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PharmaCine : Journal of Pharmacy, Medical and Health Science
Published by Universitas Singaperbangsa Karawang
ISSN : 27464199     EISSN : 27464199     DOI : https://doi.org/10.35706/pc.v3i2.8034
Core Subject : Humanities, Health, Science,
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
PharmaCine: Journal of Pharmacy, Medical and Health Science merupakah media untuk publikasi ilmiah mengenai aspek farmasi, medis dan kesehatan. PharmaCine diterbitkan 2 kali dalam setahun sebagai wadah untuk mahasiswa, farmasis, tenaga medis dan tenaga kesehatan lainnya dalam update keilmuan dan bahan literatur ilmiah. PharmaCine mempublikasikan artikel meta analisis, artikel penelitian, artikel review, dan laporan kasus. Artikel yang masuk diperiksa oleh mitra bestari (peer-reviewed) yang sesuai dengan bidang keilmuannya. Ruang Lingkup: Ruang lingkup Jurnal PharmaCine meliputi aspek farmasi, medis dan kesehatan dengan topik sebagai berikut: Farmakologi, Farmakoterapi, Farmasi Klinik, Teknologi Farmasi, Farmasi Herbal, Farmasi Sosial , Manajemen Farmasi, Biokimia Klinik, Farmakogenetik, Kimia Farmasi, Biologi Farmasi, Ilmu Kesehatan Masyarakat (Public Health)
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 69 Documents
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Studi Kasus Peraturan Pemerintahan Republik Indonesia No.51 Tahun 2009 tentang Pekerjaan “Kefarmasian Apoteker di Jombang Diduga Langgar Kode Etik Kefarmasian”: Case Study of Government Regulation of The Republic Of Indonesia No.51 of 2009 Concerning Pharmaceutical Work “Pharmacist in Jombang Suspected of Violating Pharmaceutical Code of Ethics” Wulandari, Sophy; Ramadhani, Rima Putri; Hidayat, Muhammad Naufal Nurhadi
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 5 No 2 (2024): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v5i2.12235

Abstract

Bacakground: Pharmacists are health workers who have important responsibilities in drug management. However, there are still many violations of the code of ethics and lack of understanding of the regulations governing pharmaceutical practices, which can potentially endanger patients. Aim: This study aims to analyze the impact, sanctions, and legal protection related to the provision of expired drugs to patients. Method: The method in this research is qualitative descriptive analysis. The author collected data from various sources, including relevant regulations, case studies, and academic literature, to assess pharmacists' compliance with applicable pharmaceutical regulations. Results: Many pharmacists have not fully complied with existing regulations, especially in terms of drug management and storage. The findings also indicate the need for stricter law enforcement as well as increased training for pharmacists in understanding ethics and regulations. Conclusion: dispensing expired medicines has the potential to cause serious health impacts, including decreased drug efficacy and increased risk of side effects for patients. To address violations in the management of expired drugs, the relevant regulations provide for strict law enforcement as a sanction for violators, so as to encourage compliance with existing standards. In addition, legal protection for patients is stipulated in the law, which guarantees their right to obtain safe and quality medicines, in accordance with established quality standards. Keywords : Expired medication; pharmacy code of ethics; pharmaceutical work
Formulasi Pemanfaatan Ekstrak Daun Pepaya (Carica papaya L.) Sebagai Pestisida Nabati: Papaya Leaf Extract Utilization Formulation (Carica papaya L.) as a Pesticide Vegetable Sukmawati, Sukmawati; Ameliawati, Ameliawati
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 5 No 2 (2024): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v5i2.12245

