cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 782 Documents
 74   75   76   77   78 
Aktivitas Antioksidan dan Karakteristik Body Lotion dengan Perbedaan Konsentrasi Ekstrak Daun Jeruju ( Acanthus ilicifolius ). Almaida Mulya; Rifki Prayoga Aditia; Afifah Nurazizatul Hasanah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1551

Abstract

This study aimed to determine the effect of different concentrations of Acanthus ilicifolius leaf extract on antioxidant activity and physical characteristics of body lotion. The formulations were prepared with extract concentrations of 0, 2, 4, and 6 g. Antioxidant activity was tested using the DPPH method, while physical evaluations included pH, homogeneity, emulsion type, organoleptic properties, and skin moisture. The results showed that increasing extract concentration increased antioxidant activity, with the highest inhibition value found in P3 (76.19%). All formulations were homogeneous and had oil-in-water emulsion type. The pH values ranged from 6.92 to 7.93 and were within acceptable limits. Organoleptic test showed decreased panelist preference at higher extract concentrations. Moisture test showed no signific ant difference, but all formulations increased skin hydration.
Pengaruh Menopause Terhadap Kardiovaskular Guadelupe Maria Melisa Wiriadinata; Dewa Ayu Agus Sri Laksemi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1556

Abstract

Menopause is the permanent cessation of menstruation for 12 consecutive months without any underlying pathological cause. This occurs due to ovarian follicular atresia, which leads to the cessation of estrogen production. The menopausal transition begins 5 to 10 years before menstruation ceases. During menopause, estrogen levels decline, leading to biological changes in the body, such as an increase in total cholesterol, low-density lipoproteins (LDL), triglycerides, and apolipoprotein B, as well as a decrease in high-density lipoprotein (HDL), an increase in visceral fat, and the development of metabolic syndrome. Various characteristics of menopause have been evaluated in relation to cardiovascular disease (CVD) risk, including age at menopause onset, type and stage of menopause, endogenous estradiol levels, and menopause-related symptoms. These factors have been found to be associated with CVD risk, with the highest risk occurring in women with ovarian failure and relatively early menopause. Women with early menopause (aged 40–44 years) have a hazard ratio of 1.55 (95% CI: 1.38–1.73) for coronary artery disease events compared to women with menopause at age 50–54 years. Women with premature ovarian failure tend to have a shorter life expectancy compared to those who experience late menopause, primarily due to an increased risk of cardiovascular disease.
Profil Kepatuhan dan Hubungan Pemberian Allopurinol dengan Perubahan Kadar Asam Urat pada Pasien di Puskesmas Bandar Khalifah, Percut Sei Tuan Salmah Handayani Lubis; Fenny Hasanah; Desy Natalia Siahaan; Eka Ayu Lestari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1069

Abstract

Background: Hyperuricemia is a metabolic disorder that may lead to gout arthritis and complications if not optimally managed. Allopurinol is the first-line therapy, but treatment success is strongly influenced by patient adherence and achievement of target uric acid levels. Objective: This study aimed to analyze the adherence profile and the correlation of allopurinol administration with changes in uric acid levels among patients at Bandar Khalifah Primary Health Center. Methods: A prospective descriptive observational design was conducted on 55 patients receiving allopurinol therapy from February to April 2025. Data were collected from medical records, laboratory results, and the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire. Results: Most patients (96%) experienced a reduction in uric acid levels, but the mean post-therapy level (6.46 mg/dL) remained above the target of <6 mg/dL. Mild adverse effects were reported in 14.5% of patients, while 85.5% had no complaints. High adherence was found in 54.5% of patients, moderate adherence in 30.9%, and low adherence in 14.6%. Conclusion: Allopurinol therapy demonstrated good clinical effectiveness and safety; however, dose optimization and regular monitoring are required, particularly in patients with low adherence or comorbidities, to achieve the recommended uric acid target.
Analisis Fitokimia Berbasis GC-MS dan Evaluasi Aktivitas Antioksidan Metode DPPH dari Ekstrak Etanol dan N-Heksan Daun Bidara (Ziziphus mauritiana Lam.) Maharani Zahra; Rahma Yulia; Syarifah Nadia; Bunga Rimta Barus
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1146

