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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 4 (2023)" : 60 Documents clear
Uji antibakteri gel hand sanitizer ekstrak daun bawang (Allium fistulosum) tehadap bakteri Staphylococcus aureus Nurasni Nurasni; Elfia Neswita
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.263

Abstract

The ability to inhibit bacterial growth from hand sanitizer gel is quite good. Leeks (Allium fistulosum) contain allicin which can function as an inhibitor of the growth of Staphylococcus aureus bacteria. This research aimed to eamine the antibacterial activity of Staphylococcus aureus from Hand Sanitizer gel containing leek extract. The procedure includes making simplicia, characterization, and making extracts through maceration with concentrations of 20%, 30%, and 40%, then carrying out an antibacterial test using the agar diffusion method. The test results showed that the bacterial inhibition zone at concentrations of 20%, 30%, and 40% respectively was 3.5 mm; 5.0mm; and 5.9 mm in the medium category. This research concludes that the formulation with the best concentration is the formulation with a concentration of leek extract as large as the inhibition zone for Staphylococcus aureus bacteria in the medium category.
Analisis kadar natrium benzoat pada kecap pedas yang beredar di pasaran dengan metode kromatografi lapis tipis (KLT) dan spektrofotometri Uv-Vis Tamara Army; Ainil Fithri Pulungan; Ridwanto Ridwanto; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.266

Abstract

Sodium benzoate is one of the preservatives allowed in food and beverages. The objective of this research was to determine the level of sodium benzoate found in spicy soy sauce. Qualitative tests are first carried out on samples with the Thin Layer Chromatography (KLT) method, and quantitative tests are carried out using the spectrophotometry Uv-Vis method to determine the preservative level of sodium benzoate. Qualitative tests on KLT plates were carried out by optimising eluents (N-Butanol: Ethyl Acetate: Ammonia, Methanol: Ethyl Acetate: Ammonia, and Isopropanol: Ammonia), where the results of the three eluents showed that the Isopropanol: Ammonia eluents had Rf values from three samples that were close to each other with the comparison Rf values. The results of quantitative analysis on spectrophotometry Uv-Vis showed the total levels of Spicy Soy Sauce A 264.16±12.3206 mcg/g, Spicy Soy Sauce B 317.8±21.8643 mcg/g and Spicy Soy Sauce C 110.2±23.5356 mcg/g. Based on these results, it can be concluded that sodium benzoate levels in samples A, B, and C meet the requirements of the maximum usage limit standard, which is not more than 600 mg/kg.  
Kualitas Rendang Daging Kambing dengan Penambahan Irisan Bawang Batak (Allium chinense G. Don) Ditinjau dari Kadar Protein dan Kadar Lemak Nur Asmaq; Kabul Warsito
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.267

Abstract

This research aims to determine the quality of lamb rendang by adding sliced Batak onions (Allium chinense G. Don) to make it. The materials used in this research were lamb, Batak onions, chilies, shallots, garlic, galangal, ginger, turmeric, lemongrass, turmeric leaves, bay leaves, lime leaves, coconut, and salt. The method used in this research was an experimental method with a completely randomized non-factorial design with four treatments and four replications. The parameters tested were the lamb rendang's protein and fat content. The treatments in this study were P0 (control/rendang without adding Batak onions), P1 (addition of 5% Batak onion slices/meat weight); P2 (accumulation of 10% Batak onion slices/weight of meat), P3 (collection of 15% Batak onion slices/weight of heart). This study showed that the addition of sliced Batak onions in making rendang had a significant effect (P<0.01) on lamb rendang's protein and fat content. The protein content in the P3 treatment showed a value of 29.51%, while the fat content in P3 was 15.38%.
Skrining Fitokimia, Formulasi, dan Karakteristik Fisik Sediaan Soothing Gel Daging Daun Lidah Buaya (Aloe vera (L.) Burm.f.) Rosalinda Mahdalena Sinaga; Minda Sari Lubis; Gabena Indrayani Dalimunthe; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.274

