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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 752 Documents
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Fitokimia Rosemari (Rosmarinus officinalis) untuk Mencegah Degradasi Kolagen dan Pembentukan Kerutan: sebuah Tinjauan Pustaka Parimartha , Nyoman Ledy Trisna; Laksemi , Dewa Ayu Agus Sri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1486

Abstract

of the most visible manifestations. Aging disrupt the balance between collagen synthesis and degradation, leading to fragmentation of collagen fibers and loss of skin elasticity. Natural phytochemicals have gained increasing attention as potential agents for preventing or delaying skin aging due to their antioxidant and anti-inflammatory properties. Rosemary (Rosmarinus officinalis) contains a variety of bioactive compounds with potential dermatological benefits. Major phytochemicals identified in rosemary include phenolic acids such as rosmarinic acid, diterpenes such as carnosic acid and carnosol, as well as flavonoids and volatile terpenoids. These compounds have demonstrated strong antioxidant activity and the ability to modulate molecular pathways associated with skin aging. Evidence from in vitro studies suggests that rosemary phytochemicals can reduce reactive oxygen species (ROS) production, suppress inflammatory signaling pathways, and inhibit the expression of MMPs involved in collagen degradation. Emerging clinical evidence, particularly from oral supplementation studies, also suggests improvements in skin elasticity, wrinkle depth, and oxidative stress biomarkers, supporting the translational potential of rosemary phytochemicals in human skin. Available evidence supports the potential application of rosemary-derived compounds in dermatological and cosmeceutical formulations aimed at preventing collagen degradation and wrinkle formation. This literature review summarizes current evidence on the phytochemical composition of rosemary and the molecular mechanisms through which its bioactive compounds may contribute to the prevention of skin aging.
Formulasi Dan Aktivitas Antioksidan Sirup Air Kelapa Tua (Cocos nucifera L) Dan Ekstrak Buah Merah (Pandanus conoideus L) Dengan Metode DPPH Ahmad, Siti Mun Muhliza; Astuti, Ratih Arum; Muslihin, A.M.
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1496

Abstract

Background: Mature coconut water (Cocos nucifera L.) has the potential as a health drink but is often discarded as waste. Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that is rich in antioxidants. The combination of both is expected to produce a beneficial herbal syrup preparation. Objective: To formulate a combination syrup of mature coconut water and red fruit extract and to determine its antioxidant activity using the DPPH method. Methods: Red fruit extract was obtained by maceration using 96% ethanol. Phytochemical screening was performed on both ingredients. The syrup was prepared with the addition of sugar, citric acid, vanilla, and CMC. Physical evaluation included organoleptic, homogeneity, pH, viscosity, and clarity tests. Antioxidant activity was tested using the DPPH method at a wavelength of 517 nm using a UV-Vis spectrophotometer. Results: Phytochemical screening showed that mature coconut water contains alkaloids, while red fruit extract contains flavonoids, tannins, saponins, and alkaloids. The syrup evaluation met SNI requirements: organoleptic (reddish-orange color, characteristic odor, sweet taste), homogeneous, pH 5–6, viscosity 250 mPa·s, and clear. The IC50 values of the syrup in three consecutive replicates were 550.34 μg/mL, 2282.3 μg/mL, and 2863.4 μg/mL, which are classified as weak antioxidant activity (IC50 > 200 ppm). Conclusion: The combination syrup of mature coconut water and red fruit extract exhibits weak antioxidant activity but meets the physical quality standards of the preparation. This preparation has the potential to be developed as a herbal health drink.
Efek Terapi Adjuvan Gel Kolagen terhadap Kadar Matriks Metaloproteinase-8 Saliva pada Gingivitis Pasca Scaling Root Planing Fitri, Haria; Kasuma , Nila; Hardisman, Hardisman; Ali , Hirowati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1500

