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Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 24606065     EISSN : 25483013     DOI : 10.15408/jkv
Core Subject : Science,
Chemistry
Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of chemistry.
Arjuna Subject : Umum - Umum
Articles 425 Documents
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Potential Use of Indonesian Medicinal Plants for Cosmetic and Oral Health: A Review Irmanida Batubara; Muhammad Eka Prastya
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i1.16252

Abstract

Medicinal plants have gained much importance in cosmetic development due to their abundant bioactive compounds and relatively fewer side effects. Indonesia comprises a diverse range of medicinal plants, along with multiple ethnicities and cultures. For decades, Indonesian traditional medicinal plants, known as jamu, had been utilized for skin care, skin whitening, and oral health. In the present review, several Indonesian medicinal plants have been discussed in relation to their potency for cosmetic and oral health. Recent scientific evidences showed that medicinal plants reviewed in this paper have the appropriate bioactivities with the major requirements for cosmetic and oral health including antioxidant, antiglycation, skin whitening via tyrosinase inhibitor and melanogenesis inhibition, antiacne activities (against Propionibacterium acnes and Staphylococcus epidermidis) and biofilm degradation against Streptococcus mutans, Staphylococcus aureus and Candida albicans. One of plant, namely Zingiber officinale reported having all of those requirements indicating the most potential for cosmetic and oral health agents. In summary, further research on Indonesian medicinal plants should be conducted to provide holistic knowledge for the development of cosmetic and oral health products.
β-Sitosterol Compound from Dichloromethane Extracts of Kalanchoe tomentosa (Crassulacea) Leaves and Inhibition of α-amilase Activity Lilis Siti Aisyah; Yenny Febriani Yun; Firidia Puspita; Adelia Ilfani
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.18443

Abstract

Kalanchoe tomentosa is one of the plants of the Crassulaceae tribe that can lower blood sugar and contains compounds of terpenoids, flavonoids, alkaloids, saponins, tannins, fatty acids, steroids, and triterpenoids. This study aims to isolate and identify chemical compounds from dichloromethane extract of Kalanchoe tomentosa leaves, as well as to test the inhibitory activity of the α-amylase enzyme. Extraction was carried out by maceration using dichloromethane as a solvent, then dichloromethane extract was purified using column chromatography, the pure isolate  was obtained in the form of white powder, and an inhibition test was carried out against the α-amylase enzyme. The thin layer chromatography data of pure isolates compared to pure β-sitosterol are similar. Based on the research data, it can be concluded that the chemical structure of the pure isolate is β-sitosterol, the methylene chloride extract of K. tomentosa leaves has an inhibitory activity against the α-amylase enzyme with an inhibition value of 65%. This value is greater than the positive control of acarbose which only has 37% inhibition and β-sitosterol compound by 6.7%. This value is smaller when compared to the control of acarbose at the same concentration which obtained 5% inhibition.
Deconvolution of TEOS/TEVS Xerogel by Single or Dual Organic Catalyst Addition Anna Sumardi; Muthia Elma; Aptar Eka Lestari; Zaini Lambri Assyaifi; Adi Darmawan; Isna Syauqiah; Erdina Lulu Atika Rampun; Yanti Mawaddah; Linda Suci Wati
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.17597

Abstract

Currently, xerogel has been applied as a filtration material, especially in membrane desalination. However, the xerogel matrix structure for desalination have to be designed properly in order to allow rejection of salt and obtain good hydro-stability, thus, silica precursor in the form of TEOS (tetraethyl orthosilicate)/TEVS (triethoxy vinyl silane) and organic acid catalyst are suitable material for fabrication. The aim of this study is therefore to fabricate and perform deconvolution of TEOS/TEVS xerogel by adding single or dual catalyst, using FTIR (Fourier-transform Infrared Spectroscopy) and Fityk software. The xerogel was fabricated by dried silica sol and calcined using RTP technique (rapid thermal processing) at 450 °C.  Prior to this fabrication, the silica sol was synthesized by sol gel method, using a mixture of silica precursor TEOS/TEVS, ethanol solvent, and varied addition of single catalyst (citric acid) as well as dual catalyst (citric acid + ammonia) for 2 hours, at 50 °C. Subsequently, the xerogel was characterized by FTIR and the deconvolution was obtained through Gaussian approach, with Fityk software. All TEOS/TEVS xerogel samples indicated existence of silanol (Si-OH), siloxane (Si-O-Si) and silica-carbon (Si-C) functional groups. The xerogel deconvolution of TEOS/TEVS using single catalyst exhibit a peak area ratio of Si-OH/Si-O-Si, and this is similar to the dual catalyst counterpart of 0.24 (unit area) and 1.86 (unit area), for Si-C area ratio. This shows the addition of single catalyst was enough to produce deconvolution in TEOS/TEVS xerogel, dominated by siloxane functional group and carbon bonds with the ability to enhance membrane material hydro-stability’s fabrication.
Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines Tri Mayanti; Nur Insani Amir; Dewa Gede Katja; Sofa Fajriah; Ahmad Darmawan; Unang Supratman; Khlaijah Awang; Yoshihito Shiono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.15976

