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Usadha
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 29632161     DOI : https://doi.org/10.36733/usadha.v2i2
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Usadha: Jurnal Integrasi Obat Tradisional, bertujuan untuk mendorong integrasi Obat Tradisional ke dalam sistem pelayanan kesehatan modern dalam bentuk pertukaran informasi ilmiah baik di kalangan peneliti, praktisi obat tradisional dan tenaga medis, pemegang kebijakan, industri dan stakeholder lainnya, dalam upaya pengembangan obat tradisional untuk masyarakat. Usadha menerima berbagai macam hasil penelitian dari berbagai bidang ilmu baik dalam bentuk artikel original, artikel review, maupun komunikasi singkat yang berkaitan dengan upaya untuk mendorong integrasi dan pengembangan obat tradisional mulai dari hulu hingga ke hilir, yang dapat meliputi namun tidak terbatas pada: 1) eksplorasi dan identifikasi bahan obat tradisional; 2) identifikasi zat aktif dari bahan alam; 3) pembuktian ilmiah khasiat dan keamanan obat tradisional baik preklinis maupun klinis; 4) pengembangan teknologi ekstraksi dan isolasi senyawa bahan alam; 5) teknologi produksi dan penghantaran obat berbasis bahan alam serta kosmetika herbal; 6) pengembangan produk nutrasetika dari bahan herbal; 7) sistem pelayanan obat tradisional di klinik dan komunitas; 8) kebijakan di bidang obat tradisional, konservasi dan budidaya tanaman obat tradisional; dan lainnya yang dalam lingkup obat tradisional. Usadha diterbitkan oleh Fakultas Farmasi Universitas Mahasaraswati Denpasar, dengan jumlah terbit 3 kali dalam setahun pada bulan April, Agustus, dan Desember.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 66 Documents
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Obat Herbal Berbasis Bukti Untuk Hepaprotektor Dewi Agustini, Ni Putu; Anita Dewi, Ni Luh Kade Arman; Megawati, Fitria; Wulandari, Ratna
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5925

Abstract

Liver damage can occur due to infection, viruses, drug use, and the environment. Paracetamol is a drug that has analgesic and antipyretic effects, but on the other hand the use of paracetamol in excessive doses (15/day) can cause liver damage. This can occur because the process of paracetamol metabolism in the liver forms a reactive metabolite known as N-acetyl-pbenzoquinonemine (NAPQI). The hepatoprotective mechanism can be seen from the ability of Ichnocarpus frutescens to ward off free radicals formed from the process of lipid oxidation due to the reactive metabolite of paracetamol, namely NAPQI. The method used is a literature review which is a systematic, explicit and reproducible method for carrying out identification, evaluation and synthesis of research works and ideas that have been produced by researchers and practitioners. The data base used is National and International Journal Websites such as Google Scholar.
EFEKTIFITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER PADA BEBERAPA TANAMAN OBAT TERHADAP PERTUMBUHAN BAKTERI STAPHYLOCOCCUS AUREUS Zahki, Muhammad
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.5927

Abstract

Infection is one of the diseases that can be transmitted to humans which until now still has to be seriously resolved. Staphylococcus aureus infection is a problem that is of great concern due to the increase in bacterial resistance to various antibiotics. With the widespread resistance of bacteria to existing drugs, further encouragement must be carried out on the importance of efforts to create new alternatives by administering infectious disease prevention drugs using raw materials from nature. The research method uses secondary data taken from literature studies, which are analyzed from data related to the effectiveness of medical plants. Data collection techniques in this research are in the form of reviews from scientific journals, published national and international journals. The results obtained from several research literatures that are effective against the growth of staphylococcus aureus bacteria are Moringa leaves. Where at low concentrations, Moringa leaves provide a large diameter of the inhibition area for bacterial growth and if the given concentration is increased, the diameter of the area of ​​bacterial inhibition produced will be even greater. This is also supported by several previous studies that have been carried out by many researchers that Moringa leaves have antibacterial activity against antibiotic-resistant pathogenic bacteria, especially Staphylococcus aureus bacteria and Moringa leaves contain several secondary metabolite compounds that actively inhibit bacterial growth, namely flavonoids, saponins and tannins.
ARTIKEL REVIEW: Penggunaan Obat Herbal Dalam Upaya Swamedikasi atau Pengobatan Sendiri Pada Penyakit Batuk Dan Flu Suardika, I Wayan Gede; Amesti Dewi , Ni Made Wahyuni; Megawati, Fitria
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.5972