Abstract

Background: Many people do not understand how to use synthetic pesticides so that they can be harmful to humans. The use of pesticides made from nature can be a solution for the community, not only materials that are easily available but also ingredients that are safer because they use natural ingredients. Papaya leaves (Carica papaya L.) contain saponin and flavonoid compounds where these compounds can cause the death of pests.  Aim: This study aims to formulate it in pesticide preparations and then evaluate it so that it can be seen that the concentration of pesticide preparations is good  Method: This type of research is experimental in the laboratory by making 3 formulas consisting of F1 with a concentration of 8% papaya leaf extract, F2 12% and F3 16%. The tests include organoleptic, homogeneity and pH. Result: The results showed that the organoleptic tests carried out on all formulations did not have much difference, starting from the smell and shape they both had a liquid form, a distinctive smell of papaya leaves, only the concentrations from small to large experienced a brown to greenish-brown color. The homogeneity test results from the three formulations were not homogeneous and the pH test results were the more extracts, the higher the pH value. Conclusion:. Papaya leaf extract with concentrations of 8%, 12%, and 16% can be formulated in the form of pesticide preparations. Keywords: Excessive Synthetic Pesticides, Papaya Leaves (Carica papaya L.), Pesticides, Pests
Perbandingan Pertumbuhan Jamur Aspergillus fumigatus pada Media PDA (Potato Dextrose Agar) dengan Alternatif Media dari Tepung Sagu Rumbia (Metroxylon Sagu): COMPARISON OF THE GROWTH OF ASPERGILLUS FUMIGATUS MUSHROOMS ON PDA MEDIA (PotatoDextrose Agar) WITH ALTERNATIVE MEDIA FROM RUMBER SAGO FLOUR (Metroxylon sago) Asdinar, Asdinar; Asrawati, Asrawati; Adam, Adam
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 5 No 2 (2024): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v5i2.12333

Abstract

Background: Aspergillus fumigatus is a fungus that causes an opportunistic disease called Aspergillosis. Most tests used to determine the cause of fungal infections are carried out using the culture method. A popular growth medium for fungi is PDA media, which contains potato extract which is a source of carbohydrates. So that a substitute medium can be made that contains carbohydrates, sago flour is the highest carbohydrate producer, namely 84.7 grams per 100 grams of sago flour. Aim: To determine the comparison of the growth of Aspergillus fumigatus fungi on PDA media (potato dextrose agar) with alternative media from sago starch (Metroxylon sago). Method: This research methodology is pure experimentation with posttest only with control group design. Using the fungal culture method, with PDA media as control + and alternative media of sago starch sold at the Lambocca traditional market, Bantaeng, as test media with 3 concentration variants, namely concentrations of 12%, 14% and 16%. Result: Based on the findings of the research carried out, it can be concluded that five times the Aspergillus fumigatus treatment group was able to grow fungus which was grown in alternative media with concentration variants of 12%, 14%, 16%, and positive control. Conclusion: Media made from sago starch can be used as an alternative medium for growing Aspergillus fumigatus fungi. By looking at the average diameter of fungal colony growth at a concentration of 16% with an average of 10.85 mm, a concentration of 14% which is 9.3 mm and a concentration of 12% which is 7.5 mm. with the results of statistical tests, the p value = 0.000, which indicates there is a significant difference. Keywords: Aspergillus fumigatus, PDA, Sago flour
Uji In Silico Interaksi Senyawa Tropis Alami dan Sintetik Terhadap Protein Bcl-2 Sebagai Agen Antikanker Payudara: In Silico Study of Tropical and Synthetic Compounds Targeting Bcl-2 Protein as Breast Cancer Therapeutic Agents Therisia, Stefany; Masriani, Masriani
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13137

Abstract

Breast cancer remains the leading cause of death among women worldwide. Resistance to chemotherapy and adverse effects of conventional treatments have driven the search for alternative therapeutic agents derived from natural compounds. One of the key molecular targets involved in cancer cell apoptosis is the Bcl-2 protein family. This study aimed to systematically review in silico molecular docking studies of natural compounds from tropical plants and synthetic molecules targeting the Bcl-2 protein as potential therapeutic agents for breast cancer. A total of 21 original research articles published in the last five years were analyzed based on the source of compounds (plant-derived or synthetic), active constituents, protein database (PDB) codes, and binding affinity values. The results indicated that most compounds demonstrated strong inhibitory potential against Bcl-2, with notable examples such as Niaziminin B from Moringa oleifera (−14.96 kcal/mol) showing one of the highest binding affinities. This review highlights the potential of natural compounds from tropical plants and synthetic molecules as promising candidates for breast cancer therapy through Bcl-2 inhibition. Further in vitro and in vivo studies are required to confirm their biological activity and toxicity profiles in the drug development process. Keywords: Breast cancer; Bcl-2; Molecular docking; Tropical plants; Synthetic compounds.
Pengaruh Variasi Konsentrasi Cera Alba sebagai Stiffening Agent pada Lip Balm Ekstrak Buah Parijoto (Medinilla speciosa Blume): The Effect of Cera Alba Concentration Variations as a Stiffening Agent in Parijoto Fruit (Medinilla speciosa Blume) Extract Lip Balm Dewi, Sinta Mutiara; Endriyatno, Nur Cholis
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13174

Abstract

Parijoto fruit extract has antioxidant activity with an IC50 value of 19.73 ppm. Parijoto extract needs to be formulated into a lip balm to maximise its potential. Lip balm preparations require a stiffening agent used to maintain shape, texture, and stability. The stiffening agent used in this study is cera alba. The aim of this research is to determine the effect of varying concentrations of cera alba as a stiffening agent on the physical properties of lip balm preparations made from parijoto fruit extract (Medinila speciosa Blume). This research is an experimental study. The parijoto fruit extract was prepared by maceration extraction using 96% ethanol. The preparations were made with 3 formulas with different concentrations of cera alba as a stiffening agent: FI (10%), FII (15%), and FIII (20%). Subsequently, physical tests of the lip balm preparations were conducted, including organoleptic tests, pH tests, homogeneity tests, adhesion tests, spreadability tests, viscosity tests, moisture content tests, and irritation tests. The results of the physical property analysis of the lip balm preparations were analysed descriptively and inferentially using statistical software with one-way ANOVA and post hoc Tukey tests. Based on the results, the variation in cera alba concentration as a stiffening agent influences the physical properties of the lip balm extract from parijoto fruit (Medinila speciosa Blume), including pH, viscosity, adhesion, and spreadability, but does not significantly affect moisturising ability. In this study, FI with 10% cera alba concentration was established as the best formula based on the fulfilment of all physical property tests (pH, viscosity, adhesion, spreadability) and the statistical test results. Keywords: Parijoto fruit; Cera alba; Lip balm; Stiffening agent.
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Pratama, Reza; Simamora, Boy Ignatius; Oktriyani, Anissa Nadya
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Pemanfaatan Umbi-Umbian sebagai Bahan Pengisi dalam Pengembangan Pakan Ikan Berbasis Nutrisi Alami: Utilization of Tubers as Filler Ingredients in the Development of Natural Nutrition-Based Fish Feed Haetami, Kiki; Budiana, Yoga Nugraha; Abun, Abun
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13186

Abstract

Freshwater fish feeds are typically high in protein (>25%), creating a need for cost-effective carbohydrate fillers that do not compromise growth performance. Tuber crops (cassava, taro, sweet potato, potato) are promising carbohydrate sources; however, antinutritional factors and processing methods largely determine their success. This review searched literature on Google Scholar. Inclusion criteria were studies on aquaculture fish species that reported at least one performance outcome (growth/SGR, FCR, PER) or digestibility, and that specified the tuber organ/material and the applied processing. Exclusion criteria were non-aquatic studies, studies without performance/digestibility data, and non-scholarly secondary sources. Two reviewers screened independently, with disagreements resolved by consensus. A narrative/thematic synthesis was conducted. Fermentation and/or heat processing consistently reduced antinutritional factors and improved starch digestibility. In tilapia and catfish, carbohydrate substitution from tubers was generally safe at ~20–30% of diet carbohydrates without significant deterioration in SGR/FCR when adequate processing was applied; higher inclusion levels depend on species, life stage, and detoxification intensity. Tuber crops are therefore promising filler ingredients, particularly when preceded by fermentation. Practically, a 20–30% substitution can serve as a starting point for formulation, followed by optimization by species and production stage. Keywords: Tuber crops; Filler materials; Spare protein; Processing; Aquaculture.
Optimasi Formula Granul Effervescent Ekstrak Rimpang Temu Putih (Curcuma zedoaria) dengan Variasi Pemanis Alami sebagai Antioksidan: Optimization and Antioxidant Evaluation of Effervescent Granules Containing White Turmeric (Curcuma zedoaria) Rhizome Extract with Natural Sweeteners Zaelani, Diki; Awaliyah, Ratu Siti Robiatul; Santoso, Rahmat; Emawati, Emma; Pratama, Reza
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13193

Abstract

White turmeric (Curcuma zedoaria), a member of the Zingiberaceae family, contains bioactive compounds with antioxidant potential, but its utilization remains limited due to its bitter taste and less practical traditional preparations. This study aimed to optimize the formulation of effervescent granules containing white turmeric rhizome extract using different natural sweeteners and to evaluate their physical properties and antioxidant activity. The effervescent granules were prepared by the wet granulation method using stevia (F1, 17.5%), palm sugar (F2, 10%), and corn sugar (F3, 14.5%) as sweeteners. The granules were evaluated for physical characteristics (organoleptic properties, moisture content, flow rate, angle of repose, dissolution time, pH, foam height, and hedonic test) and antioxidant activity using the DPPH method both qualitatively and quantitatively. The results showed that all formulas met the standard physical requirements of effervescent granules. The best formulation was obtained from F3 (corn sugar) with the highest acceptance score in the hedonic test. The antioxidant activity of white turmeric extract exhibited an IC₅₀ value of 53.53 ppm, while the effervescent granules showed strong antioxidant activity with IC₅₀ values of 62.53 ppm (F1), 62.62 ppm (F2), and 62.79 ppm (F3). These findings indicate that variations in natural sweeteners influence the sensory characteristics without significantly reducing the antioxidant potency of the formulation. Keywords: Effervescent granules; Curcuma zedoaria; Natural sweeteners; Antioxidant, Formulation optimization.
Evaluasi Pasca Pelatihan Pada Pelatihan Penugasan Khusus Tenaga Kesehatan Berbasis Tim (Tugsus) di Puskesmas Tahun 2024: Post-Training Evaluation of Team-Based Special Assignment (Tugsus) at Primary Health Centers in 2024 Rahman, Fauzi; Anisah, Ani; Prameswari, Kania
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13250

Abstract

Indonesia faces significant challenges with the uneven distribution of human resources for health (HRH), especially in Disadvantaged, Border, and Outermost Areas (DTPK). To address this, the Ministry of Health launched the Team-Based Special Assignment (Tugsus) program, supported by targeted training for health workers. This study aimed to evaluate the implementation of this training after its completion, focusing on the relevance of the training materials, their application in the field, and the impact of Tugsus teams on the performance of Primary Health Centers (PuskesmasThis study employed a cross-sectional evaluation design conducted in a single data collection phase. The approach used was a mixed method, combining qualitative and quantitative approaches, the study was conducted from April 28 to May 07, 2025. Data were gathered via online questionnaires 188 of 240 program alumni (Batches 27-29), 33 supervisors, and 59 colleagues. Results indicate that the training materials are highly suitable (average 91. 31%) for practical needs and are widely applied (average 94. 33%). The highest application rates are seen in soft skills, such as Coaching (98. 40%), and routine activities, like Posyandu (99. 47%). In contrast, application of systemic topics, such as Accreditation (85.64%), is somewhat lower. The presence of Tugsus teams shows a significant positive effect, mainly by filling critical HRH gaps. However, a gap remains between the ideal concepts taught during training and the realities faced in the field, primarily due to structural barriers like limited local HR and facilities. The evaluation results show that this training provides participants with relevant competencies, but to enhance the program's future impact, there should be a focus on strengthening the capacity of the Puskesmas system to adopt innovations, rather than solely emphasizing individual competencies. Keywords: Post-Training evaluation; Team-Based special assignment; Primary health center.

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