Abstract

Gingivitis is a reversible inflammatory condition of the gingival tissue without attachment loss, primarily caused by plaque accumulation, which can trigger an immune response. Matrix metalloproteinase-8 (MMP-8) is an enzyme that contributes to collagen degradation. Scaling and root planing (SRP) is the standard therapy; however, it may induce a transient inflammatory response and result in suboptimal tissue regeneration, thereby necessitating adjunctive therapy. This study aimed to evaluate the effect of adjunctive collagen gel therapy on salivary matrix metalloproteinase-8 levels in gingivitis. This experimental study employed a pre- and post-test control group design involving 50 subjects divided into five groups: healthy control, gingivitis treated with SRP, and gingivitis treated with SRP combined with 1%, 2%, and 4% collagen gel. Salivary MMP-8 levels were measured to assess the inflammatory response. Statistical analysis revealed that collagen gel at concentrations of 1% and 2% had a significant effect on MMP-8 levels. In conclusion, Collagen gel at 1% and 2% concentrations significantly modulated salivary MMP-8 levels, suggesting a potential role in the tissue remodeling phase following SRP.
Pengetahuan, Sikap, dan Perilaku Pengguna Metode Kontrasepsi Jangka Panjang dan Pendek di Daerah Terpencil Indonesia Fitriani , Hani Sri; Wikaningtyas , Pratiwi; Zazuli , Zulfan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1507

Abstract

The use of long-acting contraceptive methods (LACMs) in Indonesia remains relatively low despite government efforts to increase their adoption to reduce maternal and child mortality. This study aims to examine differences in knowledge, attitudes, and practices (KAP) between LACM users and non-LACM users, as well as to identify factors influencing contraceptive method selection among women of reproductive age in a rural area of Indonesia. A cross-sectional design was employed involving 394 respondents selected through Cluster Random Sampling, all of whom completed validated and reliable questionnaires. Data were analyzed descriptively. The Mann–Whitney test was used to compare KAP between LACM and non-LACM users. Chi-square tests and logistic regression analysis were conducted to identify factors associated with contraceptive method selection. The results showed significant differences between the two groups. LACM users demonstrated higher levels of knowledge, more positive attitudes, and better contraceptive practices compared with non-LACM users. Factors associated with LACM use included high knowledge (OR = 2.415; p = 0.001), education above primary school level (OR = 7.03; p = 0.003), exposure to print media (OR = 28.331; p = 0.000), and obtaining contraceptives from community health centers (OR = 6.6; p = 0.009). In conclusion, short-acting contraceptive users exhibited lower knowledge, attitudes, and practices than LACM users. Therefore, individuals with low KAP levels should be prioritized in reproductive health education and promotion programs.
Formulasi Transdermal Patch Nanoemulgel Ekstrak Dadap Serep (Erythrina subumbrans (Hassk.) Merr.) dan Rimpang Kencur (Kaempferia galanga L.) sebagai Kandidat Laktagogum Herbal Berbasis Usadha Monika , Ni Luh Gde Mona; Yunita , Ella
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1510

Abstract

Traditional Usadha-based herbal lactagogues, such as Erythrina subumbrans and Kaempferia galanga, are used by lactating mothers; however, their delivery in practical, standardized forms is limited. This study aimed to formulate a nanoemulgel transdermal patch containing E. subumbrans extract and K. galanga extract, evaluate its physicochemical properties, and assess its safety for skin irritation as a potential herbal lactagogue. Extracts of E. subumbrans and K. galanga were added to the nanoemulsion base. The nanoemulsions were incorporated into HPMC/PVP-based transdermal patch matrices by solvent casting. The resulting patches were evaluated for physicochemical properties and tested for skin irritation. Phytochemical screening confirmed the presence of flavonoids, tannins, triterpenoids, saponins, and alkaloids in both extracts. The total flavonoid contents were 47.44 mg QE/g for E. subumbrans and 36.79 mg QE/g for K. galanga. The nanoemulsion exhibited greater than 90% transmittance, mean droplet size of 7.79 nm, and polydispersity index (PDI) of 0.193. The patches met acceptable physical criteria, including a thickness of 0.20 mm, weight variation with %CV less than 10%, and folding endurance over 300. pH values ranged from 6.00 to 6.58. In a human patch test, no erythema or edema was observed; only mild pruritus (mean = 0.2) was reported in two participants. The formulated nanoemulgel transdermal patches demonstrated favorable physicochemical properties and were non-irritating. These patches show potential as a herbal lactagogue delivery system; further studies on lactation  efficacy and long-term stability are recommended.
Aktivitas Sedatif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Terhadap Mencit (Mus musculus) Jantan Fitrianti, Wiwit Ayu; Muslihin, A.M.; Astuti, Ratih Arum
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1513

