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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 17 Documents
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Search results for , issue "Vol. 9 Issue 7 : 2017" : 17 Documents clear
Antimicrobial Effect of Bacillus Spp. on MRSA Samarah Jafar Alwash; Zahraa A. Jabur; Maha Mohammad; Saad Sabah Fakhry; Farqad Farhan Abdulhammed
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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There are many antimicrobial peptides produced by Bacillus species, which have a bacteriostatic and/or bactericidal activity. The aim of this study is to investigate the antimicrobial activity of Bacillus spp. against methicillin-resistant Staphylococcus aureus (MRSA) by analyzing 59 Bacillus spp. isolated from rice and spices using the agar well diffusion method in terms of their general inhibition effects on some MRSA isolates. Nine isolates were found to be effective against MRSA and their effects were compared with some antibiotics. The study showed that many Bacillus spp. has antimicrobial effect against MRSA3 which is resistant to all antibiotics except vancomycin. It has been found that Bacillus lentus is more effective against MRSA when compared with some antibiotics. Further studies may be required to assess the use of Bacillus lentus as therapeutic and bio preservative in food processing industry.Keywords: MRSA, Bacillus lentus, Antimicrobial peptides, Antibiotic, API-CHB-50.
Fatty Liver and Liver Malondialdehyde Expression in Severe Malnourished Wistar Rats that given Virgin Coconut oil Compared to Corn Oil in World Health Organization Formula I Gusti Ayu Putu Eka Pratiwi; Soetjiningsih .; I N. Mantik Astawa; I Gusti Ayu Trisna Windiani; I Gede Ngurah Harry Wijaya Surya
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Objective: There is a lack of antioxidant in severe malnutrition, and it may lead to increase oxidative stress. Fatty liver is one of severe malnutrition (SM) cardinal features. Virgin coconut oil (VCO) contains high antioxidant capacity and medium chain triglyceride. It is supposed to improve those problems. Methods: Posttest only control group design study was done to observe whether VCO could decrease fatty liver and liver malondialdehyde (MDA) expression in 38 male wistar rat with SM. The rats were divided into two group which were VCO Group (Group A) and Control Group (corn oil (Group B)). They were given feeding World Health Organization (WHO) Formula for SM (Formula 75 and Formula 100) that contained VCO or corn oil. After being SM, this formula was fed until 28 days. In the 29th day, they were sacrificed, and liver samples were obtained for fatty liver analysis and MDA expression. Results: Fatty liver was less in Group A (mean 13.74 cell in 5 view field (SD 1.32) than Group B (mean 20.74 cell in 5 view field (SD 2.01), and it was statistically significant (p=0.000). Cut off point for determining low and high liver MDA expression based on o ROC curve were <2.9% (low) and ≥2.9% (high). Low MDA expression (<2.9%) was higher in Group A than Group B (p <0.05). Conclusions: This study found less fatty liver and low liver MDA expression in severe malnourished rat given VCO than corn oil.  Keywords: Virgin coconut oil, Fatty liver, Malondialdehyde, Severe malnutrition.
Lipoprotein-Associated Phospholipase A2 Activity increase the Sensitivity of Framingham Score for detecting the incidence of Acute Myocardial Infarction in sub-population of Indonesian Male Patients Andi Wahjono; Saifur Rohman; Miryanti Cahyaningtias; Rina Yudha; Yanna Indrayana; Mifetika lukitasari; Rusdianto Rusdianto; Aditya Kurniawan; Djanggan Sargowo; Sasmojo Widito; Dadang Hendrawan; Jayarani Fatimah Putri; widodo Ph.D
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker of cardiovascular disease. Framingham score is currently a widely used risk stratification tool for detecting the incidence of acute myocardial infarction (AMI), although it is not very sensitive. Adding Lp-PLA2 to the Framingham score can raise the odds ratio (OR) for AMI, but requires further research.Objectives: In this study, we examine the role of Lp-PLA2 in increasing the sensitivity of the Framingham score for detecting the incidence of AMI.Methods: This study was a case-control study of 97 male patients, 60 of whom had AMI and were treated in the intensive care unit as test subjects, and 37 of whom were non-AMI patients with normal treadmill test used as controls.Results:Lp-PLA2 activity was found to be higher in the AMI group than that in the control group (83.97 ± 27.15 nmol/ml/min vs. 55.04 ± 31.99 nmol/ml/min). Eighteen patients (30%) with AMI were included in the high-risk category according to the Framingham score; this number increased to 36 patients after the addition of Lp-PLA2 activity to the Framingham score. Analysis using a receiver operating characteristic (ROC) showed a cut-off value for Lp-PLA2 activity associated with AMI of approximately 74.21 nmol/ml/min with an accuracy of 67%. The OR for detecting AMI incidence increased after the addition of Lp-PLA2 activity from 1:01 (CI 95%, 0.414–2.48) to 4.67 (CI 95%, 1.88-11.61).Conclusions:   The addition of Lp-PLA2 activity may increase the sensitivity of the Framingham score for detecting the incidence of AMI.
