cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Abd. Kakhar Umar
Contact Email
abdulkaharumar@gmail.com
Phone
+6282216335184
Journal Mail Official
sciphar@etflin.com
Editorial Address
Sungai Manonda Street, Syukur Aisle No. 2, RT 004/ RW 001, Duyu Village, Tatanga District
Location
Kota palu,
Sulawesi tengah
INDONESIA
Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 112 Documents
 7   8   9   10   11 
Effect of Gene Polymorphisms on Oral Antidiabetic Drug Response in Patients With Type 2 Diabetes Mellitus Hidayati, Nur Rahmi; Perwitasari, Dyah Aryani; Faridah, Imaniar Noor; Susilo, Rinto
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402321

Abstract

Diabetes mellitus is currently one of the global health threats. The prevalence and incidence of this disease continue to increase, both in industrialised and developing countries, including Indonesia. There are different types of DM marker gene polymorphisms in each racial group. These genetic variations contribute to the response of oral antidiabetic drugs. This article aims to conduct a narrative review of the influence of gene polymorphisms on oral antidiabetic drug response in patients with type 2 diabetes mellitus. Article searches were conducted in PubMed, Scopus, Google Scholar, and Wiley published from 2014 to 2024. From the screening, 30 articles met the criteria. The articles reported various gene polymorphisms associated with the efficacy of oral antidiabetic therapy in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus with certain gene variations, there was no significant decrease in HbA1c values after taking medication. Gene polymorphisms may affect the pharmacokinetics of oral antidiabetics and therapeutic response in patients with type 2 diabetes.
Pharmacoeconomic Analysis of Drugs Used in Chronic Outpatients at Berkah Pandeglang Regional Hospital Yusransyah, Yusransyah; Nurhikmah, Ihda; Maharani, Zahra Citra; Stiani, Sofi Nurmay; Shobah, Afifah Nur; Udin, Baha
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403343

Abstract

Hypertension and type 2 diabetes mellitus (T2DM) are chronic conditions requiring long-term pharmacotherapy, placing significant financial pressure on patients and healthcare systems. Drug selection should prioritize both clinical efficacy and cost-efficiency, particularly in resource-limited settings. This study conducted a pharmacoeconomic evaluation of commonly used therapies at RSUD Berkah Pandeglang using a retrospective, non-experimental design. Data were collected from 2023 outpatient records and analyzed from the hospital’s perspective. Cost-effectiveness was assessed using the Average Cost-Effectiveness Ratio (ACER). For hypertension, amlodipine (n=20) had a lower ACER (Rp 283,913) than candesartan (n=15; Rp 883,000), indicating higher cost-effectiveness. In T2DM patients, metformin (n=25) was more cost-effective (ACER: Rp 317,746.75) than glimepiride (n=25; ACER: Rp 607,148.84). These findings support prioritizing amlodipine and metformin as first-line treatments in similar public healthcare settings to improve therapeutic outcomes while managing costs.
Protective Effects of Java Plum (Syzygium cumini) Leaf Extract on Serum Biomarkers in Lead-Exposed Rats Ansori, Fachrurrazi Al; Rita, Rauza Sukma; Almurdi, Almurdi
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403345

Abstract

Lead (Pb), a heavy metal recognized as a hazardous environmental toxin, triggers oxidative stress by catalyzing oxidation reactions that produce free radicals, ultimately leading to cell death. Liver cell damage due to lead can decrease serum albumin levels, while kidney damage can increase serum uric acid levels. To counteract this oxidative stress, the intake of exogenous antioxidants is necessary. Java plum (Syzygium cumini) leaves are abundant in natural antioxidants, including flavonoids and phenolic compounds. The compounds possess antioxidant potential by scavenging free radicals. The purpose of this study was to determine the effects of an extract of S. cumini on serum albumin and uric acid in rats induced with lead acetate. All treatments lasted 30 days. Testing for serum albumin and uric acid was performed using the DiaSys method. One-way ANOVA followed by the Bonferroni post hoc test revealed significant differences (p < 0.05) in serum albumin levels among the groups: the normal group (4.13 g/dL), the positive control (2.86 g/dL), and the treatment group (3.93 g/dL). Similarly, significant differences were observed in serum uric acid levels: the normal group (1.47 mg/dL), the positive control (3.14 mg/dL), and the treatment group (1.64 mg/dL). These results indicate that S. cumini extract helps mitigate the adverse effects of lead exposure on serum albumin and uric acid levels in rats. A p-value of less than 0.05 indicates that the observed differences are statistically significant and unlikely due to chance.
NLP Analysis of Mannan-Based Drug Delivery Trends Pratama, Reza; Cabellon-Semense, Daisy Jane; Sulastri, Lela; Arifka, Mia; Rizikiyan, Yayan
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403339

