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Jurnal Natural
Published by Universitas Syiah Kuala
ISSN : 14118513     EISSN : 25414062     DOI : https://doi.org/10.24815/jn
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Immunology & microbiology Neuroscience Physics
Jurnal Natural (JN) aims to publish original research results and reviews on sciences and mathematics. Jurnal Natural (JN) encompasses a broad range of research topics in chemistry, pharmacy, biology, physics, mathematics, statistics, informatic and electronic.
Arjuna Subject : Matematika - Matematika (Lain-Lain)
Articles 457 Documents
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ANTIMICROBIAL ACTIVITY OF METHANOL EXTRACT FROM STEM BARK OF Cinnamomum sintoc Nurdin Saidi; Hira Helwati; Lailatul Qhadariah Lubis; Muhammad Bahi
Jurnal Natural Volume 17, Number 2, September 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v17i2.8049

Abstract

Antimicrobial activity of methanol extract from stem bark of Cinnamomum sintoc has been evaluated against Candida albicans, Staphylococcus aureus and Escherichia coli. The extraction of compound was carried out by maceration, then isolation by column chromatograph, which yielded five (5) subfractions (A-E). Activity against fungus C. albicans, S. aureus bacteria dan E. coli using agar dilution method in paper disk. Methanol extract was not potent against antifungal activity but shows antibacterial activity with medium category. Subfraction C showed that antibacterial activity against S. aureus and E. coli with weak category, but subfractions D and E did not show any activity.
Thermal and physical properties of CNF/glutaraldehyde-gelatin-based hydrogel ROSLIANA LUBIS; SRI WAHYUNA SARAGIH; WARDATUL HUSNA IRHAM; AJMAIN AJMAIN; SAISA SAISA
Jurnal Natural Volume 23 Number 1, February 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i1.29935

Abstract

The use of hydrogel as a wound dressing material is currently being massively developed. In addition to functioning to protect wounds, the use of hydrogel can also provide moisture in a measured manner and can be used as a drug delivery medium. In this study, hydrogel based on CNF and glutaraldehyde crosslinking agent and addition of gelatin were developed with various compositions 0.25; 0.5; 0.75 g to increase the ability of CNF and hydrogel to absorb water so that it is good to be applied as a wound dressing. The composting of the three materials aims to obtain a hydrogel with good thermal and physical properties. Based on physical character for a good ratio of swelling (666,62%) and degree of cross-linking (94%) on the hydrogel with a composition variation of 0.5 g of CNF addition. For the thermal stability of hydrogel var 2, TMax 591oC provides better thermal stability than var 1 and var 3. The morphology of hydrogel shows very small and evenly distributed pores on the surface which can absorb more water.
Agronomical traits performance and variability of the SSD F4 mungbean population SURJONO HADI SUTJAHJO; NUR KHOLISOH; HESTI MAULIDA; SITI MARWIYAH; DESTA WIRNAS; EDIZON JAMBORMIAS
Jurnal Natural Volume 23 Number 2, June 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i2.24136

Abstract

Genetic variability is critical in order to create candidates for new superior varieties. This research objective was to evaluate the performance and variability of agronomical traits on the mungbean SSD F4 V422H/129 population. The research was conducted at IPB University, Bogor, from March to June 2021. The SSD F4 VR422H/129 population (378 genotypes with single plant as a representative of one genotype) and five check varieties were evaluated. The treatments were arranged in augmented design for RCBD in three replications. For agronomical traits, every F4 plant and 10 sample plants for each check variety were observed. Statistical analysis includes mean, frequency-distribution, heritability, genetic variability, correlation. The days to flowering, days to harvesting, generative periods, plant height on F4 V422H/129 were not significantly different from Vima 5, while total pod number, total pod weight, total seed weight, pod length were significantly higher. The agronomical traits were affected by genetic factors (heritability 0.71-0.99%), except for days to harvest. Based on the high genetic variability (CGV 0.62-0.64%), it was possible to select of total pod weight, total seed weight, or pod length in the next generation V422H/129. The total seed weight had a significant positive correlation with total pod weight and pod length.
Potential side effects of medicine on patients with tuberculosis fixed-dose combination in dr. Pirngadi Hospital, Medan EVA SARTIKA DASOPANG; FENNY HASANAH; IDA FAUZIAH; SALMAN SALMAN; TEDY KURNIAWAN BAKRI
Jurnal Natural Volume 20 Number 1, February 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v20i1.15285

Abstract

Tuberculosis is caused by the bacterium Mycobacterium tuberculosis, which by only using a few new antibiotics, can kill the bacteria. Tuberculosis treatment has several stages, namely intensive and advanced stages. Compliance with the use of OAT is an imported factor in the success of TB treatment. The use of many drugs can cause side effects that result in patients stopping treatment when it creates the TB treatment process to fail. Improved adherence can do by using a fixed-dose combination OAT. In the intensive phase, the patient will get a fixed-dose combination containing a mixture of four antibiotics. The purpose of this study is to evaluate the potential side effects that occur during fixed-dose combination OAT treatment at an intensive stage and see the level of compliance of patients taking TB drugs. Observational sampling in TB patients was taking OAT at an acute stage by looking at side effects that arise during treatment and then analyzed using statistics and algorithm Naranjo. The results showed the most common potential side effects for fixed-dose combination OAT in the intensive stage were itching, headache and nausea with a percentage of 72% each, joint pain 45%, stomach pain 36.4%, lack of appetite and rashes 27.3% each and reddish color in the urine 18.2%. The results of the analysis using Naranjo logarithm obtained results eight, which means the side effects might cause due to the use of the drug. The results of patient compliance achieved a 100% compliance rate
VALIDATION OF ULTRAVIOLET SPECTROPHOTOMETRY METHOD FOR DETERMINATION OF MEFENAMIC ACID LEVEL IN SUSPENSION DOSAGE FORMS Nerdy Nerdy
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v17i1.6540

Abstract

Abstract. Mefenamic Acid is one type of nonsteroidal antiinflammatory drug that works to relieve pain by blocking an enzyme that produces prostaglandins. The quality requirements that must be met by pharmaceutical preparations are levels contained must meet the level requirement as listed in the Indonesian Pharmacopoeia or other standard books. The purpose of this study was to conduct a validation test of ultraviolet spectrophotometry methods for determination of the Mefenamic Acid level in the suspension preparation. The sample consisted of three suspensions preparation under the trade name obtained from a pharmacy in the Medan city. The solvent used is sodium hydroxide (NaOH) 0,1 N solution and the measurement was done at a wavelength of 286 nm. Validation parameters determined were Accuracy, Precision, Linearity, Range, Limit of Detection and Limit of Quantitation. The results of the determination of the Mefenamic Acid suspension preparation under the trade name Pondex® was 100,39±0,21%, trade name Omestan® was 99,98±0,33% and trade name Novastan® was 103,21±0,83%. All the suspension preparations were determined meet the general level requirement, that contain not less than 90,0% and not more than 110,0% of the amount stated on the label. The results meet the requirements of the validation test of analysis methods with the parameter percent recovery 100,08% for accuracy, relative standard deviation 0,04% for precision, the correlation coefficient 1,0000 for linearity, range 8 μg/mL to 12 μg/mL, limit of detection limit 0,0118 μg/mL, limit of quantitation 0,0356 μg/mL. Keywords: Validation, Spectrophotometry, Determination, Suspension, Mefenamic Acid
Immobilization of urease from Phaseolus vulgaris L. seeds using calcium alginate as a support matrix ZUSFAHAIR ZUSFAHAIR; DIAN RIANA NINGSIH; AMIN FATONI; ELY SETIAWAN
Jurnal Natural Volume 22 Number 3, October 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v22i3.26056

Abstract

Urease is an enzyme that functions as a catalyst in the hydrolysis of urea into ammonia and carbon dioxide. The industrial sector has made extensive use of urease. To date, enzymes are used in free form, deemed less effective. Therefore, enzymes are used in immobilized form because they can be utilized repeatedly. This research aimed to isolate urease from kidney bean (Phaseolus vulgaris L.) seed and immobilize it using a Ca-alginate support matrix and a trapping technique. Eight days were devoted to germinating kidney bean seeds to begin the investigation. Isolation of crude urease extract from kidney beans was carried out using phosphate buffer pH 7. It was then immobilized with Ca-alginate at different concentrations of Na-alginate and contact times The crude free and immobilized urease extract was further characterized including pH, temperature and stability of repeated use. The urease activity was determined using the Nessler method using a spectrophotometer. The results demonstrated that urease immobilization from kidney bean seeds with a Ca-alginate matrix was most effective at a concentration of 5% Na-alginate and a contact period of 60 minutes, yielding a value of 5.92 U/mL. The optimal pH of free and immobilized urease was 7 and 8, respectively, and temperatures of 35 and 40 °C, respectively. The immobilization of urease from kidney bean seeds using a Ca-alginate support matrix increased the stability of recurrent use by fivefold, while the relative urease activity remained at 52%.
A modest method of synthesis Cu- based metal-organic frameworks using benzene dicarbocxylate as a ligan for promising candidate of flue gas CO2 adsorption MUTTAQIN MUTTAQIN; FARID IMAM HIDAYAT
Jurnal Natural Volume 21 Number 3, October 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i3.20035

Abstract

Metal organic framework (MOF) is one of extraordinary materials in many technical field applications. One of them is as CO2 gas adsorbent. We studied, synthesized, and characterized Copper-based material, known as Metal organic frameworks (MOFs), using a solvothermal-based modification method. Copper salt (Cu (NO3)2. 3H2O) and benzene dicarboxylic acid (H2BDC) were mixed and then heated in an oven at 120°C, to produce low impurities, small pore and uniform particle size of materials called CuBDC. Infrared spectroscopy and XRD data confirmed the formation of CuBDC. Furthermore, the result showed that CuBDC frameworks have good thermal stability up to 330°C.  Thereafter SEM picture showed random, layered, and asymmetrical corners structure which is typical of triclinic crystal system. Lastly, specific surface areas and the porosity were analyzed using The Brunauer-Emmett-Teller (BET) method. It recorded 485 m2.g-1 of surface area while average pore volume and average pore size are 0.16 cm3.g-1 and 5.9 Å respectively.   @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536869121 1107305727 33554432 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; mso-ansi-language:IN; mso-fareast-language:IN;}div.WordSection1 {page:WordSection1;}
COMPARISON OF ENERGY DOSES 10 MV DISTRIBUTION USING PERCENTAGE DEPTH DOSE (PDD) METHOD ON LINAC: ELECTA AND SIEMENS Martha Rianna; Herty Afrina Sianturi; Hariyati Lubis; Awan Pelawi; Timbangen Sembiring; Marhaposan Situmorang
Jurnal Natural Volume 18, Number 2, June 2018
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v18i2.11133

Abstract

The patient dosing on Linac (Electa and Siemens) can be determined by Source Surface Distance (SSD) technique using Precentage Depth Doses (PDD) method. The study was conducted by measuring PDD to compare the dosage distribution calculations on Linac Electa and Siemens device of photon energy at 10 MV. PDD is done with a 100 cm SSD technique at a depth of 0 to 25 cm. The dose distribution results between the Electrical and the Siemens PDD are almost the same in that the Dmax at 10 MV Siemens photon energy occurs at a depth of 20 mm while the 10 MV Electa photon energy occurs at a depth of 21 mm. Both Linac Electa and Siemens device this at the same energy of 10 MV there is a difference of 95.23%.Keywords: Distrubusi dose, PDD, Photon Energy, Quality File Index
The removal of remazol brilliant blue dyes from liquid waste using nano montmorillonite from bentonite of Bener Meriah Aceh JULINAWATI JULINAWATI; FATHURRAHMI FATHURRAHMI; IRFAN MUSTAFA; DETA RAHMADANTI
Jurnal Natural Volume 22 Number 2, June 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v22i2.24394

Abstract

Research on the potential of nano montmorillonite as an adsorbent for Remazol Brilliant Blue dye waste has been carried out. Nano montmorillonite was isolated from Bener Meriah bentonite, Aceh, to be used as an adsorbent. The optimum conditions for adsorption of Remazol Brilliant Blue dye using nano montmorillonite occurred at a contact time of 60 minutes, pH 4, and adsorbent mass of 2 grams. The results showed that the adsorption of Remazol Brilliant Blue dye by nano montmorillonite followed the Freundlich isotherm model with R2 = 0.9858. The results of the regeneration test show that the montmorillonite nano adsorbent can be used repeatedly
TEST OF ANTI-INFLAMATION ACTIVITIES OF PEPAYA LEAF (Carica papaya L.) EXTRACT ON MALE WISTAR RATS INDUCED BY CARAGENAN 1% Fenny Hasanah; Nurul Hidayah
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.12498

Abstract

Inflammation is a normal protective response to tissue injuries caused by physical trauma, destructive chemicals, or microbiological substances. The purpose of this study was to determine the anti-inflammatory activity of papaya leaf water extract (Carica papaya L.) on the feet of male Wistar rats which were induced by carrageenan 1%. The research method used is experimental. The stages of this study include plant identification, making dry simplicia powder, simplicia characteristics, extracting papaya leaves using water, simplicia phytochemical screening and papaya leaf water extract (EADP), as well as testing for anti-inflammatory activity. Anti-inflammatory testing was carried out on 20 male Wistar rats induced with 1% carrageenan sub plantar. The test group was divided into five groups for the induction, comparison, EADP 50, 100, 200 mg/kg BW groups. The parameters observed were the volume of mouse leg udema measured by a pletismometer every 30 min for 5 h. Data obtained then calculated percent inflammation and percent inflammation inhibition. Furthermore, it was analysed by ANOVA with a confidence level of 95%. The results of the simplicia characteristics showed that the water content, water content of the sea water and soluble extracts of ethanol were 8.9%, 51.4% and 10.2% respectively. The results of simplicia and EADP phytochemical screening showed the content of flavonoids, tannins, triterpenoids, glycosides, and alkaloids. Observations of the percentage of inflammation in the induction group had the highest percentage of inflammation compared with the other test groups at time of 300 min (p 0.05). Whereas the percentage of inflammatory inhibition of all groups of test extracts has effectiveness comparable to the comparison group. EADP group 200 mg/kg BW is the best dose of extract as anti-inflammatory, where flavonoid compounds are thought to be responsible for decreasing the volume of inflammation in the legs of test animals.

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