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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 935 Documents
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Hubungan Mutu Pelayanan Kesehatanm Dengan Kepuasan Pasien Di Upt Puskesmas Bestari Kota Medan Tahun 2024 Elvi Andriany Simbolon; Kesaktian Manurung; Janno Sinaga; Donal Nababan; Frida Lina Tarigan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1593

Abstract

Health is one of the basic needs of society which is very important in supporting daily activities. As people's living standards increase, so do people's needs, hopes and demands for quality health. This situation requires health service providers such as hospitals to improve the quality of services better and provide satisfaction for consumers as users of health services. The problem formulation in this research is "Evaluation of the Relationship between Health Service Quality and Patient Satisfaction at UPT. Puskesmas Bestari, Medan City in 2024." The general objective of this research is to evaluate the relationship between the quality of health services and patient satisfaction. This type of research is observational analytics with a crosssectional design, namely research to study the dynamics of the correlation between risk factors and effects, using an approach, observational method, or data collection. This research was carried out from October 2024 to February 2025. The samples in this study were patients who came for treatment at UPT. Puskesmas Bestari in Medan City and received health services for 96 people. the majority of respondents in this study were in the age range of 36 - 40 years, 35.4%. The majority of respondents were women, namely 58.3%. Based on education level, the majority of respondents had a high school/equivalent education, 51.0%. Meanwhile, from the work aspect, the majority of respondents worked as employees or laborers with a total of 47.9%. Respondents who were satisfied were 66.7%, while respondents who were dissatisfied were 33.3%. Based on the results of research conducted at UPT Puskesmas Bestari, it can be concluded that: There is a relationship between the quality of health services from the dimension of responsiveness and patient satisfaction. There is a relationship between the quality of health services from the quality assurance dimension and patient satisfaction. There is a relationship between the quality of health services from the tangible facilities and patient satisfaction dimensions. There is a relationship between the quality of health services from the dimension of concern (empathy) and patient satisfaction. There is a relationship between the quality of health services from the reliability dimension and patient satisfaction at UPT. Puskesmas Bestari, Medan City in 2024
Skrining Fitokomia Dan Uji Aktivitas Antibakteri Ekstrak etanol daun jeluak (Microcos tomentosa (L.)) Terhadap Bakteri Escherichia coli dan Staphyloccocus aureus Toni Andareas Sitompul; Haris Munandar Nasution; Yayuk Putri Rahayu; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1599

Abstract

Background: Bacterial infections caused by Staphylococcus aureus and Escherichia coli remain major public health problems. Resistance to conventional antibiotics has driven the search for alternative antibacterial agents from natural sources. Jeluak leaves (Microcos tomentosa L.) have been traditionally used as an antimicrobial, yet scientific evidence regarding their antibacterial activity is limited. Objective: This study aimed to perform phytochemical screening and evaluate the antibacterial activity of the ethanolic extract of Jeluak leaves against E. coli and S. aureus. Methods: This was an experimental laboratory study. Extraction was carried out by maceration using 96% ethanol. Phytochemical screening included tests for alkaloids, flavonoids, tannins, saponins, steroids, and glycosides. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar at extract concentrations of 10%, 30%, 50%, and 70%. Chloramphenicol and DMSO were used as positive and negative controls, respectively. Inhibition zone diameters were measured after 24 hours of incubation at 37°C. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, steroids, and glycosides. The extract produced inhibition zones against E. coli of 6.3 mm, 9.3 mm, 12.2 mm, and 13.61 mm, and against S. aureus of 7.51 mm, 10.7 mm, 12.7 mm, and 14.28 mm, respectively. According to CLSI 2020 criteria, the 70% concentration was categorized as intermediate, while concentrations of 10–50% were resistant. The positive control was sensitive against both bacteria. Conclusion: The ethanolic extract of Jeluak leaves (Microcos tomentosa L.) possesses antibacterial activity against E. coli and S. aureus, with higher effectiveness against S. aureus than E. coli. Secondary metabolites such as flavonoids, tannins, and alkaloids are suggested to contribute to the antibacterial mechanism
Perbedaan kadar hemoglobin pada remaja putri berdasarkan status gizi di SMAN 1 Lhokseumawe Faizah Azzahara; Nur Fardian; Tischa Rahayu Fonna
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.805

