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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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Kajian Beyond Use Date Sediaan Injeksi di Salah Satu Rumah Sakit Kota Bandung Tahun 2024 Rizkita Nur Ainun; Eli Halimah; Julisiana Sanggelorang
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 1 (2025): January: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i1.1071

Abstract

Beyond Use Date or BUD is the time limit for a non-sterile or sterile mixed preparation not to be stored and used, calculated from the date or time of compounding. BUD indicates the time limit for the preparation to be in a stable state so it is very necessary to determine the BUD time. This article aims to review BUD information on 20 types of injection preparations in one of the Bandung City Hospitals conducted in 2024 using information collection methods from various sources such as related drug brochures, LexiDrug, and Drug Information Handbook. The results of the study of 13 therapeutic classes with 20 types of injection preparations show that each sterile preparation has different characteristics (active substance, solvent, dosage form and its components, duration of therapy, and storage), thus affecting the stability after reconstitution of each preparation, both those determined by each pharmaceutical industry and information obtained from LexiDrug and Drug Information Handbook. The results of this study can be used as a reference in making more applicable guidelines in determining the BUD of injection preparations in one of the Bandung City Hospitals.
Hubungan Tingkat Pengetahuan dan Kesadaran Penggunaan Tabir Surya pada Trainer Peselancar di Pantai Kuta Bali Tahun 2025 Valenia Elungan
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1085

Abstract

High exposure to sunlight in tropical areas such as Indonesia increases the risk of skin damage due to ultraviolet (UV) radiation. Sunscreen functions to protect the skin from the bad effects of UV rays, and a good level of knowledge is expected to increase awareness of its use. Surf trainers, who are frequently exposed to sunlight, need proper knowledge and awareness to prevent these negative impacts. This research aims to determine the relationship between the level of knowledge and awareness of the use of sunscreen among surfing trainers at Kuta Beach. The research used an observational design with a cross-sectional approach. The sampling technique used the accidental sampling method with a total of 57 respondents. Data was collected using a questionnaire, and data analysis was carried out using the Spearman correlation test using SPSS version 25. The results showed that 96.49% of respondents had a good level of knowledge, while only 3.5% of respondents had awareness of the use of sunscreen, which was a very low percentage. The results of statistical analysis show that there is no significant relationship between the level of knowledge and awareness of the use of sunscreen with a significance value of 0.469 (p > 0.05).
An In Vitro Usage of Origanum majorana Watery Extract as Inhibitory Antibacterial Component against Different Medically Important Bacterial Isolates Zainab Adil Ghani Chabuck
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1083

Abstract

Origanum majorana demonstrates a broad spectrum of effectiveness against various diseases, exerting antimicrobial effects against different pathogenic microorganisms. The goals of this research are to provide light on how Origanum majorana extract inhibits human pathogenic bacteria, how it may prevent biofilm development, and how it affects bacterial adhesion. The antibacterial activity of the water-based Origanum majorana extract was assessed in this research using two different methodologies. "Antibiotics were compared to its effectiveness using an agar-well diffusion assay and disc diffusion method," the first step. Additionally, the extract's ability to inhibit biofilm formation and bacterial adherence was assessed through specialized tests. All bacterial isolates of Gram negative, Gram-positive bacterial types were sensitive to Origanum majorana extract and the range of inhibition zone (30 to 24) mm. Although floxacin was effective against some of these isolates, the majority of them were resistant. Most bacterial Gram negative types were exhibit moderate adherence and biofilm activity to this extracts and some bacterial isolated of bacteria were exhibit high adherence and biofilm activity to the watery extracts of Origanum majorana. This research confirms previous findings that Origanum majorana extracts are very effective against a wide variety of clinical isolates of bacteria, including Gram-negative as well as Gram-positive varieties. Notably, the extracts were found to be more effective than commercially available antibiotics. Furthermore, the extracts displayed significant inhibition of bacterial adherence and biofilm formation. Based on these findings, Origanum majorana extracts have great promise as an effective antibacterial and anti-biofilm agent.
An Epidemiological Study On The Parasite Cutaneous Leishmaniasis In Iraq Sura Samer Alwan
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1087

