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The International Journal of Medical Science and Health Research

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Published by International Medical Journal Corp. Ltd.

ISSN : 30481376 EISSN : 30481368 DOI : -

Core Subject : Health,

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

The International Journal of Medical Science and Health Research, published by International Medical Journal Corp. Ltd. is dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, The American Journal of Medical Science and Health Research aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 529 Documents

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Case Report: Second-Degree Burns due to Hot Liquid Asphalt Cement Spillage in an Adult Patient with Comorbid Diabetes Mellitus Maha Umami Putri Qulzum; Sri Vitayani; Widjoyo
The International Journal of Medical Science and Health Research Vol. 13 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/6s9s0873

Burns represent a significant form of injury that leads to substantial tissue damage, necessitating complex management strategies tailored to the degree and total body surface area (TBSA) affected. The complexity of burn management is notably increased in patients with comorbidities such as diabetes mellitus. Diabetes mellitus can induce vascular disorders and peripheral neuropathy, which collectively impair the natural wound healing process. This report details the case of a 42-year-old male who presented to the Emergency Department of Makassar City Hospital with burns on his right and left legs. The injuries were sustained approximately 30 minutes prior from a spill of hot liquid asphalt cement at his workplace and were accompanied by a significant burning sensation. The patient, weighing 58 kg, reported no fever, headache, dyspnea, nausea, or vomiting, with normal bowel and bladder function. He had no history of similar injuries, allergies, or hypertension. However, he had a known history of diabetes mellitus, which was managed with metformin 500 mg three times daily. A family history of diabetes was present on his maternal side. Burns, or combustio, are defined as tissue damage or loss resulting from contact with thermal sources like fire and hot water, or with chemicals, electricity, and radiation. Hot water and flames are the most frequent causes of burns. The primary principle of first aid is to halt the burning process and reduce the wound's temperature. For flame-related burns, this involves the "Stop, Drop, Cover (Face) & Roll" technique.

What is the effectiveness of chiropractic manipulation compared to standard physical therapy in reducing pain intensity and improving functional mobility for patients with chronic low back pain? : A Systematic Review Satya Agung Nugroho; Nazalla Gwen Vaganesha; Hasnan Habib Afifudin
The International Journal of Medical Science and Health Research Vol. 13 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/3q1t7y20

Introduction : Chronic low back pain (CLBP) is a pervasive health issue that significantly impairs quality of life and functional capacity globally. Among non-pharmacologic interventions, chiropractic manipulation and standard physical therapy are common treatments. This systematic review aims to compare the effectiveness of these two modalities in reducing pain intensity and improving functional mobility for adults with CLBP. Methods : This systematic review adhered to the PRISMA 2020 guidelines. A comprehensive search was conducted across PubMed, Semantic Scholar, Springer, and Google Scholar to identify randomized controlled trials, systematic reviews, and meta-analyses. Studies were included if they compared chiropractic manipulation by licensed chiropractors to standard physical therapy for adult patients with CLBP lasting over 12 weeks. Primary outcomes included pain intensity and functional mobility measured by validated scales. Results Eighteen studies were included in the final analysis. The results indicate that chiropractic manipulation and standard physical therapy are largely equivalent in effectiveness for both pain reduction and functional improvement. While a few studies reported superior short-term pain relief with spinal manipulative therapy , most found no significant long-term differences between the two interventions. Adverse events associated with both treatments were infrequently reported and were generally mild and transient. Discussion: The evidence demonstrates a consistent pattern of equivalence in clinical outcomes between chiropractic care and physical therapy. This suggests that neither modality is definitively superior for the majority of CLBP patients. The significant variability in treatment protocols across studies highlights the need for individualized care plans. Patient characteristics did not reliably predict a differential response to either therapy, underscoring the importance of shared decision-making. Conclusion: Chiropractic manipulation and standard physical therapy are both effective and safe interventions for managing chronic low back pain, yielding comparable outcomes. The choice between these treatments should be guided by patient preference, accessibility, and clinical presentation. An integrative approach, potentially combining the strengths of both disciplines, may further enhance patient care.

Blunt Ocular Trauma Complicated by Iridoplegia due to Suspected Traumatic Iritis: A Case Report Pande Komang Wahyu Pradana; Ida Ayu Prama Yanthi
The International Journal of Medical Science and Health Research Vol. 13 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/hadr0n69

Background: Ocular trauma is defined as any injury affecting the eye and its surrounding structures. In Indonesia, ocular trauma is a leading cause of blindness, following cataracts, glaucoma, refractive errors, retinal disorders, and corneal abnormalities. Case: We report the case of a 52-year-old male patient who presented with a red eye after being struck by a wood splinter. Physical and ancillary examinations were conducted to establish a diagnosis of blunt ocular trauma complicated by iridoplegia secondary to suspected traumatic iritis. The patient received initial treatment in the Emergency Department, which included Prednisolone 10mg/ml administered six times daily to the left eye (OS) to reduce inflammation, Levofloxacin 5mg/ml administered six times daily as an antibiotic, and Diclofenac Sodium 50 mg taken orally twice daily. Conclusion: The primary goals of management for this patient were to restore vision and prevent infection. The purpose of this case report is to highlight the diagnostic and therapeutic approach in a patient with ocular trauma. Furthermore, the authors emphasize the critical role of ancillary examinations in this case.

The Effect of Chemotherapy on Improving The Quality of Life in Patients with Nasopharyngeal Carcinoma A. Ahmad Khaidir Agussalim; Moh. Reza Zainal Abidin; Khaeruddin HA
The International Journal of Medical Science and Health Research Vol. 13 No. 6 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/h2jbpm92

Nasopharyngeal carcinoma is the most common malignant tumor of the head and neck region found in Indonesia. Chemotherapy is a cancer treatment that utilizes drugs to halt the growth of cancer cells. The assessment of quality of life in cancer patients is frequently used as a benchmark for therapeutic success and can be employed to evaluate the long-term cost-effectiveness of therapy. This study aims to analyze the effect of chemotherapy on improving the quality of life of patients with nasopharyngeal carcinoma. The research method involved a literature review of various previous studies that discussed the effect of chemotherapy on improving the quality of life of patients with nasopharyngeal carcinoma. The analysis revealed that the health-related quality of life (HRQOL) of nasopharyngeal cancer patients undergoing chemotherapy varies due to the effects of the cancer itself, the effects of chemotherapy, and the individual's life goals and expectations. This study suggests that nasopharyngeal carcinoma patients undergoing chemotherapy should anticipate the severity of side effects by receiving premedication and ensuring physical and mental preparedness before treatment.

Case Report: Latent Syphilis in the Second Trimester of Pregnancy Vanda Tri Andini; Dian Amelia Abdi; Abdul Azis
The International Journal of Medical Science and Health Research Vol. 13 No. 6 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/acv9h929

Syphilis is a sexually transmitted infection caused by exposure to the bacterium Treponema pallidum. Syphilis is predominantly transmitted through sexual intercourse, from mother to fetus, and through blood transfusion processes. In pregnant women with syphilis, the Treponema pallidum bacterium is transmitted from the mother to the fetus through the placental capillary blood vessels. This case report discusses a 27-year-old married female patient who presented at the Cendrawasih Public Health Center (PKM) for Antenatal Care. During the examination, the patient did not report any complaints of headache, nausea, vomiting, or back pain. A history of red spots on the palms, soles, and mouth was denied. The patient also denied having any odorous vaginal discharge, or itching or burning sensations on her body. A history of sores or lumps around the genital area was denied. There were no indications of complaints related to significant weight loss, diarrhea, persistent cough, or fever. A history of joint pain or enlarged glands was also denied. Syphilis is caused by the Treponema pallidum bacterium, which has chronic and systemic characteristics. Syphilis can be generally classified into two groups: congenital and acquired. Congenital syphilis typically presents with symptoms such as hepatosplenomegaly, neurosyphilis, fever, skin lesions, comprehensive lymphadenopathy, and pneumonitis. In contrast, acquired syphilis is usually characterized by a single ulcer (chancre), a body rash, fever, and malaise. A definitive diagnosis is made using a darkfield microscope, PCR, or a direct fluorescent antibody test.

How do Stem Cell Transplantation Outcomes Differ between Various Types of Leukemia (Acute Lymphoblastic vs Acute Myeloid Leukemia) : A Systematic Review Luthfiyya Syafiqa Tahany; I Putu Hartawan Mataram
The International Journal of Medical Science and Health Research Vol. 10 No. 1 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/ctz4rm13

Introduction : This systematic review investigates the differential outcomes of stem cell transplantation (SCT) in various types of leukemia, specifically acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). SCT is a crucial therapeutic approach for these aggressive hematologic malignancies, offering potential for long-term remission. Understanding the varying outcomes between AML and ALL is vital for optimizing treatment strategies, including conditioning regimens, donor selection, and post-transplant care. Methods : The study adhered to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines. Eligibility criteria included studies focusing on adult patients ( ≥ 18 years) diagnosed with ALL or AML, examining allogeneic or autologous SCT, comparing outcomes between ALL and AML, reporting clinical outcomes like overall survival (OS), disease-free survival (DFS), treatment-related mortality (TRM), graft-versus-host disease (GVHD) incidence, or relapse rates, including ≥ 10 patients, and involving human subjects. Data extraction focused on study design, participant characteristics, SCT details, primary outcomes, and study limitations. A comprehensive search strategy utilizing Boolean MeSH keywords was applied to databases such as PubMed, Semantic Scholar, Springer, and Google Scholar. Results : From 15 included studies showed that overall survival rates varied significantly, with some reports indicating 3-year OS of 35% for AML versus 0% for ALL, while others showed 5-year OS of 23.5% for AML versus 70% for ALL. Engraftment rates generally exceeded 89%. Relapse rates ranged widely from 4% to 49%. Acute GVHD incidence varied from 19.8% to 69%. Conditioning regimens significantly impacted outcomes; high-dose cytarabine improved survival in AML, whereas etoposide increased mortality risk in ALL. Novel T-cell manipulation techniques and mesenchymal stem cell use showed promise in reducing severe acute GVHD. In conclusion : SCT outcomes differ considerably between AML and ALL due to variations in disease biology, conditioning regimens, GVHD prophylaxis, and stem cell sources. Tailoring transplantation protocols to the specific leukemia subtype and individual patient characteristics is crucial for improving survival and minimizing complications. Continued research into novel conditioning approaches, immune modulation, and cell source optimization is essential to advance SCT as a curative therapy for acute leukemias. Keywords: Stem Cell Transplantation, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Overall Survival, Graft-versus-Host Disease, Relapse Rate.

Ocular Features in Patients with Ocular Tuberculosis Nabil Bahran; Nur Aulia; Pither Sandy; Edward Pandu Wiriansyah; Ratih Natasha Maharani
The International Journal of Medical Science and Health Research Vol. 13 No. 6 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/v6q0cy55

Background: Tuberculosis (TB) is a significant global health problem, infecting millions of people each year and being one of the deadliest infectious diseases. The term ocular tuberculosis describes an infection by Mycobacterium Tuberculosis species that can affect any part of the eye (intraocular, superficial, or surrounding the eye), with or without systemic involvement. Objective: To review the ocular features in patients with ocular tuberculosis through a review of current literature. Methods: This study is a narrative review of 7 scientific articles published between 2020–2025, with searches conducted through Google Scholar, PubMed, and other databases using the keywords "ocular" and "ocular tuberculosis". Results: Most articles (6 out of 7) showed anterior segment features in ocular tuberculosis. Conclusion: There are several ocular features in patients with ocular tuberculosis, found on anterior segment examination, fundoscopy, and related to vision, history of TB in ocular TB, and history of TB treatment in ocular TB.

Type 2 Diabetes Mellitus and The Risk of Tuberculosis Sri Rahmayanti Limatahu; Darariani Iskandar; Bulkis Natsir
The International Journal of Medical Science and Health Research Vol. 13 No. 7 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/pf3ta382

Type 2 Diabetes Mellitus (T2DM) is a major comorbidity that increases the risk of tuberculosis (TB) through immune system impairment caused by chronic hyperglycemia, including macrophage dysfunction, reduced T-cell activity, oxidative stress, and cytokine imbalance. This literature review aims to analyze the relationship between T2DM and TB from the perspectives of pathophysiology, clinical impact, and healthcare system challenges. The method used is a descriptive narrative based on 10 scientific articles and case reports published between 2020 and 2025, selected through systematic searching. The results show that T2DM contributes to an increased risk of active TB, prolonged treatment duration, lower treatment success rates, and a higher risk of drug resistance. Behavioral factors such as poor glycemic control, smoking habits, and limited access to healthcare further worsen the condition of patients with this comorbidity. On the other hand, bidirectional TB-DM screening efforts in Indonesia have not been optimal due to limitations in training, infrastructure, and inter-program coordination. In conclusion, T2DM increases susceptibility to TB and worsens its progression, highlighting the need for integrated healthcare services, strict blood glucose control, and systemic policy interventions to reduce the morbidity and mortality associated with this comorbidity.

What is The Role of Genetic Predisposition in Gestational Trophoblastic Disease ? : A Systematic Review Bangar Parlinggoman Tua; Yahya Nurlianto
The International Journal of Medical Science and Health Research Vol. 13 No. 7 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/egyyrs95

Introduction : Gestational Trophoblastic Disease (GTD) encompasses a spectrum of proliferative placental disorders. While genetic alterations are integral to its pathogenesis, the role of inherited genetic predisposition remains poorly quantified. A significant gap exists between the established use of genetic markers for diagnostics and a comprehensive understanding of heritable risk. This systematic review aims to synthesize the current evidence on the role of genetic predisposition in GTD. Methods : Adhering to PRISMA 2020 guidelines, a systematic literature search was conducted across PubMed, Semantic Scholar, Springer, and Google Scholar. Eligibility criteria focused on studies investigating genetic variants, hereditary factors, or familial clustering in human subjects with any form of GTD. Data on genetic analysis types, specific markers, predisposition findings, and clinical implications were systematically extracted and synthesized. Results : From 11 included studies, the evidence for inherited predisposition was limited and heterogeneous. Strong evidence was confined to recurrent hydatidiform moles, with one systematic review identifying monogenic causes involving genes such as NLRP7, CHRNA1, DYNC2H1, and RYR1. Other studies documented molecular dysregulation in genes like p53 and BCL-2 without quantifying inherited risk. A prominent theme was the diagnostic utility of genetics, with SNP arrays, STR analysis, and cell-free DNA being used for diagnosis and differentiation rather than risk prediction. No high-level evidence for predisposition was identified. Discussion : The evidence confirms a clear heritable, monogenic cause for a subset of patients with recurrent molar pregnancies. However, for sporadic GTD, research has pivoted towards diagnostic applications that improve disease detection and management, rather than establishing quantifiable predisposition risk. While genetic tools for diagnostics are advancing, their application for risk assessment remains limited. Conclusion : The clinical role of genetics in GTD is currently centered on diagnosis rather than risk prediction. While heritable factors are definitive in rare recurrent cases, quantifiable genetic risk for the broader population remains largely unknown. Future research requires large-scale association studies to identify risk alleles and translate molecular insights into prognostic and therapeutic strategies for all forms of GTD.

What Are The Clinical And Cost-Effectiveness Differences Between Standard And Enhanced Scabies Management Protocols In Primary Healthcare Settings ? : A Systematic Review Putu Sitha Mastika Dewi; Fenny
The International Journal of Medical Science and Health Research Vol. 13 No. 7 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/vg2eqw79

Introduction: Scabies, a contagious parasitic infestation, presents a significant public health challenge globally, especially in resource-limited settings. Standard management protocols for scabies in primary care, often involving topical agents or oral ivermectin, face limitations such as reinfestation and poor adherence. Enhanced scabies management protocols, including mass drug administration (MDA) and combination therapies, have emerged to address these shortcomings. However, the comparative clinical and cost-effectiveness of these enhanced approaches versus standard protocols remain uncertain, hindering optimal decision-making. This systematic review aims to compare these aspects in primary healthcare settings. Methods: This systematic review adhered to the PRISMA 2020 guidelines. A comprehensive search was conducted across databases including PubMed, Semantic Scholar, SagePub, and Google Scholar, using PICO-based keywords. Eligibility criteria focused on comparative intervention studies (e.g., RCTs, cluster RCTs) involving human subjects with confirmed scabies, conducted in primary healthcare settings, and reporting at least one clinical outcome for active management protocols. Data on study design, participant characteristics, intervention details, primary outcomes, and economic data were extracted and synthesized. Twenty-one studies were included in the final analysis. Results: The 21 included studies comprised various designs, predominantly cluster randomized trials (n=7) and randomized controlled trials (n=9). Enhanced protocols (e.g., MDA, combination therapies) consistently demonstrated higher cure rates, often ranging from 80% to 100%, and faster symptom resolution compared to standard protocols (cure rates approximately 45% to 100%). Adverse events for both protocol types were generally mild and transient. Economic data were sparse; only two studies reported direct treatment costs for standard agents, with permethrin being more expensive than ivermectin, and sulfur often the costliest. Comprehensive cost-effectiveness analyses were largely absent, though enhanced protocols were noted to require greater upfront investment. Discussion: Enhanced scabies management protocols show superior clinical effectiveness, primarily driven by population-wide or household-level treatment strategies and combination therapies that reduce reinfestation and improve healing. While these protocols are safe, their cost-effectiveness remains largely undetermined due to limited economic data. The increased resource requirements for implementation, including training and community engagement, also pose challenges for enhanced strategies. Protocol adherence may be improved with simplified regimens in enhanced protocols. Conclusion: Enhanced scabies management protocols demonstrate superior clinical effectiveness over standard treatments in primary healthcare, particularly in high-prevalence settings, by achieving higher cure rates and faster symptom resolution with comparable safety profiles. However, their adoption is challenged by a lack of robust cost-effectiveness data and higher initial resource demands. Future research should prioritize comprehensive economic evaluations to guide policy and resource allocation for optimal scabies control.

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Contact Name
Indra Hadi

Contact Email
profesionaljournalmedicine@gmail.com

Phone
-

Journal Mail Official
pt.internationalmedicaljournal@gmail.com

Editorial Address
Equity Tower. 49th Floor. Sudirman Street. Special Region of Jakarta, Indonesia

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA