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Baidillah Zulkifli
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Trends in Infection and Global Health
Published by Universitas Syiah Kuala
ISSN : 2806646x     EISSN : 2806646x     DOI : https://doi.org/10.24815/tigh.v1i2.23580
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
TIGH publishes primary research papers, review articles, short communications and letters on the following topics: Tropical diseases Microbiology Epidemiology Public health Population health One Health Immunology Chronic diseases Surgical disease and surgical care Chemotherapy and pharmacology Maternal and child health Clinical tropical medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 44 Documents
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A study of wound healing process in post total laryngectomy patients: Serial case reports Srifia Wardianti; Iskandar Zulkarnain; Benny Kurnia; Lily Setiani; Fadhlia Fadhlia; Safarianti Safarianti
Trends in Infection and Global Health Vol 2, No 2 (2022): December 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i2.29360

Abstract

Laryngeal carcinoma is a malignancy on larynx that may occur in glottic, supraglottic and subglottic. Larynx plays role in coordination of upper aerodigestive tract such as breathing, verbal and swallowing. This reported as the third most common malignancy in the ENT-HN department. Total laryngectomy is a procedure that performed on T3 and T4 lesions. The most common complication is prolonged of the wound healing process. The process is very complex  consist of four overlapping phases that involve multifactorial divided into local and systemic factors. Local factors include oxygenation and infection, while systemic factors are age, gender, psychological stress, nutrition, chronic disease and immunocompromise conditions. In this case, seven patients underwent total laryngectomy and contributing factors of wound healing process were observed in each patient until 14th postoperative day. Some of important factors might contributed to the wound healing process in some patients such as psychological stress, nutrition and chronic disease such as diabetes mellitus and hypertension.
Pregnancy in a patient with dilated cardiomyopathy (DCM) Aulia Mustika; Aruman Yudantho
Trends in Infection and Global Health Vol 1, No 2 (2021): December 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v1i2.23285

Abstract

Pregnancy in dilated cardiomyopathy (DCM) has an extremely high risk. However, DCM is usually asymptomatic at a young age. In pregnancy with DCM, it appears progressive and becomes symptomatic. and mimicking with peripartum cardiomyopathy (PPCM). We reported a case of a 23-year-old woman who was 20 weeks pregnant with her first child complained of chest palpitations and severe faintness. These progressive symptoms have happened and started during pregnancy. This case report suggests that physiological and emotional burdens are greater during pregnancy, especially for dilated cardiomyopathy (DCM) patients. This condition often leads to the progression of the DCM. The DCM often headways from the asymptomatic phase upturn to the symptomatic stage.
Phytochemical screening and gel stability test of ethanol extract of Chromolaena odorata L. from Indonesia Putri Handayani; Hanifa Yusuf; Gholib Gholib
Trends in Infection and Global Health Vol 4, No 1 (2024): June 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i1.39971

Abstract

Chromolaena odorata L. is a widely used traditional herbal medicine known for its medicinal usage throughout the world. It has been used by the community for its anti-cancer, anti-bacterial, anti-inflammatory, antipyretic, anti-diabetic, and anti-diarrheal, and it also plays a role in hemostasis and wound healing. This study aims to analyze the chemical compounds of C. odorata leaves from Indonesia and to determine the gel stability of its ethanol extract. In this study, C. odorata leaves were collected from Lamkawe Village, Darul Imarah District, Aceh Besar Regency, Aceh, Indonesia. The extraction process was conducted using the maceration method. The active chemical compounds of the ethanol extract of C. odorata leaves were analyzed through phytochemical screening and gas chromatography-mass spectrometry (GC-MS) analysis. The results of the phytochemical screening indicated it contained terpenoids, saponins, flavonoids and phenolics. The most abundant secondary compounds identified were glycidyl palmitate (17.02%), n-9-octadecenoic acid (Z) (15.68%), hexadecanoic acid and l-(+)-ascorbic acid 2,6-dihexadecanoate (12.19%) and 16-hentriacontanone. The 7.5% ethanol extract of C. odorata leaves showed good stability.
Lumbar metastases in nasopharyngeal carcinoma (NPC) patient with uncomplete chemoradiation Andil Mulya; Lily Setiani
Trends in Infection and Global Health Vol 3, No 1 (2023): June 2023
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v3i1.30014

Abstract

Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. In Indonesia, NPC is the 4th most prevalent. Nasopharyngeal Carcinoma stage IVB as distant metastasis. The therapy in nasopharyngeal carcinoma (NPC) is Chemoradiotherapy. Concurrent chemoradiotherapy is either an established treatment modality or actively being investigated. Chemoradiotherapy have demonstrated decreased incidence of distant metastases compared with radiation only, however only if its treatment done completely. Here we present a rare case of unfinished chemoradiotherapy that caused metastases nasopharyngeal carcinoma patient. A 41-years-old consulted to ENT-HN department with main complaints of progressive cancer pain for 3 month and got worse in past 1 month. Patient also complaints for the pain at the waist, chest and headache currently. However, there was formal history of nasopharyngeal carcinoma for this patient since 2019 that had been treated with 3 cycles of chemotherapy and 26 cycles of radiotherapy. The patient was diagnosed with recurrent nasopharyngeal carcinoma post chemotherapy and radiotherapy with metastatic process. Unfortunately, the treatment underwent was not complete. A nasopharyngeal biopsy was performed and the histopathology result revealed a non-keratinizing squamous cell carcinoma nasopharynx. Lumbar CT-scan showed distant metastatic to lumbar vertebrae I-V. Nasopharyngeal carcinoma (NPC) represents a rare disease that showed as carcinoma that appears in the nasopharynx. The unfinished treatment of NPC leads to recurrent NPC and metastatic process to lumbar vertebrae I-V. Nevertheless, 20% of patients are radioresistant and experience a recurrence, which in most cases manifests with distant metastases.
3D molecular structure analysis of NS2B/NS3 proteases derived from dengue virus and Zika virus Arli Aditya Parikesit; Stefanus Bernard
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.25485

Abstract

Both dengue and Zika viruses have infected millions of people worldwide, urging the development of efficacious drugs and vaccines to fight the infection. Unfortunately, current research is yet to elucidate the structural proteomics comparison of the NS2B/NS3 from both viruses. Therefore, the main objective of this study was to comparatively study the structural proteins between dengue and Zika viruses by leveraging standard homology modelling tools. Our data provide 3D molecular structure overviews of NS2B/NS3 derived from the foregoing viruses. Sequence alignment indicated that the viruses share a 56% similarity rate of protein structures. However, in terms of function, both have NS2B that is pivotal for the activation of NS3 proteases.
Prevalence of shigellosis and associated risk factors among undergraduate students of a private university in Ogun State, Nigeria Seyi Samson Enitan; Joan Odigie; Oluyemisi Ajike Adekunbi; Okondu Ogechukwu Emmanuel; Nwachi Idume Ogbonna; Tsague Metago Claudette Laura; Chukwudi Amaechi Ofodile; Grace Eleojo Itodo; Marcel Edafetanure-Ibeh; Abiodun Oluwasegun Adetola
Trends in Infection and Global Health Vol 1, No 1 (2021): June 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v1i1.22422

Abstract

This cross-sectional, institutional-based study aimed to determine the prevalence of shigellosis and associated risk factors among Babcock University students in Ogun State, Nigeria. One hundred and twenty (120) undergraduate students, 80 females and 40 males, were asked to provide stool specimen in a sterile leak-proof single-use universal bottle with a screw-capped lid. Standard microbiological techniques were used to analyse the stool samples. A questionnaire was designed to collect demographic and clinical information from participants. The data obtained were statistically analysed using the SPSS Statistics software (version 18.0). The study showed that there was no occurrence of shigellosis among the study participants (0%), but other enteric pathogens infection were present in all participants (100%). The three most common mono-infections found among the study participants included Staphylococcus aureus (40%), followed by Escherichia coli (16.7%), and Salmonella typhi and Bacillus spp. (3.3%, each). While the most common prevalence of dual-infections included Staphylococcus aureus and Escherichia coli (33.3%), followed by Staphylococcus aureus and Salmonella typhi (3.3%). The proportion of participants who were asymptomatic (66.7%) was significantly higher than the symptomatic ones (33.3%). Identified risk factors of non-Shigella enteric infection included consumption of beef, vegetables, fruits, poultry/poultry products, as well as street foods, poor hand hygiene before eating, anal cleaning, and poor hand hygiene after toileting. Although shigellosis did not exist among undergraduate students of Babcock University, this study highlighted the existence of other enteric infections among the study participants. Therefore, the necessary preventive measures should be ensured and sustained.
Daily sources of radiation in our environment: Potential Exposure beyond hospitals Yus, Teuku M.; Wijaya, Anandhika; Satria, Darma; Riany, Khairida; Abdullah, Masna D.
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.42462

Abstract

Radiology examinations play a vital role in healthcare worldwide, but patient safety, particularly radiation protection, remains a key concern for all stakeholders. Despite this, some patients and their families still express concerns about the impact of radiation from radiology exams. Healthcare workers, including radiographers, radiologists, interventional surgeons, interventional cardiologists, and others, often find themselves explaining these concerns repeatedly before procedures. Misconceptions about the effects of radiation from medical examinations may stem from misinformation encountered by patients in the past. In reality, people are exposed to various environmental radiation sources daily, often without being aware of it, although the doses are typically low. The goal of this study was to explore the radiation sources that individuals are potentially exposed to on a daily basis. By integrating the ALARA (As Low As Reasonably Achievable) principle into radiological practice, the public should feel more reassured and less anxious about the risks. Thus, it is important for people to understand the sources of radiation in their everyday environment.
Advances in the probiotic production, innovation, and therapeutic applications in health and nutrition Sultan, Hafiz M.; Fatima, Maria; Rehman, Baqa U.; Sajid, Tehseen; Riaz, Maria; Mustafa, Faizan E.; Hassan, Sania; Imran, Syeda A.
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.42582