Abstract

Leishmaniasis is recognized as a significant health concern in Iraq. The disease begins with minor elevations (papules) and progresses into ulcers. Epidemiological investigations play a crucial role in managing and implementing effective preventive strategies for this disease. This study examines the epidemiology of cutaneous leishmaniasis in Iraq over the past 7 years. This descriptive-analytical cross-sectional inquiry analyzed data concerning patients with cutaneous leishmaniasis over the previous 7 years at the Iraq Health Center. Demographic and epidemiological data of the patients were collected from healthcare centers in Iraq through collaborative efforts with healthcare facilities. Using SPSS software, epidemiological records of the patients were extracted and subjected to statistical analysis employing the chi-square test. Out of 175 patients examined, 88 were male (53%), and 87 were female (47%). The majority of patients belonged to the age bracket of 9 months to 4 years, with the lowest number of cases in the age group of 40 to 49 years. Mainly, the manifestations of the disease were observed on the facial region and limbs. Furthermore, a statistically significant correlation was observed between age groups and the type of leishmaniasis (P > 0.05), as well as between gender and the type of leishmaniasis (P > 0.05). According to the conducted analysis, the prevalence of the disease in Iraq showed a declining trend from 2008 to 2014. This reduction in the disease incidence can be attributed to the improvement in health education status and the adherence to personal hygiene practices among the population
Hubungan Tingkat Pengetahuan Ibu dengan Tindakan Swamedikasi Diare Pada Anak di Desa Sidakarya Tahun 2024 Jeliati Ludji; I Made Purnadhibrata; Maria Nathalia I. Istianti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1096

Abstract

Self-medication is the process of recognizing symptom complaints to obtaining medication and carrying out treatment independently. Diarrhea is a disease that causes feces to come out more than three times a day with a liquid consistency that can be accompanied by blood or mucus and the frequency is more frequent than normal. This research aims to determine the relationship between the level of maternal knowledge and self-medication for diarrhea in children in Sidakarya Village. The research method uses descriptive quantitative with a cross sectional study with accidental sampling technique. The number of respondents to this research was 35 people based on calculations using the Slovin formula. The research results showed that the level of self-medication knowledge for diarrhea was categorized as high at (91.4%) and self-medication for diarrhea was categorized as appropriate at (97.1%). Based on the chi-square test, the P-value was 0.001 and the calculated r value was 0.361, indicating that there was a relationship between the level of diarrhea self-medication knowledge and diarrhea self-medication actions.
Upaya Penurunan Angka Stunting pada Balita Melalui Deteksi Dini dan Intervensi Nutrisi Ni’matul Fauziah; Ika Hepi Maidayanti; Heni Amilia Putri; Brelianti Nevy Tyara C. P.; Chindy Elsa Ramadhani; Ferdiana Putri Gita V.
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1099

Abstract

Stunting is a condition that occurs due to a lack of nutritional intake over a long period of time, thus inhibiting a child's growth. As the next generation of the nation, children need special attention in terms of their growth and development. Fulfillment of nutrition must begin before pregnancy, continued with exclusive breastfeeding after the baby is born, and continued with balanced nutritious food according to the stage of growth. This study was conducted using a literature study method to collect data related to efforts to reduce stunting rates in toddlers. The results of the study showed that community education through counseling and health education can increase understanding of nutrition and good parenting patterns. In addition, programs such as providing eggs in villages and the involvement of integrated health post cadres in early detection have also proven effective in reducing stunting rates in toddlers.
Analisis Penerapan Standar Pelayanan Kefarmasian di Puskesmas Paduraksa Kecamatan Pemalang Fitria Dwi Alvianingrum; Musa Fitri Fathkiya
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1106

Abstract

Pharmaceutical services are carried out to achieve definite results in improving the quality of life of patients in the form of direct and resposibels services related to pharmaceutical preparations. In implementing pharmaceutical services, health centers already have a standard that is used as a guideline in its implementation. The consequences of implementing pharmaceutical services that do not comply with standards are medication errors and inappropriate use of drugs, there are expired drugs and overlapping budgets. The purpose of this study was to analyze the implementation of pharmaceutical service standards in health centers, BMHP and clinical pharmacy services based on PMK No. 74 of 2016 at the Paduraksa Health Center, Pemalang District. This study is a non-experimental study with a descriptive design that will provide an analytical description of the implementation of pharmaceutical service standards at the Paduraksa Health Center, Pemalang District based on the guidelines in the Minister of Health Regulation Number 74 of 2016. The population and sample in this study were all pharmaceutical personnel who were responsible for managing pharmaceutical service standards at the Paduraksa Health Center, by conducting interviews in the form of questions and answers by giving questions verbally to pharmacists or pharmaceutical personnel at the Paduraksa Health Center, Pemalang Regency. The data in the variable analysis looked at the percentage of compliance with standards based on the Minister of Health Regulation No. 74 of 2016.
Assessment Of The Antifungal Bioactivity Of Aqueous Extract From Ziziphus Spina-Christi Leaves Against Candida SPP. Responsible For Vulvovaginal Candidiasis Alyaa Hussein Talib
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1107

Abstract

The present study was aimed at gaining knowledge about the type of pathogen responsible for Vulvovaginal Candidiasis (VVC) infections and evaluating the antimicrobial activity of plant extracts against Candida spp. antibiotic resistance. 112 samples were taken from infected women with VVC of different ages from September to December 2024. All specimens were collected from Al Hussein Teaching Hospital/ Al- Thiqar- governorate. The results showed that 67 (59.82%) of all cases had positive results for Candida spp., while 45 (40.18%) had negative results. Candida spp. Isolated from VVC were C. albicans, the most prevalent 33 (49.26%), C. glabrata, 12 (17.91%), C. krusi and C. kefyr, 9 (13.43%), and C. guilliermondii, 4 (6.90%). The antifungal sensitivity of the pathogenic Candida spp. was tested against five types of antifungals, and the results showed the highest resistance to ketoconazole was 66 (98.51%) of Candida spp. Because of the presence of these physiologically active chemicals, Zizyphus spina-christi L. exhibits antimicrobial capabilities. In this study, the main aim is to study the antifungal activity of Ziziphus spina-christi leaf extract on some resistant candida and conduct analysis to confirm that the Ziziphus spina-christi leaves have phytochemical contents. Gas chromatography-mass spectrometry (GC-MS) was used to find the bioactive components present in extracts of Z. spina-christi leaves. Finally, we decided the inhibitory activity of Ziziphus spina-christi leaves extract. The extract of Ziziphus spina-christi had alkaloids, saponins, flavonoids, phenols, tannic acid, and terpenoids, according to a preliminary phytochemical screen. In addition, GC-MS analysis of the extract confirmed the presence of many beneficial chemicals. The extract showed promising antimicrobial activity for Candida spp. (C. albicans, C. glabrata,C. krusi , C. kefyr, and C. guilliermondii)  . These results show that the Ziziphus spina-christi leaves extract is a valuable resource for bioactive chemicals with potential uses in a variety of biological contexts.
The Role of CRISPR-Cas9 in Gene Editing Mohammed J. Kadhim
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1108

Abstract

The CRISPR-Cas9 technique is a contemporary technology that has transformed the process of genetic modification, allowing scientists to target genomes in living organisms with precision and simplicity. Numerous practical applications of significant importance, including the introduction of new genes into living cells, are facilitated by the CRISPR-Cas9 system's advanced level of gene targeting, precision, and simplicity of use. An enigmatic process involving repeated DNA sequences in E. coli initiated the emergence of this CRISPR-Cas9 mechanism. After observing this phenomenon in bacteria, scientists initiated an investigation into its function. It was noted that E. coli employs it as a self-defence mechanism against bacteriophage attacks and plasmids. CRISPR-Cas9, a novel method for genetic modification, was created as a result of this investigation. This system has been re-engineered by scientists to be more broadly applicable, allowing for the modification of the genetic code of virtually any organism, surpassing the scope of self-defence. The CRISPR-Cas9 system-based gene editing mechanisms have the potential to produce substantial results that were previously difficult to achieve. Nevertheless, the question of genetic modification through the application of this technology prompts debates and demands for the resolution of the ethical, social, and legal issues that are associated with its application. The potential applications of the CRISPR-Cas9 system are seemingly boundless.
Evaluation of Some Neurotransmitters and Oxidative Stress by Manganese Chloride After Treatment with Lavender Ethanolic Extraction in Male Rats Ashwaq Jabbar Almiahy; Athraa Shakir Dakhil
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1113

Abstract

This search intended to speculate the role of lavender ethanolic extract by reducing the toxicity of manganese in male rats. 32 white male Norwegian rats were divided into 4 equal groups. Group 1: as a control group left without treatments (only 1 ml of distilled water/ animal/ day). Group 2: were dosed manganese chloride at a concentration of 100 mg/ kg b.w. / day. Animals in Group 3 and Group 4 were dosed Manganese chloride at a concentration of 100 mg/kg b.w. then lavender ethanolic extract at a concentration of 200 and 400 mg/kg respectively, all by oral gavages and treated daily for six weeks. Then the next criteria were investigated: Neurotransmitters (dopamine and Ach (acetylcholine) in the mid brain) serotonin in serum. Oxidation indicators (glutathione and malondialdehyde in the brain and superoxide dismutase and catalase in serum). The results exhibited in both groups 3 and 4 there were a significant decrease in the concentrations of Ach accompanied by a significant increase in levels of dopamine and serotonin, also return levels of MDA (Malondialdehyde) to normal, as well as a significant increase in GSH (Glutathione) concentrations in rats mid brain. Moreover, the significant rising of SOD (Superoxide dismutase) and CAT (Catalase) levels in serum of rats in these groups indicated a noticeable improvement was achieved by lavender ethanolic extraction as compared to group 2. Conclusion, the antioxidant and antitoxic activity of lavender ethanolic extract promises in grate achievement in various health fields, including medicine, food industries and cosmetics.

Page 19 of 38 | Total Record : 378

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