Abstract

Self-medication is a treatment that is carried out alone or independently with the aim of preventing or treating a disease. Diseases that are usually carried out by self-medication are coughs and flu. This article aims to look at the potential of herbal medicines in Indonesia as self-medication in the treatment of coughs and flu. The important value in this review article is the use of herbal plants in self-medication. The type of research method used in this review article is using review article studies, by collecting data derived from articles in journal form on the topic of using herbal medicines in self-medication efforts or self-medication for coughs and flu in the last 10 years. Retrieval of articles with a range of the last 10 years is still considered relevant and well used. Herbal medicine that has been widely used in the last 10 years is ginger (Zingiber officinale). Ginger is widely used because it has been proven empirically.
Artikel Review Pemanfaatan Tanaman Pisang (Musa Paradisiaca L.) sebagai Sediaan Kosmetik Firda Ekayanti, Ni Luh; Megawati, Fitria; Anita Dewi, Ni Luh Kade Arman
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.6217

Abstract

Banana plant (Musa paadisiaca L.)is a type of herbaceous fruit. The banana plant consists of roots, stems, leaves, flowers and fruit. The purpose of this article review is to find out the benefits of banana plants as cosmetic preparations. The content of banana plants include flavonoids, tannins, alkaloids, saponins and others. The type of research method used in review article is to use a literature review, by collecting journals and evaluating information from several journals or guidelines related to the use of banana plants (Musa paradisiaca l.). Banana plants can be used as cosmetic preparations in the form of pell off, loose powder, sheet mask, liquid soap, cream hair polish, lotion and gel. The parts of the banana plant that are used as cosmetic preparations are the banana weevil, stem, midrib, banana leaf, banana peel, and banana heart midrib. Keywords : banana plant for skin, banana plant cosmetics
Formulasi Dan Uji Mutu Fisik Sediaan Foot Lotion Ekstrak Etanol Daun Sirih (Piper bettle L.) Dengan Variasi Konsentrasi Asam Stearat Juliadi, Debby; Juanita, Rr Asih; Dewi Agustini, Ni Putu
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.6420

Abstract

Betel leaf extract (Piper bettle L.) is known to contain flavonoid compounds that have antibacterial activity. Betel leaf extract needs to be formulated as a foot preparation lotion to increase the comfort of use as a topical antibacterial. The composition of the emulsifier influences the physical stability of the preparation foot lotion used. This study aims to determine the variation of stearic acid preparations foot lotion, which has good physical quality and is stable in storage. This research is purely experimental laboratory research that aims at development (development), namely developing something in an existing field (development of test methods, drug formulation). The observed responses were the physical quality of the preparations, which included organoleptic tests, homogeneity tests, pH tests, spreadability tests, and adhesion tests. The physical quality of preparations of foot lotion was analyzed descriptively. This research began with a maceration process using 70% ethanol to obtain a thick betel leaf extract (Piper bettle L.). This study made three preparation formulas with foot lotion with stearic acid concentrations of 10%, 12.5%, and 15%. The preparations that have been made are then tested for their physical quality and stability during four weeks of storage. The results of this study indicate that the preparations obtained foot lotion betel leaf ethanol extract (Piper bettle L.) with a variation of stearic acid of 10% to produce preparations of foot lotion with good physical quality seen from organoleptic tests, homogeneity, pH, spreadability, and adhesion and stable in storage for four weeks.
Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K: Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K Andriese, Ni Putu Sri Ayu Sevilla Andriese; Santoso, Puguh; Ari Candra, Agung; Surya Rahadi, I Wayan
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.6733

