The Journal of Society Medicine (JSOCMED)
The Journal of Society Medicine (JSOCMED) | ISSN (e): 2964-5565 is a leading voice in the Indonesia and internationally for medicine and healthcare. Published continuously, JSOCMED features scholarly comment and clinical research. JSOCMED is editorially independent from and its The Editor-in-Chief (EIC) is Prof. dr. Aznan Lelo, PhD, SpFK. JSOCMED offers many attractive features for authors, including free online access to all research articles, online publication ahead of print, and online responses to articles published as Quick Comments. In addition, as befitting a publication of the Journal of Society Medicine, JSOCMED implements best practice in scientific publishing with an open peer review process, declarations of competing interests and funding, full requirements for patient consent and ethical review, and statements of guarantorship, contributorship, and provenance.
Articles
193 Documents
<![CDATA[Relationship between Thioredoxin Reductase (TrxR) Levels and Melasma ]]>
<![CDATA[Risanti, Rinda Chindra]]>;
<![CDATA[Jusuf, Nelva Karmila]]>;
<![CDATA[Putra, Imam Budi]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 3 (2024): March ]]>
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DOI: 10.47353/jsocmed.v3i3.131
<![CDATA[Introduction: Melasma is a common condition of acquired hypermelanosis in dermatology that often occurs in areas of the body exposed to sunlight, especially the face. Thioredoxin Reductase (TrxR) is a key antioxidant system in defense against oxidative stress through disulfide reductase activity that regulates dithiol/disulfide protein balance. High levels/activity of TrxR correlate with melanin formation and tyrosinase activity which provides additional information about the role of cellular antioxidant proteins in melanogenesis which is suspected to be related to the occurrence of melasma. The aim of this study was to determine the relationship between TrxR levels and melasma Method: This study was an observational analytical study with cross-sectional design on 30 melasma patients and 30 controls. Each patient underwent anamnesis, dermatological examination, and blood sampling to assess TrxR levels by ELISA test. These data were analyzed statistically using the Mann Whitney test. Results: This study shows that the most common distribution pattern of melasma was centrofacial in 24 people (80%). The mean TrxR level in melasma was 12.73±11.66 ng/ml. The results of the study showed that there was a relationship between high TrxR levels and melasma (p<0.001). The TrxR mean level based on the duration of suffering from melasma at <5 years was 11.4±2.89, and ≥ 5 years was 14.0±3,18 Conclusion: There is a relationship between TrxR levels and melasma.]]>
<![CDATA[Relationship between Plasma Fibronectin Levels and Stretch Marks ]]>
<![CDATA[Syahputri, Fitriend]]>;
<![CDATA[Imam Budi Putra]]>;
<![CDATA[Nelva K. Jusuf]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 4 (2024): April ]]>
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DOI: 10.47353/jsocmed.v3i4.132
<![CDATA[Introduction: Stretch marks or striae distensae are linear atrophic scars that form in areas of skin damage as a result of skin stretching. Mast cell degranulation and activation of macrophages occur as well as changes in the components of the extracellular matrix, including fibronectin. Fibronectin as a dimeric glycoprotein and components contained in the extracellular matrix, functions as a regulator of cellular processes, to maintain tissue and functions in the process of wound healing in tissues. The aim of this study was to determine the relationship between plasma fibronectin levels and stretch marks Methods: This study was an observational study with a cross-sectional design of 40 females with stretch marks and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess plasma fibronectin levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean plasma fibronectin level in stretch marks was 259.541±165.937 ng/ml. The highest age with stretch marks was 18–25 years 33 (82.5%) people. Most of them had a family history of stretch marks from their mother 20 (50%) people. The majority of stretch marks are located on gluteus regions by 10 people (25%). The result of this study showed that there was a relationship between plasma fibronectin levels causing a risk of 2.85 times for stretch marks (p = 0.041). Conclusion: There is a relationship between plasma fibronectin levels and stretch marks.]]>
<![CDATA[Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite ]]>
<![CDATA[Annisa Astari]]>;
<![CDATA[Putra, Imam Budi]]>;
<![CDATA[Jusuf, Nelva Karmila]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 3 (2024): March ]]>
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DOI: 10.47353/jsocmed.v3i3.133
<![CDATA[Introduction: Cellulite is a local metabolic disorder in subcutaneous tissue characterized by changes in skin topography, occurring in parts of the body with a large accumulation of fat tissue, especially thighs, buttocks, hips, and abdomen. Angiotensin converting enzyme is a zinc metallopeptidase, distributed on the surface of endothelial cells. Increased ACE levels cause microcirculation disorders, adipocyte hypertrophy, increased extracellular matrix, and stimulate the emergence of inflammatory cytokines which will cause an increase in the inflammatory response in the tissue, stimulate fibrogenic response and influences the appearance of cellulite. The aim of this study was too determine the relationship between ACE and cellulite. Method: This study was an observational study with a cross-sectional design of 40 cellulite patients and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess ACE levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean ACE level in cellulite was 66.78±15.38 µg/ml. The highest age with cellulite was 26–35 years 17 subjects (42.5%). Most of them had a family history of cellulite from their mother 22 subjects (55%). The majority of cellulite are located on the femoral and gluteus regions by 27 subjects (67.5%). The result of this study showed that there was a relationship between high ACE levels causing a risk of 4.5 times for cellulite (p = 0.002). Conclusion: There is a relationship between ACE levels and cellulite.]]>
<![CDATA[Relationship between QTc interval prolongation and mortality of acute ischaemic stroke patients during treatment and three months after treatment at Adam Malik Hospital ]]>
<![CDATA[Lubis, Al-Ma’ Arij Akbar]]>;
<![CDATA[Andra, Cut Aryfa]]>;
<![CDATA[Ketaren, Andre Pasha]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 3 (2024): March ]]>
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DOI: 10.47353/jsocmed.v3i3.135
<![CDATA[Introduction: QTc interval prolongation is associated with an increased risk of mortality and incident cardiocerebrovascular disease in high-risk individuals and the general population. In addition, QTc interval prolongation in patients with acute stroke is associated with a significantly greater risk of death within 3 months. Based on the description in the background above, this study aims to determine how the relationship of QTc interval prolongation to mortality in acute ischaemic stroke patients during treatment and three months post-treatment at H. Adam Malik Hospital Medan. Method: This study was an analytical study with a case control research design to determine the relationship of QTc interval prolongation to mortality in acute ischaemic stroke patients during treatment and three months post-treatment at Adam Malik Hospital Medan. The research time was carried out in March 2023 by taking a sample of cases from January 2021 to December 2022. The association of QTc interval prolongation with mortality of acute ischaemic stroke patients during treatment and three months post-treatment was analysed by Chi-square test. The statistical significance threshold used was p < 0.05. Results: In patients who died, the mean QTc interval was 490 ms (453.0 - 547.0 ms). Comorbidities in this study included 27 (32.9%) patients with Type 2 DM, 42 (51.2%) patients with hypertension, 7 (16.6%) patients with chronic kidney disease, 13 (15.8%) patients with atrial fibrillation, 1 (1.21%) with pneumonia, and 1 (1.21%) with upper feeding tract bleeding (PSMBA). Conclusion: QTc interval prolongation is associated with mortality in acute ischaemic stroke patients during treatment and three months post-treatment at H. Adam Malik Hospital Medan]]>
<![CDATA[The Relationship between Myocardial Strain Using 2D Speckle Tracking Echocardiography and Coronary Lesion Severity Measured by Syntax Score in Patients with Chronic Coronary Syndrome at Haji Adam Malik Hospital ]]>
<![CDATA[Purba, Antonius Leonardo]]>;
<![CDATA[Akbar, Nizam Zikri]]>;
<![CDATA[Sarastri, Yuke]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 4 (2024): April ]]>
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DOI: 10.47353/jsocmed.v3i4.137
<![CDATA[Introduction: Coronary heart disease continues to be the leading cause of morbidity and death worldwide. The cardiac dysfunction known as chronic coronary syndrome is caused by atherosclerosis-related obstruction or constriction of coronary arteries. Currently, One interesting non-invasive technique is GLS assessment, which has shown to be useful in predicting coronary lesions in chronic coronary syndrome patients. This study aims to evaluated the correlation between myocardial strain based on 2-D Speckle-Tracking Echocardiography and the severity of coronary lesions in chronic coronary syndrome patients at Haji Adam Malik Hospital Medan Method: This research is an analytical observational study with a cross sectional design on patients who diagnosed with chronic coronary syndrome and treated at H Adam Malik General Hospital Medan which met the inclusion and exclusion criteria. Sampling was carried out starting in January to December 2023. In bivariate analysis, the Fisher Exact test is used if the data is not normally distributed, and the chi square test is used if the data is normally distributed. P values less than 0.05 indicate statistical significance in data analysis using computer statistical methods. Results: Myocardial global longitudinal strain (GLS) based on 2-D Speckle-Tracking Echocardiography was significantly associated with the severity of coronary lesions as measured by syntax score in chronic coronary syndrome patients (p value 0.0001, OR 2.732, 95% CI 1, 81-4,11). As a predictor of coronary lesions severity based on the Syntax score in patients with chronic coronary syndrome, the global longitudinal strain (GLS) cut-off value of -17.37 demonstrates a sensitivity of 92.9% and a specificity of 83.6%. Conclusion: Myocardial global longitudinal strain (GLS) with a cut-off value of -17.37 can be used as a predictor coronary lesions severity in chronic coronary syndrome patients with a sensitivity of 92.9% and a specificity of 83.6%.]]>
<![CDATA[Correlation of P Wave Dispersion and Quality of Life of Heart Failure Due to Coronary Heart Disease Patient in Haji Adam Malik General Hospital ]]>
<![CDATA[Hillary, Lastri]]>;
<![CDATA[Nasution, Ali Nafiah]]>;
<![CDATA[Lubis, Anggia Chairuddin]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 4 (2024): April ]]>
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DOI: 10.47353/jsocmed.v3i4.138
<![CDATA[Introduction: P wave dispersion is a more sensitive cardiovascular marker which obtained by the ECG to elaborate structural and electrophysiological abnormalities in patients. This study aims to elucidate P wave dispersion prevalence in heart failure due to coronary heart disease patients and the correlation with their quality of life. Method: This analytical cross-sectional study is done in RSUP Haji Adam Malik in 133 patients with heart failure from May to June 2023. Patients had undergone clinical evaluation, physical examination, 12-lead electrocardiography (ECG), and then were given the MLFHQ to assess the quality of their lives. Data were analyzed using fischer-exact test, with p value less than 0.05 considered to be significant. Results: From the total of 133 sample of patients, there were 55 (43.2%) patients with positive p wave dispersion, among them 2 had low quality of life, 25 had moderate quality of life, and 28 had good quality of life. With mean of PWD is 27.9±15.1 ms. The group of patient with negative p wave dispersion 78 had moderate and good quality of life. P value is less than 0.01. It’s concluded that there was a positive correlation between p wave dispersion and quality of life of heart failure patients in Haji Adam Malik general hospital Conclusion: There is positive correlation between p wave dispersion and quality of life of heart failure due to coronary heart disease patients in Haji Adam Malik general hospital.]]>
<![CDATA[Relationship between Atherogenic Index of Plasma (AIP) and Mayor Cardiovascular Event (MACE) in Patients with Acute Myocardial Infarction (IMA) with Percutaneous Coronary Intervention (PCI) in Haji Adam Malik Hospital ]]>
<![CDATA[Ramzi, Defriyan]]>;
<![CDATA[Hasan, Refli]]>;
<![CDATA[Safri, Zainal]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 5 (2024): May ]]>
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DOI: 10.47353/jsocmed.v3i5.139
<![CDATA[Introduction: Atherogenic index of plasma (AIP) is a new biochemical parameter closely related to lipid metabolism in the body as a risk factor in atherosclerosis and coronary heart disease. This study aimed to determine whether AIP values could be used to predict major cardiovascular events (MACE) in the treatment period of ACS patients undergoing primary percutaneous coronary intervention processes. Methods: This study was an observational analytical study with retrospective data collection method. Patients who experienced ACS at RSUP Haji Adam Malik Medan and undergo IKP starting from April 2023 will be collected. Basic characteristic data including laboratory parameters and AIP values as well as MACE events were be collected. Data analysis were carried out whether there are differences in AIP values in MACE and Non-MACE patients, and predictive ability will be assessed through ROC/AUC curve analysis, and sensitivity and specificity values will also be obtained. Results: A total of 69 samples were obtained. A total of 25 patients (36.2%) experienced MACE. The most prevalent MACE in this study was death from all causes as many as 17 patients (24.6%). AIP value can be used as a predictor of MACE events: Death of All Causes (Cut Off value: 0.505; AUC: 0.673; P = 0.033; 95% CI 0.537 – 0.809; Sensitivity 64.7%; Specificity 59.6%), Acute Heart Failure (Cut Off value: 0.502; AUC: 0.695; P = 0.029; 95% CI 0.551 – 0.839; Sensitivity 69.2%; Specificity 60.7%), and Malignant Arrhythmia (Cut Off value: 0.582; AUC: 0.758; P = 0.026; 95% CI 0.578 – 0.938; Sensitivity 71.4%; Specificity 75.8%). Conclusion: The AIP index can be a good predictor of the incidence of MACE in ACS patients undergoing primary percutaneous coronary intervention.]]>
<![CDATA[Monocyte to High-Density Lipoprotein Ratio (MHR) as A Predictor of Major Cardiovascular Events in Acute Myocardial Infarction Patients with ST-Segment Elevation in Patients Undergoing Primary Percutaneous Coronary Intervention at Haji Adam Malik Central General Hospital ]]>
<![CDATA[Nikensari, Grace]]>;
<![CDATA[Nasution, Ali Nafiah]]>;
<![CDATA[Siregar, Abdullah Afif]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 5 (2024): May ]]>
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DOI: 10.47353/jsocmed.v3i5.140