Abstract

Introduction: Anemia remains a global health problem with high prevalence among adolescent girls, particularly in developing countries. Nutritional status is suggested to play an important role in determining hemoglobin levels through mechanisms of iron deficiency and chronic inflammation. Objective: This study aimed to analyze the differences in mean hemoglobin levels among adolescent girls based on nutritional status at SMAN 1 Lhokseumawe. Methods: This observational analytic study employed a cross-sectional design involving 100 female students selected through proportionate stratified random sampling. Hemoglobin levels were measured using a digital Hb meter, body weight using a digital scale, and height using a microtoise. Nutritional status was determined based on body mass index for age (BMI-for-age) using WHO AnthroPlus software. Data were analyzed using One-Way ANOVA followed by Bonferroni post hoc test. Results: Most respondents had normal nutritional status (64.0%), with the highest mean hemoglobin level found in the normal nutritional status group (13.030 g/dL) compared to the undernutrition (10.667 g/dL) and overnutrition (11.993 g/dL) groups. One-Way ANOVA test revealed a statistically significant difference (p=0.000). Post hoc analysis showed significant differences between undernutrition and normal nutrition groups (p=0.001), as well as between normal nutrition and overnutrition groups (p=0.004). Conclusion: There is a significant difference in mean hemoglobin levels based on nutritional status among adolescent girls. Normal nutritional status is associated with better hemoglobin levels, suggesting that nutritional interventions and iron supplementation should be intensified particularly among adolescent girls with undernutrition and overnutrition.
Hubungan Kualitas Tidur dan Paparan Iklan Makanan dan Minuman Ringan di Televisi dengan Status Gizi Murid Kelas VI di SDN Mulyasari 1 Siti ‘Afifah Khomsah; Milliyantri Elvandari; Linda Riski Sefrina
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.938

Abstract

Introduction: Nutritional status of school-aged children is an important indicator in assessing children's health and growth. Various lifestyle factors such as sleep quality and exposure to food and beverage advertisements on television are suspected to influence children's nutritional status. This study aimed to analyze the relationship between sleep quality and exposure to food and beverage advertisements on television with the nutritional status of sixth-grade students at SDN Mulyasari 1. Methods: This quantitative study employed a cross-sectional design. A sample of 48 sixth-grade students was selected randomly. Sleep quality data were collected using the Pittsburgh Sleep Quality Index (PSQI) questionnaire, while advertisement exposure data were obtained through a structured questionnaire that had been tested for validity and reliability. Nutritional status was measured based on body mass index for age (BMI/A) using WHO 2007 reference z-scores. Data analysis was performed using Spearman correlation test with a significance level of α=0.05. Results: The results showed that out of 48 respondents, 36 students (75%) had normal nutritional status, 3 students (6.2%) were underweight, and 9 students (18.8%) were obese. Statistical analysis revealed no significant relationship between sleep quality and nutritional status (p=0.255; p>0.05) nor between exposure to food and beverage advertisements on television and nutritional status (p=0.467; p>0.05). Conclusion: Sleep quality and exposure to food and beverage advertisements on television were not significantly associated with the nutritional status of sixth-grade students at SDN Mulyasari 1. These findings indicate that other factors such as dietary patterns, physical activity, family environment, and socioeconomic and cultural factors may play a more dominant role in determining the nutritional status of school-aged children. Further research is needed to comprehensively identify the determinants of nutritional status, as well as to strengthen the role of nutrition education and media supervision by parents and schools.
Pengaruh Pemberian Ekstrak Etanol Daun Etlingera comosa terhadap penurunan kadar glukosa darah dan gambaran histopatologi pankreas tikus putih jantan Faikah Dyah Utami; Nur Ramadhani; Ayu Wulandari; Syafika Alaydrus; Resa Aprilia Herlin Molano
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1081

Abstract

Etlingera comosa is a unique and newly discovered endemic plant species from Central Sulawesi, Indonesia, specifically originating from Tentena. Plants belonging to the Etlingera genus have been reported to possess considerable potential as natural antioxidants. This study aimed to evaluate the effect of the ethanol extract of E. comosa on blood glucose reduction and pancreatic histopathological changes in male white rats. A completely randomized design with a one-way treatment pattern was employed. Thirty male white rats (Rattus norvegicus) were randomly divided into six groups (n = 5 per group): normal control, positive control, negative control, and treatment groups receiving E. comosa ethanol extract at doses of 100, 200, and 400 mg/kg body weight (BW). All groups, except the normal control, were induced with streptozotocin. Blood glucose levels were measured using a glucometer, while pancreatic histopathological damage was evaluated using hematoxylin and eosin (H&E) staining. The results demonstrated significant differences in blood glucose levels throughout the treatment period, as well as significant differences in pancreatic histopathological damage scores among the experimental groups. Administration of the ethanol extract at a dose of 400 mg/kg BW produced a hypoglycemic effect that was not significantly different from the positive control (p > 0.05) but was significantly different from the negative control (p < 0.05). Similarly, the pancreatic damage score in the 400 mg/kg BW group was comparable to the positive control and significantly improved compared with the negative control. These findings indicate that the ethanol extract of E. comosa effectively reduces blood glucose levels and ameliorates pancreatic histopathological damage in streptozotocin-induced diabetic rats, with the most effective dose being 400 mg/kg BW.
Uji Larvasida Seduhan Teh Bunga Telang (Clitoria Ternatea L.) Terhadap Larva Nyamuk Aedes Aegypti Instar III Muflihah Rizkawati; Marlina Anggraeni; Ernadita Budiastuti; Riana Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1092

Abstract

Aedes aegypti is a mosquito species capable of transmitting dengue fever to humans. Vector control aimed at disrupting the mosquito life cycle is an effective strategy for preventing dengue fever. Larvicides are a class of pesticides used to kill insects at the larval stage. Butterfly pea flowers (Clitoria ternatea L.) contain active compounds such as flavonoids, which have potential larvicidal properties. This study aimed to determine the larvicidal effect of butterfly pea flower infusion (Clitoria ternatea L.). Telang flower tea was prepared at concentrations of 10%, 5%, 2.5%, and 1.25% for the treatment groups, while abate powder was used as the positive control. The study employed a completely randomized design by placing Aedes aegypti larvae into plastic cups divided into six groups with three replications, each containing 25 larvae. The treatment groups received telang flower tea at concentrations of 10%, 5%, 2.5%, and 1.25%. Larval mortality was observed over a 24-hour period. The results demonstrated larvicidal activity, as indicated by larval mortality. The effective concentration causing 50% larval mortality was 10% after 6 hours of observation, and 5% and 10% after 12 hours. In conclusion, telang flower tea (Clitoria ternatea L.) has been proven to exhibit larvicidal activity against instar III Aedes aegypti larvae at concentrations of 10% and 5%. The phytochemical compounds present in butterfly pea flowers—namely saponins, flavonoids, and tannins exert a rapid effect on larval mortality by damaging cell membranes or disrupting larval metabolic processes.
Uji Potensi Ekstrak Daun Nilam (Pogostemon cablin Benth.) Dalam Sediaan Salep Jerawat Untuk Menghambat Pertumbuhan Bakteri Cutibacterium acnes dan Staphylococcus aureus Evha Astaviana MS; Ulfayani Mayasari; Rasyidah Rasyidah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1145

