Chi Square statistical test. The results showed that the factors associated with the occurrence of dental caries in pre-school children were the habit of eating cariogenic food (p = <0.001), the habit of drinking milk with a dot bottle (p = <0.001), the frequency of brushing (p = 0.004 ), and brushing time (<0.001). From 81 children which had been observed, 49 (60.5%) had dental caries, while 32 (39.5%) did not have caries. Therefore, serious efforts were needed to prevent dental caries in pre-school children by increasing the knowledge of mothers and pre-school children about proper and correct brushing procedures and encouraging mothers to have regular dental check-ups every 6 months, so that the problems related to oral health can be detected early.
Commersial Drug Patch Test for Identifying Etiologic Drug of Adverse Cutaneous Drug Reaction Vidya Hana Dwi Ayuningtyas; Herwinda Brahmanti
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11266

Abstract

Adverse cutaneous drug reaction (ACDR) is a challenging condition for clinician, especially in determining the etiologic drug. Identification of etiologic drug become more difficult when the patient consume multiple drugs at once. As cellular immunity response is the main mechanism underlying exanthematous eruption, the most common type of ACDR, patch test rise as the reliable diagnostic modality to find the etiologic drug as this test represent the same mechanism as ACDR. In this paper, we reported commercial drug patch test application testing Griseofulvin, Amoxicillin, Ibuprofen, Aspirin and Clindamycin in 37 years old woman with history of drug induced-exfoliative dermatitis six months ago. Patch test technique involves patient preparations, test drug formulation, test drug patching and evaluation on day 2, 4 and 7. Before doing patch test, patient must not take any corticosteroid or immunosuppressant drug within one month ahead. The suspected drug consist of Griseofulvin, Ibuprofen and Clindamycin. Amoxicillin was chosen as the cross reacted drug for Griseofulvin while Aspirin was chosen as the cross reacted drug of Ibuprofen. All tested drugs were formulated as homogenous powder with 10% concentration and mixed with white paraffin. The formulated drug was patched to patient’s back using 7 mm diameter finn chamber. The evaluation result showed positive reaction towards Griseofulvin and weak positive reaction towards Amoxicillin
The Risk for Obstructive Sleep Apnea and Cognitive Function of High School Student Ferrany Thifla Aghni Brilliana; Nurfitri - Bustamam; Cut - Fauziah
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11340

Abstract

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by recurrent partial and/or total upper airway obstruction during sleep resulting in hypoxemia and arousal. One of the risk factors for OSA is obesity which its prevalence increased in Indonesia. OSA has a negative effect on cognitive function broadly. This study was aimed to determine the association between risk for OSA and cognitive function in high school students with obesity at Sulthon Aulia Boarding School, Bekasi. The study used a cross-sectional design and a simple random sampling technique. Data were taken using the Berlin Questionnaire and the Montreal Cognitive Assessment Indonesia version (MoCA-Ina) Questionnaire. The sample size is 47 subjects with inclusion criteria had overweight or obese body mass index (BMI) and were willing to be the research subjects. Subjects with a history of head injury, smoking, drinking alcohol, and taking sedative drugs were excluded from the study.  There were differences in BMI and neck circumference between high-risk subjects for OSA and low-risk subjects for OSA. The risk level for OSA was significantly associated with cognitive function (p = 0.001; OR =12.727).  High-risk subjects for OSA are recommended to lose weight and perform a polysomnographic evaluation.
Kersen Leaf (Muntingia Calabura L.) Extract Prevents Gastric Damage of Wistar Rats Exposed to 40% Ethanol Dyah Ayuning Permatasari; Arum Kartikadewi; Afiana Rohmani; Noor Yazid
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11368

