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Mohammad Rizki Fadhil Pratama
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Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya Building B 1st Floor, RTA Milono St. Km.1,5. Palangka Raya 73111, INDONESIA
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
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Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo Ni Made Dwi Sandhiutami; Sondang Khairani; Rika Sari Dewi; Zainur Rahman Hakim; Anita Rahmi Pradani
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3169

Abstract

Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.
Determination of the Active Chemical Compounds and the Antibacterial Activity of Various Fractions of Lawsonia inermis L. Sri Mulyaningsih; Febriyati Adji Rachmadani
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3221

Abstract

Lawsonia inermis L., or henna leaves, are usually used to treat wounds on the skin. Lawsonia inermis contain naphthoquinones, flavonoids, tannins, and saponins. The antibacterial activity of L. inermis leaf extract in various solvents has been extensively studied. However, which component is responsible for the antibacterial activity is still unknown. This study was intended to investigate the antibacterial effect of L. inermis fractions against Staphylococcus aureus and to discover the antibacterial chemical class in the most active fraction. The methanol extract was fractionated with n-hexane and ethyl acetate subsequently. The antibacterial activity of various fractions was tested using the well diffusion method. TLC-bioautography was used to identify the class of active chemicals as antibacterial agents. Antibacterial activity against S. aureus was highest in the ethyl acetate fraction. TLC-bioautography of the ethyl acetate fraction showed inhibition areas at Rf values of 0.25 and 0.53, respectively, indicating the naphthoquinones and phenolic compounds groups. In conclusion, naphthoquinones and phenolic compounds are suggested to contribute to the antibacterial effect of the ethyl acetate fraction of L. inermis leaves.
Metabolite Profiling of the Environmental-Controlled Growth of Marsilea crenata Presl. and Its In Vitro and In Silico Antineuroinflammatory Properties Burhan Ma'arif; Faisal Akhmal Muslikh; Dilla Amalia; Anisah Mahardiani; Luthfi Achmad Muchlasi; Pramudita Riwanti; Maximus Markus Taek; Hening Laswati; Mangestuti Agil
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3262

Abstract

This study was aimed to evaluate the metabolite contents and antineuroinflammatory potential of Marsilea crenata Presl. grown under a controlled environmental condition. The antineuroinflammatory test has been carried out in vitro using ethanolic extract of M. crenata leaves on HMC3 microglia cells. An in silico approach was applied to predict the active compounds of the extract. The HMC3 microglia cells were induced with IFNγ to create prolonged inflammatory conditions and then treated with 96% ethanolic extract of the M. crenata leaves of 62.5, 125, and 250 μg/mL. The expression of MHC II was analyzed using the ICC method with the CLSM instrument. Metabolites of the extract were profiled using UPLC-QToF-MS/MS instrument and MassLynx 4.1 software. In silico evaluation was conducted with molecular docking on 3OLS protein using PyRx 0.8 software, and physicochemical properties of the compounds were analyzed using SwissADME webtool. The ethanolic extract of M. crenata leaves could reduce the MHC II expression in HMC3 microglia cells in all concentrations with the values 97.458, 139.574, and 82.128 AU. The result of metabolite profiling found 79 compounds in the extract. In silico evaluation showed that 19 compounds gave agonist interaction toward 3OLS, and three met all parameters of physicochemical analysis. The ethanolic extract of the environmental-controlled growth of M. crenata leaves antineuroinflammatory activity on HMC3 microglia cells. The extract was predicted to contain some phytoestrogen compounds which act as 3OLS agonists.
Clinical Trials: The Role of Regulatory Agencies, Pharmacovigilance Laws, Guidelines, Risk Management, Patenting, and Publicizing Results Venkataramana Kandi; Sabitha Vadakedath; Purna Singh Addanki; Vikram Godishala; Venkata Bharatkumar Pinnelli
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.3263