Abstract

Introduction: Cutibacterium acnes and Staphylococcus aureus are Gram-positive bacteria that serve as the primary etiological agents in the pathogenesis of acne vulgaris. Bacterial resistance to conventional antibiotics and their associated side effects have driven the development of alternative therapies based on natural products. Patchouli leaves (Pogostemon cablin Benth.) are known to contain bioactive compounds with antibacterial potential; however, studies on the formulation of their topical preparations remain limited. Objective: This study aimed to evaluate the antibacterial activity of patchouli leaf extract in ointment formulations against C. acnes and S. aureus, as well as to characterize the physical quality of the resulting preparations. Methods: Patchouli leaf extraction was carried out using the maceration method with 96% ethanol as the solvent. Identification of chemical compounds was performed through phytochemical screening. Antibacterial activity testing of the extract and ointment preparations was conducted using the disc diffusion method against C. acnes and S. aureus at extract concentrations of 10%, 15%, 20%, 25%, and 30%. The ointment formulations were prepared using a PEG 400 and PEG 4000 base, followed by evaluation of their physical characteristics, including homogeneity, pH, spreadability, viscosity, adhesion, and irritation tests. Data were analyzed using one-way ANOVA followed by Duncan's post-hoc test (α = 0.05). Results: Phytochemical screening revealed that patchouli leaf extract contained flavonoids, alkaloids, terpenoids, steroids, tannins, and saponins. The inhibitory activity of the extract against both test bacteria increased with increasing concentration, with the highest inhibition zones observed at 30% concentration (19.85 mm against C. acnes and 19.23 mm against S. aureus). The ointment formulations at extract concentrations of 25% and 30% produced inhibition zones of 22.38 mm and 26.36 mm against C. acnes, and 24.10 mm and 27.46 mm against S. aureus, respectively. All physical quality parameters of the ointments (homogeneity, pH 5.96–6.41, spreadability 5 cm, viscosity 2,018–2,164 cps, adhesion 9–14 seconds) met the required standards and did not cause irritation. Conclusion: Patchouli leaf extract (P. cablin Benth.) ointment at concentrations of 25% and 30% demonstrated strong antibacterial activity against C. acnes and S. aureus, with physical characteristics that met quality standards. These findings indicate the potential development of patchouli leaf extract ointment as a natural topical alternative therapy for acne vulgaris.
Akupresur Menurunkan Tekanan Darah pada Pasien Hipertensi di Puskesmas Gang Kelor Kota Bogor Agustina Agustina; Susmadi Susmadi; Ita Pursitasari; Eros siti Suryati; Franciscus Xaverius
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1169

Abstract

Background: Hypertension remains a significant public health challenge in Indonesia, with a prevalence of 34.11% (approximately 90 million people). West Java Province reports one of the highest national prevalence rates at 39.60%, with 56,411 documented cases in Bogor City alone. Often termed "The Silent Killer," hypertension frequently presents without symptoms yet substantially increases the risk of cardiovascular disease, stroke, renal failure, and other complications. Beyond pharmacological interventions, complementary therapies such as acupressure have gained attention as holistic approaches to blood pressure management. However, evidence regarding its specific efficacy beyond educational interventions remains limited. Objective: This study aims to investigate the effect of acupressure therapy on reducing blood pressure in individuals with hypertension compared to sham acupressure combined with health education. Methods: A quasi-experimental study with pre-test and post-test control group design was conducted from June to October 2024 at Gang Kelor and Pasirmulya Community Health Centers, Bogor City. A total of 60 participants aged 45–65 years were recruited through purposive sampling from the PROLANIS chronic disease management program. The intervention group (n=30) received hypertension education and acupressure therapy targeting seven specific acupoints (GV 20, GB 20, TE 17, LI 4, LR 2, LR 3, and BL 23), while the control group (n=30) received equivalent education with sham acupressure at non-acupoints. Both groups received five sessions over four weeks. Blood pressure measurements were taken at baseline and post-intervention. Data were analyzed using independent samples t-test and paired samples t-test with a significance level of α=0.05. Results: Both groups demonstrated significant reductions in systolic blood pressure (intervention: mean difference=12.07 mmHg, p<0.001; control: mean difference=17.53 mmHg, p<0.001) and diastolic blood pressure (intervention: mean difference=6.47 mmHg, p=0.001; control: mean difference=6.87 mmHg, p<0.001). However, between-group comparisons revealed no statistically significant differences in systolic (p=0.128) or diastolic (p=0.876) pressure reductions. Baseline characteristics were homogeneous across groups, with no significant differences in age, sex, education, occupation, hypertension duration, or medication adherence.Conclusion: While acupressure combined with education effectively reduced blood pressure, the additional effect of specific acupressure points beyond education and sham acupressure was not statistically significant. Educational interventions appear to be the primary driver of blood pressure reduction in this population. Acupressure may be recommended as a complementary self-care intervention, but further research with more rigorous designs—including randomized controlled trials with adequate blinding and longer follow-up periods—is warranted to isolate acupressure's specific therapeutic effects.  
Artikel Tinjauan: Peran Telemedisin dalam Memperluas Aksesibilitas Farmasi antara Masyarakat Pedesaan dan Perkotaan Salsabila Ramadani; Mela Nursapitri; Hanifah Nur Widodo; Sudarjat Sudarjat; Indah Laily Hilmi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1203