Abstract

Latar Belakang: Mengurangi stres akibat oksidatif dan mengurangi risiko mukosa lambung. Daun Kersen dikenal sebagai antioksidan. Penelitian ini bertujuan untuk mempelajari efek ekstrak daun Kersen untuk mencegah kerusakan lambung pada tikus Wistar yang diinduksi alkohol.Metode : Penelitian ini adalah eksperimental laboratorium dengan menggunakan desain kelompok Post test saja. Sampel terdiri dari 24 tikus wistar jantan yang dibagi menjadi 4 kelompok, yaitu K-diberikan plasebo aquadest 1,8ml / 200g / hari, K + diberi etanol 40% dosis 1,8ml / 200g /, P1 dan P2 adalah tikus yang diinduksi dengan alkohol 40% dan diberikan dengan ekstrak daun Kersen (500 mg / kg berat badan untuk P1 dan 750 mg / kg berat badan untuk P2), 60 menit setelah pemberian alkohol. Skor Kerusakan lambung berdasarkan Skor Barthel-Manja. Perbedaan rata-rata pada tingkat kerusakan mukosa lambung antara kelompok yang dianalisis dengan One Way ANOVA Test dan Post hoc Lsd Test.Hasil : Rata-rata skor kerusakan lambung adalah; K- = 0,44, K + = 1,76, P1 = 0,76 dan P2 = 0,44 (p <0,001). Perbedaan derajat kerusakan mukosa lambung pada K +, P1, P2 dibandingkan dengan masing-masing K- (ρ: <0,001); (ρ: 0,143); (ρ: 1.000).Kesimpulan : Pemberian ekstrak daun Kersen dengan dosis 500mg / Kg dan 750mg / Kg mampu mencegah kerusakan mukosa lambung yang diinduksi oleh etanol 40%.
Effectivity Test of Tobacco Leaf (nicotiana tabacum l.) 96% Ethanol Extract on Culex Quinquefasciatus Larvae Mortality Ahmad Rosid Nasrulloh Arifqi; Devi Usdiana Rosyidah; Listyana Masyita Dewi; E. M. Sutrisna
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11403

Abstract

Culex quinquefasciatus acts as a vector for Filariasis disease. The transmission of this disease can be prevented by cutting the life cycle of these mosquitoes at the larvae phase. Tobacco leaf contains an alkaloid, flavonoid, essential oil, saponin, and tannin which can kill Culex quinquefasciatus larvae. This study is a laboratory experiment with a post-test only controlled group design. This study used the larvae of Culex quinquefasciatus third-instar larvae. Six hundreds larvae were divided into 6 groups and 4 repetitions (each consisted of 25 larvae), i.e. negative control (distilled water + CMC), tobacco leaf ethanol extract (EEDT) with 0.025%; 0.05%; 0.075% and 0.1% doses and positive control (temephos). The number of dead larvae was counted at 6, 12, 18, and 24 hours after treatment. The results of the Kruskal-Wallis test showed p-value = 0.000, followed by the Mann-Whitney Post-hoc test, which resulted in all four doses of EEDT significantly differed compared to the negative control. However, 0.1% concentration was insignificantly different than the positive control. This showed that the ethanol extract of Nicotiana tabacum L. was effective in killing Culex quinquefasciatus larvae and EEDT with 0.1% concentration had the same potential as temephos as a larvicide.  
Hypoxic Status Is Associated With The Intensity Of Hypoxia Inducible Factor (Hif)-1α Expression In A Premature Placenta Kartini Edwin
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.11685

Abstract

Prematurity refers to live births before 37 weeks of gestation and associated with infant morbidity/mortality. Activation of HIF during the final pregnancy phase is believed to play a critical role in the pathogenesis of premature birth and other pregnancy disorders. This study aimed to analyze the relationship between hypoxicstatus and the intensity of HIF-1α expression in a premature placenta.Stored biological materials premature placenta (paraffin blocks) was used in this study. Thirtyone samples of placental hypoxia (H) and 28 samples of premature placental non-hypoxia (N) as controls, were selected non-random consecutively. Subsequently, immunohistochemistry was performed to analyze HIF-1α expression. TheChi-square testwas used to analyze the data and a p-value <0.05 was considered statistically significant.Moderate to strong intensity of HIF-1α expressionwas observed in 58% of hypoxic placenta samples, whereas most of non-hypoxic placental samples(86%) did not expressed or expressed weaklyHIF-1α.There was a significant correlation between the intensity of HIF-1α expression and placental hypoxia (p <0.05) and Odds Ratio (OR) value was 8.31 with a 95% confidence interval (2.32-29.77). The conclusion shows that hypoxic status is associated with intensity of hypoxia inducible factor (HIF)-1α expression in a premature placenta.
Effect Of Recovery Time After Match On Muscle Explosive Power On Football Athletes Adelia Handoko; Cahyo Bagaskoro
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.12092

