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Fuad Bahrul Ulum
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Life Science and Biotechnology
Published by Universitas Jember
ISSN : -     EISSN : 29884713     DOI : https://doi.org/10.19184/lsb
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Life Science and Biotechnology publishing rigorously peer-reviewed research that seeks to advance our understanding of fundamental processes in biology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, and the public worldwide. Our journal publishes peer-reviewed research of broad interest in all areas of biology and at the interface of related disciplines (Genetics, Biodiversity, Biometry, Bioinformatics, Evolution, Ecology, Physiology, Biotechnology, Developmental biology, and Biomedical science).
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ecology, Evolution, Behavior and Systematics
Articles 25 Documents
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In Silico Biological Activity Prediction of Bioactive Compounds from Dumortiera hirsuta (Sw.) Nees. Using Way2Drug PASS Online Farhan, Abdillah Maulana; Rosida, Waki'atil; Ulum, Fuad Bahrul
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

The liverwort Dumortiera hirsuta (Sw.) Nees. is recognized as a potential source of pharmacologically active metabolites. Bioactive compounds from D. hirsuta have been previously reported through in vitro metabolomic analyses using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS). In this study, the biological activities of the GC-MS-identified metabolites were evaluated in silico using the Way2Drug PASS Online platform. The results indicated that ten metabolites from D. hirsuta exhibit medicinal potential, with Pa values greater than 0.7, suggesting a high probability of biological activity. Among these compounds, stigmasterol (Pa = 0.970) and lathosterol (Pa = 0.960) demonstrated the strongest antihypercholesterolemic potential, indicating their role as natural agents for reducing cholesterol levels. These findings highlight the pharmacological potential of D. hirsuta metabolites and warrant further validation through in vitro cholesterol-lowering assays to confirm their predicted activities.
Chemical Profiling of Locally Grown Zingiber officinale Roscoe (Ginger) Rhizomes using GC-MS and Biological Activities Farhan, Abdillah Maulana; Ilmiah , Ika iffah; Mufidi, Farah Fakhirah; Perkasa, Excel Taruna Reksa; Shodiq, Muhammad Husein; Shodiq, Abdulloh Hasan
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

Ginger (Zingiber officinale Roscoe), a widely used rhizomatous species of the family Zingiberaceae, possesses extensive medicinal value owing to its diverse phytochemical composition. This study aimed to characterize the bioactive constituents of locally grown ginger rhizomes using Gas Chromatography–Mass Spectrometry (GC–MS) to elucidate their potential pharmacological activities. GC–MS analysis enabled the detection of volatile and semi-volatile compounds based on retention time and molecular ion fragmentation patterns, providing a comprehensive chemical profile of the extract. A total of 39 compounds were identified, of which 14 exhibited relative abundances exceeding 3%. Major constituents included sesquiterpenes and phenolic derivatives known for their antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. The presence of these bioactive metabolites confirms the therapeutic potential of Z. officinale as a natural source of bioactive agents and supports its continued exploration for pharmaceutical and nutraceutical applications
Phylogenetic Analysis of Manihot sp. Based on matK and rbcL Markers Rosida, Wakiatil; Ulum, Fuad bahrul; Su'udi, Mukhamad
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

Cassava (Manihot sp.) is a staple crop of major economic and ethnomedicinal importance. Understanding the phylogenetic relationships within the genus Manihot is essential for clarifying its taxonomy and supporting genetic improvement programs. This study aimed to reconstruct the phylogeny of several Manihot species using two chloroplast DNA markers, matK and rbcL. Sequence data were retrieved from the GenBank database, and Ricinus communis was designated as the outgroup. Phylogenetic analyses were performed using the Neighbor-Joining (NJ) and Maximum Likelihood (ML) methods, each with 1,000 bootstrap replications to assess branch support. The resulting trees consistently clustered Manihot esculenta within a well-supported monophyletic group, indicating a close genetic relationship with other congeners. Distinct clades corresponding to genetic similarity were also observed among the analyzed species. These findings enhance current knowledge of Manihot systematics, providing molecular evidence that supports its taxonomic classification. Furthermore, the results contribute valuable insights for cassava breeding and conservation efforts through improved understanding of its evolutionary relationships.
Antibacterial and antioxidant activity of Endophytic Fungal Extract Isolated from the Root of Sonneratia caseolaris Noviyanto, Noviyanto; Oktiansyah, Rian; Nasution, Sakinah Salman Ahmad; Utami, Riza; Amelia, Dea
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

Sonneratia caseolaris is a mangrove species of considerable pharmacological importance; however, its natural populations are increasingly threatened by habitat degradation and overexploitation. Endophytic biotechnology provides a sustainable alternative for exploring the bioactive potential of this plant without imposing additional pressure on its fragile ecosystem. This study aimed to evaluate the antibacterial and antioxidant activities of endophytic fungal extracts isolated from the roots of S. caseolaris. Morphological and molecular techniques were employed for fungal identification, while antibacterial activity was assessed using the disc diffusion assay, and antioxidant capacity was evaluated through the DPPH radical scavenging assay. The selected fungal isolate, RSC2, exhibited strong antibacterial and antioxidant activities. Thin Layer Chromatography (TLC) analysis confirmed the presence of flavonoid compounds, and molecular identification verified the isolate as Aspergillus niger. This study reports, for the first time, the isolation of A. niger from S. caseolaris roots with the ability to produce flavonoid metabolites exhibiting notable bioactive potential. These findings provide a scientific basis for future in vivo investigations aimed at developing natural compounds from mangrove-associated endophytes as promising pharmaceutical candidates.
The Negative effects on the immune system of native chicken embryos (Gallus gallus domesticus) due to extreme environmental fluctuations before incubation lelono, Asmoro
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

Climate variability can influence avian reproductive success by altering environmental factors critical to egg viability and embryonic development. In avian species such as Gallus gallus domesticus, the period before incubation exposes eggs to fluctuating conditions that may affect their survival and the offspring’s physiological performance. This study evaluated the effects of pre-incubation environmental conditions on the growth and immune response of native chickens. Fertilized eggs were subjected to different temperature and humidity treatments before incubation to simulate natural ecological variations. The findings revealed that neither low-temperature exposure nor excessive moisture significantly reduced egg viability or embryonic development. Post-hatching observations, including biometric parameters and tonic immobility tests, showed no significant behavioral differences among treatment groups. Although all chicks exhibited daily weight gain, those from the control group displayed more stable growth patterns, indicated by lower standard error values. Measurements of innate immune response, inferred from body temperature fluctuation, were comparable across groups. These results suggest that native chicken eggs possess physiological plasticity that enables them to maintain normal embryogenesis and immune development under variable environmental conditions

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