Abstract

Telemedicine and telepharmacy play an important role in expanding access to pharmaceutical services, particularly in rural areas that face shortages of pharmacy personnel and healthcare facilities. However, comparative syntheses focusing on the differences in telemedicine implementation between rural and urban communities in Indonesia remain limited. This literature review aims to analyze the role of telemedicine in improving pharmaceutical service accessibility and to compare its implementation between rural and urban communities. The review was conducted systematically using PubMed and Google Scholar databases with the keywords “telemedicine, rural and urban telepharmacy, and telemedicine accessibility.” From 540 identified articles, 11 articles were selected based on inclusion and exclusion criteria. The findings indicate that telemedicine facilitates medication consultations, e-prescriptions, patient education, and chronic disease monitoring through various digital platforms. Several services, such as WhatsApp, Halodoc, and other digital health applications, have supported the improvement of pharmaceutical service accessibility. A significant gap was identified between telemedicine implementation in urban and rural areas, where urban communities demonstrated more optimal implementation due to better technological infrastructure and digital literacy, while rural communities continued to face limitations related to internet connectivity, healthcare facilities, and technology adoption. This literature review concludes that telemedicine significantly contributes to improving efficiency and promoting equitable access to pharmaceutical services between rural and urban communities.  
Efektivitas Intervensi Mindfulness-Based Childbirth Parenting (MBCP) bagi Ibu Hamil terhadap Kesejahteraan Psikologis Ibu: Sebuah Tinjauan Sistematis Riska Adellia; Imami Nur Rachmawati; Titin Ungsianik; Hening Pujasari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1266

Abstract

Background: Pregnancy is a critical life stage characterized by physiological and psychosocial changes that increase vulnerability to mental health disorders such as depression, anxiety, and fear of childbirth. Objective: To identify Mindfulness-Based Childbirth and Parenting (MBCP) as an intervention for reducing depression, anxiety, stress, and fear of childbirth, as well as enhancing prenatal attachment. Methods: This systematic review followed the PRISMA guidelines to analyze and present findings from randomized controlled trials (RCTs) involving pregnant women who received MBCP or other mindfulness-based interventions during pregnancy and reported outcomes related to mental health or prenatal attachment. Studies published in English between 2020 and 2025 were considered. Observational studies, reviews, and research without relevant outcomes were excluded. Literature searches were conducted in PubMed, ScienceDirect, ProQuest, Scopus, and ClinicalKey. Methodological quality was assessed using the JBI Critical Appraisal Checklist for RCTs. Due to heterogeneity in interventions and outcomes, meta-analysis was not feasible. A narrative synthesis was performed by summarizing study characteristics and thematically grouping results. Results: Ten RCTs (N=907) consistently demonstrated reductions in depression, anxiety, stress, and fear of childbirth, as well as improvements in prenatal attachment. Conclusion: MBCP interventions are effective in enhancing maternal psychological health and reducing fear of childbirth, with potential benefits for both mother and infant. Integration of MBCP into antenatal care and cultural adaptation is recommended. Further research is needed to evaluate long-term outcomes, cost-effectiveness, and implementation strategies across diverse contexts.

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