Abstract

Background: The increasing public interest in herbal medicine which is safer and rarely causes side effects has made people use more natural ingredients as a source of bioactive compounds. One promising plant is the bidara leaf (Ziziphus mauritiana Lam.), known for its rich supply of secondary metabolites, including alkaloids, flavonoids, glycosides, and terpenoids, which boast pharmacological benefits, especially in their role as antioxidants. Objective: This research is conducted to determine the phytochemical compounds and examine the antioxidant potential of bidara leaf extracts prepared with ethanol and n-hexane, using experimental method. Methods: The extraction was done through maceration using 96% ethanol and n-hexane as solvents, and then we analyzed the phytochemicals via phytochemical screening and GC-MS. For checking antioxidant activity, we used the DPPH method, which involved figuring out the maximum wavelength, the operating time, measuring absorbance, and calculating the IC50 value. Results: From the phytochemical analysis, it turned out that ethanol extracts of bidara leaves feature a richer array of bioactive compounds, including alkaloids, flavonoids, glycosides, and terpenoids or steroids, in contrast to the n-hexane extracts, which only include alkaloids, glycosides, and terpenoids or steroids. Analysis using GC-MS identified that the ethanol extract was dominated by fatty acid ester compounds, including methyl palmitate and methyl oleate, while the n-hexane extract contained non-polar compounds such as squalene and tetratetracontane. Through the DPPH approach, the antioxidant activity of ethanol and n-hexane extracts was demonstrated by IC₅₀ values of 4.488 µg/mL and 7.54 µg/mL, respectively, both of which are classified as very strong, although still lower than vitamin C, which has an IC₅₀ of 2.47 µg/mL. Conclusion: The analysis indicates that the ethanol extract exhibits stronger antioxidant activity compared to the n-hexane extract.
Analisis Kadar Total Fenolik Ekstrak Etanol Daun Ciplukan (Physalis angulata L.) Dengan Metode Partisi Bertingkat Di Kawasan Geothermal Dan Non-Geothermal Mahmudi Mahmudi; Saiful Azhari; Aida Apriani; Rinaldi Rinaldi; Rozatun Uliani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1262

Abstract

Ciplukan (Physalis angulata L.) is a tropical plant with numerous benefits and is cultivated as a raw material for biopharmaceuticals, so it is no longer known as a lying plant or a weed in vacant lots by the public. Ciplukan contains secondary metabolites that can be used as active ingredients in drugs with antihyperglycemic, anti-inflammatory, antidiabetic, and cytotoxic activities. Phenolic compounds are secondary metabolites found in almost all parts of the plant. Phenolic compounds also have antioxidant properties. This is because phenolic compounds can react with free radicals and eliminate their activity so that they are no longer harmful to human cells. This study aims to determine the total phenolic content in ethanol extracts of ciplukan (Physalis angulata L.) leaves in geothermal and non-geothermal areas using a multilevel partition method. The data used to obtain total phenolic content was calculated based on a calibration curve from the readings from a UV-Vis spectrophotometer. Total phenols were calculated using a linear regression equation from the gallic acid calibration curve. Data obtained from the laboratory were processed manually and analyzed descriptively in the form of tables and graphs. The results of the total phenolic content test of the ethanol extract of ciplukan leaves (Physalis angulata L.) for the ethyl acetate fraction of the geothermal area obtained a phenolic content of 150.88% and for the ethyl acetate fraction of the non-geothermal area obtained a phenolic content of 131.68%. The results of the total phenolic content test of the ethanol extract of ciplukan leaves (Physalis angulata L.) for the N-Hexane fraction of the geothermal area obtained a phenolic content of 125.72%, and the results for the N-Hexane fraction of the non-geothermal area obtained a phenolic content of 75.01%. These results indicate that the phenolic content of ethanol extracts of ground cherry (Physalis angulata L.) leaves in geothermal areas contains higher total phenol levels than those in non-geothermal areas. These results can also serve as a basis for developing standards for ciplukan extracts from geothermal sources as a source of natural antioxidants.
Uji Efektivitas Sedian Salep Daun Mangga Arumanis (Magnifera Indical L.) Terhadap Luka Sayat Mencit Putih (Mus musculus) Jantan Yang Diinduksi Aloksan Yerly Ramadani Lubis; Astriani Natalia Br Ginting; Roy Indrianto Bangar
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1321