Abstract

Microorganisms have long been used to produce primary and secondary metabolites essential for human health and environmental sustainability. Due to their rapid growth and reproduction rates, as well as their ability to undergo genetic modifications, microorganisms play a critical role in the manufacturing industry. Probiotics, which are non-pathogenic microorganisms, have gained significant interest due to their various health benefits, including treating vitamin deficiencies, alleviating digestive disorders, enhancing immunity, and detoxifying harmful substances. Probiotics are commonly used to address gastrointestinal issues such as inflammatory bowel disease, as well as conditions like obesity, diabetes, constipation, and colon cancer. Despite these applications, recent advancements in understanding the role of probiotics in managing these diseases have been limited. This review presents the latest insights into probiotics' role in health management. With the growing global population, researchers are focusing on strategies to meet the increasing demand for probiotics. Using advanced techniques, scientists are exploring probiotic strains that can be produced industrially and utilized to treat various medical conditions. This review compiles essential information for probiotic researchers, covering strain selection, production, and applications.
The role of local wisdom in preventing adolescent risk behaviors based on safe communities safe schools in Banda Aceh Renaldi, Teuku; Syukri, Maimun; Oktari, Rina S.; Nurjannah, Nurjannah
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.40836

Abstract

Adolescent risk behavior is a public health problem that occurs globally. The presence of the digital era is characterized by increased access to online content and contributes to the rise of risk behavior among teenagers. The Center for Study and Prevention of Violence (CSPV) at the University of Colorado, United States has developed the concept of Safe Communities Safe Schools (SCSS) as a model for preventing adolescent risk behavior in Colorado. The development of the current situation in Indonesia, especially in Banda Aceh, has given rise to the need for an equivalent concept in Banda Aceh. Adaptation and implementation of the SCSS concept from Colorado to Banda Aceh require adjustments that accommodate cultural components, including local wisdom. The aim of this study was to examine the role of local wisdom in supporting the implementation of SCSS as prevention of risk behavior among adolescents in Banda Aceh. This research uses a qualitative design with a grounded theory approach. Data collection was carried out through in-depth interviews with key informants, namely Acehnese special institutions which officially represent expertise in local wisdom in the City of Banda Aceh. These institutions are: the Regional Education Council (MPD), Aceh Tradition Council (MAA), and Banda Aceh City Ulama Council (MPU). Data analysis was carried out using applied thematic analysis. This research identifies local wisdom sourced from Islamic law, which is a cultural characteristic of the Acehnese people and has the potential to play a role in supporting the implementation of SCSS. The local wisdoms are: education in Islamic values, akhlakul karimah, special relationships between teachers and parents of students (takzim keu guree), and traditional gampong governance. The Banda Aceh City Government has implemented local wisdom education on Islamic values, including akhlakul karimah through the diniyah program in schools. Traditional gampong governance can play its role through two mechanisms: revitalizing the local wisdom of takzim keu guree through community development targeting students' parents and reviving the local wisdom of akhlakul karimah in the community targeting students and families. Local wisdom implemented through the diniyah program is in line with the implementation of SCSS in schools, and local wisdom of traditional gampong governance and takzim keu guree can be a form of support for SCSS from the community. This support can be realized considering that Sharia law and traditional gampong governance have received legal regulation for their implementation in the City of Banda Aceh. Banda Aceh's local wisdom originating from Islamic law can play a role in supporting the implementation of SCSS as a prevention of risk behavior among teenagers in Banda Aceh. This research recommends utilizing local wisdom of Sharia law and gampong governance through regulatory mechanisms and cross-sectoral cooperation.
Delayed growth rate based on bone age in children with idiopathic nephrotic syndrome at a general hospital in Banda Aceh, Indonesia Haris, Syafruddin; Dimiati, Herlina; Hasballah, Kartini; Pardede, Sudung O.
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.42807

Abstract

Paediatric nephrotic syndrome is the most common kidney disease in children, with corticosteroids as the primary treatment. While effective, corticosteroid therapy may decrease bone mineral density. Concurrent vitamin D and calcium supplementation can mitigate bone loss but does not entirely prevent it and may introduce side effects. This study assessed growth delay based on bone age in children with idiopathic nephrotic syndrome receiving long-term steroid therapy at Dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. This observational analytic study used a retrospective cohort design, with data collected from the hospitals Paediatric Polyclinic over one month. Paediatric patients diagnosed with INS who met inclusion criteria were included, and data were extracted from electronic medical records. Statistical analysis was conducted using the Mann-Whitney test. Among the 50 children included, 32 (64%) were male and 18 (36%) were female. The median corticosteroid therapy duration was 24 months (range: 284 months). No significant association was found between corticosteroid therapy duration and growth delay, as measured by BA (p=0.363). INS was more common in boys, particularly in the six to 10-year age group. Most participants had normal nutritional status and stature, with steroid-resistant nephrotic syndrome being the most prevalent type. The findings suggest no relationship between corticosteroid therapy duration and growth delay based on bone age, providing reassurance about the treatments impact on growth outcomes.

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