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Usadha
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 29632161     DOI : https://doi.org/10.36733/usadha.v2i2
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Usadha: Jurnal Integrasi Obat Tradisional, bertujuan untuk mendorong integrasi Obat Tradisional ke dalam sistem pelayanan kesehatan modern dalam bentuk pertukaran informasi ilmiah baik di kalangan peneliti, praktisi obat tradisional dan tenaga medis, pemegang kebijakan, industri dan stakeholder lainnya, dalam upaya pengembangan obat tradisional untuk masyarakat. Usadha menerima berbagai macam hasil penelitian dari berbagai bidang ilmu baik dalam bentuk artikel original, artikel review, maupun komunikasi singkat yang berkaitan dengan upaya untuk mendorong integrasi dan pengembangan obat tradisional mulai dari hulu hingga ke hilir, yang dapat meliputi namun tidak terbatas pada: 1) eksplorasi dan identifikasi bahan obat tradisional; 2) identifikasi zat aktif dari bahan alam; 3) pembuktian ilmiah khasiat dan keamanan obat tradisional baik preklinis maupun klinis; 4) pengembangan teknologi ekstraksi dan isolasi senyawa bahan alam; 5) teknologi produksi dan penghantaran obat berbasis bahan alam serta kosmetika herbal; 6) pengembangan produk nutrasetika dari bahan herbal; 7) sistem pelayanan obat tradisional di klinik dan komunitas; 8) kebijakan di bidang obat tradisional, konservasi dan budidaya tanaman obat tradisional; dan lainnya yang dalam lingkup obat tradisional. Usadha diterbitkan oleh Fakultas Farmasi Universitas Mahasaraswati Denpasar, dengan jumlah terbit 3 kali dalam setahun pada bulan April, Agustus, dan Desember.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 74 Documents
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Formulasi Sediaan Shampo Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb) dan Daun Seledri (Apium graveolens L.) sebagai Antiketombe terhadap Jamur Candida albicans Danayasa, I Kadek; Yudianti Mendra, Ni Nyoman; Sunadi Putra, I Made Agus
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7382

Abstract

Dandruff is a scalp condition characterized by an anomaly, often caused by the fungus of Candida albicans. The development of safe and effective anti-dandruff shampoo is imperative. Notably, traditional medicine employs pandan wangi and celery leaves, rich in polyphenols, flavonoids, saponins, tannins and alkaloids as potential anti-dandruff agents. The aims of this study was to formulate and evaluate the antifungal activity of a combination shampoo containing extracts form pandan wangi and celery leaves. Antifungal testing was carried out using the diffusion method using paper discs. Three formulations were prepared FI (without extract), FII (10% pandan leaf extract, 20% celery leaf), FIII (20% pandan leaf extract, 10% celery leaf). Antifungal test was evaluated using the paper disc diffusion method, with 2% ketoconazole shampoo as the positive control. Physical quality test demonstrated favorable attributes for pandan wangi and celery leaf extract shampoo, with FII and FIII exhibiting dark green colors whit distinct odors, while FI remained colorless and odorless. Furthermore, all formulations were in semi-solid dosage forms and met pH requirement for scalps (pH 6,) and produced satisfactory foam yields (6,8-8,9 cm). The antifungal activity test revealed FI as the negative control with a 7 mm and 2% ketoconazole shampoo with a 24 mm inhibition zone, while FII and FIII showed no inhibition zone. The combination of pandan wangi and celery leaf extract in shampoo preparation showed no synergic activity to inhibit the growth of Candida albicans fungus. Further investigations and clinical trials are warranted to validate its effectiveness and safety for practical application.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Jelatang (Urtica dioica L.) Terhadap Bakteri Staphylococcus aureus Esti Trisna Putri, Ni Komang; Surya Rahadi, I Wayan; Sukma Sanjiwani, Ni Made
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7416