Abstract

Background: Diabetes mellitus is a major risk factor for impaired wound healing. Conventional treatments are often expensive and carry a risk of side effects, necessitating the development of safe and effective topical therapy alternatives from natural ingredients. Arumanis mango leaves (Mangifera indica L.) are reported to contain bioactive compounds such as mangiferin and flavonoids, which have potential in the tissue regeneration process. Objective: To determine the effectiveness of an arumanis mango leaf extract ointment on the healing of incision wounds in male mice with alloxan-induced diabetes. Methods: This laboratory experimental study used 30 male BALB/c mice divided into 6 groups: normal, diabetic without treatment, diabetic with base ointment, and three diabetic groups treated with mango leaf extract ointment (concentrations of 5%, 10%, 15%). Diabetes was induced via intraperitoneal alloxan injection. Aseptic incision wounds were created on the mice's backs and topically treated with the ointment once daily for 14 days. Wound diameter and blood glucose levels were measured periodically. Data were analyzed statistically. Results: Groups treated with mango leaf extract ointment (10% and 15% concentrations) showed faster and complete wound healing (100%) by day 14, which was not significantly different from the normal group and was markedly better than the untreated diabetic group (39%). However, no significant reduction in blood glucose levels was observed in any diabetic group throughout the study. Conclusion: The arumanis mango leaf extract ointment is effective topically in accelerating incision wound healing in diabetic mice, without demonstrating systemic antihyperglycemic effects. This effect is presumed to be mediated by bioactive compounds acting locally at the wound site.
Efek Nefroprotektif Ekstrak Daun Kersen pada Tikus Model Nefrotoksisitas: Analisis Biokimia, Histopatologi, Antioksidan, dan Sitokin Asyrun Alkhairi Lubis; Razoki Razoki; Novitaria Br. Sembiring; Nina Nurdiana Hasibuan; Miranda Simanjuntak; Rikki DP Turnip; Gabriella Tarigan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1339

Abstract

Background: Gentamicin-induced nephrotoxicity is closely associated with oxidative stress and inflammation that lead to renal damage. Natural compounds with antioxidant and anti-inflammatory properties are potential nephroprotective agents. Muntingia calabura L. leaves are rich in bioactive compounds such as flavonoids and polyphenols. Objective: This study aimed to evaluate the nephroprotective effect of Muntingia calabura L. leaf ethanol extract in a gentamicin-induced rat model. Methods: Male Wistar rats were divided into five groups: normal control, negative control (gentamicin), and treatment groups receiving extract doses of 100, 200, and 400 mg/kgBW. Renal function, inflammatory cytokines, antioxidant activity, and histopathological changes were evaluated. Results: The extract demonstrated dose-dependent nephroprotective activity, with the 400 mg/kgBW dose showing the most optimal effect in improving renal function, reducing inflammatory responses, and preserving kidney histological structure. Conclusion: Muntingia calabura L. leaf extract exhibits nephroprotective potential through antioxidant and anti-inflammatory mechanisms, supporting its development as a natural therapeutic candidate.
Pengembangan Seedian Emulgel Kombinasi Fraksi Aktif Daun Kersen dan Kulit Kayu Manis Untuk Ulkus Diabetikum Brigita Julianti Manalu; Novitaria Br Sembiring; Astriani Natalia Br Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1361

Abstract

Introduction: Diabetic ulcer is a serious complication of diabetes mellitus that is often accompanied by bacterial infections, necessitating effective topical therapy. Kersen leaves (Muntingia calabura L.) and cinnamon bark (Cinnamomum sp.) are known to contain bioactive compounds with antibacterial potential. Aim: This study aims to develop and evaluate the antibacterial activity of an emulgel formulation containing a combination of active fractions from kersen leaves and cinnamon bark as a candidate for topical therapy for diabetic ulcers. Method: The active fractions were obtained through extraction and fractionation processes, then formulated into an emulgel at varying concentrations of 10%, 30%, 50%, 60%, and 70%. Antibacterial activity was tested against Staphylococcus aureus using the agar disk diffusion method, with clindamycin as a positive control and the emulgel base as a negative control. Result: The results showed that the emulgel began to exhibit antibacterial activity at a concentration of 50%, with an average inhibition zone diameter of 12.96 mm. Increasing the concentration to 60% and 70% enhanced the inhibition zones to 14.00 mm and 15.24 mm, respectively. Clindamycin produced an inhibition zone of 29.57 mm, while the negative control showed no inhibitory activity. Conclusion: The emulgel combination of active fractions from kersen leaves and cinnamon bark possesses concentration-dependent antibacterial activity and has the potential to be developed as a topical herbal preparation to support diabetic ulcer therapy.
Tinjauan Cakupan: Faktor-faktor yang Berkontribusi pada Keberhasilan Intervensi Berbasis Komunitas dalam Meningkatkan Asupan Protein Hewani pada Anak Usia 6–23 Bulan (Studi di Negara Berpendapatan Rendah dan Menengah) Fathimah Asri Fadhilah Aulia; Sri Achadi Nugraheni; Siti Fatimah Pradigdo; Muflihatun Nisa
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1399

Abstract

Purpose: The intake of animal protein among children aged 6–23 months in low-income and middle-income countries remains far below WHO recommendations. This scoping review aims to map community health worker–based interventions in improving animal protein intake during complementary feeding. Methods: Through a systematic search of the Scopus, PubMed, and EBSCOhost databases, 12 studies from various low-income and middle-income countries were analyzed using the Joanna Briggs Institute appraisal tool. Twelve studies from Africa, Asia, and Latin America met the inclusion criteria. All studies reported improvements in maternal knowledge related to animal-source protein (ranging from 19% to 37%) and positive changes in complementary feeding practices, including increased consumption of animal-source foods and improved dietary diversity. Several studies also demonstrated favorable impacts on child nutritional status, with reductions in stunting of up to 8.1%. Five main intervention strategies were identified: face-to-face nutrition education, community-based behavior change communication, home visits, combined lipid-based supplementation, and practical learning approaches. Ten enabling factors were consistently reported, particularly adequate CHW training, strong health system support, high CHW motivation, family involvement, and availability of local animal-source foods. Conversely, nine major barriers were identified, most notably household economic constraints, which were reported across all studies. Conclusion: Community-based interventions led by community health workers are effective in improving animal-source protein intake and complementary feeding practices among children under two years of age in LMICs. Program success depends on the interaction between well-trained and supported CHWs, enabling household and community environments, and broader socioeconomic conditions. Addressing structural barriers, especially household economic limitations, is essential to sustain and scale up effective interventions.
Pengembangan Formulasi Tablet Karbon Aktif Kayu Gelam (Melaleuca Sp) sebagai Alternatif Pengobatan Antidiare Tuti Alawiyah; Raihanah Raihanah; Setia Budi; Sismeri Dona
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1402

Abstract

Background: Diarrhea remains a major global health problem requiring effective and safe therapeutic interventions. The utilization of natural activated carbon presents a promising alternative for antidiarrheal therapy. Objective: This study aimed to develop an activated carbon tablet formulation derived from Kayu Gelam (Melaleuca sp.) and to evaluate the physical and chemical quality of the resulting tablets. Methods: Activated carbon was obtained through carbonization and chemical activation processes, then formulated into three tablet formulas with varying concentrations of polyvinylpyrrolidone (PVP) as a binder: 2% (Formula 1), 3% (Formula 2), and 4% (Formula 3). Tablet quality evaluation included pH measurement, weight uniformity, hardness, friability, and disintegration time. Data were analyzed using one-way ANOVA. Results: The pH values of Formulas 1, 2, and 3 were 6.15, 6.65, and 6.85, respectively, all within the neutral range (5.8–7.4) and safe for biological systems. The average tablet weights were 157.0 mg, 153.5 mg, and 158.5 mg, respectively, meeting weight uniformity requirements. Hardness values were 6.47 kg, 6.83 kg, and 7.67 kg, indicating adequate mechanical strength. Friability values were 0.664%, 0.763%, and 0.502%, all below the acceptable limit of 1%. Disintegration times were 13.01 min, 13.65 min, and 13.85 min, respectively, satisfying the requirement of less than 15 minutes. One-way ANOVA revealed significant differences (p < 0.05) in pH, hardness, friability, and disintegration time among the three formulas, while weight uniformity showed no significant difference (p > 0.05). Conclusion: All formulated Kayu Gelam activated carbon tablets met the required physical and chemical quality parameters, demonstrating their potential for further development as an alternative antidiarrheal tablet preparation.

Page 76 of 79 | Total Record : 782

 74   75   76   77   78 

Filter by Year

2018 2026


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 2 (2026) JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue