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The International Journal of Medical Science and Health Research
Published by International Medical Journal Corp. Ltd.
ISSN : 30481376     EISSN : 30481368     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
The International Journal of Medical Science and Health Research, published by International Medical Journal Corp. Ltd. is dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, The American Journal of Medical Science and Health Research aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 529 Documents
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A Comprehensive Literature Review of Prevention of Osteoporosis and Sarcopenia in Older Adults Erick Persson Jeffry; Charles Sanjaya Seikka
The International Journal of Medical Science and Health Research Vol. 8 No. 1 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/zhaj4q59

Abstract

Background: The prevention and management of osteoporosis and sarcopenia in older adults has garnered significant attention in recent years, as these conditions are increasingly recognized as critical public health issues affecting the aging population. Literature Review: The connection between sarcopenia and osteoporosis is elaborated upon by (A. Greco et al., 2019), who emphasize the role of resistance exercise in stimulating muscle hypertrophy and the importance of key nutrients, such as protein and vitamin D, in preventing these conditions. In addition, the systematic reviews conducted by (E. Rus et al., 2020) and (Mareschal et al., 2020) reveal that nutritional interventions, particularly in hospital settings, are crucial in combating the high prevalence of sarcopenia among older adults. Moreover, the importance of routine assessments of bone and muscle health in geriatric care is emphasized by (Barnsley et al., 2021), advocating for comprehensive interventions that address both osteoporosis and sarcopenia to improve health outcomes. Finally, the review by (Hou & Madden, 2022) highlights the effectiveness of dietary protein supplementation in conjunction with exercise for sarcopenic older adults, suggesting that combined interventions can lead to significant improvements in muscle mass and strength. However, the need for further research to optimize these strategies for different populations within the aging demographic is acknowledged. Conclusion: In conclusion, the literature collectively emphasizes that a holistic approach combining nutrition and physical activity is essential for the effective prevention and management of osteoporosis and sarcopenia in older adults. Such integrated strategies not only aim to enhance muscle and bone health but also improve overall quality of life for this vulnerable population.
A Comprehensive Literature Review of Relationship of Inflammatory Bowel Disease and Celiac Disease Erick Persson Jeffry; Charles Sanjaya Seikka
The International Journal of Medical Science and Health Research Vol. 8 No. 1 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/1c7e3135

Abstract

Background: The relationship between Inflammatory Bowel Disease (IBD) and Celiac Disease (CeD) has garnered significant attention in recent research, revealing complex interactions that may inform both pathogenesis and treatment strategies. Literature Review: The variability in prevalence rates of CeD among IBD patients, as reported by (Bengi et al., 2019), underscores the complexity of these diseases and the interplay of genetic, environmental, and immunological factors. This is further supported by (Hyun, 2021), who explore the connections between metabolic disorders and IBD, suggesting that chronic intestinal inflammation may predispose individuals to additional health issues, thereby reinforcing the idea of shared inflammatory pathways. Additionally, (Akiyama et al., 2022) elucidates the increased prevalence of CeD in patients with immune-mediated inflammatory diseases, indicating that the coexistence of these conditions can influence clinical outcomes. Finally, (Yemula, 2024) emphasizes the role of gut microbiota in the pathophysiology of CeD, suggesting that microbial changes may influence both conditions. The interconnectedness of IBD and CeD is evident, with shared genetic, immunological, and environmental factors driving the relationship. The literature collectively advocates for further research to clarify these interactions and improve patient management strategies, particularly regarding screening and dietary considerations. Conclusion: In conclusion, the relationship between IBD and CeD is characterized by complex interactions influenced by shared genetic predispositions, environmental factors, and dysregulated gut microbiota. The findings underscore the necessity for a nuanced understanding of these conditions to enhance diagnostic approaches and treatment strategies.
A Comprehensive Literature Review of Relationship of Insuline Resistance and Thyroid Cancer Erick Persson Jeffry; Charles Sanjaya Seikka
The International Journal of Medical Science and Health Research Vol. 8 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/2xadk854

