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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 782 Documents
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Analisis Pengetahuan Dan Kepatuhan Pengobatan Pasien Diabetes Melitus Tipe 2 Di Puskesmas Kedungmundu Semarang Rizky Budi Santoso; Nadya Putri Arissanti; Anak Agung Pradnya Paramitha Vidiani; Anisa Devi Kharisma; Anisa Nova Puspitaningrum
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1472

Abstract

Type 2 Diabetes Mellitus is a chronic disease caused by metabolic disorders characterized by hyperglycemia due to impaired insulin secretion or action. Long-term management is required to prevent complications, making patient adherence to treatment essential. Patients’ knowledge of their disease significantly influences their attitudes and behaviors in undergoing therapy. This study aims to examine the relationship between knowledge levels and medication adherence among patients with Type 2 Diabetes Mellitus at Kedungmundu Public Health Center, Semarang. This research employed an analytical observational design with a cross-sectional approach conducted from March to June 2025. A total of 225 respondents were selected randomly using a simple random sampling method. The instruments used were the DKQ-24 questionnaire to assess knowledge and the Proportional Measurement of Adherence (ProMAS) questionnaire to evaluate medication adherence. Data were analyzed using Spearman's rank correlation test. The results showed that most respondents had a high level of knowledge (60.0%) and a high level of adherence (49.8%). Statistical analysis using the Spearman test revealed a significant relationship between knowledge and medication adherence (r = 0.536, p < 0.001). The higher the patients’ knowledge level, the higher their adherence to treatment. In conclusion, patients’ knowledge plays a crucial role in enhancing medication adherence among individuals with Type 2 Diabetes Mellitus. Therefore, structured health education should be emphasized as an effective strategy to improve disease management and patient outcomes.
Perbandingan Efektivitas Antibakteri Ekstrak dan Sediaan Hand Soap Gel Daun Peppermint (Mentha piperita L.) Terhadap Bakteri Staphylococcus aureus Penyebab Infeksi Kulit Candrika Candrika; Nufadila Nazmi; Halimah Raina Nasution; Ziza Putri Aisyia Fauzi; Khaira Banu; Lusi Mardika Ariyanti; Hardiyanti Rukmana
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1479

Abstract

Background: Peppermint leaves (Mentha piperita L.) contain various secondary metabolites, including flavonoids, alkaloids, tannins, and steroids, which exhibit antibacterial activity. The development of peppermint extract into a hand soap gel requires evaluation of its physical stability and antibacterial effectiveness. Aim: This study aimed to formulate a hand soap gel from peppermint leaf ethanol extract and evaluate its physical characteristics, stability, and antibacterial activity against Staphylococcus aureus. Methods: Peppermint leaves were extracted by maceration using 70% ethanol. Hand soap gel formulations containing 3%, 6%, and 9% extract concentrations were prepared and evaluated through organoleptic, homogeneity, spreadability, foam height, pH, viscosity, and stability tests under different storage temperatures. Antibacterial activity was determined against Staphylococcus aureus using the agar diffusion method. Results: The ethanol extract demonstrated antibacterial activity with a maximum inhibition zone of 17.1 mm at 50% concentration. All hand soap gel formulations showed good physical characteristics and stability under various storage temperatures. The antibacterial activity of the formulations increased with extract concentration, producing inhibition zones ranging from 20.8 to 21.1 mm, categorized as very strong activity. Statistical analysis using one-way ANOVA showed significant differences among treatment groups (p < 0.05). Conclusion: Peppermint leaf ethanol extract can be successfully formulated into a stable hand soap gel preparation with very strong antibacterial activity against Staphylococcus aureus.
Uji Efektivitas Gel Ekstrak Buah Tomat (Solanum lycopersicum L.) Terhadap Staphylococcus aureus Yulia Kristyanti; Evanisia More
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1489

