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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 12 Documents
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Search results for , issue "Vol 38 No 3 (2021)" : 12 Documents clear
HUBUNGAN ANEMIA DENGAN TINGKAT KEPARAHAN DAN PERJALANAN PENYAKIT STROKE ISKEMIK AKUT Eugenia Isadora; Budi Riyanto Wreksoatmodjo; Tara Puspitarini Sani
NEURONA Vol 38 No 3 (2021)
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Introduction: Stroke is the second leading cause of death and the third leading cause of disability throughout theworld. Anemia or reduced hemoglobin level can worsen the tissue damage caused by ischemia; including ischemic braintissue caused by ischemic stroke. Aim: This research aims to determine the association between anemia and stroke severity and clinical course basedon the NIHSS score among acute ischemic stroke patients in Atma Jaya Hospital during 2014-2019 Methods: A cross-sectional study using secondary data from Atma Jaya Stroke Registry from 2014-2019. A totalsampling method obtained 347 samples with complete pertinent data. Anemia was defined as Hb level <12 g/dL for womenand <13 g/dL for men. Stroke severity was measured by NIHSS score. Association between variables was calculated withthe chi-square test. Results: The risk factor associated with the severity of stroke was hypertension (p=0.013). There was no significantassociation between anemia and stroke severity on admission (p=0.895) and hospital discharge (p=0.773). There was nosignificant association between anemia and the clinical course of acute ischemic stroke (p=0.09). Discussion: Factors that may contribute to the various results of similar studies were differences in study design,anemia as a comorbid condition, genetic factors, sample size, and differences in measurement methods of stroke outcomeor severity. Keywords: Anemia, ischemic stroke, NIHSS, severity
HUBUNGAN APOE-4 DAN JENIS KELAMIN DENGAN FUNGSI BAHASA DAN MEMORI PADA LANSIA Abigail Madeline; Yuda Turana; Yvonne Suzy Handajani
NEURONA Vol 38 No 3 (2021)
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Background: The APOE-4 allele, which globally has an estimated prevalence of 3-41%, is one of the strongestgenetic risk factors for Alzheimer’s disease dementia which generally has an early symptom of decreased memory functionAim: To determine the relationship between the APOE-4 gene and gender on cognitive function, especially languageand memory domains. Methods: This research is a descriptive-analytic study with a cross-sectional study design. Data collection was carriedout in September 2019. Respondents in this study were 97 elderly (aged ≥ 60 years). Data collection was carried outby filling out questionnaires and assessing cognitive function (using the Boston Naming Test with a cut-off value of <13 anddelayed free recall with a cut-off of <6, which shows impairment) and laboratory examination of the APOE-4 genotype.The data analysis test was performed using the Chi-square test. Results: It was found that the average age of the respondents was 66.78 years???? and most of them were female(72.2%). A total of 27.8% of respondents were found to have a positive APOE-4 gene. The percentage of impaired languageand memory functions was 24.7% and 46.4%. respectively. Based on data analysis, it was found that there was arelationship between the APOE-4 gene with language function (p = 0.004) and gender with language function (p = 0.014)and memory function (p = 0.042). Discussion: There is a significant relationship between the APOE-4 gene with language function and gender withlanguageand memory functions.
PROFIL KLINIS DAN LUARAN STROKE ISKEMIK AKUT DENGAN TROMBEKTOMI MEKANIK BERDASARKAN LOKASI OKLUSI DI RSUPN DR. CIPTO MANGUNKUSUMO Kevin Kevin; Taufik Mesiano; Mohammad Kurniawan; Rakhmad Hidayat; Affan P. Permana; Al Rasyid; Salim Harris
NEURONA Vol 38 No 3 (2021)
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Introduction: Occlusion in anterior circulation gives variable clinical manifestations. Mechanical thrombectomy promises almost two times higher recanalization rate as opposed to thrombolysis. Aim: To evaluate the clinical and outcome profile of acute ischemic stroke patients who underwent mechanical thrombectomy based on the occlusion site. Methods: This was a retrospective cohort conducted at Cipto Mangunkusumo National Referral Hospital from May 2017 to January 2020. All acute ischemic stroke patients in anterior circulation who underwent mechanical thrombectomy with or without bridging intravenous thrombolysis were analyzed. Occlusion site and recanalization rate were scored based on arteriogram. Results: Sixteen patients had occlusion in ICA-M1 segment, while ten others were in the M2 segment. NIHSS value was two points higher in ICA-M1 occlusion (p>0.05), which further analysis found that the proportion of aphasia manifestation was higher in the ICA-M1 segment (50.0% vs 20.0%; p=0.218). Demographical and clinical characteristics were similar between the two groups. Thrombolysis did not modify the occlusion site on thrombectomy (p>0.05). Despite statistical insignificancy, ICA-M1 occlusion showed an earlier time trend from admission to recanalization. The M2 segment had a higher proportion of mTICI 2b/3 recanali????ation (50.0% vs 70.0%; p=0.428) and mRS 0-2 on discharge (12.5% vs 50.0%; p=0.053). Discussion: Aphasia was more common in proximal occlusion???? which drove family members to bring patients earlier to the hospital. The functional outcome on discharge was lower in proximal occlusion due to more extensive and permanent brain tissue loss. Future coordination is warranted to improve the therapeutic time from admission to recanalization. Keywords: functional outcome, ischemic stroke, mechanical thrombectomy, occlusion site