Abstract

Mannan, a polysaccharide derived from various sources, has gained attention for its biocompatibility and potential in targeted drug delivery. Since its initial use in 1911 as an ointment base, mannan has been applied in cancer therapy, vaccine development, and as an antimicrobial agent. However, research is still largely dominated by in vitro and preclinical studies, with few clinical trials conducted to date. This study aims to provide an overview of mannan's advancements, its uses in drug delivery, the mechanisms involved, the research gaps, and the underexplored areas with significant potential. This study analyzed 321 peer-reviewed articles selected from Scopus (2000-2024), employing natural language (NLP) and bibliometric mapping to identify key materials, application areas, and research trends. Mannan’s flexible molecular structure allows for copolymerization with polymers such as chitosan, alginate, polyacrylate, and polycaprolactione, enabling improved targeting, mucoadhesion, and controlled drug release. Chitosan emerged as the most frequently used co-polymer, particularly in nanogel formulations for cancer and inflammatory diseases. Keyword impact analysis also revealed growing interest in mannans role in post-COVID-19 cytokine storm mitigation and vaccine enhancement, despite limited representation in clinical pipelines. Optimization of polymer ratios, crosslinker use and formulation strategies, remains essential to improving translational outcomes. Future research should also focus on clinical trials to demonstrate its effectiveness. In conclusion, this study underscores mannans role as promising biomaterial for next-generation drug delivery systems, while identifying gaps in clinical validation, mechanistic insight, methodological consistency. To advance toward commercial and clinical applications, future research should integrate machine learning models for predicting formulation parameters and drug release profiles. This findings offer a roadmap for the design, standardization, and eventual commercialization of mannan-based delivery platforms.
Pometia pinnata in Pharmaceutical Research: Bioactivity, Mechanisms, and Formulation Prospects Sulastri, Lela; Sugihartini, Nining; Efiana, Nuri Ari
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403331

Abstract

A literature review was conducted to gather information on the pharmacological properties and pharmaceutical dosage forms made from the Matoa plant (Pometia pinnata). The review aimed to provide a basis for further research and explore the potential of Matoa in the health sector. The method involved searching electronic media platforms, specifically Google Scholar, PubMed, and Open Knowledge Maps, using targeted keywords such as "Matoa,” "Pometia pinnata,” "Matoa preparation formulation,” "Pometia pinnata pharmaceutical preparation,” "Preparation of Pometia pinnata," and "Function of Pometia pinnata." The inclusion criteria included original research, full-text articles, and open-access journals, all published within the last 10 years, in both Indonesian and English. After screening, 64 articles were identified from the 185 search results. The review revealed that various parts of the Matoa plant, including leaves, fruit, stem bark, fruit peel, and roots, possess pharmacological properties such as antibacterial, analgesic, antioxidant, sunscreen, anticancer, antidiarrheal, anti-HIV, anti-obesity, diuretic, nephrotoxic, and antihypertensive activities. Additionally, various pharmaceutical dosage forms containing Matoa were studied, including topical preparations such as lotions, creams, liquid soap, and body scrubs, as well as oral preparations like effervescent powders, herbal drinks, and jelly candies. The review suggests that numerous research opportunities remain to further explore the potential of Matoa in the pharmaceutical and healthcare fields, as well as to develop innovative dosage forms for optimal results.
Antibacterial Activity of Kecombrang (Etlingera elatior) Stems Against Skin Infection-Causing Bacteria Adini, Syilvi; Kumala, Shirly; Setyahadi, Siswa
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403322

Abstract

Skin infections caused by Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes often exhibit resistance to conventional treatments. This issue has led to the exploration of medical plants, such as kecombrang stems (Etlingera elatior), which are known for their antibacterial properties. This study aimed to evaluate the antibacterial activity of kecombrang stem and to identify its active compounds. The methanolic extract of kecombrang stems was tested against the three bacteria using the disc diffusion method at concentrations of 80%, 40%, and 20%. The Minimum Inhibitory Concentration (MIC) was determined using the microdilution method and an ELISA reader. TLC-Bioautography was employed to identify the antibacterial compounds present in the extract. The methanol extract of kecombrang stems exhibited antibacterial activity against S. aureus, S. epidermidis, and P. acnes, with an inhibition zone diameter ranging from 9.23 ± 0.472 to 25.53 ± 0.378 mm. The MIC results showed that the minimum concentration of 78.12 ppm could inhibit the growth of S. aureus by 33.74%, S. epidermidis by 14.45%, and P. acnes by 3.5%. The results of TLC Bioautography analysis indicate that flavonoids exhibit antibacterial properties. The kecombrang stem has the potential to serve as an antibacterial agent against bacteria that cause skin infections.
Improving Hospital Pharmacy Service Quality Using Lean Management Principles Sembiring, Grace Faskarina; Saragi, Sahat; Amyulianthy, Rafrini
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403346

Abstract

Optimal pharmaceutical services are a crucial factor in enhancing the overall quality of hospital care. Pharmacy installations often face challenges such as non-compliance with standard operating procedures, prolonged service waiting times, and inefficiencies in drug stock management. This study aims to analyze improvements in pharmaceutical service processes through the application of Lean Management, with the goal of enhancing effectiveness, efficiency, and patient satisfaction. This research employed a qualitative descriptive approach using observations, interviews, and secondary data analysis. The setting of the study was the Pharmacy Installation at RSIA Viola Bekasi. The implementation of Lean Management was initiated and conceptualized in collaboration with the researchers and hospital management. Prior to the intervention, the average waiting time for compounded prescriptions ranged from 30 to 45 minutes, while non-compounded prescriptions took approximately 15 to 20 minutes. After the Lean intervention, these waiting times decreased significantly to an average of 20.17 minutes for compounded prescriptions and 6.5 minutes for non-compounded prescriptions—indicating an efficiency improvement of approximately 33% to 68%, depending on the type of service. The application of Lean Management also led to notable reductions in waste, improved service flow, and more effective drug inventory management through the adoption of Just-in-Time (JIT) and First Expired, First Out (FEFO) systems. These changes enhanced both the operational performance and responsiveness of the pharmacy unit. In conclusion, the findings confirm that Lean Management is an effective strategy for improving pharmaceutical service quality. By systematically addressing inefficiencies and streamlining processes, Lean principles not only support patient-centered care but also contribute to broader hospital service optimization. This study also adds to the Lean Management literature by offering contextual evidence from a maternal and child healthcare facility in the Indonesian hospital setting
Liquid Soap with Pineapple Hump Extract and Nanoformulation Against Staphylococcus aureus Lubis, Minda Sari; Fauzi, Ziza Putri Aisyia; Dewi, Sri Harti; Rani, Zulmai; Yuniarti, Rafita
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403348

Abstract

Staphylococcus aureus is a Gram-positive bacterium that frequently causes skin infections and can become resistant to various antibiotics. Pineapple (Ananas comosus) waste, particularly the hump, contains active compounds such as bromelain, saponins, and flavonoids with known antibacterial properties. This study aimed to determine the antibacterial potential of liquid soap formulated with extract and nanoextract of pineapple hump against S. aureus. The pineapple hump was extracted using maceration with 96% ethanol, followed by nanoparticle formulation using a high-speed homogenization method. Liquid soap was made with three formulas, one formula contains a concentration of 12.5% extract and two formulas contain 1.25% nanoextract of pineapple hump. Antibacterial activity was evaluated using the disc diffusion method, and the diameter of the inhibition zones was measured. Results showed that all tested concentrations produced antibacterial activity, with the 12.5% concentration (Formula 1) exhibiting the highest inhibition zone (23.2 mm), followed by 1.25% nanoextract nano liquid soap (18.41 mm) (Formula 3) and 1.25% nanoextract liquid soap (14.53 mm) (Formula 2). The positive control (Dettol Handwash) produced a larger inhibition zone (20.08 mm). Data analysis using one-way ANOVA revealed significant differences for each formula, with a p-value of less than 0.05. These findings indicate that nanoextract of pineapple hump formulated in liquid soap has potential as a natural antibacterial agent against S. aureus.
Web-Based Pharmacoinformatics Platform for Generic Drug Information in Gorontalo, Indonesia Paneo, Mohamad Aprianto; Tuloli, Teti Sutriyati; Nakoe, Moh Rivai; Pakaya, Nikmasari; Thomas, Nurain; Anggai, Rifka Anggraini; Latif, Multiani S.
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404366

Abstract

This study aims to evaluate the effectiveness of a web-based drug information application in providing accessible and reliable drug-related information to the public in Gorontalo Province, Indonesia. A prospective, non-randomized study was conducted with 205 participants from the Gorontalo community. Participants completed a structured questionnaire assessing their experience with the "Cari Obatmu" feature on the Ikatan Apoteker Indonesia (IAI) Gorontalo website. The questionnaire covered various aspects such as user interface, search efficiency, clarity of drug indications, side effects, and usability. Descriptive statistics, Cronbach's Alpha for reliability, One-Way ANOVA for demographic differences, and effect size analysis were used in data analysis. The findings indicated high user satisfaction, with mean scores ranging from 4.16 to 4.28 across different aspects assessed. A Cronbach’s Alpha value of 0.975 confirmed excellent internal consistency of the data. The One-Way ANOVA analysis revealed no significant differences in satisfaction scores among demographic groups (p = 0.636), with effect sizes being minimal. The web-based drug information application was well-received, particularly for its functionality and ease of use. However, further improvements are necessary to enhance user experience and feature development. These findings highlight the potential to expand web-based drug information tools to improve public health outcomes in Indonesia, considering the diverse demographic and user needs.
Hair Growth and Antibacterial Effects of Nanoparticle-Based Cosmeceutical Tonic from Pogostemon cablin and Morus alba Leaves Dyavaprathivi, Made Anindya Ayu; Maisa, Yustrida; Sandhiutami, Ni Made Dwi
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404370

Abstract

Hair loss affects a substantial portion of the global population, regardless of age or gender. One effective strategy to address this problem is the use of hair tonics that stimulate hair follicle activity and promote hair growth. This study developed an innovative cosmeceutical nanoparticle-based hair tonic combining Nilam and Mulberry leaf extracts, termed nanoNilamBerry. The formulation was prepared using the ionic gelation method and evaluated on rabbits over 28 days by assessing hair length, growth rate, and hair weight. The nanoNilamBerry formulation fulfilled the physicochemical requirements of a nanoparticle system and demonstrated good stability at 4 °C, 25 °C, and 40 °C for up to 28 days. In antibacterial assays against Staphylococcus epidermidis, the Nilam–Mulberry extract produced an inhibition zone of 16.36 ± 0.35 mm, while nanoNilamBerry exhibited a larger zone of 18.4 ± 0.30 mm. The hair tonic formulation showed no signs of skin irritation. The nanoNilamBerry treatment resulted in a hair growth rate of 0.13 ± 0.03 cm/day and a final hair weight of 32.36 mg, compared to 0.09 ± 0.01 cm/day and 27.3 ± 0.31 mg for the simple Nilam–Mulberry extract. Overall, the nanoNilamBerry hair tonic demonstrated superior efficacy, promoting hair growth 3.04 times faster than the untreated control and 1.45 times faster than the non-nano extract combination. These findings indicate that nanoNilamBerry not only provides effective antibacterial protection but also significantly enhances hair follicle stimulation and growth performance.

Page 9 of 12 | Total Record : 112

 7   8   9   10   11 

Filter by Year

2022 2026


Reset
Filter By Issues
All Issue Volume 5 Issue 1 Volume 4 Issue 4 Volume 4 Issue 3 Volume 4 Issue 2 Volume 4 Issue 1 Volume 3 Issue 4 Volume 3 Issue 3 Volume 3 Issue 2 Volume 3 Issue 1 Volume 2 Issue 4 Volume 2 Issue 3 Volume 2 Issue 2 Volume 2 Issue 1 Volume 1 More Issue