Abstract

The content of aloe vera (Aloe vera (L.) Burm.f.) can make the skin not dry quickly and feel moisturised. Soothing gel is a preparation that works effectively to restore skin moisture, provide comfort and a cooling effect on red and irritated skin so that the skin condition returns to normal and prevents skin dryness. The study aimed to determine the various secondary metabolites in aloe vera leaf flesh, to determine differences in concentrations of aloe vera leaf flesh in soothing gel preparations on the physical characteristics of the practices and to determine material changes before and after stability tests were carried out using the cycling test method. The research method was used experimental, with the independent variables varying the aloe vera leaf flesh concentration 0% (blank), 1%, 2%, and 3%, and the dependent variable secondary metabolites and physical characteristics. The sample preparation method is wet sorting, and other methods used are phytochemical screening, viscometry, and cycling tests. The results of the phytochemical screening showed that aloe vera leaf flesh contains secondary metabolites of flavonoids, glycosides, tannins, saponins, and steroids. The results of the soothing gel formulation with variations in the aloe vera leaf flesh concentration of 0%, 1%, 2%, and 3% showed differences in colour, distinctive aroma, consistency, spreadability, adhesion, pH, and viscosity that met the requirements. The stability test results using the cycling test method showed physical changes in consistency, spreadability, adhesion, pH, and viscosity. However, these changes still met the requirements for good gel preparation according to SNI 16-4399-1996.
Analisis resiko kesehatan lingkungan pencemaran timbal (Pb) pada hasil laut yang beredar di pasar Sambu Medan Tina Meirindany; Khodijah Tussolihin Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.279

Abstract

Plumbum (Pb) is a heavy metal that damages and pollutes the environment. The presence of these heavy metal damages and pollutes the environment. The presence of these heavy metals changes marine biota's life and threatens human health through contaminated food chains. The results of measuring lead (Pb) levels in anchovies and squid circulating in the Sambu Market in Medan exceed the 2009 SNI threshold. This study aims to estimate the exposure to lead (Pb) of those who eat anchovies and squid in the Sambu Market with Desktop Risk Analysis of Environmental Health. The research results show that the risk magnitude (RQ) of exposure to Plumbum (Pb) in people who consume anchovies and squid is RQ>1. Based on risk management, the safe consumption rate is at least 0.06 grams per day for adults with a body mass of 55 kg. Risk management is also carried out by managing sources of reciprocal pollutants (Pb) by controlling the amount of industrial waste that may be discharged into waters, which requires direct supervision from the local Environmental Service.
Uji aktivitas antioksidan dan evaluasi fisik sediaan emulgel kombinasi ektraks daun kelor dan ekstrak daun karamunting Adhi Gunawan; Annisa Fatmawati; Wahyu Yuliana Solikhah; Nafa Meilingga Putri; Baiq Husnul Hotimah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.283

Abstract

Antioxidants can be used as skin care cosmetics by preventing the formation of new free radicals, neutralizing and avoiding chain reactions, thereby slowing down premature aging caused by damage skin. Emulgel is a topical preparation that has several advantages, including thixotropic, non-greasy, easy to spread, easy to clean, mild, easy to rinse, longer shelf life, transparent, and comfortable to use. The aim of this study was to form a combination of Moringa leaf (Moringa oleifera Lam) extract and Karamunting leaf extract into an emulsion dosage form and determine the antioxidant activity using the DPPH method. The emulgel base formulation uses Carbopol as a gelling agent and a combination of Moringa and Karamunting leaf (Melastoma malabathricum L.) extracts with various concentrations (25% : 75%, 50% : 50%, 75% : 25%). The results showed that the emulgel preparation combined with Karamunting leaf extract and Moringa leaf extract met all the physical test standards for the preparation, and the results of the antioxidant activity test showed that formula I had the highest antioxidant activity, with IC50 value is 40.07 ppm, which means it is a very strong antioxidant.
Uji aktivitas antibakteri ekstrak etanol asam sunti terhadap bakteri Streptococcus mutans Novika Utami; Haris Munandar Nasution; Rafita Yuniari; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.286

Abstract

Asam sunti is belimbing wuluh, which is processed into a special food additive from Aceh Province because it becomes dregs and interferes. Belimbing is processed into asam sunti for seasoning or additional dishes. Belimbing contains active compounds such as alkaloids, triterpenoids, saponins, tannins, and flavonoids. Because Belimbing has an antibacterial pharmacological effect, it has been shown to fight bacteria that cause dental caries. The main cause of dental caries is the activity of Streptococcus mutans bacteria. The researcher took the research problem regarding the test of the inhibitory power of asam sunti extract. They know the antibacterial activity of 96% ethanol extract. The method used in this study was an experimental method with independent variables, namely asam sunti simplicia and asam sunti concentration. The main variables were the secondary characteristics and the metabolite content of the asam sunti ethanol extract. The tests included inhibiting asam sunti's ethanol extract against bacteria. The results of plant identification showed that the antibacterial inhibition zone of the ethanol extract of asam sunti belimbing wuluh ethanol extract with a concentration of 20% (18.54) mm, 40% (20.79) mm, and concentration of 60% (21.48) mm including Thus is known that the concentration of ethanol extract of asam sunti Belimbing wuluh on 20%-60% is an effective concentration to inhibit Streptococcus mutans bacteria The concentration of the ethanol extract has very strong antibacterial powder, causing a large inhibition zone.
Tingkat kepuasan pelayanan pasien BPJS kesehatan terhadap pelayanan obat di apotek X Kota Sibolga Salmah Handayani Lubis; Fenny Hasanah; Eva Sartika Dasopang; Lathifur Rasyidah Tanjung
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.292

