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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TICARGRELOR IN BULK AND COMPARISON WITH OTHER PUBLISHED METHODS BS Muddukrishna
Journal of Global Pharma Technology .
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Abstract

The following article consist of highly sensitive and easy RP-HPLC method to estimate Ticagrelor in bulk. Ticagrelor was separated using Shimadzu LC-20-AD with auto sampler and PDA/UV detector. The separation was achieved using a C18 Vydac Monomeric 120A (5.0 micron, 250 x 4.6mm) column. Acetonitrile: Water Milli Q (60:40 v/v) at a flow rate of 1.0 ml/min was used as the mobile phase. The method was linear having line equation f(x)=1.90442e-005*x-0.302059 with correlation coefficient (R2) of 0.997. The method was precise having  RSD as 0.27% (intraday precision). The LOD & LOQ were 0.083μg/mL and 0.25μg/mL respectively. The developed method was validated for precision, linearity, system suitability and robustness; hence proves that it is highly applicable to estimate Ticagrelor in day to day analysis.
Molecular Detection and Prevalence of, Cryptosporidium Parvum, Entamoeba Histolytica and Giardia Lamblia among Patients with Diarrhea at Al- Rifea city/Thi-Qar Province Bassad Akrab Al- Aboody
Journal of Global Pharma Technology .
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Abstract

Diarrhea  is defined as having extra stools than are usual for that individuals or as passage of watery stool for more than three times in 24 hours, caused by various pathogens such as  bacteria, viruses and parasites and protozoa consider as important causes of diarrhea and other gastrointestinal infections in humans they include mostly Cryptosporidium parvum, Entamoeba histolytica and Giardia lambella, this study aimed to determined the prevalence of parasitic agents in stool samples  of diarrheic  patients , this study is carried out in Thi –Qar Province / Al-Refaie district in Al-Refaie general Hospital which included collection of stool samples from diarrheic patients at a period extended from October / 2017 – January / 2018 , (96) stool samples taken from patients with different ages to both sexes examined by PCR technique. The results showed The percentage of positive samples were 63.5% while 36.5% was negative C. parvum (11.9%), E. histolytica (22.6%) and G. lamblia (65.5%), no significant statistical differences between males, females and between Urban and Rural areas while there was significant statistical differences between age groups (the highest rate in less than 1 – 10 years and lowest age group was (11 – 20 years).Keywords: Cryptosporidium parvumm, Entamoeba histolytica and Gardia lamblia, Polymerase chain reaction (PCR), Protozoa.
Synthesis, Identification, Theoretical and Experimental Studies for Carbon Steel Corrosion Inhibition in Sea Water for New Urea and Thiourea Derivatives linkage to 5-Nitro Isatin Moiety Suaad Mohammed Hussain Al-Majidi
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This research includes synthesis of some new  heterocyclic derivatives of 5-Nitroisatin namely 5-Nitro-3-(Ethyl imino acetate)-2-oxo indole (1), 5-Nitro-3-[(imino Aceto) urea]-2-oxo indole (2), 5-Nitro-3-[(imino Aceto)thiourea]-2-oxo indole (3), and 5-Nitro-3-[(imino Aceto) phenylthiourea]-2-oxo indole (4), and characterized by FTIR, 1H-NMR and  some physical properties. Theoretically, the inhibition efficiency parameters with physical properties were calculated to ensure for possibility using these compounds as inhibitors. Experimentally, studying the chosen compound of the corrosion inhibition efficiency for carbon steel in 3.5% NaCl solution by isatin derivative is chosen theoretically as the best inhibitor using potentiodynamic polarization.Keywords: Isatin derivatives, Schiff bases, Corrosion inhibitor, DFT quantum mechanical calculation.
The Accuracy of Brachial Artery Volume Flow as a Predictor of Brachiocephalic Arteriovenous Fistula Maturation Patrianef Darwis
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Objective: This study aims to investigate brachial artery volume flow accuracy in predicting AVF maturity. Methods: This was a cross-sectional study involving 80 patients that underwent AVF creation in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Parameters recorded include demographic data, ultrasound parameters in six weeks after AVF creation, and complications. Diagnosis tests were performed to determine the area under the curve (AUC), cut-off, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: Of 80 patients that underwent brachiocephalic AVF, we found that 64 (80%) successfully mature, and 16 (20%) failed to mature. Receiver operating characteristic (ROC) for brachial artery volume flow in predicting brachiocephalic AVF had AUC of 97,6 %. With cut-off brachial artery volume flow of 700 ml/minute, the sensitivity, specificity, PPV, NPV, and accuracy were 98.44 % (95 % CI 91.6-99.7%), 87.5 % (95 % CI 63,9 % - 96.5 %), PPV 96.9 % (95% CI 89.4-99.15%) NPV 84.6 % (95 % CI 66.5 % - 93.8 %) 93.33 % (95 % CI 70.1-98.8%), respectively. Conclusions: Brachial artery volume flow six weeks after AVF creation is an accurate parameter in predicting brachiocephalic AVF maturity. Keywords: brachial artery volume flow, maturity, arteriovenous fistula
Development of Health Saving Competence for University Students Valery Panachev
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The article reveals the author's approach to forming health-saving competence while studying at a university. The functions and principles of this competence formation are distinguished in the process of physical education, which will allow organizing the process of physical education at a higher level. Purpose of the study is to reveal features of forming health-saving competence of students in the process of physical education. The attainment of this goal is achieved with different theoretical and empirical method. Expanding functional connections and relations in educational work, we allocated functions of forming HSC for university students in the course of physical education. We have identified different principles and their use has allowed us to organize forming HSC on a higher level.Keywords: Functions, Principles, Components, and Psychological and Pedagogical Characteristics of Students' Health-Saving Competence Formation.
The Effect of Educational Tools Exercises on Certain Joints’ Angles in Javelin Performance and Achievement Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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Abstract

The study included a number of axes that concentrated on selecting the exercises used in the educational process by the physical education professors and mixing them using wires and plastic nets. These methods help achieving the goals of the educational exercises. The educational exercises included all the technical stages of the Javelin, and have simultaneously concentrated on its difficult aspects, since some of the stages require more than spears and medical balls, but rather tools that help the students learn the initial applications from holding the javelin to the release step, and help the students be precise with the track of the spear through the movement of the plastic, spear-like sticks in certain measurements through parallel-fixed wires, and curved-fixed as well. These tracks well help the students focus on how to perform in the technical stages without much thinking about carrying the tools or the gravity, and concentrate on struggling with steering the spear while running. After mastering the fixed tracks, the Javelin is now performed on the plastic nets. Then, the students do the Javelin using the legal tools on the legal field. The educational exercises along the helping tools were applied on the experiment group for four weeks, an average of two educational units per week. Then it was compared with the original group, and as the statistics show, the experimental group has exceeded the original group.Keywords: Educational exercises, Educational tools, Kinetic variables, Learning to perform.
Estimation of the Microscope Point Spread Function by Using an Adaptive Image Deblurring Method Hana H. Kareem
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

As one of the most widespread techniques in biological investigation and dynamic process, light compound microscopy has used to analyze the optical properties of biological images. The optical microscope is often used to study and analyze the structures of biological cells and tissues. Microscope images are characterized by a number of specific parameters. Blurring is a major cause of image degradation in optical microscopes. We present an adaptive deconvolution based on the Richardson–Lucy (RL) algorithm to restore micrographs corrupted by out-of-focus blur with parametric estimation of the point spread function (PSF) of the acquisition system by using the blind deconvolution algorithm. This technique improves the quality of digital micrographs with defocus blur effectively. The evaluation algorithm is implemented to improve image quality by removing out-of-focus blur. The algorithm proceeds by randomly generating the PSF at each generation by using non-reference image quality. The PSF is used to estimate the actual image by applying the adaptive RL algorithm. Experimental results show that the proposed blind deconvolution method can estimate the core of the PSF, make good-quality restorted images with a slight ringing effect even, when the image is hardly blurred, and select input images for the non-reference image quality method for deconvolution.Keywords: Image Processing, Image restoration, Point Spread Function, Deblurring, blind deconvolution.
Effects of Refined Sugar on Some Endocrine Glands Functions in Mice Rana Jaber Tarish Al-Baghdadi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Endocrine and nervous systems regulate blood glucose level in our bodies, but the reciprocal action yet to be addressed. To address this question, we employed the current study that included 24 mice of both sexes that were divided into control group that consumed standard mouse diet, a group that consumed high refined sugar diet (HS), a group that consumed high refined sugar and Vaccinium corymbosum L fruit powder diet (HSP). The study lasted for 3 months. The measured parameters included body weight gain, pancreas weight, glucose tolerance test and the leptin and thyroid hormone receptor gene expression. The results showed that the HS mice showed the highest body weight gain, pancreas weight, glucose blood level, and leptin gene expression. Most of those parameters went back to normal in the HSP group. In conclusion, the study reveals the deleterious effect of consuming refined sugar diet on the health and more specifically on the endocrine system response. The study shows that consuming refined sugar diet might be a precursor to initiate type 2 diabetes as a result of chronic high glucose level and insulin resistance. It also works as predisposing factor to develop obesity as the result shows high body weight gain and high leptin level indicating that the body develops leptin resistance as well. Keywords: leptin, Thyroid hormone, Refined sugar, Vaccinium corymbosum, Glucose.
The Effects of Local Alendronate with Biphasic Calcium Phosphate on Augmented Rabbit Sinus Zainab M. Hameed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Biphasic calcium phosphate   considered a good synthetic bone graft substitutes, and its effective role in sinus floor lifting. Alendronate (ALN) is a common formula of bisphosphonates that have potential effects to decrease the osteoclast differentiation. Aim of  study is -to evaluate histologic and histomorphometric effect of  local alendronate with  BCP  with  ratio( 30: 70)when used with  a  rabbit sinus. Materials and Methods:--8 male adult (New Zeeland) rabbits were selected. Sixsteen sinus floor, elevation procedures, were prepared, 2 on each animal and were distributed into two groups (n=4): the BCP group, where the sinus was grafted with, B CP with HA ׃β ̵ TCP (30 ׃70).And BCP/ALN group, where the sinus grafted with (OSTEON II), mixed with Alendronate solution, the solution was prepared by dissolving of 20 mg of ALN with 1 ml of distal water. The rabbits killed at 7, 14, 30 and 60 days after surgery and the histological   analysis were achieved. The histologic evaluation was performed using a light microscope. The new bone area represents the proportion of dark red area to the total augmented area, while the (FCT) represents the proportion of light red area to the total augmented area. Results: Although there  were significant differences  of  new  bone formation between two study groups after 7,14 and 30 days  periods ,but there's  non-significant differences occurred after 60 days . In addition, the FCT area was decreased in these two groups with the progressing healing periods, at the same time the FCT area was less in BCP/AL group; and there were   statistically nonsignificant differences between two groups after 60 days periods. Conclusions: - Local application of ALN with BCP with the (HA: β ̵ TCP (30:70)) ratio, did not have beneficial effects when augmented sinus rabbit model to increase bone formation. Keywords: Biphasic calcium phosphate; Alendronate; Rabbit maxillary sinus.
Association between Hypothyroidism and Herpes Simplex Virus with Interleukin-23 Sahar H. Al-Hindawi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Hashimoto’s thyroiditis and Hypothyroidism play a distinct role in the suppression and reactivation of herpes viruses. Herpes simplex virus infections have been assumed as one of the factors that may trigger autoimmune thyroid diseases; however, IL-23 has an important role in the pathogenesis of several inflammatory and autoimmune conditions. Objective: This study aimed to investigate the association between thyroid hormones in hypothyroid state and the Herpes simplex virus status in such patients; besides detecting the role of IL-23 in these cases. Materials and Methods: The present study included 65 Iraqi female hypothyroid patients with age ranged between 26-54 years and 25 healthy controls with age ranged between 25-50 years. Serum samples were collected from the study groups. Levels of thyroid hormones (TSH, T4, and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. The detection of herpes simplex virus IgG and IL-23 levels in the serum samples were determined by an enzyme linked immunosorbent assay (ELISA) kits. Results: The current study results revealed that serum IL-23 and HSV levels are increased significantly (P<0.001) in the hypothyroid patients group as compared with control. There was a significant positive correlation between TSH and (IL-23, HSV); also between IL-23 and HSV (P<0.01). Moreover, there was a significant negative correlations (P<0.01) between IL-23 with (T4, T3) and between HSV with (T4, T3).  Conclusion: The present study pointed to the association between thyroid hormones deficiency in Hashimoto thyroiditis cases and IL-23 levels through disruption of the patient’s immune system; and with Herpes simplex viruse-1by their role in the replication.Keywords: Hashimoto Thyroiditis, Hypothyroidism, Herpes Simplex Virus, IL-23.

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