Abstract

Acne is an inflammatory condition of the sebaceous layer accompanied by blockage and accumulation of keratin, characterized by the appearance of blackheads, papules, pustules, nodules, and cysts, which are considered to damage appearance. In addressing this condition, people tend to use natural remedies because they have fewer side effects. One of the natural ingredients that is often used is tomatoes (Solanum lycopersicum L.). Tomatoes contain many components, including flavonoids, alkaloids, and saponins, which act as antibacterial agents. The purpose of this research is to determine the effectiveness of tomato fruit extract gel as an antibacterial and the most optimal dosage of the tomato fruit extract gel. The method used in this research is the evaluation of the antibacterial ability of tomato fruit extract gel based on organoleptic physical properties, homogeneity, pH, adhesion, spreadability, viscosity, and antibacterial testing of Staphylococcus aureus using the well diffusion method on Mueller Hinton Agar medium. Based on the results of One-Way ANOVA This study shows that 75%, 85%, 95%, and the control (+) tomato fruit extract gel have antibacterial activity. Formula I, with a gel extract concentration of 75%, has an inhibition zone of 18.02 mm, and Formula II, with a gel extract concentration of 85%, has an inhibition zone of 20.84 mm. Both formulas do not have a significant difference. Meanwhile, the gel Formula III with a 95% extract concentration has greater antibacterial activity, measuring 26.65 mm, which is the same as the control (+) or shows no significant difference p>0.05. The most effective dose as an antibacterial is the gel extract of tomato fruit (Solanum lycopersicum L.) with a concentration of 95%, with an inhibition diameter of 26.65 mm, categorized as very strong in inhibiting bacterial growth. Meanwhile, the 75% and 85% concentrations with inhibition diameters of 18.02 mm and 20.84 mm fall into the strong inhibition.
Dampak Tingkat Pendidikan, Persepsi Penyakit, Kualitas Pelayanan, dan Aksesibilitas terhadap Pemanfaatan Layanan Rawat Jalan Penyakit Dalam: Scoping Review Lita Susanti; Izaak Zoelkarnain Akbar; Neka Erlyani; Fauzie Rahman; Muhammad Abdan Shadiqi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1494

Abstract

Background: Outpatient healthcare utilization, particularly in internal medicine, plays a crucial role in early diagnosis, continuity of care, and clinical outcomes. However, disparities in the utilization of these services remain a challenge due to multiple interrelated determinants. Objective: This scoping review aimed to map and synthesize the evidence regarding the influence of educational attainment, illness perception, service quality, and accessibility on the utilization of internal medicine outpatient services. Methods: The review followed the Arksey and O'Malley framework and was reported in accordance with the PRISMA-ScR guidelines. A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar for studies published between 2016 and 2026. A total of 16 studies met the inclusion criteria and were analyzed. Results: Most included studies employed quantitative cross-sectional designs, while several used qualitative and mixed-methods approaches. Educational attainment was reported as a significant determinant in 12 studies (71%), accessibility in 14 studies (82%), illness perception in 8 studies (47%), and service quality in 6 studies (35%). A combination of individual, psychological, service-related, and structural factors influenced outpatient service utilization. Educational attainment and accessibility were the most frequently reported determinants, whereas illness perception and service quality played roles in shaping healthcare-seeking behavior and continuity of care. Heterogeneity in study design, measurement approaches, and healthcare system contexts was a major limitation. Conclusion: Outpatient internal medicine service utilization is multidimensional and requires integrated strategies, including enhancing health literacy, strengthening patient-centered service quality, and reducing financial and geographical barriers, to achieve more equitable and effective healthcare delivery.
Evaluasi Potensi Interaksi Obat pada Pengobatan Pasien ISPA Anak Rawat Inap di Rumah Sakit Kota Banjarmasin. Aris Fadillah; Hasniah Hasniah; Juwita Ramadhani; Muliyani Muliyani; Muhammad Hasan Andriyanto; Nily Su’aida
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1499

Abstract

Introduction: Drug interactions represent a clinically significant drug-related problem that may compromise therapeutic efficacy and increase the risk of adverse events. In pediatric patients with acute respiratory infections (ARIs), the use of multiple medications is common, potentially elevating the likelihood of drug interactions. Objective: This study aimed to evaluate the potential drug–drug interactions in hospitalized pediatric patients diagnosed with ARIs in Banjarmasin, Indonesia. Methods: A retrospective descriptive study was conducted using secondary data retrieved from the Hospital Management Information System. All medication regimens administered to pediatric inpatients with ARIs from January to June 2024 were analyzed. Drug interaction screening was performed using the Drugs.com Interaction Checker application. Results: Among 81 patients who met the inclusion criteria, 7 patients (8.64%) received treatment regimens with potential drug–drug interactions, accounting for a total of 8 interaction events (mean 1.14 interactions per affected patient). All identified interactions were classified as moderate in severity. Pharmacodynamic interactions were predominant (87.50%), whereas pharmacokinetic mechanisms comprised the remaining 12.50%. The most frequently observed potential interaction was between gentamicin and ceftriaxone (62.50%). Conclusion: Although the prevalence of potential drug interactions in this study was relatively low, their presence—particularly moderate-level pharmacodynamic interactions—warrants systematic clinical pharmacy monitoring to enhance patient safety and prevent undesirable clinical outcomes in pediatric ARI management.
Evaluasi Rasionalitas Penggunaan Obat Antidiabetes pada Pasien Diabetes Melitus Tipe 2 dengan Komplikasi Hipertensi di Instalasi Rawat Inap Salah Satu Rumah Sakit Kota Cimahi: English Linda Purnamawati Suherman; Diana Novalina; Pudjiastuti Kartidjo; Fauziah Nurul Afifah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1501