Abstract

The research carried out to find a better treatment, improve healthcare, and benefit the current medical practice is termed clinical research. Clinical trial includes the pharmacodynamics (mechanisms of action of a new drug), pharmacokinetics (drug metabolism inside the body), therapeutics (efficacy of the drug), and adverse effects (safety of the drug) of the novel medical products. Clinical research is a process that involves human subjects and their biological specimens. The clinical trial is a meticulously planned protocol-based study of a drug/device to discover a new/better way to prevent, diagnose, and treat a disease/illness. Considering the involvement of both healthy and diseased people in clinical trials, the regulatory authorities have a significant role in the processes involving the conduction of clinical research and carefully evaluate their potential implications on humans. Because clinical trials are usually aimed at assessing the safety and efficacy of novel pharmaceutical compounds and medical devices, pharmacovigilance laws and risk management assume increased significance while conducting clinical research/trials. In this review, we attempt to discuss the regulatory authorities' roles in different geographical regions, including the United States of America, The European Union, and India. We also focus on the importance of pharmacovigilance laws and risk management during clinical trials.
Bibliometric Analysis of the Utilisation of FINDRISC in Patients with Diabetes: 2005-2021 M. Rifqi Rokhman; Bustanul Arifin; Zulkarnain Zulkarnain; Saidah Rauf; Dyah Aryani Perwitasari
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3267

Abstract

Research on risk factors for diabetes (DM) is growing. Identification of these risk factors aims to prevent DM as early as possible. This study intends to identify the utilization of the Finnish diabetes risk score (FINDRISC) and its development using bibliometric analysis. The keywords “FINDRISC AND Diabetes” were used to search for articles published in 2005-2021 in PubMed. A total of 249 articles were analyzed based on the number of publications per year, journals that publish the papers, number of publications by author and year of publication, number of publications by affiliation and year of publication, number of publications by country of origin of authors and year of publication, number of keywords, number of citations, types of articles, specific topics, and theme mapping. The data visualization was obtained from the Scopus database and the VOSviewer and Biblioshiny applications. Despite the increase in publications, the number of publications on FINDRISC in DM patients is still very few per year, with 92.8% being the primary study. Based on clusters of the country of origin, publications are still dominated by researchers from countries in the European region, and the researchers intensely relate to each other through citations. Research themes related to FINDRISC are not limited to DM risk factors. This study is the first study of a bibliometric analysis of the utilization of FINRISC in DM patients. The analysis results can be used to evaluate existing research gaps and identify future research opportunities.
Illness Risk Perceptions and Efficacy Beliefs Among Indonesian in the Course of COVID-19 Pandemic Lolita Lolita; Azis Ikhsanudin
Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i4.3287

Abstract

COVID-19, a worldwide pandemic, has posed a significant challenge to public health systems worldwide. Health risk perception and efficacy belief are primary constructs influencing individuals' protective behavior due to the outbreak. Our study investigated each item of illness risk perception, efficacy belief, and its related factors concerning the COVID-19 pandemic. An analytical cross-sectional study was conducted among 227 respondents aged 17 to 70. Data collection was conducted using convenience sampling by distributing the web questionnaire between April and July 2020. Mann-Whitney or Kruskal-Wallis bivariate analysis was performed using SPSS version 21.0 to assess the relationship between individual characteristic factors, illness risk perception, and efficacy belief. The study established that respondents had a medium to a high level of illness risk perception and a reasonable efficacy belief in dealing with the COVID-19 pandemic. Region (p=0.027) and occupation (p=0.036) differences were significantly associated with the threat and severity perception, respectively. Smoking history (p=0.037), supplement use (p=0.029), and occupation (p=0.018) differences were significantly associated with self-efficacy. Meanwhile, gender (p=0.045) differences were significantly associated with response efficacy. Therefore, the public's illness risk perception and efficacy belief could be substantial in planning, modifying, and implementing a coordinated response for risk communication in current and future epidemics.
Antibiotics Susceptibility Profile of Gram-Positive Bacteria from Primary Health Centers in Jega, Kebbi State Bilyaminu Garba Jega; Isa Musa Maishanu; Basiru Aliyu; Mohammed Ndagi Kasim
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3293

Abstract

Nosocomial or healthcare-associated infection (HCAI) is an infection acquired during receiving health care that was not present during admission. The research aimed to determine the antibiotic susceptibility pattern of gram-positive bacteria isolated from Primary Health Centers in Jega Town. A total of fifty (50) swab samples were collected from 10 different health centers and analyzed using the streak plate technique. Pure bacterial isolates were maintained and characterized using biochemical tests; their percentage of occurrence show; Staphylococcus aureus 18 (43.9%), Enterococcus feacalis 8 (19.5%), Streptococcus spp 8 (19.5%), Bacillus cereus 4 (9.8%), and Staphylococcus epidermidis 3 (7.3%). McFarland standard solution was prepared and used to control inoculants, after which the antibiotic susceptibility pattern of the isolates was determined using the disc diffusion method. Staphylococcus epidermidis was resistant to Gentamycin, and other isolates were multi-drug resistant. In light of this research, there is a need for thorough disinfection and conscientious contact control procedures to minimize the spread of these pathogens in health centers where interaction between patients, HCWs, and caregivers is widespread and frequent.
A Review of Anti-hyperglycemic Effects of Curry Leaf Tree (Murraya koenigii) Vinotha Sanmugarajah; Gowri Rajkumar
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3300

Abstract

Diabetes mellitus is becoming a metabolic disease that is defined by the level of hyperglycemia. Nowadays, it has a serious threat to public healthiness in throughout the world. Constituents and extracts isolated from diverse natural resources, mainly plants, have constantly been a rich store for controlling and treating diabetes problems. Numerous researches are ongoing to identify the suitable traditional medical drugs, medicinal herbs, and resources for managing this condition. Murraya koenigii Spreng (family Rutaceae) is commonly known as a ‘curry leaf tree’ locally. It is widely scattered in India and Sri Lanka, and leaves are commonly used for cooking. And also mainly used for various health conditions such as diabetes, anemia, diarrhea, and others. The present review aimed to critically review the anti-hyperglycemic effect of the M. koenigii based on the review, in vitro, in vivo, and clinical studies. Based on this review, the M. koenigii possess flavonoids, phenols, saponins, alkaloids, tannins, and cardiac glycosides. It has shown a potential anti-hyperglycemic effect on induced diabetic rats. This review reported the potential of M. koenigii and its extract to be a high-value dietary product in terms of its anti-hyperglycemic effects and industrial profits. Therefore, the present review supports the researchers and readers/users to realize the importance of using M. koenigii in managing diabetes mellitus. Further, this review provides a valuable document for future scientific-related clinical trials in diabetic patients.
Effect of Drug Information Service on Clinical Outcome of Patients with Type 2 Diabetes Mellitus in Padang, Indonesia Lailaturrahmi Lailaturrahmi; Fuji Araswati; Armenia Armenia; Rahmi Yosmar
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3301

Abstract

Type 2 diabetes mellitus (T2DM) has been a health burden worldwide, including Indonesia. However, T2DM therapy needs a long and complex process, which patients often do not favor, thus making them does not take medications as instructed and negatively affecting clinical outcomes. This study aimed to understand the effect of Drug Information Service provision on the clinical outcome of T2DM patients. This quasi-experimental study was conducted using one group pre-post-test design. As the clinical outcome, the fasting blood glucose levels were measured before and after the intervention. A drug information service was provided through direct explanation to the patients. Sociodemographic data were analyzed descriptively. The difference in fasting blood glucose before and after the intervention was assessed using Wilcoxon signed-rank test. Forty patients participated in this study. Most participants are female (N=34; 85%) and receive two-drugs combination therapy of metformin and sulfonylureas (N=32; 77.5%). Although there is a decrease in mean fasting blood glucose level after intervention (174.92±59.561 vs. 184.20±49.768), there is no significant difference between fasting blood glucose levels pre-intervention and post-intervention (p>0.05). It is concluded that despite the noticeable decline of blood glucose level after drug information service, its effect on blood glucose control is not significant.
Optimization of Quercetin Gel Formulation using Factorial Design Method and Antibacterial Test against Propionibacterium acnes M. Andi Chandra; Ilham Kuncahyo; Ana Indrayati
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3321

Abstract

Quercetin is a flavonoid from a group of polyphenolic flavonoid compounds. Quercetin can be used as an alternative to acne treatment, predominantly triggered by Propionibacterium acnes. This study aimed to determine the effect and proportion of carbopol 940, propylene glycol, and glycerin on the physical quality of quercetin gel, the ability of the optimum formula in an antibacterial test, and its diffusion using Franz diffusion. This study uses the factorial design method for formula optimization. Optimization was carried out with the parameters of the physical quality of the gel tested, including viscosity, dispersibility, antibacterial, and Franz diffusion. The combination of carbopol 940, glycerin, and propylene glycol affected the physical quality test of quercetin gel, carbopol and glycerin significantly affected viscosity. In contrast, glycerin and propylene glycol significantly affected Franz's dispersion, antibacterial, and diffusion properties. The optimum proportion of the combination of carbopol 940, glycerin, and propylene glycol in the manufacture of quercetin gel using the factorial design method obtained a concentration of carbopol 940 of 0.5%, glycerin of 15%, and propylene glycol of 10%. The optimum formula ability in the antibacterial test was 22.20 mm, and the cumulative percent of quercetin penetrated was 97.91%.

Page 16 of 30 | Total Record : 300

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