<![CDATA[Introduction: IMA-EST is a cardiovascular disease with high mortality and morbidity. Therefore, tools (markers) to efficiently predict mortality rates are essential to reduce these rates for effective management. Since most of the available literature suggests that MHR value can be used as a predictor of MACE, we are interested in examining MHR as a predictor of MACE in IMA-EST patients undergoing primary PCIMethods: This type of study was an observational analytic study with the research design used is an ambispective cohort. namely assessing the role of MHR Ratio as a predictor of prognosis after primary MACE in IMAEST patients. This study was conducted at HAM Hospital Medan from April-June 2023. Patients who met the inclusion and exclusion criteria were assessed for laboratory parameters such as triglyceride levels and calculated MHR index, then MACE was observed in patients who underwent primary IKP. The MACE assessed was cardiovascular death, malignant arrhythmia, cardiogenic shock, and acute heart failure during hospitalisation and 30 days post-treatment either through control at the polyclinic or by telephone and interview. Results: A total of 55 samples were obtained. The GRACE Score and MHR parameters have an area under the ROC curve > 0.7. The MHR parameter had a sensitivity of 69.2% and specificity of 64.3% and a p value <0.05. Based on ROC curve analysis, the cut-off-point parameter for estimating predictors of MVC was 22.48. The GRACE Score coefficient is 0.466 with a significance value (p value) of 0.001 that there is a correlation between the GRACE Score parameters and MHR parameters. Conclusion: High monocyte counts have an association of low HDL-C levels in the development of atherosclerosis and MACE.]]>
<![CDATA[Case Series of Guillain Barre Syndrome with Plasmaparesis in The ICU Bandung Hospital ]]>
<![CDATA[Ridwan, Romi]]>;
<![CDATA[Oktaliansyah, Ezra]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 4 (2024): April ]]>
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DOI: 10.47353/jsocmed.v3i4.141
<![CDATA[Background: Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system, which is clinically characterized by tetraplegia with or without sensory disturbances. Manifestations include weakness, progressive muscle areflexia and can cause weakness in the respiratory muscles. This causes sufferers to need mechanical ventilation assistance. ICU complications such as lung infections and sepsis occur if treatment is prolonged. Plasmaparesis in GBS is a therapy other than IVIG (IntraVenous ImmunoGlobulin) administration. Case report: We compared 2 cases, 42 years old (man A) and 31 years old (man B), with respiratory failure due to GBS were treated with plasmaparesis for 5 cycles. Patient A showed faster clinical improvement results. It took 6 days to get off mechanical ventilation on patient A, while on day 11 patient B still needed mechanical ventilation, with persistent tetraparesis. Conclusion: This case highlights the importance of using TCD and NIRS in the intensive care unit as guiding therapies in maintaining patient blood pressure, administering blood components, and early detection of complications such as cerebral vasospasm.]]>
<![CDATA[The Relationship between Age and Cerebral Atrophy on Head CT-Scan Examination at Haji Adam Malik General Hospital Medan ]]>
<![CDATA[Imansyah, Ade Nur]]>;
<![CDATA[Daulay, Elvita Rahmi]]>;
<![CDATA[Surbakti, Khairul Putra]]>
<![CDATA[ Journal of Society Medicine Vol. 3 No. 5 (2024): May ]]>
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DOI: 10.47353/jsocmed.v3i5.142
<![CDATA[Introduction: Cerebral atrophy is a condition associated with brain volume reduction and is a common manifestation of aging. Age is an important factor in the incidence of cerebral atrophy. This research aims to know the relationship between age and the incidence of cerebral atrophy in patients at H. Adam Malik General Hospital Medan. Methods: This study is an observational analytic study with a cross-sectional design conducted at the Haji Adam Malik General Hospital Medan by collecting head CT scan data from the electronic medical records of 91 patients with the period January 1st 2021 to December 31st 2022. The research time will be carried out from October 2022 to December 2023. Results: Cerebral atrophy began to be found in the age group of 20-39 years, the largest gender was male (56%), the highest level of education in patients with cerebral atrophy was elementary school / equivalent (66.7%) and D1 to D3 (66.7%), and from the area of residence, patients who experienced cerebral atrophy mostly lived in urban areas (58.7%). The age of onset of cerebral atrophy was found to be 20 years old. The types of cerebral atrophy found in the study subjects were cortical atrophy as many as 49 people (53.8%) and global atrophy as many as 10 people (11%). There was no significant relationship between age and the incidence of cerebral atrophy in patients at H. Adam Malik General Hospital (p> 0.05), but there was a significant relationship between age group and the incidence of cerebral atrophy in patients at H. Adam Malik General Hospital (p < 0.05). Conclusion: There is no significant association between age and the incidence of cerebral atrophy in patients at Adam Malik General Hospital. Additional research is needed to gain a comprehensive understanding of cerebral atrophy and its relationship with other risk factors.]]>