Abstract

Mental health is a state of well-being that includes where individuals recognize their personal potential, enabling them to manage life's pressures and be able to work productively. Treatment of mental health disorders usually involves the use of sedative drugs such as benzodiazepines, barbiturates, and several other drugs. This study aims to evaluate the sedative activity of the ethanol extract of tali kuning (A. cocculus (L.) Wight & Arn.) stem in male mice as an alternative therapy requiring sedative effects. The study was conducted using a quantitative experimental approach with a pretest–posttest control group design and the rotarod method. The experimental animals were divided into five groups: positive control, negative control, and three extract dose groups treated with the ethanol extract of tali kuning stem at 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW. The results indicated that the ethanol extract of tali kuning stem at all three doses produced sedative activity, as validated by a paired sample t‑test that revealed significant differences condition between pre‑ and post‑treatment measurements. The ethanol extract of tali kuning stem at doses of 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW demonstrated sedative activity, although statistical comparison with the positive control showed variable results depending on dose and observation time.
Studi In Vivo Efek Nefroprotektif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) terhadap Profil Kreatinin Serum Mencit Khofifah, Dian Nur; Muslihin, A. M.; Hardia, Lukman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1522

Abstract

Background: Nephrotoxicity due to the use of drugs such as gentamicin can cause kidney damage characterized by increased creatinine levels. The use of medicinal plants as nephroprotective agents is a potential alternative; one such plant is yellow rope stem (Anamirta cocculus (L.) Wight & Arn.), known to contain antioxidant compounds. Objective: This study aims to assess the nephroprotective activity of yellow rope stem ethanol extract and determine the optimal dose for reducing gentamicin-induced increases in creatinine levels in mice. Method: The study was conducted experimentally with a pre-test and post-test design using the maceration method with 70% ethanol solvent. Mice were divided into six groups, namely negative control, positive control (vitamin E), healthy control, and three treatment groups with varying extract doses. Creatinine levels were measured using the Jaffe method with a UV-Vis spectrophotometer. Results: The results showed that the yellow rope stem ethanol extract at a dose of 77 mg/kgBW was able to reduce creatinine levels significantly (p<0.05), while lower doses did not show a significant difference. Conclusion: Ethanol extract of yellow rope stems has nephroprotective activity at an optimal dose of 77 mg/kgBW, thus having the potential to be developed as a herbal agent to protect kidney function.
Konsentrasi dan Energi Urbach Nanopartikel ZnO yang Disintesis Menggunakan Enkapsulan Tween 80 Saragih, Horasdia; Yustian , William; Lingga , Ananda E.J.; Simanjuntak , Anggraini O.; Marcia, Brianna D.; Manalu, Dea R.; Oumaro , Gefriella B.; Leo, Jeanet G.R.; Kusminarti , Karin; Silalahi, Ladyos D.; La'lang , Michelle A.; Nurbayanti , Rima S.; Leo , Ruly Y.R.R.; Situmorang , Santika; Siahaan , Widya A.
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1527