Abstract

Background: The relationship between insulin resistance and thyroid cancer has garnered increasing attention in recent years, as emerging evidence suggests a complex interplay between metabolic disorders and cancer risk. Literature Review: The study by (Malaguarnera et al., 2012) outlines the role of insulin and IGFs in promoting cell proliferation and migration, implicating these factors in tumorigenesis. This perspective is echoed in the literature review by (Shih et al., 2012), which discusses the rising incidence of thyroid cancer, particularly in small tumors, and emphasizes the need to investigate the role of diabetes and metabolic syndrome further. The meta-analysis conducted by (Yeo et al., 2014) reinforces the association between diabetes and thyroid cancer, suggesting that insulin resistance may be a significant contributor to this risk. Meanwhile, (Chiefari et al., 2021) explores the mechanisms linking chronic hyperinsulinemia to cancer development, emphasizing the importance of inflammatory processes in this relationship. Recent research by (Xu et al., 2022) specifically isolates the effects of insulin resistance in euthyroid patients, further supporting the notion that insulin resistance is a risk factor for differentiated thyroid cancer. Lastly, (Wu et al., 2024) synthesizes the current understanding of diabetes and thyroid cancer, identifying several mechanisms, including oxidative stress and hyperinsulinemia, that may underlie this association. Conclusion: In conclusion, the reviewed literature collectively underscores the significance of insulin resistance as a potential risk factor for thyroid cancer. It highlights the need for further studies to elucidate the biological mechanisms involved and to explore the implications for prevention and treatment strategies. The complexity of the relationship between metabolic disorders and cancer risk suggests that a multi-faceted approach is necessary for future research.
A Comprehensive Literature Review of The Role Of Leptin In The Pathogenesis Of Systemic Lupus Erythematosus Erick Persson Jeffry; Charles Sanjaya Seikka
The International Journal of Medical Science and Health Research Vol. 8 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/na4bby48

Abstract

Background: The exploration of leptin's role in the pathogenesis of systemic lupus erythematosus (SLE) has garnered increasing attention in recent years, as evidenced by a series of studies that delve into the multifaceted relationships between this adipokine and autoimmune processes. Literature Review: Initial findings by (Francisco et al., 2018) suggest that leptin not only acts as an inflammatory marker but also plays a significant role in modulating immune responses, with leptin deficiency in mouse models protecting against autoantibody production and renal disease. (B. Taylor, 2021) expands on the pro-inflammatory effects of leptin, particularly its role in promoting Th1 and Th17 responses while diminishing Treg activity, a dysregulation observed in various autoimmune diseases, including SLE. The systematic review by highlights the complexity of leptin's role, indicating that it may function both as a pro-inflammatory and regulatory factor in SLE. This duality suggests that further research is needed to clarify the context-dependent effects of leptin on immune responses (). (M Kamel et al., 2023) contribute to this discussion by examining the association between serum leptin and disease activity in Egyptian SLE patients, reiterating the potential of leptin as a biomarker for disease progression, particularly in those with nephritis ((M Kamel et al., 2023)). Conclusion: In conclusion, the collected literature underscores the critical role of leptin in the pathogenesis of SLE, positioning it as both a biomarker and a potential therapeutic target. The evidence suggests that elevated leptin levels contribute to the dysregulation of immune responses characteristic of SLE, particularly through their impact on Treg populations and inflammatory pathways. However, the complexity of leptin's role necessitates further investigation to fully elucidate its mechanisms and implications for therapeutic interventions in SLE.
The Analysis Study of Diagnostic Performance and Accuracy of Mammography as Screening and Diagnostic of Breast Cancer: A Comprehensive Systematic Review Lisa Haerunisa; Doni Noviartha
The International Journal of Medical Science and Health Research Vol. 8 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/8a3ben43

