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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 170 Documents
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STRUMA MULTI NODOSA NON TOKSIKA INTRATHORAKAL Apa pilihan approach operasinya? Haruskah dilakukan Median Sternotomy? Mochamad Aleq Sander; Fina CS
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 1 No. 2 (2011): Oktober 2010 - Maret 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v1i2.1513

Abstract

Mochamad Aleq Sander, dr., M.Kes., SpB., FinaCSFakultas Kedokteran Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145e-mail: aleq.sander@yahoo.comblog: bedahunmuh.wordpress.comAbstractIntrathoracal non toxic multi nodular struma is lumpy enlargement of thyroid glandwithout hypothyroidism that extend from cervical thyroid gland into thoracal cavity. Accordingto anatomy location of thyroid, their name were substernal, retrosternal, mediastinal,intrathoracal, plunging, anterior and posterior mediastinal, and aberrant mediastinal. Theorigin of blood supply of mediastinal struma was inferior thyroidea artery, especially casesfrom aorta, subclavia artery, internal mammary artery, or ima thyroidea artery. According toStudy got that seven patients with mediastinal struma had intrathoracal blood supply directly.Surgery could cervical approach and/or thoracotomy according to anatomic location andtype of intrathoracal struma.Keywords: intrathoracal strumaAbstrakStruma multi nodosa non toksika intratorakal adalah pembesaran kelenjar tiroid yang tampakberbenjol-benjol tanpa disertai tanda-tanda hipertiroidisme yang mengalami ekstensi kearahinferior dari kelenjar tiroid servikal hingga masuk ke dalam rongga thoraks. Jaringan tiroidyang berada di rongga toraks diberi nama sesuai tempat anatominya yaitu substernal, retrosternal,mediastinal, intrathorakal, plunging, anterior dan posterior mediastinum, serta mediastinumaberrant. Suplai darah untuk struma mediastinum biasanya dari arteri tiroidea inferior, padakasus tertentu suplai darah dapat berasal dari aorta, arteri subklavia, arteri mamaria interna,atau dari arteri tiroidea ima. Hasil penelitian didapatkan bahwa dari tujuh orang yang mengalamistruma mediastinum ternyata memiliki sumber perdarahan langsung dari intrathorakal. Tindakanoperasinya bisa melalui cervical approach dan/atau thoracotomy, hal ini tergantung dari lokasianatomis dan tipe struma intratorakal yang diderita oleh pasien.Kata kunci: struma intratorakal
Cost-effectiveness of esomeprazole and pantoprazole as prophylaxis stress-related mucosal disease therapy in Intensive Care Unit Ferina Damayanti; Endang Darmawan; Setiawan Didik
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

High risk of bleeding in a patient with a critical condition in an Intensive Care Unit (ICU) resulting requirement use needs prophylaxis for decrease bleeding incident during ICU is entirely accurate. This research is to determine the cost and effectiveness of esomeprazole and pantoprazole as Stress Related Mucosal Disease (SRMD) in the hospital ICU in Surakarta. This research is a retrospective cohort study. The subject is about all inpatients in ICU with the age of 18 to 65 who get esomeprazole and pantoprazole as stress ulcers prophylaxis during December 2016 – December 2018 that meets the criteria inclusion and exclusion criteria. Subjects on this research are 166 patients, where each group esomeprazole therapy (83 patients) and pantoprazole (83 patients). The effectiveness of treatment was observed based on the minor and major bleeding. Furthermore, the cost of therapy is calculated based on the total price paid by the patient for prophylaxis therapy on SRMD and treatment bleeding SRMD that count as Incremental cost-effectiveness ratio (ICER) value. The research result shows that no real difference between patients treated with esomeprazole (88%) and pantoprazole (80,7%) as prophylaxis therapy SRMD (p = 0.286). The use of esomeprazole can save money by IDR 13,456,368.00 (ICER) compared to pantoprazole for each cost reduction in the event of bleeding.
Analysis precision of joint pain in Apotek Kimia Farma Mejasem Tegal Shellma Noor Aida; Heru Nurcahyo; Joko Santoso
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.15957

Abstract

This research aims to find out and analyze the accuracy of self-medication for joint pain in the community, especially those who buy drugs at the Apotek Kimia Farma, Mejasem, Tegal. The sampling technique in this study uses the purposive sampling method, which determines sampling by determining specific characteristics according to the research objectives so that it is expected to answer the research problem. This research is classified into descriptive research, namely research with a method to make a systematic description of the accuracy of self-medication for joint pain in the community who visited the Apotek Kimia Farma Mejasem. The instruments used in this study were demographic data and questionnaires. The work steps used in data collection in this study used interview techniques guided by the questionnaire. The results of the study were as follows, community self-medication in joint pain showed the correct percentage of people with an indication of 85%, the percentage of people who were right in the group of 85%, the percentage of people who had the correct dose of 71%, and the percentage of people who were alert to drug side effects was 27%. In conclusion, most people who buy drugs at the Apotek Kimia Farma Mejasem were correct in self-medication for joint pain, except for the awareness of drug side effects. The percentage of people who had the correct dose was 71%, and the percentage of people alert to drug side effects was 27%.
A method validation and analysis of lead content in lipstick products sold in e-commerce using atomic absorption spectrophotometer (AAS) Dian Prasasti; Divanda Liling Sasanti
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.17250

Abstract

Lipstick is the most widely cosmetic that used to beautify the appearance of the face. Lipstick that safe to use has an amount of lead metal less than 20 ppm. This study aims to ensure that the analytical method used has been validated, to determine the metal content of lead in lipsticks that sold in e-commerce, to determine the average metal content of lead using an Atomic Absorption Spectrophotometer (AAS) and to determine the safety of the lipstick. The methods used to validation are determine linearity, accuracy, precision, LoD, and LoQ. Samples were obtained from e-commerce with criteria that had price less than IDR 17,500, had sales history at least 10,000 units and had shipments from within the country. Sample preparation was carried out by wet digestion method, then analyzed qualitatively by tube test and analyzed quantitatively by measuring its absorption using AAS. The results obtained from this study are the linearity of validation parameter is 0.9959, the percent accuracy is entirely in the range 80-110%, the percent precision is less than 11% and the LoD and LoQ numbers are 0.630 ppm and 1.908 ppm. The average levels of lead contained in lipsticks that sold in e-commerce for brands A to F are 33.285±0.918 ppm; 33.576±0.918 ppm; 35.029±0.918 ppm; 38.372±1.836 ppm; 39.390±0.918 ppm; and 32.994±0.918 ppm. Lipstick brands A, B, C, D, E, and F contain more than 20 ppm lead metal so they are not safe for daily use.
Cost-effectiveness analysis of cefazolin and clindamycin in postpartum patients at PKU Muhammadiyah Hospital Yogyakarta Anggita Esa Putri Fitrichia; Susan Fitria Candradewi; Dewi Inggit Karnasi; Adnan Adnan
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.17289

Abstract

Postpartum infections can occur after normal or cesarean delivery. Proper administration of antibiotics can reduce the risk of postpartum infection The occurrence of postpartum infections can increase the cost of childbirth. The purpose of this study is to find out the cost-effectiveness of antibiotic therapy at PKU Muhammadiyah Hospital Yogyakarta.  This study was retrospective observational and was conducted during October to December 2020. The inclusion criteria in this study were postpartum patients who received cefazolin and clindamycin therapy and were over 20 years old, while the exclusion criteria in this study were patients who died, had incomplete data, and had complications of the disease. The effectiveness of antibiotic therapy was measured from the clinical outside of body temperature and length of hospitalization. Cost-effectiveness were assessed from ACER (Average Cost-effectiveness Ratio) and ICER (Incremental Cost-effectiveness Ratio). The results showed that the effectiveness of antibiotics based on the clinical outcome temperature and length of  cefazolin of 81.3% and 2.7 days while in clindamycin by 18.8% and 1.8 days. The ACER (Average cost effectiveness ratio) based on the clinical output of body temperature in both groups was IDR 64,348 (cefazolin) and IDR 98,319 (clindamycin). ACER values based on long of stay (LOS) clinical discharge in both groups amounted to IDR 19,375 (cefazolin) and IDR 10,268 (clindamycin). The value of ICER (Incremental Cost- effectiveness Ratio) cefazolin against clindamycin based on the clinical output of temperature and length of hospitalization (LOS) respectively is IDR 54,129 and IDR 37,590 for each effectiveness achieved. The conclusion of this study is that the use of cefeazoline is more therapeutically effective than clindamycin with greater therapeutic costs.
Comparison of physical properties and effectiveness of facial wash gel nipah shell (Nypa fruticans Wurmb.) activated charcoal with palm shell (Elaeis guineensis Jacq.) activated charcoal as a facial cleanser Uce Lestari; Eugenia Griselta; Muhaimin Muhaimin
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.17328

Abstract

Activated charcoal is an amorphous carbon that has a high absorption capacity and can be made using plantation waste such as nipah shell and palm shell. Activated charcoal from nipah shell and palm shell have high absorption when used to absorb dirt and oil on the face by being formulated as a facial wash in the form of a gel. This study was conducted to compare the physical properties and effectiveness of facial wash gel with activated charcoal nipah shell and activated charcoal palm shell with a concentration of 4% of each activated charcoal and determine which facial wash gel has better physical properties and effectiveness than the control positive namely Biore Men Charcoal. The physical properties tested included: organoleptic observation, homogeneity, spreadability, pH, foaming ability, cycling test, irritation test, moisture and oil test using a skin analyzer and dirt absorption effectiveness test using a digital microscope. The results showed that facial wash gel activated charcoal palm shell had physical properties closer to control (+) and better effectiveness, with an average oil reduction percentage of 17% compared to facial wash gel activated charcoal nipah shell, which was 15%. From these results, it can be concluded that facial wash gel activated charcoal palm shell has better physical properties and is more effective in cleaning oil and dirt on the face compared to facial wash gel activated charcoal nipah shell.
Bioactive Compounds Content and Pharmacological Activities of Chili Pepper (Capsicum Sp.) Swastiari Dwi Yanti; Warsi Warsi
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.17401

Abstract

Chili pepper (Capsicum sp.) is an essential spice belonging to the Solanaceae family. Chili pepper is consumed as a food source, additive in the food industry, and necessary medicine. Chili pepper is rich in nutrients and secondary metabolites to generate new bioactive compounds. Chili pepper fruit contains bioactive compounds including alkaloids, capsaicinoid, carotenoids (anteraxanthin, β-carotene, capsanthin, violaxanthin, β-cryptoxanthin, zeaxanthin, lutein epoxide, capsorubin, and neoxanthin), peptides (defensin, thionin-like peptide), phytol, fatty acids (myristic acid, methyl stearic, methyl linoleic), phenolic (chlorogenic acid) and flavonoids (quercetin, luteolin, rutin). The compounds in chili pepper constitute a bioactive source that acts as an antioxidant, antimicrobial, antifungal, anti-inflammatory, anti-obesity, anti-diabetic, and dyslipidemia. This review intends to describe the content of bioactive compounds that are very beneficial for health. This review is expected to increase chili consumption and its application in the food industry
Comparison of Antioxidant Activities of Ethyl Acetate Extracts of Two Varieties of Sweet Potato Tuber [Ipomoea Batatas (L.)] Using Two Extraction Methodsomoea batatas (L.)] MENGGUNAKAN DUA METODE EKSTRAKSI Hendy Suhendy; Defri Risviana; Imas Ratnasari
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.18069

Abstract

The decrease in antioxidant activity can be caused by the destruction of antioxidant compounds due to heating. Several studies stated that there was no significant difference between the antioxidant activity of extracts from cold extraction and hot extraction. This study compares the antioxidant activity of the ethyl acetate extract of two varieties of sweet potato using two different extraction methods. Simplicia was extracted by hot extraction using reflux and cold extraction using maceration. The antioxidant activity of the extracts was tested by the DPPH method using UV-Vis spectrophotometry. There are two types of sweet potato used in this research; firstly, the outer skin of the tuber is purple, the inside is purple (UU), and, secondly, the outer skin is purple, the inside is orange (UO). The IC50 UUR (Purple-Purple Refluxed), UOR (Purple-Orange Refluxed), UUM (Purple-Purple Macerated), UOM (Purple-Orange Macerated) , and ascorbic acid values were 4.583, 4.614, 0.755, 18.142, and 2.680 g/ml; thus, the extraction method and sweet potato varieties affect the antioxidant activity of the extract. Maceration is the best method for UU, while reflux is the best method for UO.
EFEK PEMACUAN APOPTOSIS FRAKSI ETIL ASETAT EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia Jack) TERHADAP SEL HeLa Isnaniati Romadhoni Indarwati Nurkhasan
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 2 No. 1 (2012): Januari
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v2i1.1151

Abstract

Pasak bumi is one of the Indonesian original plants having anticancer activity. Eurycomanone was isolated from Eurycoma longofolia, Jack root was proven to have cytotoxic effect and induce apoptosis on Hela cells. The objective this study was to know the cytotoxic activity of ethyl acetate fraction of ethanolic extract of the Eurycoma longifolia, Jack root on Hela cells and the mode of death. Ethyl acetate fraction was obtained from the ethyl acetate soluble fraction from residue of chloroform fraction of ethanolic extract of Eurycoma longifolia Jack roots. The cytotoxic assay was performed using MTT test method with concentration series used in this study were 1000; 750; 500; 400; 200; 100; 50; 12,5; 6,25; 3,125; and 1,5625 µg/ml. Absorbance was measured at wavelength of 550 nm using ELISA reader. Apoptosis assay were observed using Giemsa staining. MTT assay indicated that etil asetat fraction of ethanolic extract of the Eurycoma longofolia, Jack root showed cytotoxic activity againts Hela cells with IC50 value 3,70 µg/ml. The result of apoptosis assay indicated that the ethyl acetate fraction of ethanolic extract of the Eurycoma longofolia, Jack root induce apoptosis. The apoptotic cells was observed wrinkle, rounded and dark colors leading to chromatin condensation.
Evaluasi Efektivitas dan Keamanan Penggunaan Obat Anestesi Umum di RS PKU Muhammadiyah Yogyakarta Istiqoma Dewi Kurniawati Zullies Ikawati Inayati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 2 No. 1 (2012): Januari
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v2i1.1152

Abstract

Anesthesia is given to more than 75 million surgical patients annually, wordwide. An ideal anesthetic drug would induce anesthesia smoothly and rapidly while allowing for prompt recovery after its administration is discontinued. The drug would also prossess a wide margin of safety and be devoid of adverse effects. The objective of the study was to get an overview on use of general anesthesia at PKU Muhammadiyah hospital, Yogyakarta which included aspects of dose induction relevance, effectiveness of general anesthesia based on onset dan duration recovery and safety based on cardiovascular and respiratory side effects which happened due to induction anesthesia.The study used descriptive case series design carried out prospectively. Data were obtained from observation of elective surgery patient in Instalasi Bedah Sentral at PKU Muhammadiyah hospital, Yogyakarta. Sample were collected by concecutive sampling methods on Maret-Juni 2010. Onset, duration recovery were monitored after induction anesthesia. Systolic and diastolic blood pressure, heart rate, saturation were monitored 0 minute before induction and 5 minute after induction anesthesia.From 84 patient, as many as 72,62% were relevant dose with induction and 27,38% were irrelevant dose. Effectivity anesthesia based on onset was 100% effective Recovery from isoflurane was 4-11 minute faster than with sevoflurane and 1-4 minute faster than hallotane. Cardiovascular side effect was not significant between relevant and irrelevant dose Induction. No respiratory side effect was found.

Page 13 of 17 | Total Record : 170

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