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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 119 Documents
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Evaluation of Quality of Life in Breast Cancer Patients: A Cross-Sectional Comparative Study between Targeted Therapy and Conventional Chemotherapy Pratama, Kharisma Jayak; Luthfiyanti, Niken
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404453

Abstract

Breast cancer is one of the most common cancers worldwide, with treatment often involving conventional therapies such as chemotherapy. Although effective, chemotherapy is often accompanied by significant side effects and reduces patients' quality of life. Targeted therapy, which targets specific molecular mechanisms in cancer cells, offers the potential to address these issues with higher efficacy and fewer side effects. This study aims to compare the quality of life of breast cancer patients receiving targeted therapy with chemotherapy. The study design used a comparative cross-sectional design involving 60 patients (30 receiving targeted therapy, 30 receiving chemotherapy) selected via consecutive sampling at RSUD Moewardi in Surakarta (January–June 2025). Data were collected using the validated Indonesian version of the EORTC QLQ-C30 questionnaire. Statistical analysis included parametric t-tests and non-parametric Mann-Whitney U tests. The study results showed that the targeted therapy group had better role functioning (p = 0.047.95% CI=0.044-0.053) and significantly lower pain (p= 0.001.95% CI=0.000-0.002) and nausea (p = 0.019.95% CI=0.016-0.021) symptoms compared to chemotherapy. Global health status did not differ significantly (p= 0.545.95% CI=0.536-0.556). Age (p = 0.012.95% CI=0.08-0.012) and stadium (p = 0.001.95% CI=0.001-0.003) significantly influenced global QoL. Targeted therapy provided advantages in functional aspects and specific symptoms, although not in global QoL. A key study limitation is its cross-sectional design, which prevents the establishment of causal relationships between the type of therapy and quality of life outcomes.
Analysis of Antibiotic Therapy Accuracy and Drug Interaction in Pneumonia Inpatients at The Islamic Hospital Jakarta Cempaka Putih Khairani, Sondang; Manninda, Reise; Ariani, Lusiana; Iskandar, Benni; Hidayati, Nabila Nur
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404456

Abstract

Polypharmacy may increase the risk of drug interactions affecting toxicity and therapeutic efficacy in pneumonia patients. This study aimed to analyse evaluation of pneumonia management, polypharmacy, relationship between polypharmacy and occurrence of drug-drug interactions, and relationship between drug-drug interactions and length of hospital stay of pneumonia patients. The study design used a quantitative descriptive approach with cross-sectional and retrospective data collection and a total sample of 113 samples that met the criteria. Analyses were performed using Spearman's rho correlation test to assess the association of polypharmacy with drug interactions, and the association of drug interactions with length of hospital stay. Medication accuracy was measured using PDPI (The Indonesian Lung Doctors Assosiaciation) guidelines, drug interactions using drugs.com and/or Medscape.com. Results showed 59.29% of patients were female, with the majority aged over 65 (55.65%). Most patients (91.15%) paid with BPJS, 62.61% were hospitalised for 1-5 days and 81.74% had comorbidities. Treatment accuracy in this study was 49.56%. 106 drug interactions were identified in a total of 226 cases. 66% of the interactions were pharmacodynamic with moderate severity (79%), such as the interaction between combivent and ondansetron. Mild pharmacokinetic interactions were common, especially between ranitidine and paracetamol (22 cases). There is a correlation between polypharmacy and drug interactions with a p-value 0.000 and there is a correlation between the number of drug interactions and length of hospitalisation with p-value 0.000. Conclusion of this study is polypharmacy increases the risk of drug interactions and affects the length of hospital stay in pneumonia patients.
Effect of Tween 80 and Span 80 Surfactants Systems on the Malus domestica Emulsions for Anti-Cutibacterium acnes Handoyo, Theodorus Rexa; Resmi, Juniar Kalpika; Hutabarat, Rahmi; Guanse, Yovi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Red apple (Malus domestica) extract, rich in hydrophobic quercetin, was formulated into oil-in-water (O/W) emulsion using a 22 factorial design to evaluate Tween 80 (8-10 g) and Span 80 (2-4 g) concentrations, targeting pH (4.5-6.0), transmittance (90-100%), and viscosity (10-2000 cPs). Design-Expert® 13 analysis identified formulations F1, FA, and FAB within acceptable physical property ranges, with all red apple emulsions exhibiting O/W type, skin-compatible pH (5.20-5.48), high transmittance, and suitable viscosity. Freeze-thaw cycling (3 cycles, -15/25°C) and centrifugation showed physical stability with non-significant changes for F1 (p > 0.05). The agar well diffusion assay was performed on F1 (n = 3), which exhibited optimal physical parameters and met stability criteria, revealing Cutibacterium acnes inhibition zones up to 22.7 ± 0.577 mm. Thus, F1 emerges as a promising nanoemulsion candidate demonstrating antibacterial activity against acne-causing bacteria.
Inappropriate Use of Parenteral Analgesics for Mild Pain and Uncomplicated Fever in the Emergency Department: Findings from an Internal Audit Dewi, Rissa Maharani; Rosyid, Abdur; Timur, Willi Wahyu; Nastiti, Nindita Sari; Ningrum, Dwi Monika; Widiyanto, Dimas
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501519

