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The International Journal of Medical Science and Health Research

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Published by International Medical Journal Corp. Ltd.

ISSN : 30481376 EISSN : 30481368 DOI : -

Core Subject : Health,

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The International Journal of Medical Science and Health Research, published by International Medical Journal Corp. Ltd. is dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, The American Journal of Medical Science and Health Research aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 529 Documents

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How Do Comprehensive Geriatric Assessment Approaches Impact Functional Status And Quality Of Life For Older Adults With Multiple Geriatric Syndromes? Dodi Novriadi; Yudhi Hajianto Nugroho; Mutia Juliana
The International Journal of Medical Science and Health Research Vol. 12 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/m656qp44

Introduction: The global aging population has led to an increased prevalence of multiple geriatric syndromes such as frailty, multimorbidity, cognitive impairment, and functional decline. Comprehensive Geriatric Assessment (CGA) is a multidimensional, multidisciplinary diagnostic process designed to evaluate medical, psychological, and functional capabilities of older adults to develop coordinated treatment and follow-up plans. CGA aims to improve functional status, quality of life (QoL), and reduce adverse outcomes like falls and hospital readmissions. Methods: This systematic review analyzed studies involving older adults aged 65 years and above, focusing on CGA interventions compared to standard care. Data were extracted from randomized controlled trials and observational studies conducted in various healthcare settings including hospitals, community, and ambulatory units. Functional status and QoL outcomes were assessed using validated tools such as the Short Physical Performance Battery (SPPB) and EQ-5D. Results: CGA interventions demonstrated significant improvements in physical function, with SPPB scores increasing by up to 3.18 points at six months post-intervention. Quality of life measures also showed positive changes in both physical and mental health domains. Secondary outcomes included reductions in falls, frailty scores, and improvements in nutritional status and depressive symptoms. Discussion: The evidence supports CGA as an effective approach to managing complex health needs in older adults. Despite resource requirements, CGA offers long-term benefits by enhancing functional independence and overall well-being. Integration of tele-rehabilitation and digital monitoring may further improve accessibility and efficiency. Conclusion: Comprehensive Geriatric Assessment significantly improves functional status and quality of life in elderly populations. Continued efforts to standardize CGA protocols and train multidisciplinary teams are essential to maximize its global impact.

What is the comparative effectiveness of cognitive behavioral therapy versus medical treatment in improving sexual function for women with sexual dysfunction? Yunike Putri Nurfauzia; I Made Adi Saputra Wijaya; Mutia Juliana; Yahya Nurlianto
The International Journal of Medical Science and Health Research Vol. 12 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/sndsqr62

Introduction: This review investigates the comparative effectiveness of Cognitive Behavioral Therapy (CBT) versus medical treatments in improving sexual function among adult women diagnosed with sexual dysfunction. Sexual dysfunctions studied include provoked vestibulodynia (PVD), hypoactive sexual desire disorder (HSDD), vaginismus, and related conditions. Methods: Fifteen studies, primarily randomized clinical trials, were analyzed. Interventions included various forms of CBT (couple-based, group-based, mindfulness-based) and medical treatments such as lidocaine, sildenafil, bupropion, and topical steroids. Outcomes measured were sexual function, pain, sexual satisfaction, psychological distress, and relational factors. Results: CBT consistently showed significant improvements in sexual function, psychological well-being, and relationship satisfaction. For example, one study reported a 66% improvement in sexual performance after 12 weeks of CBT, and another showed an 18-point increase in sexual function scores at six months follow-up. Medical treatments provided rapid relief of physiological symptoms like pain and lubrication deficits, with effect sizes sometimes comparable to CBT. However, CBT was more effective in addressing psychological and relational aspects. Discussion: CBT’s holistic approach addresses both physiological and psychological factors, offering longer-lasting benefits and skill development for patients. Medical treatments are advantageous for quick symptom relief and ease of administration. Combined approaches may optimize outcomes. Conclusion: Both CBT and medical treatments are effective, but CBT offers broader and potentially more durable improvements in sexual health. Treatment choice should be individualized based on patient needs and dysfunction type.

What is The Association Between Low Serum Vitamin A Levels and The Risk of Developing Gestational Trophoblastic Disease Yunike Putri Nurfauzia; I Made Adi Saputra Wijaya; Mutia Juliana; Yahya Nurlianto
The International Journal of Medical Science and Health Research Vol. 12 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/cbg2nb15

Introduction: Gestational Trophoblastic Disease (GTD) comprises a group of disorders characterized by abnormal trophoblastic proliferation, including hydatidiform mole and gestational trophoblastic neoplasia (GTN). Vitamin A, known for its role in cellular differentiation and immune modulation, has been studied for its potential association with GTD risk and treatment outcomes. Methods: A systematic review of recent studies was conducted, focusing on serum vitamin A levels in GTD patients and the effects of vitamin A supplementation on treatment response. Included studies ranged from cross-sectional analyses to randomized controlled trials involving human subjects diagnosed with various GTD subtypes. Results: Ferraz et al. (2020) reported normal serum vitamin A levels (0.3–0.7 mg/dL) in patients with complete hydatidiform mole, indicating no association between low vitamin A levels and GTD risk. Conversely, Hidayat et al. (2020) demonstrated that vitamin A supplementation (6,000 IU/day) combined with methotrexate chemotherapy in low-risk GTN patients led to a more rapid decline in beta-human chorionic gonadotropin (β-hCG) levels and reduced chemotherapy resistance compared to chemotherapy alone. Discussion: While low serum vitamin A does not appear to predispose to GTD, supplementation may enhance chemotherapy efficacy, possibly through antioxidant and immunomodulatory mechanisms. However, limited sample sizes and study heterogeneity warrant further research. Conclusion: Vitamin A supplementation shows promise as an adjunct therapy in GTD treatment, improving outcomes in select patients, though it is not linked to disease risk. Larger, controlled studies are needed to confirm these findings

What Are The Comparative Mortality Rates, Healthcare Costs, And Patient-Reported Quality Of Life Outcomes For End-Stage Renal Disease Patients Undergoing Dialysis Versus Kidney Transplantation? Kadek Cahya Adwitya; Arinda Rindang Nastietie; I Gede Yasa Arga Winangun; Anastasya Savira; Putu Bagus Wisnu Mahadiputra; Putu Rico Aditya Pangestu
The International Journal of Medical Science and Health Research Vol. 12 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/7z993f23

Introduction: End-stage renal disease (ESRD) requires renal replacement therapy (RRT) to sustain life, primarily through dialysis or kidney transplantation. Treatment choice significantly affects mortality, quality of life, and healthcare costs. Methods: This report synthesizes findings from multiple comparative studies, including retrospective cohorts, prospective cohorts, and randomized controlled trials, evaluating outcomes of dialysis (hemodialysis and peritoneal dialysis) versus kidney transplantation. Outcomes assessed include mortality rates, quality of life measures, psychological impacts, and healthcare resource utilization. Results: Mortality rates were consistently lower in kidney transplant recipients compared to dialysis patients, with transplantation showing survival rates up to 91% at 10 years versus 40.9% for hemodialysis and 22.8% for peritoneal dialysis. Quality of life and psychological well-being were significantly better in transplant patients, with improvements in sexual function, reduced anxiety and depression, and enhanced social support. Healthcare costs varied, with some evidence suggesting higher monthly expenditures for dialysis, particularly continuous ambulatory peritoneal dialysis. Exercise interventions improved physical function in both groups. Discussion: Kidney transplantation offers superior survival and quality of life benefits but is limited by donor availability and patient eligibility. Dialysis remains essential for many patients but is associated with higher mortality and psychological burden. Shared decision-making and patient education are critical to optimize treatment selection. Conclusion: Kidney transplantation is the preferred treatment for eligible ESRD patients due to better survival and quality of life outcomes. Further research is needed to improve dialysis modalities and address cost-effectiveness.

Can Musculoskeletal Ultrasound Improve Early Detection And Mon- Itoring Of Musculoskeletal Manifestations In Patients With Systemic Lupus Erythematosus? Luthfiyya Syafiqa Tahany; Sinarty Hartanto
The International Journal of Medical Science and Health Research Vol. 12 No. 4 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/94q1p503

Introduction: Musculoskeletal manifestations are common in systemic lupus erythematosus (SLE) and significantly impact patient quality of life. Traditional clinical assessments often underestimate joint inflammation. Musculoskeletal ultrasound (MSUS) has emerged as a sensitive, non-invasive imaging modality to detect synovitis, tenosynovitis, and bone erosions in SLE patients. Methods: A comprehensive review of recent clinical trials, cohort studies, and observational research was conducted, focusing on the use of MSUS in detecting and monitoring musculoskeletal involvement in SLE. Studies included grayscale and power Doppler ultrasound protocols assessing multiple joints over various follow-up periods. Results: MSUS consistently detected subclinical synovitis and tenosynovitis, correlating strongly with clinical disease activity indices such as CDAI and DAS28. Persistent power Doppler signals were predictive of structural joint damage and lower remission rates. MSUS also demonstrated utility in monitoring treatment response, with faster reductions in ultrasound inflammation scores observed in patients treated with Janus kinase inhibitors. However, variability in ultrasound protocols and scoring systems was noted across studies. Discussion: MSUS enhances early detection and precise monitoring of musculoskeletal disease activity in SLE, complementing clinical evaluation. Challenges include lack of standardized scanning protocols, operator dependency, and limited correlation with patient-reported outcomes. Standardization efforts like the EULAR-OMERACT scoring system are promising for improving consistency. Conclusion: MSUS is a valuable tool for improving diagnosis, prognosis, and treatment monitoring in SLE-related musculoskeletal disease. Further research and standardization are needed to optimize its integration into routine clinical practice.

The Analysis Study of Effect of Maternal Calcium Supplementation And Pediatric Health : A Comprehensive Systematic Review Ferianis Setiawati; Anis Prima Dewi, Anis Prima Dewi
The International Journal of Medical Science and Health Research Vol. 12 No. 4 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/s6t8ag16

Background: Maternal calcium supplementation significantly impacts pediatric health, influencing growth and development. However, the effects on bone growth and mineralization remain inconsistent. Research in low habitual calcium intake populations shows sex-specific outcomes. Pregnancy-induced calcium supplementation has mixed outcomes, with increased mobilization during lactation and minimal impact on offspring growth. Further investigation is needed to improve pediatric health outcomes in diverse dietary calcium intakes. Methods: This systematic review was conducted in strict compliance with the PRISMA 2020 guidelines, ensuring methodological rigor and transparency. The review included only full-text articles published in English between 2013 and 2024, with a focus on high-quality sources. Editorials and review articles lacking a DOI were excluded to maintain the integrity and reliability of the dataset. An extensive literature search was performed using reputable databases, including ScienceDirect, PubMed, and SagePub, to identify studies relevant to the research objectives. Result: The initial database search yielded over 100 publications. Through a rigorous three-stage screening process, eight studies were carefully selected for inclusion based on their relevance and adherence to the established criteria. These selected studies underwent a thorough and critical analysis, offering a detailed evaluation of the impact of maternal calcium supplementation on pediatric health outcomes. Conclusion: Calcium supplementation is crucial for maternal and fetal health during pregnancy, reducing risks like gestational hypertension and pre-eclampsia. World Health Organization recommends 1500-2000 mg daily. Further research is needed to understand sex-specific growth patterns and IGF1-related pathways.

Postoperative External Beam Radiotherapy and Radioactive Iodine versus Radioactive Iodine Alone In Differentiated Thyroid Cancer-Systematic Review And Meta-Analysis Maren Irgiwi Fadlilah; Nova Agusta Isdiarto; Arundito Widikusumo
The International Journal of Medical Science and Health Research Vol. 12 No. 4 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/ahd9ss16

Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with an increasing incidence globally. Radioactive iodine therapy (RAI) is the standard adjuvant treatment after thyroidectomy, but the role of postoperative external beam radiotherapy (EBRT) remains controversial, with conflicting evidence regarding its efficacy in improving local-regional control and overall survival. Objective: This study aimed to evaluate the effectiveness of combining EBRT with RAI compared with RAI alone in improving local-regional control and disease-free survival in adult patients with DTC. Methods: A systematic review and meta-analysis were performed based on PRISMA guidelines. A literature search was performed using PubMed, Science Direct, and Google Scholar, focusing on studies published after 2005. Inclusion criteria included patients with DTC who received EBRT and RAI versus RAI alone. Data were analyzed using Review Manager (RevMan) version 5.4 with a random effects model to calculate effect sizes and assess heterogeneity. Results: Of the 12,000 articles identified, three studies with a total of 606 participants met the inclusion criteria. Meta-analysis showed that EBRT had no significant impact on overall survival or distant metastasis rate (RR = 0.59; 95% CI: 0.14–2.54; p = 0.48; I² = 92%), but has potential benefit in local-regional control, especially in high-risk patients with unresectable tumors or poor RAI uptake. Discussion: The role of EBRT in the management of DTC remains controversial due to the retrospective nature of most studies and variations in treatment protocols. Although it may improve local-regional control, its impact on survival is inconclusive. The potential for increased morbidity and the lack of prospective trials highlight the need for further research to identify subgroups of patients who may benefit most from EBRT. Conclusion: This meta-analysis suggests that EBRT does not provide significant clinical implications compared with RAI alone. Further studies with standard treatment regimens are needed to clarify the role of EBRT in DTC management.

What Is The Comparative Effectiveness Of Anti-VEGF Therapy Versus Laser Photocoagulation In Reducing Visual Impairment For Patients With Diabetic Macular Edema? : A Systematic Review Mia Audina; Olivia Putri Chairunnisa; Irawati
The International Journal of Medical Science and Health Research Vol. 12 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/q6g37r53

Introduction: Diabetic macular edema (DME) is a leading cause of vision loss in working-age adults, driven by vascular endothelial growth factor (VEGF)-induced fluid accumulation. While laser photocoagulation was once the standard treatment, anti-VEGF therapies (e.g., ranibizumab, aflibercept, bevacizumab) have emerged as superior alternatives. This study compares the effectiveness of anti-VEGF therapy versus laser photocoagulation in improving visual and anatomical outcomes in DME patients. Methods: A systematic review was conducted following PRISMA 2020 guidelines, analyzing 40 studies (2016–2023), including 24 randomized controlled trials (RCTs). Inclusion criteria comprised adult DME patients, direct anti-VEGF vs. laser comparisons, and ≥6-month follow-up. Data were extracted on visual acuity (BCVA), central macular thickness (CMT), safety, and treatment frequency. Results: Anti-VEGF therapy significantly outperformed laser, with BCVA gains of +6.8 to +10.5 letters versus +1.1 to +1.4 letters for laser (Li et al., 2019; Heier et al., 2016). CMT reductions were greater with anti-VEGF (-123 µm to -313 µm) compared to laser (-85.9 µm). Early response (within 3 months) predicted sustained benefits, maintained for up to 5 years. Combination therapy (anti-VEGF + laser) reduced injection frequency by 20–40% without compromising efficacy. Safety profiles favored anti-VEGF, with rare serious ocular adverse events (<1%), while laser carried risks of peripheral vision loss. Discussion: Anti-VEGF therapy is the gold standard for DME, offering superior functional and anatomical outcomes. Combination strategies may reduce treatment burden, though protocols require standardization. Socioeconomic barriers to frequent injections remain understudied. Conclusion: Anti-VEGF agents are more effective than laser in treating DME, with sustained visual and anatomical benefits. Future research should focus on long-term outcomes, cost-effectiveness, and optimizing combination therapies.

What Are The Long-Term Neurological And Cognitive Outcomes Of Various Pharmacological Interventions For Patients With Chronic Epilepsy? : A Systematic Review Mohammad Jathy Oktariansyah; Fifa Yuniarmi; Kanuyasa Widyatama; Alestya Putri Jathy
The International Journal of Medical Science and Health Research Vol. 12 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/553f7590

Introduction: Epilepsy is a chronic neurological disorder characterized by recurrent seizures, significantly impacting patients' quality of life. The management of epilepsy primarily involves pharmacological interventions aimed at reducing seizure frequency and improving neurological function. Recent advancements in antiepileptic drugs (AEDs) have provided new options, particularly for patients with refractory epilepsy. Methods: This systematic review evaluated the long-term neurological and cognitive outcomes of various pharmacological interventions for adults with chronic epilepsy. Studies were included if they involved adult participants, examined AEDs, measured cognitive or neurological outcomes, and had a follow-up period of at least 12 months. A comprehensive search was conducted across multiple databases, yielding 40 relevant studies. Results: The findings indicate that newer AEDs, such as brivaracetam and cenobamate, demonstrate significant efficacy in reducing seizure frequency, with median reductions ranging from 48.8% to 78%. However, cognitive effects varied; while some medications like topiramate had low incidences of cognitive adverse events, others such as carbamazepine were associated with declines in cognitive function. Discussion: The interplay between seizure control and cognitive outcomes is complex. Improved seizure management may lead to positive neurological adaptations, although certain AEDs can adversely affect cognitive function. The variability in outcomes underscores the need for individualized treatment approaches based on patient-specific factors. Conclusion: Long-term pharmacotherapy for epilepsy reveals a dual narrative of efficacy and cognitive impact. While advancements have improved seizure control, careful consideration of cognitive side effects is essential for optimizing patient outcomes.

What Is The Prevalence And Characteristics Of Chronic Pain Among Stroke Survivors Within The First Two Years Post-Stroke ? : A Systematic Review Mohammad Jathy Oktariansyah; Fifa Yuniarmi; Kanuyasa Widyatama; Alestya Putri Jathy
The International Journal of Medical Science and Health Research Vol. 12 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/2n0cms61

Introduction: Chronic pain is a prevalent and debilitating issue among stroke survivors, significantly affecting their quality of life and rehabilitation outcomes. This study aims to evaluate the prevalence and characteristics of chronic pain within the first two years post-stroke. Methods: A systematic review adhering to PRISMA guidelines was conducted, focusing on studies that included adult stroke survivors within 24 months post-stroke and assessed chronic pain lasting more than three months. Data extraction involved analyzing study designs, participant characteristics, pain prevalence, assessment methods, and treatment approaches. Results: The analysis of 40 studies revealed a wide variability in chronic pain prevalence among stroke survivors, ranging from 19.4% to 100%. Common pain types included shoulder pain (62.3%) and spasticity-related pain (74.3%). Pain assessment primarily utilized the Visual Analog Scale (VAS) and Numerical Rating Scale (NRS), with reported pain intensities varying significantly. Discussion: Chronic pain in stroke survivors often leads to reduced functionality and impaired quality of life. The complexity of pain, including central post-stroke pain and complex regional pain syndrome, necessitates a multidisciplinary approach to management. Psychological factors such as depression further complicate pain experiences, highlighting the need for integrated care strategies. Conclusion: Addressing chronic pain in stroke survivors requires a comprehensive understanding of its prevalence, characteristics, and treatment options. Future research should focus on developing standardized assessment tools and effective, personalized treatment protocols to enhance rehabilitation outcomes.

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Contact Name
Indra Hadi

Contact Email
profesionaljournalmedicine@gmail.com

Phone
-

Journal Mail Official
pt.internationalmedicaljournal@gmail.com

Editorial Address
Equity Tower. 49th Floor. Sudirman Street. Special Region of Jakarta, Indonesia

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA