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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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The Chemical Evaluation of Natural Extracts of Marjoram Essential Oils as Antioxidants Assad Abbas Khalaf
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1220

Abstract

Essential oils of Marjoram (Marjorana hortensis) has been evaluated for possible antioxidant activity. Essential oils were hydrodistilled and the chemical composition of volatile fraction was determined by GC. γ-Terpinene, sabinene, β-phellandrene, terpinen-4-ol and di (2-ethylhexyl) phthalate were the major constituents of Marjoram.  The reducing power of essential oils of Marjoram was measured by the ferricyanide method. Different concentrations of Marjoram oil (MO) 25, 50, 75, 100 and 200 ppm were investigated. Higher absorbance at 700 nm of the reaction mixture indicated greater reducing power. The reducing power of an antioxidant is an important parameter reflecting one aspect of its antioxidant properties. The obtained results revealed that increasing the antioxidant capacity is MO in all tested concentrations.   The antioxidant capacity of fat-soluble antioxidant was expressed as equivalents of α-tocopherol (nmol/g oil) using a molar absorption coefficient of α-tocopherol (є= 4.0 × 103 M-1 Cm-1. The percent of H2O2 scavenging activity of the tested EOs increased in the MO at all tested concentrations. There was a significant difference among all EOs samples in the percent of H2O2 scavenging activity. a positive correlation has been observed between concentrations and antioxidant activity for 3 days' test period. There were significant differences among the tested EOs in their antioxidant activities. For 3 days, the antioxidant activity of the tested EOs decreased statistically in MO. BHT on the peroxide value of sunflower oil as mmol eq O2/kgoil in the seventh day
The Dermatoglyphics, Health and Diseases in Last Ten Years' Review Samar Abdulwahab Abdulla; Huda Abdul hameed Abdulrahman; Neyaf Majid Alageedi; Mohammed J.I. Al-Shammari
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1225

Abstract

In the art and science of dermatology, ridge patterns and surface markings are studied on the finger’s skin, palm, foot toes, and soles. It is helpful for research into illnesses that may have a hereditary component. Dermatoglyphics has developed into a practical instrument in the fields of biology, anthropology, genetics, medicine, and dentistry over the past few centuries. The state of medical dermatoglyphics today is such that different systemic illnesses are linked to fingerprint patterns. Breast cancer, smokeing tobacco, bronchial asthma, diabetes mellitus, and several others were maintained. The sophisticated and contemporary uses of dermatoglyphics in the diagnosis of various oral, systemic, and dental conditions are covered in this article. It also emphasizes how beneficial dermatoglyphics is as a medical diagnostic tool for a variety of systemic illnesses. An approach to investigating the genetic relationships of oral, craniofacial, and systemic illnesses that is easily accessible, affordable, practical, trustworthy, and noninvasive is dermatoglyphics. Therefore, dermatoglyphics is a great tool for screening the population for numerous medical and dental conditions in addition to providing personal identification.
Chemical Productions and Immunological Assessments of Cancer Vaccines According to Α-Galactosylceramide and Ganglioside Antigen Noor Abd Al-Zahra Ali; Aysar Ahmed Ali; Khawla Abdulkader Ossama
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1227

Abstract

iNKT cells, sometimes known as the immune system's "Swiss Army knife," have become key components of cancer vaccination treatments. Glycolipids that activate iNKT cells, including α-galactosylceramide (αGalCer), have been used to create self-adjuvanting anti-tumor vaccinations and can boost the immune response to co-delivered cancer antigens. The chemicals synthesis of ganglioside antigens, specifically (Neu5Gc) GM3 and GM3 antigen, and conjugations to αGalCer, and packaging into liposome as effective platforms for their in vivo deliverying are the main topics of this work. In mouse and human cell experiments, liposome containing, (Neu5Gc) GM3-αGalCer, GM3-αGalCer, and equimolar quantities of conjugates have thoroughly described and their capacities to activate iNKT cell has verified ex vivo. All subclasses of IgG antibodies were produced as a result of the candidates' potential to generate both TH1 and TH2 cytokines, according to in vivo immunization tests. Interestingly, this study shows serum antibody produced against the TACA were cross-reactive, both when they were produced separately and together. If tumor-selective antigens is selected, the ensuing antibodies response can be wider than expected, which has implications for future vaccine formulations.
Synthesis and Characterization of New Thiazine Compounds Derivatized From 1-(Pyrazin-2-Yl)-3-(Benzylidene) Propanone and Study of Their Biological Effectiveness Saad Salim Jasim; Shakhawan Beebany; Jawdat Hilmi Abdulwahid; Khalid A. Al-Badrani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1236

Abstract

This study examines the synthesis and characterization of new compounds produced from chalcone, confirming their favorable yield and excellent purity utilizing Using FT-IR and 1H and 13C NMR spectroscopy. The compounds showed efficacy comparable to that of conventional antibiotics, demonstrating substantial bactericidal activity against Staphylococcus aureus and Escherichia coli. Interestingly, molecule S10 had stronger antibacterial activity, possibly as a result of its efficient electronic pairings. Furthermore, the compounds demonstrated resilience for up to 45 seconds when tested for stability under helium-neon laser irradiation. Longer exposure (60 seconds), however, caused discernible color and melting point alterations, suggesting thermal or photochemical deterioration. These results point to the possibility of additional pharmacological uses for molecules produced from chalcone.
The Effect Of Ferritin Concentration As A Result Of Iron Deficiency and Its Effect On Corona Patients Maha Jalil Jabbar; Hatef Rahim Mahdi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1238

Abstract

Ferritin is considered a protein that contains iron and includes two types of subunits: ferritin light chain (FTL) and ferritin heavy chain (FTH), which increases when inflammation increases, especially in the heart and kidneys, and helps in converting ferrous iron into iron. The light subunit is present in the liver and spleen and has a role in storing iron (1). Coronavirus (COVID-19) caused by the new coronavirus SARS-CoV-2 is a disease It is new to humanity, as it is accompanied by symptoms during the disease, including blood abnormalities, with activation of the immune system and phagocytic monocytes, and damage to the lungs. In our study, we showed that ferritin is an indicator of the severity of the disease and mortality (2). Acute respiratory syndrome (Coronavirus), which causes pneumonia and damages the heart, liver, and kidneys, is caused by the appearance of acute inflammatory cytokines that lead to death (3). A cytokine is a small protein that transmits messages to help stimulate the body’s immune response, and its rise causes increased inflammation, and these Cytokines secreted by macrophages (TNF-α, IL-10, IL-6) where there is high inflammation in the plasma. An indicator of the progress and severity of the disease (3).
Risk Factors of Recurrent Diabetic Ketoacidosis in Karbala Teaching Hospital for Children Ahmed Kareem Mohammed; Zena Kareem Mohammed
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1241

Abstract

Diabetic ketoacidosis (DKA) is defined as life threatening condition that happen mainly in T1DM and less frequently with T2DM in certain situation, an increase in the serum concentration of ketones greater than 3 mmol/L, a blood sugar level greater than 11mmol/L (although it is usually much higher), and a blood (usually arterial) pH less than 7.3 and it is the most frequent acute hyperglycemic emergency in persons with diabetes mellitus (DM). The main cause of morbidity and mortality in children with diabetes is DKA from both type1 DM (T1DM) and T2DM. Children with diminished metabolic control or previous episodes of DKA are at higher risk, as are prepubescent and adolescent girls, children with psychiatric disorders, such as eating disorders, and children who come from challenging families with lower socioeconomic status and inadequate health insurance as well as low general education levels.
Effect Of Lowing Long-Term Levels Of Ionizing Radiation On Some Of Physiological Parameters and Oxidative Stress Among Radiologic Technologists Marwa Karim Taha; Asaad Taha Al-Douri; Haifa Saeed Lattif
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1246

Abstract

Technicians in radiology departments are continuously exposed to ionizing radiation, which can affect biological systems. This study aimed to investigate the effects of low-level ionizing radiation (IR) on antioxidant enzymes and blood components in radiology personnel. The study involved forty participants aged 30 to 45 years, divided into three groups: G1 as the control group (n=10), G2 consisting of 15 radiologists, and G3 comprising 15 radiology technology workers. Participants in G2 and G3 had work experience ranging from 5 to 15 years and were employed in X-ray and CT scan departments at General K1 Hospital, Kirkuk. The measured parameters included white blood cells (WBCs), platelets, and lymphocytes, as well as malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and albumin as indicators of redox status. The results showed a significant increase in MDA levels among radiology workers compared to the control group, while SOD, TAC, and albumin levels decreased (P<0.05). Additionally, radiation-exposed workers had a higher mean count of WBCs and lymphocytes than the control group (P<0.05), whereas platelet levels were significantly lower (P<0.05). This study indicates that occupational radiation exposure can cause short-term changes in blood cells and increase the circulating redox state in healthcare workers operating in CT and IR environments compared to those not exposed to radiation. These findings highlight the importance of regular health monitoring for radiology personnel to mitigate potential long-term effects of radiation exposure.
Synthesis and Study the Anti-Bacterial Effect of New Oxazepine Derivatives Fatima Jabbar Hassoun; Mohammed Fadhil Hassan; Muqdad Irhaeem Kadhim
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1255

Abstract

in this study was preparation heterocyclic compounds of seven ring know Oxazepine compounds through reaction of schiff base compounds with cyclic anhydride (malic anhydride), schiff bases compounds synthesis by reaction between amins and different aldehyde compounds and the prepared compounds were identification by infrared (IR). The biological activity of the prepared compounds was studied and its effect on two bacteria (Escherichia coli)positive bacteria and (Staphylococcus aureus) negative bacteria.
Eksplorasi Ekstrak Wortel (Daucus Carota L.) Sebagai Tabir Surya pada Analisis SPF (Sun Protection Factor) Sediaan Lotion Muhammad Elfani Tasya; Agung Nur Cahyanta; Desi Sri Rejeki
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1260

Abstract

Sunlight is the main source of energy for life, but ultraviolet radiation can have negative impacts on the skin, such as sunburn, pigmentation, wrinkles, premature aging, and the risk of skin damage due to excessive exposure. One way to protect the skin from these effects is to use sunscreen. Carrots contain antioxidant compounds that can bind free radicals and prevent cell damage due to oxidation, so they have the potential to be used as a natural ingredient in making sunscreen. This research aims to formulate and test the physical properties of carrot extract lotion as a sunscreen and determine the extract concentration that has the optimal Sun Protection Factor (SPF) value. The method used is experimental by making lotion formulations, testing their physical properties, and measuring the SPF value of each formulation. The research results showed that the KN, F1, F2, and F3 lotion formulations had a semi-solid form which met the formulation requirements. However, KN's SPF value is only 1.23 which does not meet sunscreen standards. Meanwhile, F1 has SPF 8.3 (extra effect category), F2 with SPF 15.06 and F3 with SPF 24.1 (ultra category). F3 shows the best results because with SPF 24.1, this formulation is close to SPF 25 which can protect the skin for up to 4 hours with twice daily use. The higher the concentration of carrot extract, the better its effectiveness in lotion formulation as a sunscreen.
Evaluasi Waktu Tunggu Pelayanan Resep di Instalasi Farmasi RS Surya Insani Pasir Pangaraian Sofina Lusia Harahap; Nur'aini Nur'aini; Arifah Devi Fitriani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1284

Abstract

The implementation of pharmaceutical service standards in hospitals must be supported by the availability of pharmaceutical resources, organization oriented towards patient safety and standard operational procedures, where pharmaceutical resources include human resources as well as facilities and infrastructure. The purpose of this study was to determine the evaluation of prescription service waiting time at the Surya Insani Pasir Pangairan Hospital pharmacy. This study used qualitative research (In-depth interview) from this study the sample was 6 (six) people, namely 2 key informants, 2 main informants and 2 triangulation/additional informants totaling 6 people. The results of the study Human resources on prescription service waiting time at the Surya Insani Pasir Pangaraian Hospital Pharmacy Installation, Riau are still lacking. The required standard is 13 and the available is 9 so it requires 4 more people, facilities and infrastructure for waiting time for prescription services at the Pharmacy Installation of Surya Insani Hospital Pasir Pangaraian Riau meet 85% and there are still obstacles to speeding up services, the policy for waiting time for prescription services at the Pharmacy Installation of Surya Insani Hospital Pasir Pangaraian Riau is that SOP is enforced for 10 minutes for non-compounding and 20 minutes for compounding., supervision of waiting time for prescription services at the Pharmacy Installation of Surya Insani Hospital Pasir Pangaraian Riau is that SOP is enforced as a reference for work, there is training and education for waiting time for prescription services at the Pharmacy Installation of Surya Insani Hospital Pasir Pangaraian Riau., Suggestions are expected for hospitals As information for Surya Insani Hospital Pasir Pangairan so that they can intervene in order to make good Health Human Resource planning, As information material for Surya Insani Hospital Pasir Pangairan regarding things that are considered good or not considered good so that they can be an improvement in the future.

Page 22 of 38 | Total Record : 378

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