Abstract

Football is one of the most prestigious forms of sports that are in great demand by the public. Many football clubs that take part in the competition have a tight match schedule. This causes the recovery time for athletes to be short and lead to fatigue. The purpose of this study was to determine the effect of recovery time after the match on the explosive power of leg muscles in soccer athletes. This study was an experimental study with a pretest-posttest group design. The sampling method used was simple random sampling to get 40 research subjects divided into 2 groups, namely groups with recovery time of 2 days and groups with recovery time of 5 days. The assessment used is measurement of explosive limb muscle power using the vertical jump technique before and after receiving the recovery period. To test the normality of data using Shapiro-Wilk continued with the comparative data test in the form of an unpaired t test. The results of the study in groups with a recovery time of 2 days were worth -3.7cm and the group with a recovery time of 5 days was 2.9cm. These results were analyzed using unpaired t-test showing p value = 0,000 (p<0.05) which showed there were significant differences between the two groups. The conclusion of this study is that there is an effect of recovery time after the game on the leg muscle explosive power in soccer athletes. Recovery time of 5 days is better than 2 day after competition. It is very important to pay attention to recovery time in athletes, the recommendation of this study is a minimum of 5 days.
Kebar Grass Extract (Biophitum Petersianum) Increases Diameter Of The Seminiferous Tubules Of Diabetic Mice Faraida Arvilla
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.12150

Abstract

Diabetes is a metabolic disease that can affect the male reproductive system. The condition of hyperglycemia will increase the production of ROS, causing oxidative stress. Oxidative stress causes microangiopathy, triggers cell apoptosis, interferes with spermatogenesis, thereby affecting the diameter of the seminiferous tubules. Kebar grass contains of flavonoid and vitamin E which can be used to reduce ROS reactions and inhibit oxidative stress. This research was to prove that kebar grass extract can increase diameter of the seminiferous tubules of diabetic mice. Total of 30 samples were divided into 5 groups: negative control group (K-) was given CMC-Na, positive control group (K+) was given metformin 2mg/kg, groups P1, P2 and P3 received 2mg/kg metformin and kebar grass extract with different dosages (67.5mg/kg, 135mg/kg and 270mg/kg). The treatment lasted for 35 days. On the 36th day the mice were sacrificed and the testes were taken, then histological observations were made with HE staining to measure the diameter of tubules. The result showed that there was a significant difference in the diameter of seminiferous tubules with p value=0,000. Kebar grass extract can increase the diameter of seminiferous tubules of diabetic mice.
Correlation : Anatomical Variations of Nasal Cavity and Paranasal Sinuses and the Quality of Life Based on SNOTT-22 Score Rani Rahmawati
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.13763

Abstract

This study aims to determine the correlation between the anatomical variations of nasal cavity and paranasal sinuses and the quality of life based on SNOT-22 score in the patients who underwent paranasal sinuses CT scan. The samples are 36 patients with age ≥ 18 years. The method is Chi Square test / Fisher's test and Spearman’s rho test. The results showed that anatomical variations of the nasal cavity and paranasal sinuses from most of the patients who underwent paranasal sinuses CT scan had septal deviation n = 29, p = 0.007 (p <0.05) and concha bullosa n = 15, p = 0.029 (p <0.05). There was a significant correlation between total anatomical variation and quality of life based on SNOT-22 score in the patients who underwent paranasal sinuses CT scan p = 0.025 (p <0.05). There was no correlation between the anatomical variations of frontal cells, agger nasi cells, ethmoid bulla, uncinate process and haller cells and the quality of life based on SNOT-22 score in the patients who underwent paranasal sinuses CT scan.  

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