Investigating the Relationship between Organizational Memory and Management of Organizational Conflicts in Chaharmahal and Bakhtiari Social Security Staff Meisam Jamalzadeh
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Human resources, the most important and valuable factor, are from different sources of organization and conflict is a phenomenon that has positive and negative effects on the performance of individuals and organizations. The ability to deal with the conflict and its management is of a great importance to the success of the managers of the organizations. Therefore, the purpose of this study is to investigate the relationship between organizational memory and management of organizational conflicts among Chaharmahal and Bakhtiari social security staff. The research method is descriptive and survey method. The statistical population of this research includes all employees of Chaharmahal and Bakhtiari social security and the sample is 150 with Cochran formula. For measuring the variables, a researcher-made organizational memory questionnaire and Stefan Robbins organizational conflict management questionnaire were used. The reliability of the questionnaires was calculated using Cronbach's alpha method and validity of the questionnaire is confirmed by content method. Pearson correlation coefficient was used to analyze the data using SPSS 19 software. The results showed that there is a significant positive correlation between 5 components of organizational memory (personal skills, mental models, organization structure, data retrieval and information recording) and management of organizational conflicts among Chaharmahal and Bakhtiari social security staffs.Keywords: Organizational memory, Management of organizational conflicts, Social security organization.
Antimicrobial Resistance among Escherichia Coli Causing UTIs in Women Hawraa Wahab Aziz; Israa Adnan Ibraheam; Hawraa Sabah Almusawi; Zeana AL Hindi; Tsahel H. Al-Dulaimi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Urinary tract infections (UTIs) are common bacterial infections, particularly in women. E. coli is  one of the most frequently isolated  bacteria in (UTIs), , it also caused of childhood diarrhea, severe anemia, ,kidney failure, pneumonia, sinusitis and endocarditis. The current study tried to detecting Antimicrobial Resistance Among Escherichia coli Causing UTIs in women. Of the total 48 isolates of Escherichia coli, very high rates of resistance was seen with Ticarcillin 48 (100%), Piperacillin48 (100%), Aztreonam 46 (95.8%), Cefepime and 44 (91.6%)  Ceftazidime 44 (91.6%) . High rates of sensitive was seen with Imipenem 48 (100%), Meropenem 48 (100%), Amikacin 46(95.8%) , Gentamicin 32 (66.6%) , Piperacillin\Tazobactam 32(66.6%), Tobramycin 28 (58.3%) and ciprofloxacin 26(54.1%) , while of Minocycline 8 (16.6 %) has intermediate susceptibility to antibiotics study .According to the last results  the most effective antibiotics were Meropenem , Imipenem and Amikacin so they are considered the best drugs used for treatment of UTIs which caused by Escherichia coli.  Keywords: Antibiotics, E. coli, Urinary Tract Infection, Vitek, Antimicrobial Susstebility.
High Level of Uterine Endocervical Interleukin-8, Matrix Metalloproteinase-8, and Interleukin 1Β as a Risk Factor for Preterm Labor Suwardewa TGA; Suwiyoga K K; Mantik Astawa N; Sutirta Yasa IWP
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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The preterm birth is a birth that takes place on a gestational age between 20–36 weeks and six days. The preterm birth   is the leading cause of neonatal mortality and morbidity. Despite the current treatment procedures, the incidence of preterm birth has not changed in the last two decades. Incomplete understanding of the pathophysiological mechanisms underlying preterm labor is the major obstacle to prevent preterm birth. Recently, endocervical inflammation has been thought as a risk factor of a preterm labor. Several important substances such as endocervical IL-8, MMP-8, and IL-1β, has been considered to play a key role on preterm birth through cervical ripening. With those assumptions, the detection of a higher level of uterine endocervical IL-8, MMP-8, and IL-1β can be used to predict preterm labor. The design of this study is an observational case control study with a case group, which consisted of pregnant women with 20–36 weeks and six days of gestational age who had signs of labor, and the control group consisted of pregnant women with 20–36 weeks and six days of gestational age who had no signs of labor. The material used for this study is cervical mucous, and the enzyme-linked immunosorbent assay method was used to assess the level of IL-8, MMP-8, and IL-1β at laboratory of Veterinary Medicine of Udayana University Denpasar. In this study we used 48 samples, among which 24 were case group, and 24 as a control group. The mean age of the women, gestational age, and parity from both group are (27.04 vs 28.62 years old), (31.8 vs 29.50 weeks), and (0.96 vs 1.29) respectively, which are statistically homogenous (p > 0.05). Each level of interleukin-8, matrix metalloproteinase, and interleukin-1β suggests a risk factor of a preterm labor for: 35 times (OR = 35.00; CI 95% = 6.95–176.39; p = 0.001); 6.6 times (OR = 6.60; CI 95% = 1.25–34.95; p = 0.016), and 8.3 times (OR = 8.3; CI 95% = 2.15–32.3; p = 0.001), orderly. Among these cytokines, one that contributes most through a preterm birth is interleukin-8 (61%), followed by matrix metalloproteinase-8 (27%), and interleukin-1β (12%).Conclusion: Endocervical inflammation with high level of IL-8, MMP-8, and IL-1β is a risk factor for preterm labor. IL -8 gives the most contribution on preterm labor.Keywords: Preterm birth, Endocervical IL-8, MMP-8, and IL-1β.
The Relationship between Employees’ Work Commitment and Organizational Policies (Housing and Urban Development Office of Chaharmahal and Bakhtiari Province) Meisam Jamalzadeh
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Today, organizations' attention to maximize the capabilities of their employees has substantially grown. However, it should be noted that employees do not necessarily apply all their capabilities to accomplish the objectives of the organization. One of the most important reasons for this is the lack or shortage of organizational commitment of the staff. Accordingly, this study strived to investigate the relationship between employees’ commitment and organizational policies in the Housing and Urban Development Office of Chaharmahal and Bakhtiari province. The research method is applied in terms of the type of research and is a survey method in terms of data collection method. To achieve the research objectives, among from 456 employees of the Housing and Urban Development Office of Chaharmahal and Bakhtiari province, 243 individuals were selected as the study sample. Using a researcher-made questionnaire, employees' commitment and organizational policies were assessed. In order to test the research hypothesis, LISREL software and the structural equation modeling analysis method were used. The results of the study indicated the relationship between different components of organizational policies such as role clarity and role conflict with organizational commitment of the employees.Keywords: Employees’ Organizational Commitment, Organizational Policies, Housing and Urban Development.
Exotoxins A, T and S among Pseudomonas Aeruginosa Isolates from Clinical and Hospital Environment Samples Ahmed Jamal Hussein; Frial Gemeel Abd
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Pseudomonas aeruginosa is one of the most widely recognized Gram-negative   opportunistic pathogens related with nosocomial infections. The presence of several virulence factors, for example, exotoxins of the bacteria making a genuine risk to the patient. This study was intended to detect Exotoxin A, T and S genes in P. aeruginsoa isolates utilizing PCR system. It includes (30) isolates of bacteria diagnosed by traditional techniques and confirmed by the API 20Eand Vitek 2 Systems  , DNA isolated and subjected to amplify using specific primers for bacteria. The consequences of PCR amplification for the genes encoding for exotoxin A, T and S demonstrated that all P. aeruginosa isolates showed the presence of the genes encoding for exotoxin A and exotoxin T corresponding to 100 % of the isolates while twenty two (22) isolates comparing to 73.33 % of the total thirty (30) isolates were recorded to be positive for exotoxin S gene . It can be concluded that exotoxins are a conspicuous virulence factors for P. aeruginosa and responsible for a genuine threat to patients.Keywords: Exotoxin, Pseudomonas aeruginosa ,Toxin ,Environmental Isolate. 
Detect Heat Shock Protein 70 and Tumor Necrosis Factor Alpha in Obese Breast Cancer Patients Moaed E. Al-Gazally; Alaa S. Al-Awad; Sheerin H. Abbas
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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This study include the measurement of heat shock protein 70 (Hsp 70) and tumor necrosis factor alpha (TNF-α) in breast cancer(BC) by Enzyme-linked immunosorbent assay(ELISA) method. In addition, study the relationship between both (HSP-70 and TNF-α) with obesity≥ 30 Kg/M2 for patients (No.58) and controls (No.30) with age (20-50 years).Hsp-70 elevated while TNF-α decreased in obese BC patients. BC incidence is very low before age 25 and increases in age up 40 years. Increasing of BMI lead to increasing in the breast cancer incidence. Result Hsp-70 elevated statically significant where mean of Hsp-70(56.32 ± SD =18.78, p-value= 0.0001) while TNF-α decreased significantly where mean of TNF-α (163.81pg/ml ± SD = 64.94, p-value= 0.0001) in obese BC patients. The concentration of TNF insignificant decreased where), there is significant the obesity significant with BC patients (p-value = 0.048).Conclusion: Obesity is risk factor for BC. Concentration of Hsp-70increased while TNF-α decreased after Chemotherapy. 
The Effectiveness of Different Teaching Methods According to the Kolb Theory in Performance Accuracy of Some Basic Skills and Neuralgic Inhibition in Tennis Aqeel Yahya Hashim Abdulaziz; Zainab Nadhim Shakir Al. Gburi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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In an attempt to use modern techniques in learning skills and believing that there is a need to re-examine the method used and provide the potential for the student to obtain information from them to ensure the process of education and to change the methods that are widespread based on memorization and conservation and literal application and replace them with modern methods to ensure the development of thinking and creativity capabilities of teachers and students And to benefit from modern information and techniques , And experimenting through the effectiveness of different teaching methods in accordance with the patterns of the theory of the circle Kolb in the performance of the accuracy of some basic skills in tennis. The aim of the research was to identify the classification of students according to the Kolb theory and the different teaching methods suitable for each classification, and to identify the best groups that were used according to Kolb's theory of performing some basic skills in tennis. The researchers hypothesized that the use of various teaching methods according to "Kolb theory is positively effective in learning some basic skills in tennis. he fields of research were the human field: students of the Department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa, class III / for the academic year (2016 - 2017) .The period field from 1/11/2016 until 1/8/2017, and the spatial field ,in the internal gymnasium of the department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa . The researchers used the experimental method in the two groups (experimental) method. On this basis, the researchers selected the sample of the students from the third stage of the Department of Physical Education and Sports Sciences / Faculty of Education for Girls / University of Kufa with (25). After excluding (7) female students from the original society for their participation in the exploratory experiment, the sample was selected by 18 female students in the simple random way , Which was divided into two experimental groups according to the classification form of the theory of Kolb, which classified the sample to the practical and theoretical and according to the qualifications of each student, the first experimental group (the practical) (10) students and applied the method of solving problems in teaching basic skills in tennis , And the second experimental group (theorists) (8) students. The method of mental training in teaching was applied to the basic skills of the tennis game. The special units were prepared for each group after presentation to the experts and the preparation of the tools for experimental procedures such as computer use , video clips and strips educational, rackets and tennis balls, and form evaluating the performance of accuracy, was applied (8) educational units on the two sets of research experimental, by one unit for each week, as it has been implementing the teaching style of solving problems with the first experimental group (practically) and the style of mental training with the second experimental group (theorists), and the conclusions obtained between the results of tribal tests and dimensionality and there is a significant moral differences and in the interest posteriori tests and both sets, and either posteriori tests results were the absence of significant differences between the two groups differences The pilot, and the researchers recommended that the need to use Kolb's theory circle in teaching. Keyword: Methods and methods of teaching, Kolb theory, Learning patterns, Tennis and precision performance.

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