Abstract

Background: Breast cancer is the most commonly diagnosed cancer in women, excluding skin cancer, and the second leading cause of cancer death after lung cancer. Screening mammography, introduced in the mid-1970s, aimed to diagnose breast cancer at earlier stages and reduce disease-specific mortality. This systematic review aims to evaluate the diagnostic performance and accuracy of mammography as screening and diagnostic of breast cancer by analyzing available studies on literatures of the last 10 years. Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. It excluded editorials, reviews from the same journal, and submissions without a DOI. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Result: Initially retrieving 360 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) eight relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: Mammography remains a cornerstone in breast cancer screening due to its high specificity and moderate sensitivity. However, the combination of mammography with other modalities such as MRI and ultrasound can enhance diagnostic performance.
The Analysis Study of Comparison Clinical Scoring System in Pulmonary Embolism: A Comprehensive Systematic Review Meirisa; Stevany Nurifin; Mely Christina Damanik
The International Journal of Medical Science and Health Research Vol. 8 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/kscw3e06

Abstract

Background: Pulmonary embolism is a significant diagnostic challenge in emergency departments due to its life-threatening nature and non-specific symptoms. Diagnostic systems like CTPA have been developed to address these challenges, but their limitations and radiation exposure raise concerns about patient safety. Comparing clinical scoring systems for pulmonary embolism can enhance diagnosis yield and optimize resource allocation. Methods: This systematic review adhered to PRISMA 2020 guidelines, focusing exclusively on full-text articles published in English between 2014 and 2024. Editorials and review articles without a DOI were excluded to ensure the utilization of high-quality sources. A literature review was conducted utilizing reputable databases including ScienceDirect, PubMed, and SagePub to identify relevant studies. Result: The initial database search identified nearly 200 publications pertinent to the topic. After a thorough three-stage screening process, eight studies were chosen that satisfied the established inclusion criteria for detailed analysis. The studies underwent a thorough critical evaluation, facilitating a detailed examination of the comparison clinical scoring system in pulmonary embolism. This targeted methodology guaranteed that the analysis utilized robust evidence closely aligned with the study's aims. Conclusion: Pulmonary embolism diagnosis accuracy has been significantly improved by integrating clinical scoring systems with D-Dimer testing and PERC. Combinations like WS + PERC and RGS + PERC achieved near-perfect sensitivity, reducing failure rates. However, trade-offs exist between sensitivity and specificity, necessitating further research.
The Analysis Study of Diagnosis and Surgical Management of Hemorrhoids: A Comprehensive Systematic Review Jiwa Zhaqi Adiguna; Betti Merdiani Putri; Metti Herliani
The International Journal of Medical Science and Health Research Vol. 8 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/m7yypt94

Abstract

Background: Although its precise prevalence is unknown, haemorrhoidal illness is a common reason for surgical consultation. Epidemiological studies are uncommon, and the numbers differ. According to a previous study, the global prevalence ranged from 3 to 30%. With about 3.3 million scheduled or emergency visits annually, it is regarded as the fourth most common gastrointestinal diagnosis in the US. The aim: The aim of this study to show about diagnosis and surgical management of hemorrhoids. Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. This search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, SagePub, and Sciencedirect were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: Eight publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: Despite more complicated postoperative effects that may drive patient refusal, surgical treatment is associated with higher effectiveness and is necessary for less than 20% of patients who arrive with haemorrhoidal illness. We have emphasised surgical management-related elements that can help the practitioner make treatment decisions.
The Analysis Study of Diagnosis and Surgical Management of Appendicitis:A Comprehensive Systematic Review Jiwa Zhaqi Adiguna; Betti Merdiani Putri; Metti Herliani
The International Journal of Medical Science and Health Research Vol. 8 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/drdgfj46