RASIO NEUTROFIL LIMFOSIT SEBAGAI PREDIKTOR LUARAN KASUS CEDERA KEPALA SEDANG DAN BERAT: STUDI MULTISENTER Hanif Gordang Tobing; Yovanka Naryai Manuhutu; Syaiful Ichwan; Renindra Ananda Aman; Setyo Widi Nugroho; Samsul Ashari; David Tandian; Mohammad Saekhu; Wismaji Sadewo; Affan Priyambodo; Kevin Gunawan; Ande Fachniadin
NEURONA Vol 38 No 3 (2021)
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Introduction: Traumatic brain injury (TBI) is the most common cause of death in populations less than 40 years old in developed and developing countries. The clinical outcome after TBI is still an issue and difficult to predict. Besides Glasgow Coma Scale (GCS), neutrophil to lymphocyte ratio (NLR) as one of the neuroinflammation biomarkers also can predict outcomes after TBI Aim: To measure the association between NLR and GCS as predictors of moderate and severe TBI outcomes. Methods: This prospective study included moderate and severe TBI patients who underwent craniotomy in a multicenter hospital from November 2019 to November 2020. Chi-square analytic test was used to determine the relationship between demographics, clinical symptoms, NLR and GCS as predictors outcome of moderate and severe TBI. Results: About 54 patients with moderate and severe TBI consist of 41 (75.9%) male and 13 (24.1%) female patients, mean age 27.6 ± 15.3 years, preoperative GCS is 13 (7 - 13), with asymmetric pupil 33 (61.1%), seizures 5 (9.3%), hemiparesis 1 (1.86%), and GCS postoperative on the fifth and seventh day is 14 (6 - 15). Preoperative NLR was 7.4 (1.9-26.2), the cut-off for NLR as a predictor for improved GCS was at 9.8 with a specificity and sensitivity of 87%. Discussion: Low NLR had an association with the patient’s improved GCS, while a high NLR had an association with a non-improving GCS, so that the relationship between RNL and GCS could be used as an outcome predictor of moderate and severe traumatic brain injury patient. Keywords: glasgow coma scale, neutrophil to lymphocyte ratio, predictor, traumatic brain injury
HUBUNGAN FAKTOR SOSIODEMOGRAFI TERHADAP SKOR QUALITY OF LIFE IN EPILEPSY INVENTORY-10 PASIEN EPILEPSI DEWASA DI RSUD DR. SOETOMO Dwiastri Iris Sarwastuti; Paulus Sugianto; Hanik Badriyah Hidayati; Azimatul Karimah
NEURONA Vol 38 No 3 (2021)
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Introduction: Several socio-demographic factors, such as age, sex, marital status, level of education, and employment status can determine adult epilepsy patients’ quality of life, which Quality of Life quantitively presents in Epilepsy Inventory-10 (QOLIE-10) score. Aim: This study was to understand the correlation between age, sex, marital status, level of education, and employment status on adult epilepsy patients’ QOLIE-10 score at Soetomo General Hospital. Methods: Analytical observational study using accidental sampling of adult epilepsy patients at Soetomo General Hospital in June 2019-December 2019 was implemented. Several socio-demographic factors were obtained, including age, sex, marital status, level of education, employment status, and their QOLIE-10 score calculation. Correlation analysis against the QOLIE-10 score was carried out, including the Spearman test for socio-demographic factors of age and level of education; and the Mann-Whitney test for socio-demographic factors of gender and marital status, and employment status. Results: Obtained a total of 47 samples with the most common characteristics such as aged 18-25 years (29.8%), male (53.2%), married (57.4%), had the last educational level in senior high school (68.1%), and unemployed (68.1%). Correlation analysis showed an insignificant relationship between age, sex, marital status, recent education, and employment status on the QOLIE-10 score of adult epilepsy patients (p≥0.05). Discussion: Age, sex, marital status, recent education, and employment status did not show a significant relationship to the QOLIE-10 score of adult epilepsy patients. Keywords: epilepsy, QOLIE-10
UJI DIAGNOSTIK ICE PACK TEST DAN REPETITIVE NERVE STIMULATION SERTA KOMBINASINYA PADA MIASTENIA GRAVIS Winnugroho Wiratman; Bazzar Ari Mighra; Fitri Octaviana; Astri Budikayanti; Luh Ari Indrawati; Triana Ayuningtyas; Ahmad Yanuar Safri; Manfaluthy Hakim
NEURONA Vol 38 No 3 (2021)
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Introduction: Diagnosis of myasthenia gravis (MG) is based on clinical symptoms, physical examination and supporting examination; so far, no examination has become the primary standard in the enforcement of MG. Supporting examinations that are fast, non-invasive and easy to do are ice pack test (IPT) and repetitive nerve stimulation (RNS). Aims: To find the sensitivity and specificity of the IPT, RNS examination, and the combination of both in enforcing the diagnosis of MG. Methods: This study was conducted with a cross-sectional design using primary data and medical records of suspicious MG patients with ptosis in Cipto Mangunkusumo General Hospital between July-November 2019. Results: Of the 38 subjects with ptosis, 35 subjects were confirmed MG with positive SF-EMG/AChR antibodies/response therapy. The ice pack test was positive in 29 subjects (76.3 %). The diagnostic test results of the ice pack test have sensitivity 80%, Specificity 66.67%, area under the curve (AUC) value of 73.3%, the RNS has a sensitivity of 60%, specificity 100%, AUC value 80%, while the combination test has sensitivity 94.28%, specificity 66.67% and AUC value 80.5%. Discussion: The combination of IPT and RNS has good diagnostic value so it can be used as a supporting examination to the diagnosis of MG. Keywords: diagnostic test; ice pack test; myasthenia gravis; ptosis; RNS
MANAJEMEN NON-OPERATIF ABSES SEREBELLUM Putri Irsalina; Paulus Sugianto
NEURONA Vol 38 No 3 (2021)
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A brain abscess is a severe infection that needs to be treated early. The increased mortality for brain abscesses is caused by modern diagnostic imaging and antibiotics that can penetrate into the central nervous system and abscesses. A cerebellar abscess was reported, with the chief complaint of chronic progressive headache. Head contrast magnetic resonance imaging (MRI) results show the presence of a right cerebellar abscess with a source of infection with otitis media and mastoiditis. Prover antibiotics and contrast head MRI evaluation show resolution of abscess diameter. Keywords: Cerebral abscess, cerebellar abscess, otitis media
NEUROMIELITIS OPTIK DENGAN ANTIBODI IGG-AQP4 SERONEGATIF Astra Dea Simanungkalit; Vivien Puspitasari
NEURONA Vol 38 No 3 (2021)
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Optic neuromyelitis (NMO), also known as Devic’s disease, is an autoimmune disease that results in recurrent demyelination of the central nervous system, particularly the optic nerve and spinal cord. The IgG antibody is an antibody that has high specificity for NMO-SD and plays an important role in the disease course. However, in a minority of cases, there are patients with NMO-SD with seronegative results. This article reports a case of a woman with an NMO-SD diagnosis without IgG-AQP4 antibodies. Keywords: Devic’s disease, IgG-AQP4, neuromyelitis optic, seronegative NMO
MANAJAMEN SPASTISITAS PALSI SEREBRAL MENGGUNAKAN TEKNIK SELECTIVE PERCUTANEOUS MYOFASCIAL LENGTHENING Prastiya Indra Gunawan; Muhammad Rizki Darmawan M; Riza Noviandi
NEURONA Vol 38 No 3 (2021)
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Cerebral palsy (CP) is a condition of a permanent and non-progressive defect in the brain that occurs at an early age. It interferes with brain development and shows abnormalities in position, muscle tone and motor coordination, and other neurological disorders. ????ecent diagnostic guidelines state that cerebral palsy can be established early. The first step in diagnosing cerebral palsy is identifying risk factors. Intervention in the structure and function of the body is the main domain in managing cerebral palsy. This intervention aims to correct anatomical structural abnormalities that can interfere the body function. Spasticity is the most common anatomical structural abnormality found in cerebral palsy. The Selective percutaneous myofascial lengthening (SPML) technique is helpful as a minimally invasive procedure that treats spasticity with more minor complications than conventional surgical techniques. Keywords: cerebral palsy, selective percutaneous myofascial lengthening, spasticity
FAKTOR RISIKO KEJADIAN NYERI PUNGGUNG BAWAH PADA SOPIR OJEK ONLINE MOBIL Arinta Puspita Wati; Dennis Adi Purnama; Maria Belladonna Rahmawati; Trianggoro Budisulistyo
NEURONA Vol 38 No 3 (2021)
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Introduction: Low back pain (LBP) is one of the musculoskeletal problems that lead to disability, decreased productivity, and quality of life that usually happens among workers, employees, or drivers. An increase in demand using online car taxi services may lead to LBP. Aim: This preliminary study aims to determine the risk factors for LBP in online car taxi drivers. Methods: This observational analytic study was conducted using a cross-sectional design towards online car taxi drivers aged 25-64 years old in Semarang, with a minimal sample (n=15) calculated by the Lemeshow equation. The inclusion criteria for the sample in this study, i.e. online car-male taxi drivers who experience LBP, while the exclusion criteria were history of lumbar trauma or musculoskeletal disease. Data were taken by primary data, the Modified Oswestry Disability Index (MODI) questionnaire, and the numerical rating scale (NRS); then, the data were analyzed using Chi-square and logistic regression test. Results: Crosstabs showed an association of LBP with a period of working (p=0.011) and pain disability (p=0.017). At the same time, body mass index (BMI), physical activities, and exercise habits (p=0.231, p=0.168, and p=0.462, respectively) had no significant result on LBP in online car taxi drivers. Discussion: Risk factors for LBP in online car taxi drivers were a period of working and pain disability. Risk factors of BMI, physical activities, and exercise habits were not statistically significant.

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