Abstract

Excessive exposure to ultraviolet (UV) radiation can cause skin damage, necessitating the development of effective and transparent sunscreen materials. ZnO nanoparticles are a promising candidate; however, they often suffer from agglomeration, which degrades their optical performance. This study aims to investigate the effect of varying concentrations of Tween 80 as an encapsulating agent on the optical and structural characteristics of ZnO nanoparticles. The nanoparticles were synthesized using a rotor–stator homogenization method with Tween 80 concentrations ranging from 2 to 5 mL (each dissolved in 50 mL of ethanol), followed by characterization using UV–Vis spectroscopy. The results indicate that increasing the concentration of Tween 80 enhances the concentration of ZnO nanoparticles without significantly altering the average particle size (~2.44 nm), resulting in a monodisperse system. Urbach energy analysis reveals that crystal order improves up to an optimum at 4 mL of Tween 80, followed by a slight decrease at higher concentrations. Optically, all samples exhibit strong absorption in the UV region and high transmittance in the visible range (95–100%). These findings demonstrate that the synthesized ZnO nanoparticles have strong potential as a sunscreen. It is concluded that Tween 80 plays a crucial role in controlling the growth, crystal structure, and optical properties of ZnO nanoparticles, with the optimum concentration yielding the best performance.
Evaluasi Mutu Fisikokimia dan Aktivitas Antioksidan Minuman Isotonik Ekstrak Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Khasanah, Nadziatul; Muslihin, A.M.; Rossardy, Marzella Dea; Fadli, Justitia Cahyani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1529

Abstract

as having potential as a natural antioxidant agent. One potential way to utilize this plant is by innovating it into an isotonic drink product. Objective: This study aimed to evaluate the physicochemical properties and antioxidant activity of an isotonic drink formulated with yellow rope stem extract. Methods: he extraction process was conducted using the maceration method with 70% ethanol as the solvent. The isotonic drink was developed into three formulas, which were then tested for their physicochemical properties and antioxidant activity using the DPPH method. Results: The results indicated that the best formula was FII, with an overall hedonic score of 4,6 (neutral). All three formulas showed identical pH values (4,0) and Total Soluble Solids (TSS) of 7%, while the total acidity decreased progressively: FI (1,024%), FII (0,896%), and FIII (0,704%). The isotonic drinks from yellow rope stem extract for formulas FI, FII, and FIII produced IC50 values of 35,61, 46,56, and 57,69 μg/mL, respectively. Based on these data, FI and FII were identified as having very strong antioxidant intensity, while the FIII showed activity classified in the strong category. Conclusion:.The test results demonstrate that the isotonic drink made from yellow rope stem extract exhibits antioxidant potential with intensity levels ranging from strong to very strong.
Sistem Penghantaran Obat Mutakhir: Tantangan Formulasi Nano untuk Fitokimia yang Sulit Larut dalam Air Palungan, Juliana; Kamilah , Rona Hawa; Firmansah , Moh.; Putri, Sima Asmara Dewa Marya Mahardika; Rahmah , Winda Wahyu Setya; Thaher , M Iman Tarmizi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1537

Abstract

The poor water solubility and low oral bioavailability of various phytochemical compounds (BCS Classes II and IV) continue to be major obstacles in the development of modern therapeutics, despite their remarkable therapeutic potential. This narrative review critically evaluates the use of nanoscale drug delivery systems to overcome the biopharmaceutical limitations of hydrophobic phytochemicals and pinpoints key challenges in clinical translation and industrial-scale production. The review provides a comprehensive analysis of the latest literature on the effectiveness of nanotechnology-based physicochemical modifications, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, polymeric micelles, liposomes, and phytosomes. The review's results indicate that nano-carrier engineering significantly enhances solubility, avoids first-pass metabolic degradation, and enables targeted delivery. Specifically, nanoformulations have proven effective at penetrating the dense matrix of the tumor microenvironment (TME) in cancer therapy, crossing the blood-brain barrier (BBB) in neurodegenerative diseases, and protecting drugs from stomach acid in infectious and metabolic conditions. However, the transition toward commercialization is hindered by issues of long-term physicochemical stability (e.g., lipid polymorphic transitions) and challenges in standardizing botanical raw materials. These issues affect the reproducibility of large-scale production, ultimately delaying the availability of these promising therapies to patients in need. In conclusion, while nanoformulations offer transformative solutions for overcoming phytochemical biological barriers, standardizing protocols, innovating green synthesis, and fostering interdisciplinary collaboration are essential for overcoming scalability barriers and preparing these innovations for clinical application.

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