Abstract

Type 2 diabetes mellitus (T2DM) with hypertension complications requires rational and standardized pharmacological management to prevent cardiovascular deterioration. This study aimed to evaluate the pattern and level of rationality of antidiabetic drug use in T2DM patients with hypertension complications in the inpatient ward of a hospital in Cimahi City for the period of January 2023 to December 2024. This study utilized a retrospective descriptive-analytical observational design involving 79 medical records that met the inclusion criteria. The assessment of rationality was measured using five parameters based on the Indonesian Ministry of Health guidelines: appropriate indication, drug selection, dosage, administration interval, and duration of therapy. The majority of patients were elderly females (62%). Prescribing patterns indicated that 50.6% of patients received a combination therapy of insulin and oral hypoglycemic drugs (OHDs), 31.7% received OHD monotherapy, and 12.6% received insulin monotherapy, with metformin and glimepiride being the most prescribed OHDs. The evaluation results of the rationality level reached 100% for the parameters of appropriate indication and duration of therapy, 96% for appropriate administration interval, 90% for appropriate dosage, and 70% for appropriate drug selection. The majority of inappropriateness stemmed from the selection of insulin regimens that had not been optimally individualized to the patients' clinical profiles. Overall, the antidiabetic management was classified as rational; however, a multidisciplinary approach and strong coordination between physicians and clinical pharmacists are crucial to optimize therapy individualization and adherence to standard guidelines.
Perbandingan Biaya Global Hemodialisis dan Dialisis Peritonal Pada Penyakit Ginjal Tahap Akhir: Tinjauan Sistematis Berdasarkan Tingkat Pendapatan Negara Affifatu Annisa; Dwi Endarti; Auliya Abdurrohim Suwantika; Wening Wulandari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1504

Abstract

The increasing prevalence of end-stage renal disease poses an economic challenge to healthcare systems worldwide. Hemodialysis and peritoneal dialysis are currently the most commonly used renal replacement therapy modalities, but their costs vary across components and economic contexts. This systematic review aims to compare the costs of hemodialysis and peritoneal dialysis across countries, considering income levels and economic perspectives. A systematic literature search was conducted using EBSCO, ProQuest, PubMed, Scopus, and SpringerLink databases, with studies conducted between 2015 and 2025. Studies reporting cost analyses of hemodialysis and/or peritoneal dialysis were included. The selection process followed PRISMA guidelines, and the methodology was assessed using the CHEERS 2022 checklist. A total of 33 studies were included for discussion across low- to high-income levels. Economically, peritoneal dialysis was found to be more cost-effective than hemodialysis in most of these studies. The difference in cost structure is attributed to direct medical costs, which constitute the largest component of costs. Hemodialysis treatment is more expensive due to the costs of dialysis machines, service facilities, labor, and infrastructure, as well as lost productivity and indirect medical costs. Advantages of peritoneal dialysis include lower transportation costs, reduced productivity loss, and accessibility to low- and middle-income countries. Several studies have also shown that peritoneal dialysis yields quality-adjusted life years (QALYs) comparable to hemodialysis. This systematic review concludes that peritoneal dialysis can be cost-effective in most high-income countries. It should be considered a treatment modality of choice to improve efficiency, control long-term costs, and support health insurance management.
Beban Ekonomi Transplantasi Ginjal sebagai Terapi Pengganti Ginjal pada Pasien Penyakit Ginjal Kronik Stadium Akhir: Tinjauan Sistematis Qurrata Akyuni; Dwi Endarti; Auliya Abdurrohim Suwantika; Wening Wulandari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1505