Abstract

Health-related issues are one of the most pressing needs of society. Indonesia has government-run health insurance that is directly under its control. When patients obtain services that are considered appropriate or above expectations, patient satisfaction is achieved. This research uses a survey research approach and is descriptive. Surveys distributed to respondents were used to collect data. Eighty respondents who met the inclusion requirements were sampled. The data used is primary data, information obtained directly from respondents, with data collection methods such as providing questionnaires, which are filled in by the respondents themselves and sent back to the researcher. The findings of the study, which were based on SPSS patient characteristics analysis, showed that females accounted for the most significant percentage of respondents (43), followed by the 46-55 years age group (32.5%) and housewives (27.5%), (n=26; 32.5%) had the highest hypertension diagnosis on SPSS analysis, while (n=18; 69%) had the highest drug name of amlodipine. The results, according to the Servqual model, showed that the guarantee dimension had the largest average of 98%(Assurance), while the responsiveness dimension had the lowest average of 92% (waiting time).
Aktivitas Analgesik dan Antiinflamasi Nanoemulsi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) secara In Vivo Recky Patala; Viani Anggi; Isna Paula; Nur Sakina
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.295

Abstract

Pain and Inflammation are our body's average protective measures. The presence of an inflammatory process is characterised by typical features, namely the appearance of redness, swelling in the area of inflammation, heat, and the onset of pain. One of the traditional plants widely obtained in Indonesia is Curcuma longa L. Curcuma longa L. contains flavonoid and curcumin compounds known to have analgesic and anti-inflammatory effects. The ethanol extract of Curcuma longa L. rhizome is formulated in nanoemulsion dosage form to reduce toxicity, improve drug distribution efficiency, and increase the bioavailability of drugs with low absorption. This study aims to determine the effect of the administration of nanoemulsion of ethanol extract of Curcuma longa L. at doses of 20 and 25 mg/kg bw on analgesic and anti-inflammatory activities carried out on male white rats of Wistar strain induced by 1% acetic acid and 1% carrageenan. Rats were divided into five groups (n=5), namely standard control (nanoemulsion without extract), positive control (mefenamic acid nanoemulsion for analgesic test and diclofenac sodium nanoemulsion for anti-inflammatory test), negative control (1% acetic acid nanoemulsion and 1% carrageenan nanoemulsion), P1 (extract nanoemulsion dose of 20 mg/kg bw), and P2 (extract nanoemulsion dose of 25 mg/kg bw). Furthermore, the number of writhing was measured from 5 to 60 minutes, and the leg volume changed from 1 to 6 hours. The results showed a decrease in the number of writhes with an increase in % Protection and significant inhibition of inflammation (p<0.05) in both doses of 20 mg/kg bw and 25 mg/kg bw with a per cent protection of 35.21% and a decrease in oedema volume by 64.79%. Nanoemulsion of Curcuma longa L. extract at doses of 20 and 25 mg/kg bw has activity as an analgesic and anti-inflammatory induced by 1% acetic acid and 1% carrageenan
Identifikasi DNA babi sebagai metode validasi untuk autentikasi halal menggunakan polymerase chain reaction Mariyani Mariyani; Ni nyoman Yuvita Yani; Ikhsan Hi. Amir Sene
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.296

Abstract

To protect consumers from fake halal labelling on food products, cosmetics and medicines, a method is needed to guarantee a product's Halal. Pork is one type that is often used to mix with beef because the two types of meat have physical similarities if not carefully considered. DNA-based analysis, often used for halal authentication, is the real-time PCR method, so this study aims to prove that conventional PCR methods can detect DNA at the same concentration. This study uses two parameters: the specificity test carried out using pig DNA samples and cow and chicken DNA as a comparison. The second parameter is the detection limit test on absolute DNA carried out at 4 concentrations, namely 50, 5, 0.5 and 0.05 ng/µL, while the relative detection limit test (pork-cow mixture) with variations in pork concentration, namely 100%, 5%, 3%, 1%, and 0.5%. The analysis showed that the primers were specific to pig DNA with an absolute detection limit of 0.05 ng/µL and a relative detection limit of 0.5%. This PCR method meets the validation requirements for identifying target species so that it can be used for halal authentication of various products.

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