Abstract

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.
Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines Nunung Kurniasih; Asep Supriadin; Desi Harneti; Rizky Abdulah; Mohamad Nurul Azmi bin Mohamad Taib; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.20068

Abstract

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.
Differential Pulse Voltammetry Technique Using Ferrocene-Modified Carbon Paste Electrodes for Determination of Pb(II) In Kepok Banana Irdhawati Irdhawati; Feby Silvia; Emmy Sahara; Nur Alisyah Gani
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.16610

Abstract

The voltammetry method is a field of electrochemistry that measures electric current at a certain potential, which can be used to determine the concentration of inorganic and organic compounds that can be oxidized or reduced. In this research, the differential pulse voltammetry (DPV) technique has been used to determine the content of Pb(II). The carbon paste electrode (CPE) and ferrocene-modified carbon paste electrode (CPE-Fc) were used as working electrodes. This study aims to improve the sensitivity of Pb(II) measurement. Two parameters were optimized were ferrocene composition and scan rate. The validation parameters involved the linear concentration range, detection limit, quantization limit, precision and accuracy. The optimum ferrocene composition was found at 6%, and scan rate was 15 mV/s using CPE, increase to 20 mV/s using CPE-Fc. The validation results showed  the linearity using CPE-Fc  wider than CPE at the peak potential of 0.515 V. The detection and quantization limit values using CPE were 0.1551 µg/L and 0.1556 µg/L, and down to 0.1089 µg/L and 0.1090 µg/L using CPE-Fc. The precision determination for both of CPE and CPE-Fc had good results, indicated by the Horwitz ratio less than two. Percentage of recovery using CPE-Fc of 85.59  8.18%. CPE-Fc at the optimum measurement conditions was used to determine the levels of Pb(II) in kepok banana, and the result was obtained 4.4306  0.0009 mg/kg. The level of Pb content was found to exceed the established threshold based on Standard National Indonesia (ISN) No. 7387:2009  which is 0.5 mg/kg.
Theoretical Study of Xanthone Derivative Corrosion Inhibitors Using Density Functional Theory (DFT) Fitria Ramadhani; Emriadi Emriadi; Syukri Syukri
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i1.11953

Abstract

The potential corrosion inhibitor properties of xanthone compounds and its derivatives (gartanin, 8-desoxygartanin, α-mangostine, and β-mangostine) can be demonstrated through Density Functional Density Theory (DFT) at the theoretical level B3LYP/6-31G(d, p). Quantum chemical parameters such as the energy of the highest molecular orbital occupied by electrons (EHOMO), the energy of the lowest molecular orbitals not occupied by electrons (ELUMO), energy gap (Egap / ΔE), dipole moment (µ), and total energy (Etot) can be calculated using DFT method. The DFT data analysis equation can determine the value; potential energy (I), electron affinity (A), absolute electronegativity (χ), global hardness (η), global softness (σ), number of transfer electrons (ΔN), electrophilicity (ω), and corrosion inhibition efficiency (IE%) . The results of quantum chemical parameter calculations show the potential inhibitory properties of gartanin > α-mangostine > β-mangostine > 8-desoxygartanin > xanthone, with the calculated corrosion inhibition efficiency value of gartanin of 86.54%.
Ligninase Profiling and Optimization of Laccase Production from Indigenous Wood Rot Fungus (WRF) KLUM2 in Kirk Medium-Alkali Lignin Kayu Jati (MK-ALKJ) Siti Mutmainah; Evi Susanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.20895

Abstract

The production of ligninase by wood rot fungus (WRF) is determined by carbon source and growth condition. The goal of this study is to determine the ligninase profile produced by WRF KLUM2 in Kirk Medium using teak wood alkaline lignin as a carbon source known as Kirk Medium-Alkali lignin Kayu Jati (MK-ALKJ), optimization of dominant ligninase production in the MK-ALKJ compared to the one that is produced in the Kirk’s medium with glucose as a carbon source (MK-Glucose). This research was conducted in an experimental laboratory consisting of: (1) spore suspension preparation, (2) ligninase profiling at various growth times, (3) ligninase profiling at various temperature variations, (4) optimization of laccase production including pH and the amount of nitrogen source. Growth was identified based on the specific activity of lignin peroxidase (LiP), manganese peroxidase (MnP), and laccase. The results showed that relatively the three types of ligninase, namely LiP, MnP, and laccase, were produced in the same amount by the wood rotting fungus isolates KLUM2 in MK-ALJK. All three were produced with the highest yield of respectively 55.65; 52.48; 57.64 U/mg. Laccase as the dominant ligninase can be optimized to reach 83.52 U/mg by inoculating 2.107 spore cells in MK-ALKJ in 37 °C, pH = 3.5, and a nitrogen source of 20mM (NH4)2SO4 for 6 days. Therefore, it can be concluded that the ligninase activity of indigenous WRF KLUM2 in MK-ALJK medium is higher than in the MK-Glucose.
Hydroxyapatite (HAp) From Tenggiri Fish Bones As Abrasive Material In Toothpaste Formula Lia Anggresani; Yoli Nopita Sari; Rahmadevi Rahmadevi
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.19165

Abstract

Cavities are one of the factors of dental and oral health problems that can be prevented by brushing teeth using toothpaste. Toothpaste can be made from a variety of chemicals, one of which is hydroxyapatite (HAp) which has good biocompatible properties. Hydroxyapatite can be obtained by utilizing tenggiri fish bone waste which has the main element of calcium. Fish bones soaked with NaOH and acetone are then calcined at 800 °C for 3 hours to obtain CaO powder and characterized its elemental content using X-Ray Fluorescence (XRF). CaO obtained was then reacted with (NH4)2HPO4 with a mole ratio of Ca/P 1.67 then heated at 90 °C, added NaOH up to pH 12, then the obtained deposits are filtered and calcined at 900 °C.  The solids obtained from the calcination are then characterized using X-Ray Diffraction (XRD) and Scanning Electron Microscope (SEM). Hydroxyapatite (HAp) was formulated into toothpaste with the concentrations of 0% (F0), 45% (F1), 50% (F2), and 55% (F3). Toothpaste was evaluated using organoleptic tests, homogeneity tests, foam height tests, dispersability tests, pH and hedonic tests. XRD analysis shows that the resulting hydroxyapatite (HAp) has a crystal structure in accordance with ICSD standard No. 96-900-3549. SEM analysis showed that granular particles measuring 0.1 μm–0.3 μm in size. All formulated toothpastes (F0, F1, F2, and F3) meet the requirements of a good toothpaste.  Hydroxyapatite (HAp) can be formulated into a good toothpaste with a concentration of 45%.
A Cytotoxic Flavanone from The Pod Peels of Theprosia vogelii Hook.f. Valentina Adimurti Kusumaningtyas; Nia Sri Hardianti; Melina Melina; Lia Dewi Juliawaty; Yana Maolana Syah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.17551

Abstract

Tephrosia vogelii Hook.f. is a species of the family Fabaceae (Leguminoceae). These plants are termed ″Polong-polongan″ in Indonesia, and are known to contain active flavonoid groups. Previous studies have shown the isolation of one known flavanone: isolonchocarpin from methanol extract, and the structure obtained was established based on chemical evidence as well as spectroscopic methods, including NMR, and also by a comparison with published data. This research is aimed at evaluating the cytotoxic property of methanol extract against larvae of Arthemia salina Leach, using the Brine Shrimp Lethality Test (BSLT) method. The results show potent cytotoxicity at LC50 of 41.40 ppm.

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