Abstract

End-stage renal disease (ESRD) imposes a substantial economic burden on healthcare systems worldwide, extending well beyond its clinical implications. This burden is predominantly attributable to the requirements of renal replacement therapy (RRT), with kidney transplantation representing one of the most cost-intensive components of ESRD management. The complexity and continuity of long-term care needs further amplify the financial pressure on health systems globally. This systematic review was undertaken to identify and evaluate the economic burden associated with chronic kidney disease (CKD) across various RRT modalities, namely hemodialysis, peritoneal dialysis, and kidney transplantation, within diverse healthcare contexts. A systematic literature search was conducted in Scopus, PubMed, SpringerLink, and ProQuest, encompassing English-language observational studies and economic evaluations published between 2015 and 2025 that reported direct medical costs, non-medical costs, productivity losses, and related economic indicators. A total of 15 studies from multiple countries were analyzed, revealing a broadly consistent pattern of findings. Healthcare expenditures were found to escalate markedly with advancing CKD stage and the initiation of RRT. Multiple economic evaluation frameworks were employed, including disease burden analysis, cost-benefit analysis, comparative cost analysis, and cost-utility analysis. Hemodialysis incurred the highest annual costs, followed by peritoneal dialysis. While kidney transplantation requires a greater upfront investment, it has considerably lower long-term annual costs than continuous dialysis. The review ultimately affirms that kidney transplantation constitutes a more economically efficient therapeutic strategy for ESRD management, with meaningful potential to alleviate the broader global economic burden associated with this condition.
Indonesia Pengaruh Edukasi Terstruktur Berbasis Booklet Terhadap Kepatuhan, Kualitas Hidup, Dan Kadar Glukosa Darah Sewaktu Pasien Diabetes Melitus Tipe 2 Di Puskesmas Kota Tasikmalaya, Jawa Barat, Indonesia Listya Permatasari; Tri Murti Andayani; Fita Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1526

Abstract

This study aimed to analyze the effect of structured booklet-based education on medication adherence, quality of life, and random blood glucose levels in patients with type 2 diabetes mellitus at primary health care centers in Tasikmalaya City. This research employed a quasi-experimental design with a pretest–posttest control group approach. A total of 72 respondents were divided into an intervention group (n=36) and a control group (n=36). Medication adherence was assessed using the Morisky Green Levine Scale (MGLS), quality of life was measured using the Diabetes Quality of Life–Brief Clinical Inventory (DQoL-BCI), and clinical outcomes were evaluated using random blood glucose levels. The results showed that the intervention group experienced a significant improvement in medication adherence (p<0.001) and a significant reduction in random blood glucose levels (p<0.001). Quality of life also improved significantly within the intervention group (p<0.001); however, the difference in posttest quality of life between groups was not statistically significant (p=0.317). The improvement in quality of life observed in both groups may have been influenced by routine primary health care services, repeated attention during the study (Hawthorne effect), as well as support from health cadres or the surrounding environment that was not specifically measured. ANCOVA analysis demonstrated that after controlling for confounding variables, structured booklet-based education had a significant effect on medication adherence (p<0.001) and random blood glucose levels (p=0.048), but not on quality of life (p=0.055). In conclusion, structured booklet-based education was effective in improving medication adherence and reducing random blood glucose levels, but it did not show a statistically significant effect on quality of life in patients with type 2 diabetes mellitus.
Perbandingan Hambatan Implementasi Resep Elektronik di Berbagai Fasilitas Pelayanan Kesehatan: Sebuah Tinjauan Sistematis Yusup Maulana; Susi Ari Kristina; Chairun Wiedyaningsih
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1530

Abstract

Background: Electronic prescribing (e-prescribing) is increasingly implemented to improve patient safety and healthcare efficiency. However, its implementation across different healthcare settings continues to face complex and varied barriers. Aim: This systematic review aims to identify barriers to e-prescribing implementation, compare variations in barriers across healthcare facility types, and develop evidence-based recommendations. Methods: A systematic literature search was conducted in Scopus, PubMed, and ScienceDirect following PRISMA guidelines, supplemented by manual reference screening and grey literature searches. Eligible studies included English-language qualitative and mixed-methods research focusing on implementation barriers. Data were analyzed using thematic synthesis, while methodological quality was assessed using the Joanna Briggs Institute (JBI) tools and the Mixed Methods Appraisal Tool (MMAT). Results: Ten studies met the inclusion criteria, covering hospitals, primary care clinics, community pharmacies, and residential aged care facilities. Four major categories of barriers were identified: technical and system challenges, workflow barriers, human and behavioral factors, and organizational and regulatory constraints. Barrier patterns varied significantly across facility types, with technical barriers being most dominant in hospitals, transitional barriers in primary clinics, operational pressures in pharmacies, and low user motivation in residential aged care facilities. Conclusion: Successful e-prescribing implementation requires an integrated approach addressing technical, organizational, and human factors. Implementation strategies must be tailored to the specific characteristics of each healthcare setting to support patient safety and sustainable healthcare quality.

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