Abstract

Introduction: Acute appendicitis (AA) is a prevalent cause of acute abdominal pain requiring emergency care. It poses a significant global healthcare burden, with a lifetime risk of 2–9%, peaking between ages 10 and 30. Complicated appendicitis accounts for 16–40% of cases, with a mortality rate of up to 5%. Advances in diagnosis and treatment, including imaging modalities and surgical techniques, have sparked debates on optimal strategies. Non-operative treatments like antibiotics are effective for uncomplicated cases but have recurrence risks, while complicated cases typically require surgical intervention. Methods: This systematic review adheres to PRISMA guidelines and evaluates studies from 2010–2024 on AA diagnosis and surgical management. Inclusion criteria encompass observational studies, RCTs, and cohort studies reporting diagnostic accuracy, surgical outcomes, and patient prognosis. Search strategies target databases like PubMed, Embase, Cochrane Library, and Scopus. Data extraction focuses on diagnostic methods, surgical techniques, and outcomes. Results: Preliminary findings from eight studies indicate varying outcomes based on diagnostic tools, surgical approaches (laparoscopic vs. open), and geographical practices. Complications, recurrence rates, and recovery times were analyzed to highlight trends and gaps in current knowledge. Conclusion: This review shows the importance of accurate, cost-effective diagnostic tools and tailored management strategies. Global variability in practices impacts outcomes, emphasizing the need for standardized protocols to optimize care and resource utilization in acute appendicitis management.
The Comprehensive Systematic Review of Traumatic Brain Injury and Visual Disorders Cintya Ristimawarni; Kaharuddin Yunus; Nazza Rizky Ramdhagama
The International Journal of Medical Science and Health Research Vol. 8 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/ktc29w90

Abstract

Background: Traumatic brain injury (TBI) is a leading cause of death and disability globally, affecting predominantly children, young people, and the elderly. Complications include concussions, focal injuries, and diffuse damage. Visual impairments caused by traumatic brain injury can have an influence on quality of life and functional independence. Understanding the relationship between TBI and visual abnormalities is critical for creating effective diagnostic tools and treatment plans. Methods: This systematic review followed PRISMA 2020 guidelines, concentrating solely on full-text articles published in English from 2014 to 2024. Editorials and review articles lacking a DOI were excluded to ensure the use of high-quality sources. A literature review was performed using reputable databases such as ScienceDirect, PubMed, and SagePub to identify pertinent studies. Result: The preliminary database search revealed more than 200 relevant papers on the subject. Following a comprehensive three-stage screening process, eight studies were selected that met the specified inclusion criteria for in-depth analysis. The research were subjected to rigorous critical assessment, enabling an in-depth analysis of traumatic brain injury and visual disorders. This focused approach ensured that the analysis employed strong evidence closely linked with the study's objectives. Conclusion: TBI patients often experience visual dysfunctions, affecting their outcomes. The severity and type of injury significantly influence these issues. Comprehensive eye examinations are crucial for detecting subtle impairments, and long-term monitoring and rehabilitation strategies are essential for improved patient care.
Revisit Perito Implant® Technique : A Narrative Review M M Afif; Nabil Dhiya Ulhaq
The International Journal of Medical Science and Health Research Vol. 8 No. 4 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/k3s3w468

Abstract

Infrapubic penile implant surgery is a viable option for patients with severe penile curvature, shortening, and        impaired penile rigidity due to fibrosis of the corpora cavernosa (Sadeghi-Nejad, 2007). Studies have shown that patients        who undergo penile implant surgery, particularly the infrapubic approach, experience significantly better erectile function and treatment satisfaction compared to those receiving other treatments such as sildenafil citrate and intracavernous prostaglandin E1 (Rajpurkar & Dhabuwala, 2003). The infrapubic approach offers advantages such as ease of reservoir placement, rapid implantation, and direct vision during the procedure, as well as avoiding an extra incision on the scrotum, which can hinder rehabilitation (Montague & Angermeier, 2000; Vollstedt et al., 2017). Additionally, it has     been noted that the infrapubic approach can be quickly learned by urologists who are already comfortable with the transscrotal approach (Kramer & Chason, 2010). However, it is important to consider the drawbacks associated with the infrapubic approach, such as the higher risk of surgical errors during the placement of the device in the corpora (Kramer et al., 2010)

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