Abstract

Nettle leaf (Urtica dioica L.) is the most widely known species in the urtica genus and has many benefits for the community, namely for medicine, cosmetics and for consumption. Nettle leaves contain alkaloids, flavonoids, and saponins. These compounds can be known to have antibacterial activity. Staphylococcus aureus bacteria are gram-positive bacteria that can produce a yellow pigment, are facultative aerobes and colonies tend to be shaped like grapes. Naturally Staphylococcus aureus is a normal flora in humans, which is often found on the skin, nose and eyes. This study aims to determine the antibacterial activity of nettle leaf ethanol extract (Urtica dioica L.) against Staphylococcus aureus bacteria . The sample used was nettle leaves (Urtica dioica L.) taken in Buruan Village, Kec. Penebel, Kab. Tabanan. This research was conducted using laboratory experimental methods. The ethanol extract of nettle leaves was prepared by the maceration method using 96% ethanol and the viscous extract was obtained using a rotary evaporator . This study used the disc diffusion method with nutrient agar media. The concentrations of the nettle leaf ethanol extract used were 5%, 10%, and 15%. The antibacterial activity test showed that the ethanol extract of nettle leaves could inhibit the growth of Staphylococcus aureus bacteria at each concentration of nettle leaf extract (Urtica dioica L.) with the following inhibition zone diameters: concentrations of 5% (6.55 mm), 10% (1.06 mm), and 15% (0.48 mm). The nettle leaf ethanol extract had the highest antibacterial activity at a concentration of 5%, namely 6.55 mm, which was included in the medium category. Keywords : nettle leaf (Urtica dioica L.), antibakterial, Staphylococcus aureus.
Tingkat Pengetahuan Penggunaan Obat Tradisional dalam Pengobatan Swamedikasi pada PKK Banjar Tegal Buah Denpasar Barat Purnama Sari, Ni Kadek Akari; Tangkas Suwantara, I Putu; Udayana Antari, Ni Putu; Megawati, Fitria; Dewi Agustini, Ni Putu
Usadha Vol 3 No 1 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i1.7577

Abstract

  Treatment using traditional medicine has become integrated into Indonesian society and is used to treat health problems through self-medication. Traditional medicine is a nation's cultural heritage that needs to continue to be preserved and developed to support health development. This research aims to find out how self-medication uses traditional medicine in the PKK Banjar Tegal Buah West Denpasar. This type of research is quantitative survey research with data collection techniques using questionnaires and using a Likert scale in conducting surveys with questionnaire measuring instruments. This research was conducted from April to May 2023. The population in this study were all PKK mothers who had carried out self-medication using traditional medicine and the sample in this study was 100 respondents. The instrument used was a questionnaire sheet with 20 questions. Based on the results of research on the level of knowledge of the use of traditional medicine in 100 PKK respondents with the criteria for a good level of knowledge, 88 people (88%) while 12 people (12%) of respondents were included in the sufficient category.
Uji Efektivitas Antiinflamasi Ekstrak Etanol dan Fraksi Daun Ciplukan (Physalis angulata L.) Terhadap Mencit Putih Jantan (Mus musculus) Listina, Osie
Usadha Vol 3 No 1 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i1.8757

Abstract

Inflammation is a local protective response caused by tissue damage. Antiinflammatory drugs steroids and non steroids have many side effects so that there are many antiinflammatory development derived from natural materials, especially in plants.This study aimed to determine the anti-inflammatory effects of ethanol extract, N-hexane fraction and ethyl acetate fraction with doses of 600mg/kgBW, 1200mg/kgBW and 1800mg/kgBW. The method used was the production of udem induced with 1% carragenin subplantar. The study was conducted by administering carragenine as an inflammatory mediator on the feet of mice, then administering orally suspension Ethanol extract, N-hexane fraction and ethyl acetate fraction. Sodium CMC was as a negative control and diclofenac sodium was as a positive control. Measurements were taken every 30 minutes for 6 hours after induction of 1% carragenin. Based on the result of research, ethanol extract with dose of 600mg/kgBB had anti-inflammatory power of 48,43%, N-hexane fraction with dose 1200mg/kgBB had antiinflammatory power of 33,21% and ethyl acetate fraction with dose 1800mg/kgBB had anti inflammatory power equal to 50,08% and the most effective dose of anti inflammatory power of ethanol extract and ciplukan leaf fractionation at fraction of ethyl acetate 1800mg / kgBB with anti inflammatory value of 50,08%.
Potensi Kayu Manis sebagai Obat untuk Meredakan Nyeri Haid: Literature Review Sari, Gusti Ayu Putu Laksmi Puspa; Ari Kusuma Yana, I Gusti Agung; Lilis Adnyani, Ni Putu
Usadha Vol 3 No 1 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i1.8916

