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Patricia Wulandari
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Crown: Journal of Dentistry and Health Research
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 30261473     EISSN : 30261473     DOI : https://doi.org/10.59345/crown
Core Subject : Health, Science,
Dentistry Health Professions Medicine & Pharmacology Neuroscience Public Health
Focus Crown: Journal of Dentistry and Health Research (Crown) focused on the development of dentistry sciences and health research for human well-being. Scope Crown: Journal of Dentistry and Health Research (Crown) publishes articles which encompass all aspects of dentistry and health research , especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 25 Documents
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The Effect of Applying an Interdisciplinary Approach in the Management of Patients with Temporomandibular Joint (TMJ) Disorders at Dr. M. Djamil General Hospital, Padang, Indonesia Gunawan, Gunawan; Edi Sahputra
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.113

Abstract

Introduction: Temporomandibular joint (TMJ) disorders are a common health problem with significant global prevalence. Effective management of TMJ requires an interdisciplinary approach involving various health professions, such as dentists, physiotherapists, and psychologists. Methods: This study aims to evaluate the effect of applying an interdisciplinary approach in the management of patients with TMJ disorders at Dr. M. Djamil General Hospital, Padang, Indonesia. A retrospective cohort study was conducted on TMJ patients referred to an interdisciplinary team between 2018 - 2023. Patient data was collected from electronic medical records and analyzed to compare the outcomes of patients who received an interdisciplinary approach with those who received a traditional approach. Results: The results showed that the application of an interdisciplinary approach in the management of TMJ patients at Dr. M. Djamil General Hospital, Padang, Indonesia was associated with significant improvements in patient symptoms, including pain, joint dysfunction, and quality of life. Patients who received an interdisciplinary approach also demonstrated higher levels of satisfaction with their care. Conclusion: Implementation of an interdisciplinary approach in the management of TMJ patients at Dr. M. Djamil General Hospital, Padang, Indonesia was associated with significant improvements in patients' symptoms and their level of satisfaction with treatment. This approach is recommended for the management of TMJ patients in all clinical settings.
Analysis of Machine Learning-Based Dental Caries Risk Prediction Model at Cairo Hospital, Egypt Sami, Ayman
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.114

Abstract

Introduction: Dental caries is the most common chronic disease in children and adults throughout the world. Prevention of dental caries is very important to maintain healthy teeth and mouth. The aim of this study was to develop and analyze a machine learning (ML)-based dental caries risk prediction model in patients at Cairo Hospital, Egypt. Methods: Patient data was collected from medical records at Cairo Egypt Hospital. These data include demographic information, oral habits, and dental status. Different ML models, such as random forest, logistic regression, and support vector machine (SVM), were trained and evaluated to predict the risk of dental caries. Results: The developed ML model showed good performance in predicting the risk of dental caries. The random forest model had the highest accuracy, namely 87%, followed by logistic regression (85%) and SVM (82%). Conclusion: The ML model developed in this study can be a valuable tool to predict the risk of dental caries and to assist dentists in dental caries prevention efforts.
Evaluation of the Efficacy and Safety of Low Power Diode Laser Therapy for the Treatment of Chronic Gingivitis in Skopje Hospital Macedonia Spiroski, Milla; Igor Belenichev
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.115

Abstract

Introduction: Chronic gingivitis is the most common inflammatory periodontal disease, affecting up to 50% of adults. Low-power diode laser therapy (LLLT) has been proposed as an alternative treatment for chronic gingivitis. Methods: A double-blind randomized controlled study was conducted to evaluate the effectiveness and safety of LLLT in the treatment of chronic gingivitis. Thirty patients with chronic gingivitis were randomly divided into two groups: the control group (n=15) and LLLT group (n=15). The LLLT group received LLLT therapy for 10 minutes per session, twice daily for 14 days. Plaque index (PI), gingival bleeding index (GI), periodontal pocket depth (PPD), and degree of attachment loss (CAL) were measured before and after treatment. Results: The LLLT group showed significant reductions in PI, GI, PPD, and CAL compared with the control group. The difference between the two groups was statistically significant (p<0.05). No side effects were reported during the study. Conclusion: LLLT has been proven to be effective and safe in the treatment of chronic gingivitis. LLLT may be a useful alternative treatment option for patients with chronic gingivitis.
The Effect of Using Oral Probiotics on Dental and Oral Health in Type 2 Diabetes Mellitus Patients at Dr. M. Djamil General Hospital, Padang, Indonesia Farhanah, Farhanah
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.116