Abstract

One of the original Indonesian plants that has medicinal properties is Dewandaru (Eugenia uniflora Linn.). Dewandaru shows cytotoxic activity against cancer cells so it has the potential to be used as a drug preparation. The potential compound from the leaves of Dewandaru is Curzerene. This research was conducted to identify the interaction between the compounds of dewadaru leaves and PI3K receptors in prostate cancer. This study uses a computational method known as molecular docking. Bond energies, visualization of bonds, and types of bonds between compounds and receptors were observed. The PI3K receptor has fulfilled the method validation test requirements. The results showed that compounds from the dewadaru plant could inhibit one target protein from prostate cancer which was expressed with the lowest ∆Gbinding value, namely Curzerene compound (-7.65 kcal/mol) in PI3K protein. The interaction between Curzerene compounds has a lower binding energy value when compared to the original ligands at the PI3K receptor. Thus, it can be concluded that the Curzerene compound in the dewadaru plant used in the study has a good interaction with the PI3K receptor in prostate cancer. This compound has the potential to be developed as an anticancer drug. It is necessary to carry out in vivo testing and modification of the structure of the compound so that it can be used as an effective anticancer therapy in prostate cancer. Keywords: Prostate cancer, Curzerene, Dewandaru leaves, In silico
Potensi Tabir Surya pada Tanaman Herbal: Literature Review Wulaningtyas, Ni Ketut Maha; Kusuwa Wardani, I Gusti Agung Ayu; Vernandes Sasadara, Maria Malida
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7065

Abstract

Paparan sinar matahari dengan intensitas yang tinggi dan secara berlebihan dapat menimbulkan berbagai efek samping, salah satunya adalah kerusakan pada kulit. Oleh karena itu, diperlukan upaya yang tepat untuk mencegah efek-efek yang merugikan bagi kulit, salah satunya adalah dengan penggunaan tabir surya. Tabir surya memiliki kemampuan dalam melindungi kulit dengan cara menunda eritema yang dinyatakan Sun Protection Factor (SPF). Tabir surya yang bersumber dari bahan alam dapat dijadikan alternatif bagi konsumen yang memiliki kulit sensitif terhadap penggunaan tabir surya dari zat aktif kimia. Literature review ini bertujuan untuk mengetahui bahan alam yang memiliki potensi sebagai tabir surya berdasarkan nilai SPFnya.Pencarian literatur dilakukan melalui database Pubmed, Google Scholar dan Science Direct, dengan menggunakan kata kunci yang sesuai. Artikel yang terpilih adalah artikel yang memenuhi kriteria inklusi, yakni artikel yang bersifat original research dan dipublikasikan maksimal 10 tahun terakhir serta sesuai dengan kata kunci yang telah disusun. Berdasarkan hasil penelitian diketahui bahwa terdapat beberapa tanaman yang memiliki proteksi untuk melindungi kulit terhadap sinar ultraviolet seperti tanaman kecombrang (Etlingera elatior), binahong (Anredera cordifolia), Dengen (Dillenia serrata), Kebiul (Caesalpinia bonduc), alga hijau (Ulva reticulata Forsskal), jeruju (Acanthus Ilicifolius), moringa (Moringa oleifera), Zea mays dan(Persea americana). Potensi tabir surya yang dihasilkan oleh tanaman tersebut disebabkan karena adanya kandungan senyawa polifenol seperti flavonoid dan tannin yang berperan sebagai antioksidan kuat.
Tingkat Pengetahuan Penggunaan Tanaman Obat Tradisional Sebagai Alternatif Pengobatan Pada Masyarakat Desa Wisata Bindu Dewi Agustini, Ni Putu; Megawati, Fitria; Juliadi, Debby; Widiari, Ni Nyoman Sri
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7145