Abstract

According to the World Health Organization (WHO), in 2015, globally, an average of more than 50% of women experienced menstrual pain. The recorded incidence of menstrual pain or dysmenorrhea in Indonesia is 64.25%, which includes primary dysmenorrhea (54.89%) and secondary dysmenorrhea (9.36%). Menstrual pain is a common menstrual symptom in women who menstruate. This condition is characterized by cramps and cramps, colicky pain in the lower abdomen which disrupts daily activities. Menstrual pain may be caused by excessive or unbalanced levels of prostanoids and eicosanoids released from the endometrium during menstruation.
Literature Review: Potensi Daun Sirsak (Annona muricata L.) sebagai Obat Penurun Kadar Kolesterol Nur Aini, Ika; Laily, Rosdiana; Fikky Dian , Roqobih
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.9140

Abstract

  Cholesterol is a fat or lipid from the sterol group produced by the body. The higher the cholesterol level in the blood, the greater the risk of atherosclerosis, which is the first step in triggering other cardiovascular diseases such as hypertension, coronary heart disease, and even stroke and death. One of the synthetic drugs commonly used to treat high cholesterol is statins, especially atorvastatin. However, long-term use of atorvastatin can cause several side effects, including muscle pain, liver damage, type 2 diabetes, and digestive disorders. Because of the risk of these side effects, many people turn to herbal-based alternative treatments which are considered safer. Self-medication can be done to reduce high cholesterol levels. Self-medication is a community effort to obtain and use traditional medicine independently. One of the traditional medicines that is believed to lower cholesterol levels is soursop leaves. This research aims to look at the potential of soursop leaves as a medicine to lower cholesterol levels and provide a choice for people who want to reduce their cholesterol levels, especially for sufferers of hypercholesterolemia. This article is a literature review article using the literature review study method. A literature search was carried out using the Google Scholar database, namely articles or guidelines on the potential of soursop leaves as a medicine to lower cholesterol levels published in the last 10 years. The research results show that soursop leaves have a significant effect on reducing cholesterol levels. So soursop leaves can be considered a safe and effective herbal treatment for hypercholesterolemia.
Mini Review: Potensi Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp) sebagai Antibakteri Yuda, Putu Era Sandhi Kusuma; Pramesti , Luh Ratih Widhia; Widyani Nayaka , Ni Made Dwi Mara; Anita Dewi, Ni Luh Kade Arman; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7036

Abstract

  Infectious diseases by bacteria are one of the problems in the world of health. The therapy that can be given to people with bacterial infections is antibiotics. However, the increasing incidence of antibiotic resistance and bacterial infections requires other antibiotic alternatives such as those sourced from natural materials. Bay leaf (Syzygium polyanthum (Wight) Walp) included in the Myrtaceae family is one of the plants that is widely known among Indonesian people which empirically has properties in curing various diseases. Bay leaves are known to contain secondary metabolite compounds such as flavonoids, tannins, alkaloids, saponins, triterpenoids, steroids, eugenol, and essential oils that function as antibacterials. This literature review aims to discuss the antibacterial activity of bay leaves against gram-positive and gram-negative bacteria as well as the components of active compounds in bay leaves and their mechanism as antibacterials. The method used in the preparation of this review article is the literature study method. This research uses secondary data taken from the results of other researchers' research in the form of scientific articles that have been published in national and international scientific journals with a year limit from 2014 to 2023. Based on the literature study that has been done, it is known that bay leaves have potential as antibacterials against both gram-positive and gram-negative bacteria. The antibacterial activity is known to be related to the content of active compounds such as flavonoids, tannins, alkaloids, saponins, triterpenoids, steroids, phenols, and essential oils.
Formulasi Dan Uji Mutu Fisik Dari Granul Effervescent Ekstrak Daun Salam (Syzyginum polyanthum) Dewi, Ni Luh Samila; Suradnyana, I Gede Made; Juliadi, Debby
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7180

Abstract

  Bay leaf is one plant that has benefits as traditional medicine, acting as an antioxidant with flavonoid content. The processing is still very simple, which has an impact on the short shelf life of the herb. One alternative to prevent this is to formulat e bay leaf extract into effervescent granule preparations, which provide a more comfortable feeling with a large concentration of active substances. This study aims to determine the difference in the physical quality of effervescent granule preparations wit h variations of effervescent salts and to determine the concentration of acids and bases that produce effervescent granules of bay leaf extract with good physical quality. In 3 effervescent granule preparation formulas, the variation in acid and base concentrations (citric acid, tartric acid, and sodium bicarbonate) is F1 by 9.4%; 18.7%; 27%, F2 by 8.6%; 17.2%; 29%, and F3 by 7.9%; 15.8%; 31%. Physical quality evaluation of effervescent granule preparations includes organoleptis, flow velocity, rest angle, disperse time, pH, and moisture content. Quantitative data were analyzed with the One Way Anova test to determine the difference in physical quality of the three effervescent granule preparation formulas. Based on the results of physical quality tests, the three greenish-white granule formulas were obtained, the characteristic smell of bay leaf extract, and the granule form with a flow speed of 10 g / second, a stati onary angle in the range of 31-35 °, a dispersion time of < 5 minutes, a pH in the range of 5-6, and a moisture content of < 5 minutes. The results of One Way Anova testing found that the three formulas with variations of effervescent salts have different physical qualities, and acid-base concentrations that produce good physical qualities, namely F1 and F3
Formulasi dan Uji Mutu Fisik Sediaan Lip Balm Ekstrak Umbi Bit (Beta vulgaris L.) Tiarini, Diah Galuh; Suradnyana, I Gede Made; Juliadi, Debby
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7181

Abstract

Dry and chapped lips are one of the problems often faced by some people that will cause pain and discomfort. Lip balm is made from the main ingredient oil or fat that will provide moisture to the lips. The addition of color to lip balm preparations will add its own attractiveness, especially for women, because occasionally it can help improve facial aesthetics. Beetroot (Beta vulgaris L.) It is one of the plants that contains betacyanin pigment which has the potential as a natural dye and has very strong antioxidant activity. The purpose of this study was to determine whether there was a difference in the physical quality of lip balm preparations with variations in beetroot extract (Beta vulgaris L). This research is a laboratory study by formulating beetroot ethanol extract into lip balm preparations in 3 formulas with variations in extract concentration, namely formula I (6%), formula II (10%), and formula III (14%). Physical quality tests of the preparations observed are organoleptis, homogeneity, adhesion, and dispersion. Analysis of organoleptical data and homogeneity was carried out descriptively while the results of adhesion and dispersion tests were analyzed with inferential statistics using IBM SPSS statistics 26 at a 95% confidence level with the One-Way ANOVA test. The results of this study showed that there were differences in the physical quality of beetroot extract lip balm (Beta vulgaris L.) at a FI (6%) with a FII (10%) and FIII (14%) especially in the dosage color, adhesion, and spreadability.
Pengujian Fitokimia dan Penentuan Kadar Flavonoid Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Lusi Puspitasari, Ni Wayan; Sukma Sanjiwani, Ni Made; Wahyu Udayani , Ni Nyoman
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7278

Abstract

  Flavonoids are polyphenolic compounds, so they have the chemical properties of phenolic compounds, which are slightly acidic, soluble in bases, and are polyhydroxy (hydroxy groups) and polar. Flavonoids are found in many plants such as butterfly pea. This study aims to determine the presence or absence of flavonoids in the ethanol extract of butterfly peas and the levels of flavonoids contained in the extract of butterfly peas (Clitoria ternatea L.). This research was conducted by extracting the butterfly pea flower by maceration with ethanol and phytochemical testing of flavonoids. Flavonoid content was determined by the Chang method using UV-visible spectrophotometry. The data obtained were analyzed using Lambert Beer's law. The results of this study indicate that the ethanol extract of butterfly pea flowers positively contains flavonoid compounds which cause a red color after phytochemical testing. Determination of the levels carried out obtained an average level of flavonoids of 0.28107%.

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