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) can increase the risk of periodontal disease and oral infections. Oral probiotics are believed to help maintain healthy teeth and mouth in T2DM patients. This study aims to evaluate the effect of using oral probiotics on dental and oral health in T2DM patients at Dr. M. Djamil General Hospital Padang. Methods: A total of 60 T2DM patients were randomly divided into two groups: the probiotic group (n=30) who received oral probiotic supplements for 12 weeks and the control group (n=30) who received a placebo. Plaque index, gingival index, and periodontal pocket depth were measured at the beginning and end of the study. Results: In the probiotic group, there was a significant reduction in plaque index (p=0.001) and gingival index (p=0.002) compared to the control group. Periodontal pocket depth also showed a significant decrease in the probiotic group (p=0.005). Conclusion: The use of oral probiotics for 12 weeks can improve dental and oral health in T2DM patients by reducing plaque index, gingival index, and periodontal pocket depth.
Comparison of the Efficacy and Safety of Composite Dental Filling Materials (Nano-Hybrid and Microhybrid): A Double Randomized Clinical Study in Ulan Bator Hospital, Mongolia Byamba, Daava
Crown: Journal of Dentistry and Health Research Vol. 2 No. 2 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.117

Abstract

Introduction: Composite dental filling materials are widely used for dental restoration because of their aesthetic properties and durability. However, the choice of appropriate filling material is still a matter of debate. The aim of this study was to compare the effectiveness and safety of nano-hybrid and microhybrid composite dental filling materials in a double-blind randomized clinical study at Ulan Bator Hospital, Mongolia. Methods: A total of 60 patients with posterior dental caries were recruited and randomly assigned to receive nano-hybrid or microhybrid composite dental fillings. Patients were clinically evaluated at 6 months, 12 months, and 24 months after patching to assess patch retention, color change, sensitivity, and other complaints. Results: The patch retention rates in the two groups were not significantly different (p>0.05). The color change in the nano-hybrid group was less than that in the microhybrid group (p<0.05). Tooth sensitivity in the two groups was not significantly different (p>0.05). No other complaints were reported by the patient. Conclusion: Nano-hybrid and microhybrid composite dental filling materials have equivalent effectiveness and safety within a period of 24 months. However, nano-hybrid showed less color change compared to microhybrid.
Antibacterial Test of Cherry Leaves Ethanol Extract (Muntingia calabura L.) Against Streptococcus mutans Amalia, Annora Rizky; Riyan Setiyanto; Alfina Nurrahman; Ariska Rahmawati Utami; Dewi Weni Sari
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.128

Abstract

Introduction: Streptococcus mutans is a bacteria that plays an important role in the occurrence of dental caries. Use of antibiotics to treat infections Streptococcus mutans often causes side effects. Cherry leaves (Muntingia calabura L.) contain active compounds that have the potential to have antibacterial effects. This research aims to determine the inhibitory power of cherry leaf ethanol extract against Streptococcus mutans in vitro. Methods: This research uses an experimental method with a post-test-only control group design. Cherry leaf ethanol extract was made by maceration method using 96% ethanol solvent for 5 days. The antibacterial test was carried out using the paper disc diffusion method with varying concentrations of cherry leaf extract, namely 20%, 40%, and 60% w/v dissolved in 10% DMSO. The positive control used was the amoxicillin antibiotic disc, while the negative control used 10% DMSO. Results: The results of the antibacterial test of the ethanol extract of cherry leaves in this study showed that at a concentration of 20% it had an average inhibitory power of 9.16 mm, the extract with a concentration of 40% had an inhibitory power of 11.33 mm, and at a concentration of 60% it had an inhibitory power of 12. 16mm. The positive control amoxicillin had an inhibitory power of 18.67 mm. Conclusion: Cherry leaf ethanol extract has potential as an alternative therapy to overcome Streptococcus mutans bacterial infections.
Formulation and Evaluation of Toothpaste Combining Clove Flower Extract (Syzygium aromaticum L.) and Chamomile Flower Essential Oil (Matricaria chamomilla) Elmaria; Paramawidhita, Risqika Yuliatantri; Rika Arfiana Safitri
Crown: Journal of Dentistry and Health Research Vol. 2 No. 2 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i2.145

Abstract

Introduction: Herbal remedies like clove and chamomile have been traditionally used for their potential oral health benefits. This study aimed to formulate and evaluate a toothpaste combining clove flower extract (Syzygium aromaticum L.) and chamomile flower essential oil (Matricaria chamomilla) for its efficacy in promoting oral hygiene. Methods: Clove flower extract was obtained through ethanol extraction, while chamomile essential oil was procured commercially. Various toothpaste formulations (F1-F3) were prepared with varying concentrations of the herbal extracts, alongside a control formulation (F0) without the extracts. The formulations underwent comprehensive evaluation, including organoleptic assessment, pH determination, homogeneity testing, and foam height analysis. Additionally, antimicrobial activity against common oral pathogens (Streptococcus mutans and Staphylococcus aureus) was assessed using the agar well diffusion method. Results: All formulations (F0-F3) exhibited acceptable organoleptic properties, pH levels within the safe range for oral use, and homogeneity. However, foam height varied among formulations, with F1-F3 showing lower foam compared to the control (F0). Notably, F2 and F3 demonstrated significant antimicrobial activity against both S. mutans and S. aureus, suggesting their potential in combating oral pathogens. Conclusion: The combination of clove flower extract and chamomile essential oil in toothpaste formulations holds promise for enhancing oral hygiene due to their antimicrobial properties. Further research is warranted to optimize foam height and explore the long-term clinical effects of this herbal toothpaste.
Successful Management of Dry Socket with Alveogyl Following Posterior Mandibular Tooth Root Extraction: A Case Report Arsheilla Ika Maulida; Kusumastiwi, Rr. Pipiet Okti
Crown: Journal of Dentistry and Health Research Vol. 2 No. 2 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i2.159

Abstract

Introduction: Dry socket, or alveolar osteitis (AO), is a prevalent post-extraction complication characterized by intense pain and delayed healing. The etiology is multifactorial, often linked to trauma, infection, and lifestyle factors. Alveogyl, a medicated dressing containing iodoform, butamben, and eugenol, is commonly employed in dry socket management due to its analgesic, antiseptic, and healing properties. This case report presents the successful treatment of dry socket with Alveogyl following the extraction of retained mandibular third molar roots. Case presentation: A 22-year-old female patient presented with severe, radiating pain four days after the extraction of retained mandibular third molar roots. Clinical examination revealed an open socket with exposed bone and localized inflammation, indicative of dry socket. The patient's medical history was unremarkable, and she denied any contributing factors such as smoking or oral contraceptive use. The socket was irrigated with saline, and Alveogyl dressing was applied. Conclusion: The patient reported complete pain resolution and demonstrated significant healing at the one-week follow-up. This case underscores the efficacy of Alveogyl in managing dry socket, providing pain relief, and promoting healing. The prompt diagnosis and treatment of dry socket are crucial in mitigating patient discomfort and ensuring optimal healing outcomes. The use of Alveogyl as part of a comprehensive treatment approach can contribute to successful dry socket management.
CRISPRi-Mediated Repression of gtfB Attenuates Streptococcus mutans Virulence and Promotes Ecological Homeostasis in a Preclinical Cariogenic Biofilm Model Khairiel Anwar; Maria Rodriguez; Sony Sanjaya; Danniel Hilman Maulana; Karina Chandra; Isadora Selestine
Crown: Journal of Dentistry and Health Research Vol. 3 No. 1 (2025): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v3i1.234

Abstract

Introduction: Streptococcus mutans is a primary etiological agent of dental caries, largely due to its capacity to form robust, acidogenic biofilms. This virulence is critically dependent on glucosyltransferases, particularly GtfB, which synthesizes the adhesive extracellular glucan matrix. Conventional antimicrobial strategies often lack specificity, leading to oral dysbiosis. This study aimed to develop and evaluate a highly targeted CRISPR interference (CRISPRi) system to silence the gtfB gene in S. mutans, thereby inhibiting its cariogenic potential without adversely affecting the viability of key oral commensal species. Methods: A CRISPRi system, comprising a nuclease-deactivated Cas9 (dCas9) and a single guide RNA (sgRNA) targeting the gtfB promoter, was engineered into S. mutans UA159. The efficacy of gtfB silencing was quantified via qRT-PCR. The consequential effects on bacterial growth kinetics, insoluble glucan synthesis, and single-species biofilm formation were assessed using spectrophotometry, anthrone assays, crystal violet staining, and confocal laser scanning microscopy (CLSM). The ecological impact was investigated in a multi-species biofilm model containing S. mutans and the commensal bacteria Streptococcus gordonii, Streptococcus oralis, and Actinomyces naeslundii, with microbial composition analyzed by species-specific qPCR. All research activities were conducted in Indonesia. Results: The CRISPRi system induced a profound and specific downregulation of gtfB mRNA expression by over 98% (p<0.001) in the engineered S. mutans strain compared to the wild-type. This silencing did not impair bacterial planktonic growth. However, it led to a significant reduction in insoluble glucan production by 85% (p<0.001) and a corresponding 79% decrease in total biofilm biomass (p<0.001). CLSM imaging confirmed the formation of structurally deficient biofilms with minimal extracellular matrix. In the multi-species model, repression of S. mutans virulence significantly altered the biofilm ecology, resulting in a 65% reduction in the proportional abundance of S. mutans and a concomitant increase in the representation of commensal species, thereby fostering a community structure more aligned with oral health. Conclusion: Targeted repression of the gtfB gene using a CRISPRi-based approach effectively 'disarms' S. mutans, neutralizing its primary cariogenic mechanism without being bactericidal. This strategy not only attenuates its virulence but also shifts the ecological balance in favor of beneficial commensal bacteria. These findings underscore the therapeutic potential of gene-targeted virulence modulation as a precise, ecologically-sound strategy for the prevention and treatment of dental caries.
Clinical and Inflammatory Efficacy of a Novel Bioactive Borate Glass Air-Abrasion Powder for Peri-implant Mucositis Treatment: A Split-Mouth Randomized Controlled Clinical Trial Nur Diana; Indri Yani Septiana; Aprilia Sari; Michelle Birne
Crown: Journal of Dentistry and Health Research Vol. 3 No. 1 (2025): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v3i1.235

Abstract

Introduction: Peri-implant mucositis (PIM) is a prevalent inflammatory condition requiring effective biofilm management. This study aimed to evaluate the clinical and inflammatory efficacy of a novel bioactive borate glass (BBG) air-abrasion powder compared to a standard glycine-based powder for treating PIM. Methods: This was a split-mouth randomized controlled trial conducted at Palembang, Indonesia. Forty-two patients with two implants each, both diagnosed with PIM (Bleeding on Probing [BOP] positive, Probing Pocket Depth [PPD] 4 mm), were enrolled. In each patient, one implant site was randomly assigned to receive sub- and supragingival air-abrasion with the BBG powder (Test Group), while the contralateral implant received treatment with glycine powder (Control Group). Clinical parameters, including Modified Plaque Index (mPI), Modified Gingival Index (mGI), PPD, and BOP, were recorded at baseline (T0), 4 weeks (T1), and 12 weeks (T2). Peri-implant sulcular fluid (PISF) was collected to quantify levels of Interleukin-1 Beta (IL-1β) and Tumor Necrosis Factor-Alpha (TNF-α). Patient-reported discomfort was assessed using a Visual Analog Scale (VAS). Results: Both groups showed significant improvements in all clinical parameters from T0 to T2 (p < 0.001). At the 12-week follow-up (T2), the Test group demonstrated a statistically significantly greater reduction in mean PPD (Test: 1.21 + 0.28 mm vs. Control: 0.83 + 0.31 mm; p < 0.001) and a higher percentage of BOP resolution (Test: 88.1% vs. Control: 66.7%; p = 0.012). Furthermore, the reduction in IL-1β and TNF-α concentrations from T0 to T2 was significantly greater in the BBG group (p < 0.01 for both). Both treatments were well-tolerated with low VAS scores. Conclusion: Within the limitations of this study, non-surgical treatment of peri-implant mucositis using the novel bioactive borate glass air-abrasion powder resulted in superior clinical and inflammatory outcomes compared to standard glycine powder. This bioactive approach presents a promising advancement in peri-implant maintenance therapy.

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