Abstract

Public knowledge about the use of plants as medicine is mostly limited to hereditary knowledge as a form of interaction between the community and the environment, especially plants. Currently medicinal plants or herbal plants have been widely used in the medical or health fields. Today's society prefers to use products that come from nature for safety reasons. This study aims to determine the level of knowledge of the use of traditional medicine as an alternative treatment in the community of Bindu Tourism Village. The research method used is a descriptive survey method with a cross-sectional design where the research object is only observed once without any pre-test and post-test with data collection techniques using questionnaires distributed via online in Bindu Tourism Village. The data obtained from the research results were then processed by calculating the percentage of respondent answers. The results of the questionnaire data analysis obtained from 104 respondents showed that the people who had a good level of knowledge were 51 people (49%), 46 people (44%), and the level of knowledge in the poor category were 7 people (7%). The average value of knowledge from 104 respondents is 77% which is included in the range (76%-100%), so the level of knowledge of respondents is good.
Formulasi Dan Uji Mutu Fisik Ekstrak Etanol Rimpang Kunyit Putih (Curcuma Zedoaria) Pada Sediaan Tablet Dengan Variasi Bahan Polivinil Pirolidon Dan Starch 1500 Rika, Putu; Juliadi, Debby; Putra, I Made Agus Sunadi
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7363

Abstract

The white turmeric plant (Curcuma zedoaria) is a species from the Zingiberaceae family which is very important in traditional medicine and the medicinal industry. Apart from being used as a food or beverage ingredient, white turmeric is also used as a traditional medicine, such as stomach ache medicine, stomach booster, fever reducer and can treat skin diseases. This study aims to determine the effect of the concentration of polyvinyl pyrrolidone binder and starch 1500 disintegrating agent on the physical properties of tablets and to obtain a white turmeric rhizome ethanol extract tablet formula which has the best physical quality test. The method used in the manufacture of tablets is the wet granulation method, because this method can improve flow properties and increase compressibility. The results of this study on the physical quality testing of FI and FIII tablets have fulfilled the physical quality test requirements for tablets, but FII has not fulfilled the physical quality test requirements for tablet preparations because FII does not meet the disintegration time test requirements, this is influenced by the concentration of polyvinyl pyrrolidone binder (PVP) was higher than Starch 1500 disintegrant. In this study, FIII had the best physical quality test, where FIII was a physical quality test and had the fastest tablet disintegration time, which was 10 minutes. This is influenced by the higher concentration of Starch 1500 disintegrant, which is 8% compared to the polyvinyl pyrrolidone (PVP) binder, which is 5%.
Efek Ekstrak Etanol Buah Dewandaru (Eugenia uniflora L) terhadap Penurunan Kadar Glukosa Darah dan Perbaikan Sel Beta Pankreas pada Mencit yang Diinduksi Aloksan Maharani, Ade Dwi Karisma; Santoso, Puguh; Udayani, Ni Nyoman Wahyu
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.7384

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from impaired insulin secretion. Dewandaru fruit (Eugenia uniflora L.) contains flavonoids which act as free radical scavengers and reduce oxidative stress. This study aims to prove that the administration of ethanol extract of dewadaru fruit at doses of 200 mg/KgBW and 400 mg/KgB can reduce blood glucose levels and repair damage to pancreatic β cells in alloxan-induced male white mice (Rattus norvegicus) wistar strain diabetes mellitus. This study used 32 mice aged 2-3 months weighing 25 grams intraperitoneally induced by alloxan (0.5 ml/kg). Mice were divided into four treatment groups, namely K- (alloxan), K+ (glibenclamide), P1 (dose of dewadaru fruit extract 200 mg/kgBB), P2 (dose of dewadaru fruit extract 400 mg/kgBB) Quantitative data by calculating blood glucose levels and the number of pancreatic β cells were analyzed using Paired T-Test. P2 is the dose of dewadaru fruit extract 400 mg/kg BW. In the repair of pancreatic β cells it was stated that the average damage to pancreatic β cells at a dose of 200 mg/KgBB was 67.5 and at a dose of 400 mg/KgBW was 89.1. This study proves that the ethanol extract of dewadaru fruit is able to lower blood glucose and inhibit the rate of damage to pancreatic β cells in mice with diabetes mellitus. Keywords: dewadaru, diabetes mellitus, blood glucose, pancreatic β cells

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