Abstract

Inappropriate prescribing of parenteral analgesics in patients with mild pain or uncomplicated fever remains a relevant concern in emergency care. This study reports findings from a retrospective internal audit conducted in the emergency department of a private hospital in Banjarbaru, Indonesia, to evaluate the appropriateness of non-steroidal anti-inflammatory drug (NSAID) use. Medical records of 384 emergency department visits were reviewed, including data on pain intensity using the Numeric Rating Scale (NRS), clinical indications, route of administration, and immediate adverse reactions. Inappropriate use was defined as administration of parenteral NSAIDs in patients with mild pain (NRS 1–3) or uncomplicated fever when oral therapy was feasible, based on Royal College of Emergency Medicine (RCEM) guidelines. The audit identified inappropriate parenteral NSAID use in 7 patients (3.6%). These cases were associated with mild, immediate adverse effects such as nausea and dizziness. Although the proportion was small, the findings indicate potentially avoidable use of injectable analgesics and highlight the need for improved adherence to guideline-based analgesic selection. Reinforcement of routine pain assessment, clinician re-education, and periodic prescribing audits are recommended to support rational and patient-centered analgesic use in emergency settings.
Ethanolic Extract of Curcuma zedoaria Enhances Burn Wound Healing in Male White Rats Yuliawati, Yuliawati; Kasmadi, Fathnur Sani; Elisma, Elisma; Dewi, Hasna; Afryandes, Amelya; Puteri, Vanya Gita
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501488

Abstract

In addition to its widespread use as a culinary spice, white turmeric rhizome (Curcuma zedoaria (Christm.) Roscoe) exhibits important pharmacological activities, including anti-inflammatory, anticancer, and antioxidant effects. The rhizome contains secondary metabolites such as flavonoids, alkaloids, saponins, phenols, tannins, and terpenoids, which are believed to contribute to its potential efficacy in treating burns. This study used a fully randomized post-test-only control group design consisting of five treatment groups: P1 (5% ethanol extract of white turmeric rhizome), P2 (10%), P3 (15%), K⁺ (positive control: Bioplacenton), and K⁻ (negative control: Vaseline flavum). Parameters observed included reduction in burn wound diameter and collagen density, which were assessed through histological analysis. The results showed significant differences between treatment groups (p < 0.05). The 10% concentration showed the highest wound healing activity, reaching a healing rate of 54.72% and producing denser collagen compared to the other treatments. However, its effect did not exceed the positive control (Bioplacenton). The 5% concentration showed moderate healing activity (43.84%) with intermediate collagen density, while the 15% concentration produced the lowest effect. Overall, the findings indicate that the ethanol extract of white turmeric rhizome, particularly at a concentration of 10%, enhances burn wound healing and increases collagen formation, supporting its potential as a natural therapeutic agent for the treatment of burns.
Health-Related Quality of Life in Patients with COVID-19 in Indonesia: A Cross-Sectional Study Fajriansyah, Fajriansyah; Lestari, Keri; Zulfahmidah, Zulfahmidah
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501487

Abstract

Evidence on health-related quality of life (HRQoL) among hospitalized COVID-19 patients in Indonesia remains limited, particularly during the acute phase of infection. This study aimed to describe HRQoL and its associated sociodemographic and clinical factors among hospitalized COVID-19 patients in Indonesia. A cross-sectional study was conducted among adult patients with polymerase chain reaction confirmed COVID-19 who were hospitalized at Rumah Sakit Darurat COVID-19 (RSDC) Wisma Atlet, Jakarta, between October - December 2021. HRQoL was assessed using the validated Bahasa Indonesia version of the EQ-5D-5L questionnaire, including the utility index derived from the Indonesian value set and the EQ visual analogue scale (EQ-VAS). Descriptive statistics were used to summarize HRQoL distributions, and group differences were analyzed using the Mann–Whitney U test and Kruskal–Wallis test. A total of 154 patients were included in the analysis. The mean EQ-5D-5L utility index was 0.762 (SD 0.23; 95% CI: 0.726–0.798), and the mean EQ-VAS score was 75.00 (SD 15.81; 95% CI: 72.48–77.52). Utility index values ranged from 0.311 to 1.000, with 31.17% of participants reporting full health. Among the EQ-5D-5L dimensions, anxiety/depression was the most frequently reported problem (68.83%). Statistically significant differences in utility index scores were observed across sex, age groups, and occupational status (p < 0.05). In conclusion, hospitalized COVID-19 patients in Indonesia reported moderately high overall HRQoL, while psychological problems particularly anxiety and depression were highly prevalent. These findings highlight the importance of integrating mental health support into inpatient care and recovery services. 
GC-MS Analysis and In Vivo Antimalarial Activities of Seed Extract and Solvent Fractions of Telfairia occidentalis in Plasmodium berghei-infected Mice Sunday, Nsikakabasi Enefiok; Osigwe, Chinyelu Clementina; Enin, Godwin Ndarake; Uwaeme, Ugonma Florence; Essien, Grace Emmanuel; Okokon, Jude Efiom
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Telfairia occidentalis Hooke. F. (Cucurbitaceae family), a vegetable whose parts are used for both nutritional and medicinal purposes was investigated for anti-malarial activity in mice. The dried seed powder was separately cold extracted in 50% ethanol and gradient solvents (n-hexane, dichloromethane, ethyl acetate and methanol) along polarity gradient to obtained crude ethanol extract and solvents fractions of T. occidentalis seed. Based on previously established median lethal dose, the seed extract (138-553 mg/kg) and solvents fractions (276 mg/kg) were investigated for in vivo activity against Plasmodium berghei infection in mice using suppressive, prophylactic and curative standard models. Gas chromatography-mass spectroscopy (GC-MS) analysis of the active fraction was also done to identify its chemical constituents. The seed extract and fractions (138-553 mg/kg, p.o.) exerted significant (p < 0.05–0.001) chemosuppressive activity against P. berghei infection in suppressive (65.67%; 18.33 ± 3.71 days), prophylactic (55.39%; 17.66 ± 2.18 days) and curative (77.48%; 18.00 ± 1.15 days) tests with methanol fraction having the highest activity. GC-MS analysis of the active methanol fraction revealed the presence of polyunsaturated fatty acids and monoterpenes which have been implicated previously in antimalarial activity of plants. These results revealed the strong antimalarial potentials of the methanol seed fraction and its phytochemical constituents which can be exploited in the development of antimalarial remedies.
Adaptation and Transformation of Honestdocs Business Model In The Era of Digital Health Technology Saragi, Sahat; P., Embriana Dinar; Jamaludin, Aditya
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

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Abstract

The rapid development of digital health technology has encouraged startups to continuously adapt their business models in response to regulatory, technological, and market challenges. This study aims to explore how a digital health startup in Indonesia adapts and transforms its business model within the evolving digital healthcare ecosystem. This research employed a qualitative exploratory case study design focusing on HonestDocs as a single case. Data were collected through semi-structured in-depth interviews with three key informants representing strategic managerial roles and were analyzed using thematic analysis following Braun and Clarke’s framework. To enhance credibility, interview findings were compared with selected internal documents and operational information. The findings indicate that business model adaptation in this case is characterized by three main patterns: the use of lightweight digital infrastructure, the integration of personalized customer service, and flexible operational strategies in responding to regulatory and logistical constraints. The study also shows that organizational culture and collaborative work practices appear to play an important role in supporting operational adaptability. However, the findings should be interpreted with caution, as this study is based on a single case and relies primarily on internal managerial perspectives, which may limit generalizability. Despite these limitations, the study provides exploratory insights into how digital health startups in emerging markets may respond to structural constraints and evolving user needs.
Association Between Medication Adherence and Quality of Life Among Tuberculosis Patients: A Study at Permata Kuningan Hospital Anwarudin, Wawang; Hanum, Salwa Diana; Marlindasari, Liska; Sya'bany, Anna Khalida; Azizah, Nur
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) remains a major global health concern, particularly in high-burden countries such as Indonesia. Although TB is curable, prolonged therapy, potential adverse effects, and social stigma may affect medication adherence and patients’ quality of life (QoL). Evaluating the association between adherence and QoL is important to support patient-centered TB management. This study aimed to examine the association between medication adherence and quality of life among tuberculosis patients at Permata Kuningan Hospital. A cross-sectional analytic study was conducted involving 62 TB patients selected through purposive sampling. Medication adherence was assessed using the Morisky Medication Adherence Scale (MMAS-8), and quality of life was measured using the EQ-5D-5L instrument. Data were analyzed using Spearman rank correlation. Most patients demonstrated high adherence (95.2%) and reported good quality of life (96.8%). Statistical analysis showed a significant positive correlation between medication adherence and quality of life (r = 0.384; p = 0.002), indicating that higher adherence was associated with better quality of life. These findings suggest a significant association between medication adherence and quality of life among TB patients. Strategies to support adherence, including education, counseling, and monitoring, may be considered as part of comprehensive TB care to optimize patient-centered outcomes.

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